4D-175 / 4D Molecular Therap - LARVOL DELTA

Gene Therapy for Non-Hereditary Retinal Disease: Age-Related Macular Degeneration, Diabetic Retinopathy, and Beyond. (PubMed, Genes (Basel)) - "This manuscript reviews ongoing gene therapy clinical trials for these disorders, including ABBV-RGX-314, ixoberogene soroparvovec (ixo-vec), and 4D-150. ABBV-RGX-314 utilizes an adeno-associated virus (AAV) vector to deliver a transgene encoding a ranibizumab-like anti-VEGF antibody fragment, demonstrating promising results in Phase 1/2a and ongoing Phase 2b/3 trials...Other therapies reviewed include EXG102-031, FT-003, KH631, OLX10212, JNJ-1887, 4D-175, and OCU410. These therapies offer potential advantages of reduced treatment frequency and enhanced safety profiles, representing a paradigm shift in management towards durable and efficacious cellular-based biofactories. These advancements in gene therapy hold promise for improving outcomes in AMD and addressing the complex challenges of DME and DR, providing new avenues for the treatment of diabetic eye diseases."

Gene therapy • Journal • Review • Age-related Macular Degeneration • Diabetic Macular Edema • Diabetic Retinopathy • Gene Therapies • Macular Degeneration • Ophthalmology • Retinal Disorders • Wet Age-related Macular Degeneration • VEGFC

Preclinical characterization of 4D-175, a novel AAV-based investigational intravitreal gene therapy for geographic atrophy (ARVO 2024) - "Preclinical evaluation of 4D-175 demonstrated dose-dependent sCFH transgene expression and prevention of complement activation in human RPE cells in vitro and favorable tolerability following IVT administration to NHPs. Results from ongoing ocular safety and biodistribution analyses are anticipated in early 2024."

Gene therapy • Preclinical • Age-related Macular Degeneration • Dry Age-related Macular Degeneration • Ocular Inflammation • Ophthalmology • Retinal Disorders

"$FDMT 4DMT Acquires Complement Pathway Inhibitor Payload for 4D-175 Product Candidate for Geographic Atrophy https://t.co/XzrxQZvEkf #trading" (@stock_titan)

Age-related Macular Degeneration • Dry Age-related Macular Degeneration