teicoplanin / Generic mfg. - LARVOL DELTA

Prosthetic joint infections in shoulder and elbow: An evaluation of micro-organisms in periprosthetic shoulder and elbow joint infections across the United Kingdom. (PubMed, Shoulder Elbow) - "Teicoplanin with gentamicin was the most used peri-operative anti-microbial protocol (35%). CNS, C. acnes and MSSA were common in shoulder PJI and CNS and MSSA in elbow PJI. Peri-operative antibiotic protocols and intra-operative sampling methods varied."

Journal • Infectious Disease • Orthopedics

Penicillin remains an effective agent against Group A Streptococcus in low- and middle-income countries: A systematic review and meta-analysis of antibiotic resistance and associated genes. (PubMed, S Afr Med J) - "This review comprehensively characterises the latest evidence on the prevalence of antibiotic resistance in Strep A in LMICs. Strep A in LMICs continues to be highly susceptible to antibiotics in vitro, primarily to penicillins. Strep A macrolide resistance patterns in LMICs are similar to those observed in high-income countries. The findings of this review may serve to inform effective treatment decisions and public health interventions."

Clinical • Journal • Retrospective data • Review

ICG clearance as an indicator of augmented hepatic clearance and subtherapeutic drug concentrations in septic patients. (PubMed, BMC Anesthesiol) - "AHC is a prevalent phenotype in sepsis and identifies a patient subgroup at high risk for subtherapeutic concentrations of hepatically or partially cleared antibiotics. ICG-derived parameters, particularly ICG-PDR, are robust predictors of inadequate drug exposure, supporting the use of dynamic liver function monitoring to optimize antibiotic dosing in septic patients."

Journal • Critical care • Infectious Disease • Septic Shock

Leukocytoclastic Vasculitis and Profound Cytopenias Following Teicoplanin Therapy: A Case Report on Glycopeptide Cross-Reactivity. (PubMed, Clin Ther) - "This case highlights the risks of glycopeptide cross-reactivity and the importance of close hematologic monitoring."

Journal • Allergy • Cardiovascular • Hematological Disorders • Immunology • Neutropenia • Renal Disease • Thrombocytopenia • Vasculitis

Model-based optimisation for teicoplanin dosing in patients undergoing maintenance haemodialysis. (PubMed, Clin Microbiol Infect) - P=N/A | "The current study proposed an optimised dosing strategy to maximise PTA in patients undergoing maintenance haemodialysis, although prospective validation is recommended before clinical implementation. Furthermore, the estimated high clearance variability underscores the need for TDM in teicoplanin dosing for this population."

Journal • Infectious Disease

Analysis of Antimicrobial Resistance Trends and Characteristics of Vancomycin-resistant Enterococcus faecium Isolated in the Republic of Korea from 2018 to 2023 (PubMed, Jugan Geongang Gwa Jilbyeong) - "The analysis revealed that all strains were resistant to vancomycin, levofloxacin, and ciprofloxacin, but susceptible to linezolid and chloramphenicol...Among these, 55 strains (30.7%) exhibited the VanB phenotype and showed intermediate resistance or susceptibility to teicoplanin...Multilocus sequence typing analysis revealed ST17 (48.1%) and ST192 (11.1%) as the predominant sequence types, consistent with the global distribution patterns of vancomycin-resistant E. faecium (VREfm). This study provides critical insights into the antibiotic resistance trends and genetic characteristics of VREfm in the Republic of Korea, offering a foundation for antibiotic resistance prevention and infection control efforts."

Journal • Infectious Disease

Postoperative spondylodiscitis: Five-year, single-center retrospective analysis. Is it really postoperative? (PubMed, Med J Malaysia) - "It Should be kept in mind that in cases where the POSD patients do not benefit from empirical treatment, the causative agent may be an agent other than the common microorganisms, for example M. tuberculosis, and if the agent cannot be detected, finding the diagnosis from treatment is also an option."

Journal • Retrospective data • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis • CRP

Staphylococcus aureus bloodstream infection at a referral children's hospital in Cape Town, South Africa, 2018-2022. (PubMed, BMC Infect Dis) - "S. aureus BSI remains a major cause of morbidity and mortality in children. Admission to ICU during a BSI episode was significantly associated with 28-day mortality. Furthermore, over time changes to the epidemiology of S. aureus BSI have occurred at RCWMCH."

Journal • Critical care • Human Immunodeficiency Virus • Infectious Disease • Septic Shock

Design Optimization for Developing Population Pharmacokinetic Models in Critically Ill Children: Application to Teicoplanin, Piperacillin and Meropenem. (PubMed, Clin Pharmacokinet) - "This work emphasizes the importance of optimizing study designs to improve accuracy and precision in the model parameters while reducing the number of samples needed. This is a relevant advantage especially when dealing with critically ill pediatric patients."

Journal • PK/PD data • Pediatrics

An observational study on multidrug resistance in pediatric patients with urinary tract infections. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Escherichia coli demonstrated high resistance to nalidixic acid (84.4%), ampicillin (78.1%), and ciprofloxacin (78.1%), while maintaining high susceptibility to fosfomycin (90.6%), ertapenem (81.3%), gentamicin (71.9%), and nitrofurantoin (71.9%)...exhibited high resistance to tetracycline (64.3%), and levofloxacin (63%). but remained sensitive to linezolid (93.27%), vancomycin (85.71%), teicoplanin (78.57%), and tigecycline (71.4%)...Fosfomycin, nitrofurantoin, and carbapenems retain efficacy, though over-reliance may accelerate resistance. Regular, pediatric-specific AMR surveillance and antimicrobial stewardship programs are essential to preserve treatment efficacy and improve outcomes in this vulnerable population."

Journal • Observational data • Infectious Disease • Nephrology • Pediatrics • Pneumonia

Surface Functionalization of TiO2 With an Albumin-Teicoplanin Complex to Prevent Implant-Associated Infections. (PubMed, J Biomed Mater Res A) - "Direct functionalization of TiO2 with the AB-TP complex yields a stable, durable, and antibacterial surface capable of withstanding physiological conditions. This approach bypasses the limitations of adhesive layers and demonstrates potential for application in orthopedic implant coatings."

Journal • Infectious Disease • Orthopedics

Aerobic Pathogens and Antimicrobial Susceptibility in Odontogenic Infections: A One-Year Observational Study from Southwestern Romania. (PubMed, Medicina (Kaunas)) - "remained susceptible to penicillin G (82.3%), amoxicillin-clavulanate (76.4%), and clindamycin (70.5%), but only 55.0% to erythromycin. Most S. aureus isolates were methicillin-susceptible (92.9%), while coagulase-negative staphylococci showed high methicillin resistance (59.3%) yet full susceptibility to linezolid, vancomycin, and teicoplanin. Enterobacterales were resistant to ampicillin (90%) and amoxicillin-clavulanate (65%) but remained susceptible to ceftriaxone (80%) and ciprofloxacin (85%)...aeruginosa isolates were fully susceptible to piperacillin-tazobactam, ceftazidime, cefepime, and meropenem...Surgical drainage remains central to management, and antibiotic therapy should be guided by local susceptibility patterns. These data provide baseline information to inform empirical therapy and stewardship efforts and highlight the need for multicenter studies including anaerobic and molecular analyses."

Journal • Observational data • Infectious Disease

Clinico Microbiological Profile of Diabetic Foot Ulcers: A Retrospective Study. (PubMed, Cureus) - "This study has enhanced our understanding of the epidemiology of diabetic foot ulcers by identifying common pathogens. The antibiotic susceptibility pattern of the pathogens will help clinicians provide better empirical therapy, thereby promoting faster wound healing."

Journal • Retrospective data • Diabetes • Infectious Disease • Metabolic Disorders • Pneumonia

A Six-Year Surveillance of Nasal Methicillin-Resistant Staphylococcus aureus Colonization on Intensive Care Unit Admission: Do We Need Screening? (PubMed, Infect Dis Rep) - "All 29 strains were susceptible to vancomycin, linezolid, and daptomycin, while one strain was resistant to teicoplanin (3.5%). Screening should be performed because MRSA colonization may be a risk factor for invasive infections; however, screening all patients would be prohibitively expensive and labor-intensive. Instead, it may be more appropriate to identify risk factors and then screen select patients."

Journal • Chronic Kidney Disease • Critical care • Infectious Disease • Pneumonia • Renal Disease • Respiratory Diseases

Acute Pericarditis After Percutaneous Coronary Intervention. (PubMed, Cureus) - "He was treated as possible infective pericarditis with intravenous (IV) teicoplanin and piperacillin-tazobactam, which was stepped down to oral co-trimoxazole on discharge. Three weeks after completing the oral antibiotics, he was re-admitted again with fevers and chest pain...He was continued on colchicine and started on ibuprofen. Due to the recurrent episodes of pericarditis, he was also commenced on a weaning course of prednisolone. The patient's symptoms subsequently improved after treatment, and he is awaiting follow-up with his Cardiologist, alongside a repeat ECHO prior to the appointment."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Myocardial Infarction • Pain

Separation and Analysis of Chiral Compounds by Nano-Liquid Chromatography Using Glycopeptide Antibiotics. (PubMed, Methods Mol Biol) - "This chapter describes the separation and analysis of some chiral compounds using stationary phases containing glycopeptide antibiotics, namely vancomycin or teicoplanin, by nano-liquid chromatography. The synthesis, the chemical compounds, the experimental conditions, and the instrumentation are described. Two examples of chiral separation of some drugs and amino alcohols are reported."

Journal

A case report on severe atypical bullous erysipelas induced by Escherichia coli in an immunosuppressed individual. (PubMed, Front Immunol) - "Following the initial ineffective treatment with cefuroxime, the regimen was escalated to meropenem in combination with teicoplanin. Upon confirmation of the pathogenic microorganism, the treatment was de-escalated to piperacillin/tazobactam within 24 hours, supplemented by comprehensive wound management (iodophor wet dressing, lithospermum oil application, and red light therapy) and organ support therapy...This case underscores three critical warnings: 1) the pathogen spectrum of erysipelas in immunosuppressed hosts shows a significant shift, necessitating vigilance against the possibility of Gram-negative bacterial infections, such as Escherichia coli; 2) atypical bullous skin lesions can serve as an early indicator of severe infection, with a rapid clinical course progressing to shock within 24 hours; 3) a tiered anti-infective strategy is paramount - initially broad-spectrum coverage for both Gram-negative and Gram-positive bacteria (e.g., anti-pseudomonal β-lactams..."

Journal • Dermatology • Immunology • Infectious Disease • Inflammatory Arthritis • Pain • Rheumatoid Arthritis • Rheumatology • Septic Shock

Impact of hypoalbuminemia severity on total teicoplanin concentrations after 3 days loading dose: a retrospective observational study. (PubMed, J Infect Chemother) - "The more severe the hypoalbuminemia, the lower the total TEIC Ctrough; however, predicted free TEIC Ctrough might not be affected. Overall, setting lower target total TEIC concentrations may be beneficial in case of hypoalbuminemia."

Journal • Observational data • Retrospective data

Australian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Surveillance Outcome Program (AESOP) Bloodstream Infection Annual Report 2024. (PubMed, Commun Dis Intell (2018)) - "The isolate was vancomycin and teicoplanin resistant and harboured vanA and optrA genes. Overall, 54.6% of E. faecium isolates belonging to the eight predominant STs harboured the vanA or vanB gene. AESOP 2024 has shown that enterococcal bacteraemia episodes in Australia continue to be frequently caused by polyclonal ampicillin-resistant high-level gentamicin-resistant vanA- or vanB-positive E. faecium which have limited treatment options."

Journal • Infectious Disease

Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP) Bloodstream Infection Annual Report 2024. (PubMed, Commun Dis Intell (2018)) - "However, in addition to the β-lactams, 34.8% of MRSA were resistant to erythromycin; 28.9% to ciprofloxacin; 13.1% to gentamicin; 11.0% to tetracycline; and 2.7% to cotrimoxazole. A daptomycin-resistant MRSA from New South Wales was identified...When applying the European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints, teicoplanin resistance was detected in three MSSA isolates. Linezolid or vancomycin resistance was not detected. Resistance to the non-β-lactam antimicrobials was largely attributable to the predominant healthcare-associated MRSA (HA-MRSA) clone ST22-IV [2B] (EMRSA-15), and to the community-associated MRSA (CA-MRSA) clone ST45-V [5C2&5], which has acquired resistance to multiple antimicrobials including ciprofloxacin, clindamycin, erythromycin, gentamicin, and tetracycline...Although polyclonal, approximately 72% of CA-MRSA clones were characterised as ST93-IV [2B] (Queensland clone), ST5-IV [2B], ST45-V [5C2&5], ST8-IV..."

Journal • Infectious Disease

Trends and patterns of UTIs in Sindh, Pakistan with a focus on vancomycin-resistant enterococci. (PubMed, Pak J Pharm Sci) - "VRE phenotypes were checked using vancomycin and teicoplanin discs...All Enterococci were resistant to cefotaxime, ampicillin and co-amoxiclav and susceptible to linezolid...The negligent-opportunistic M. morganii has emerged the fourth-leading cause of UTIs. We recommend focusing on VanRS system, a potential target of novel therapeutics for VRE."

Journal • Infectious Disease • Nephrology

A SINGLE CENTER RETROSPECTIVE EXPERIENCE ABOUT INFECTIONS AND ANTIMICROBIALS USE DURING CAR T-CELLS HOSPITALISATION FOR RELAPSED/REFRACTORY LYMPHOMA (SIE 2025) - "Twenty-six lymphoma pts were treated from April 2021 to December 2024: 16 DLBCL, 5 PMBCL and 5 MCL received Axi-Cel (14 pts), Tisa-Cel (7 pts) and Brexu-Cel (5 pts)...Eighteen pts received Tocilizumab, 17 pts Dexamethasone, 10 pts received high dose Metilprednisolone, 4 pts had Anakinra...The most prescribed molecule was piperacilline-tazobactam in 1st line for 24 pts; follows meropenem used in 11 pts as 2nd line and vancomycin in 11 pts as 2nd antibiotic and in 8 pts as 3rd molecule. Three pts received Linezolid (as 2nd, 3rd and 4th molecule respectively), two pts fosfomycine (as 3rd and 4th molecule in association), one pt teicoplanine as 3rd molecule, 1 pt Ceftaroline as 5th antibiotic. Drugs like Cefiderocol and Vaborem were used 3 times: the latter was used as 4th and 5th molecule in 2 pts and Cefiderocol as 1st line in the context of known A.Baumannii and S. Maltophilia colonisation...For mold prophylaxis, 14 pts received Mycafungin, 6 pts Isavuconazole, 4 pts..."

CAR T-Cell Therapy • Retrospective data • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Infectious Disease • Lymphoma • Primary Mediastinal Large B-Cell Lymphoma • Respiratory Diseases

The effects of the combined use of carbon quantum dots and antibacterial agents on pathogenic bacteria. (PubMed, Turk J Biol) - "A synergistic effect was particularly observed when CCQDs-2 were combined with antibiotics such as gentamicin, levofloxacin, and clindamycin, suggesting potential mechanisms such as membrane permeability disruption and efflux pump saturation. These findings underscore the promising potential of carbon-based QDs as innovative, biocompatible solutions to address the critical global challenge of antimicrobial resistance."

Journal • Infectious Disease

Tolerability of subcutaneous teicoplanin administration in an Australian tertiary hospital clinical setting. (PubMed, Intern Med J) - No abstract available

Journal

An Antibiotic-Based Scoring Model for Predicting Early and Late Hematologic Toxicity Following CD19 CAR-T Therapy in B-ALL Patients (ASH 2024) - "High-risk antibiotics (HR ABX) were identified as the most used ones, including meropenem, teicoplanin, piperacillin, and ceftazidime. A high score represents a greater risk of severe cytopenia, either occurring early (before day 28) or prolonged (6-months follow-up). Finally, patients with high scores in the model exhibited notably poorer clinical outcomes."

Clinical • Anemia • B Acute Lymphoblastic Leukemia • Hematological Disorders • Hematological Malignancies • Neutropenia • Oncology • Thrombocytopenia