diflorasone diacetate / Generic mfg. - LARVOL DELTA

The immunosuppressive effect of glucocorticoids in human primary T cells is mainly mediated via a rapid inhibition of the IL-2/IL-2R signaling axis. (PubMed, Cell Commun Signal) - "Our study, by showing that GCs rapidly suppress the IL-2/IL-2R expression and signaling without significantly affecting proximal TCR signaling, has highlighted a clear mechanism of action of GCs that contributes to their therapeutic efficacy."

IO biomarker • Journal • IL2RA • LCK • ZAP70

Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on Potential miRNA Biomarkers. (PubMed, J Xenobiot) - "Among the drugs that exhibit the same miRNA expression profile as hesperidin, potential candidates include desoximetasone, curcumin, flurandrenolide, trifluridine, fludrocortisone, diflorasone, gemcitabine, floxuridine, and reversine. Further investigation of these drugs is essential to improve the treatment of cardiovascular disease. Additionally, supporting the clinical use of miRNAs as biomarkers for diagnosing and predicting CVD is crucial."

Biomarker • Journal • Cardiovascular • HDAC5 • WNK1

A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease. (PubMed, iScience) - "In short, gallamine triethiotide, diflorasone, fenoterol, and pralidoxime ameliorate steatosis similarly to resveratrol/sirolimus. The implementation holds great potential in reducing screening time in the early drug discovery stages and in delivering promising compounds for in vivo testing."

Journal • Hepatology • Non-alcoholic Fatty Liver Disease

Cytotoxic activity of phytochemicals from Garcinia mangostana L. and G. benthamiana (Planch. & Triana) Pipoly against breast cancer cells. (PubMed, Nat Prod Res) - "Molecular docking simulation study of 1, 2, 4 and 5 with 2OCF and 4PIV implied that the induction of apoptosis for both cancer cells involve ER and FAS signaling pathways. Future study on the lead optimization of 5 is highly recommended."

Journal • Breast Cancer • Oncology • Solid Tumor

Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6- epi-Garcimultiflorone A. (PubMed, J Am Chem Soc) - "Using this strategy, we achieved the enantioselective total syntheses of the type A PPAPs (-)-nemorosone and (-)-6- epi-garcimultiflorone A. Diverse photocyclization substrates have been investigated leading to divergent photocyclization processes as a function of tether length. Photophysical studies were performed, and photocyclization mechanisms were proposed based on investigation of various substrates as well as deuterium-labeling experiments."

Journal

Nortriketones: Antimicrobial Trimethylated Acylphloroglucinols from Ma̅nuka (Leptospermum scoparium). (PubMed) - J Nat Prod - "Unlike their tetramethylated analogues, the nortriketones were inactive against the herbicide target enzyme p-hydroxyphenylpyruvate dioxygenase. The Raman spectra of leaf oil glands in different ma̅nuka varieties can be used to distinguish plants that contain nortriketones from those that accumulate triketones."

Journal • Biosimilar

Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells. (PubMed, Phytomedicine) - "Conclusion Our data demonstrate the anti-angiogneic effects of garcimultiflorone K in both in vitro and in vivo models. Garcimultiflorone K appears to have potential in the treatment of angiogenesis-related diseases."

Journal

Erythema with pustular folliculitis: a rare drug eruption induced by infliximab (AAD 2019) - "...Infliximab was discontinued and an alternative therapy with ustekinumab has sustained remission of the CD...He was treated with topical diflorasone diacetate with adequate response and opted to continue infliximab therapy...The present report highlights that the severe ACDR of folliculitis, as in Case 1, requires systemic therapies. This is the first report on ACDRs to TNF-alpha inhibitors successfully treated with GMA."