LiVal (lithium valproate) / BioLink Life Sci - LARVOL DELTA

Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy (Neurology) - PMID: 24089388; "More subjects receiving valproic acid (49%) had attention deficits than subjects receiving ethosuximide (32%) or lamotrigine (24%) (p = 0.0006). Parental assessment did not reliably detect attention deficits before or after treatment (p < 0.0001)...This study provides Class I evidence that valproic acid is associated with more significant attentional dysfunction than ethosuximide or lamotrigine in children with newly diagnosed CAE."

Adverse events • Epilepsy

The effect of antiepileptic drugs on thyroid function in children (Seizure) - PMID: 24091037; P=NA, N=223; "Valproate-treated patients had decreased fT4 and increased TSH levels at months 1, 6, and 12. Carbamazepine-treated patients had decreased fT4 levels at months 1, 6, and 12 and increased TSH levels at months 1, and 6...The frequency of subclinical hypothyroidism at month 12 was 28% in valproate, 21.4% in oxcarbazepine, 18.2% in phenobarbital, 13.9% in carbamazepine, and 0% in levetiracetam groups."

Adverse events