fentanyl patch (MRQ 01) / Nippon Kayaku, Maruishi Pharma - LARVOL DELTA

Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study. (PubMed, J Intensive Care) - "Remifentanil can be used safely for pain management in mechanically ventilated Japanese patients in the ICU."

Clinical • Head-to-Head • Journal • P3 data • PK/PD data • Critical care • Pain

SR 57227A, a serotonin type-3 receptor agonist, as a candidate analgesic agent targeting nociplastic pain. (PubMed, Biochem Biophys Res Commun) - "We previously reported that pain-like behaviors in mice can be induced by environmental cues in which a pain stimulus was previously presented, and that pain was reduced using fentanyl (an opioid). Unlike opioids, SR 57227A induced no preference behaviors as measured by the conditioned place preference test. These data suggested that SR 57227A is an effective alternative pain reliever to opioids that targets chronic pain."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Mood Disorders • Pain • Psychiatry • FOS

"Israel promotes settlement plan for sensitive East Jerusalem area https://t.co/8gevONkQ01" (@Reuters)