teicoplanin / Generic mfg. - LARVOL DELTA

Bacterial Contamination in Stored Blood for Transfusion and Associated Infectious Risks Among Patients with Cancer at Mbarara Regional Referral Hospital, in Uganda. (PubMed, J Blood Med) - "The isolates exhibited variable resistance to erythromycin, clindamycin, teicoplanin, vancomycin, tetracycline, nitrofurantoin, rifampicin, and trimethoprim-sulfamethoxazole. The four bacterial isolates were resistant to common antibiotics, which poses a risk of transmission of antibiotic-resistant strains to immunocompromised recipients with cancer. Notably, there was no infectious risk posed post-transfusion presumably due to the concurrent antibiotic therapy."

Journal • Infectious Disease • Oncology • Renal Cell Carcinoma

Methicillin resistance and antimicrobial non-susceptibility trends among Staphylococcus aureus clinical isolates in Aseer, Saudi Arabia (2013-2024): A retrospective laboratory-based surveillance study. (PubMed, PLoS One) - "In this single-center Aseer surveillance, MRSA became the majority of S. aureus during 2013-2024 and showed broad multidrug non-susceptibility, while vancomycin and daptomycin retained full in vitro activity. These local findings support sustained laboratory-based surveillance, Aseer-tailored empirical and stewardship guidance, and confirmatory testing of the emerging low-level linezolid non-susceptibility signal."

Journal • Retrospective data • Infectious Disease

Spectrum, Clinical Characteristics, and Outcomes of Infections in Renal Allograft Recipients: A Three-Year Prospective Study (TTS 2026) - "UTIs were treated requently with broad-spectrum antibiotic,meropenem and ceftriaxone, followed by piperacillin–tazobactam, colistin, fosfomycin, and oral cephalosporins...Gram-positive infections were managed with linezolid, teicoplanin, or vancomycin.Skin and soft-tissue infections clinically significant, including herpes zoster (3.0%), cutaneous aspergillosis, viral warts (HPV), non-tuberculous mycobacterial wound infection,and multiple staphylococcal abscesses... Infections are a major contributor to morbidity in renal allograft recipients. Strengthening infection surveillance, preventive measures, and prompt treatment may help improve patient survival and long-term outcomes."

Clinical • Chronic Kidney Disease • Glomerulonephritis • Herpes Zoster • Infectious Disease • Lupus Nephritis • Nephrology • Nontuberculous Mycobacterial Disease • Pneumonia • Respiratory Diseases • Tuberculosis • Varicella Zoster

An unsual case of late onset mycophenolate mofetil induced pancytopenia with sterile oral ulcers in a kidney transplant recipient: A case report (TTS 2026) - "Meropenem and Caspofungin started empirically...G-CSF(300 mcg OD) initiated,teicoplanin (Day 5 for neutropenic fever), 2 units PRBCs, 2 SDP platelets (for gross hematuria), and romiplostim 50 mcg SC...KTRs surviving febrile neutropenia face 31% acute rejection and 15% graft loss risk from persistent dose reduction. Our patient requires vigilant immunological monitoring on steroid-tacrolimus regimen with plan to reintroduce MMF in a lower dose later."

Case report • Clinical • Febrile Neutropenia • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Infectious Disease • Leukopenia • Neutropenia • Thrombocytopenia • Transplant Rejection • Transplantation

Staphylococcus pettenkoferi: an underrecognized species with clinically relevant antimicrobial resistance. A comprehensive genomic European study. (PubMed, Emerg Microbes Infect) - "Susceptibility rates were below 70% for cefoxitin, erythromycin, and levofloxacin, whereas high susceptibility (>90%) was observed for vancomycin, teicoplanin, dalbavancin, aminoglycosides, oxazolidinones, trimethoprim-sulfamethoxazole, fusidic acid, and tetracycline. Nearly all isolates (92.1%) were fosfomycin-resistant...This study provides a comprehensive genomic and phenotypic assessment of antimicrobial resistance in S. pettenkoferi, revealing widespread multidrug-resistant lineages, including ceftobiprole- and daptomycin-resistant isolates across distinct clades. These findings underscore the need for continued surveillance and improved diagnostics for this increasingly encountered CoNS species."

Journal • Infectious Disease • Inflammation

Clostridioides (Clostridium) Difficile Infection in the First Year after Hematopoietic Stem Cell Transplantation: A Single Center Experience from a Tertiary Care Center in India. (PubMed, Indian J Hematol Blood Transfus) - "Twenty-six and 14 patients respectively were initially treated with oral vancomycin and teicoplanin monotherapy. It shows that oral teicoplanin is a good therapeutic option and needs to be explored further in the form of randomized clinical trials. FMT, though challenging, is doable in our settings."

Clinical • Journal • Bone Marrow Transplantation • Infectious Disease • Transplantation

Clinical outcomes of teicoplanin for Corynebacterium species bacteremia: A retrospective observational study. (PubMed, Eur J Clin Microbiol Infect Dis) - "TEIC may represent a reasonable treatment option for Corynebacterium species bacteremia. Favorable outcomes were observed even among immunocompromised patients with hematological malignancies."

Clinical data • Journal • Observational data • Retrospective data • Hematological Disorders • Hematological Malignancies • Oncology

Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr-Pyrazole Chemistry. (PubMed, ChemMedChem) - "While the chemoenzymatic synthesis of the more hydrophilic type I GPAs like vancomycin has aided our understanding of GPA crosslinking pathways, type II-V GPAs remain underexplored...Here, we explore the use of modified Knorr-pyrazole chemistry to provide access to hydrophobic peptidyl-CoA substrates of the type II/IIa GPAs, kineomicin and actinoidin, and the type IV GPA, teicoplanin. Yields of peptidyl-CoAs were improved 3-7-fold through careful tuning of reaction solvents and the arylthiol used for displacement of the pyrazole. The type II/IIa GPA scaffolds explored in this study displayed the highest in vitro OxyC activity seen to date, likely due to both improved synthesis and their structural properties."

Journal • Infectious Disease

Treatment patterns and reoperation rates in periprosthetic joint infection identified 1 - 6 months after arthroplasty in Japan: A descriptive analysis using nationwide claims data. (PubMed, Int J Clin Pharmacol Ther) - "This claims-based descriptive analysis indicated that treatment escalation and reoperation were observed after claims-defined postoperative PJI identified 1 - 6 months after arthroplasty. Because pathogen data were unavailable and receipt of anti-MRSA agents was used as a treatment-based classification, these findings should be interpreted as descriptive treatment-pattern data rather than microbiologically confirmed comparisons."

Journal • Diabetes • Hepatology • Infectious Disease • Metabolic Disorders • Orthopedics • Pain

Disseminated Septic Emboli From Aortic Valve Infective Endocarditis in an Immunocompromised Patient: A Case Report. (PubMed, Cureus) - "We report the case of a 50-year-old woman with cervical squamous cell carcinoma receiving pembrolizumab and infliximab who presented with fever, progressive blistering skin lesions, non-pruritic rash, and new right-sided neurological deficits...The patient initially received empirical piperacillin-tazobactam and gentamicin for severe sepsis. Following multidisciplinary microbiology review, antimicrobial therapy was escalated to meropenem and teicoplanin to provide broad-spectrum coverage while the diagnostic evaluation was ongoing because of extensive cerebral, pulmonary, and soft tissue infection in an immunocompromised host...This case highlights the diagnostic complexity of disseminated infection in immunocompromised oncology patients, particularly when septic emboli and cerebral abscesses mimic metastatic disease or immune-related adverse events. Early multidisciplinary assessment and prompt antimicrobial therapy were essential in achieving clinical..."

IO biomarker • Journal • Cardiovascular • Cervical Cancer • Cervical Squamous Cell Carcinoma • Dermatology • Hepatology • Infectious Disease • Oncology • Septic Shock • Squamous Cell Carcinoma • Steven-Johnson Syndrome

In vitro activity of ceftaroline against clinical isolates of Gram-positive bacteria in paediatric patients: ATLAS programme 2018-2023. (PubMed, JAC Antimicrob Resist) - "High susceptibility to daptomycin, linezolid, teicoplanin, tigecycline (from the FDA), trimethoprim/sulfamethoxazole and vancomycin was demonstrated against these isolates for both breakpoints...High susceptibility to linezolid, levofloxacin, tigecycline and vancomycin was demonstrated against these isolates across regions from both breakpoints, whereas, for ceftriaxone, higher susceptibility following the CLSI than EUCAST was observed...Ceftaroline demonstrated potent activity against key GPB. This study significantly contributes to the limited current information on paediatric antimicrobial resistance patterns across AfME, APAC, Europe and LATAM."

Journal • Preclinical • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia

Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Pathogens Causing Central Line-Associated Bloodstream Infections in Adult Intensive Care Unit Patients at a Tertiary Care Hospital. (PubMed, Cureus) - "CLABSIs continue to be notable healthcare-associated infections among ICU patients with CVCs, affecting 35 (14.29%) of the 245 patients included in the study. The prevalence of multidrug-resistant Gram-negative bacteria, particularly Klebsiella pneumoniae and Acinetobacter baumannii, underscores the necessity for ongoing microbiological surveillance, ICU-specific antibiograms, stringent infection control measures, judicious empirical antibiotic therapy, antimicrobial stewardship, and prompt removal of superfluous central lines to mitigate the incidence of CLABSIs. They may support the development of local ICU-specific antibiograms and institutional infection-control and antimicrobial-stewardship policies."

Journal • Critical care • Infectious Disease • Pneumonia

Methicillin-Resistant Staphylococcus aureus Bacteremia Originating From a Ureteral Stent-Associated Urinary Tract Infection: A Case Report. (PubMed, Cureus) - "Targeted therapy with teicoplanin led to rapid clinical improvement and microbiological clearance. This case highlights that ureteral stents may serve as a source of MRSA bacteremia even in the absence of complete obstruction, emphasizing the importance of prompt source control and appropriate antimicrobial therapy."

Journal • Infectious Disease • Nephrology

Resistance to Human-Reserved Antimicrobials in Clinical and Commensal Enterococcus faecalis and Enterococcus faecium from Dogs and Cats. (PubMed, Antibiotics (Basel)) - "faecium exhibited significantly higher resistance rates than E. faecalis, particularly to ampicillin, fluoroquinolones, erythromycin, nitrofurantoin, and vancomycin...Clinical E. faecium isolates showed significantly higher resistance than commensal isolates to antimicrobials commonly used in veterinary medicine, including ampicillin, fluoroquinolones, erythromycin, gentamicin, streptomycin, and tetracycline. Conversely, no significant differences were observed for antimicrobials reserved for human medicine, including linezolid, vancomycin, teicoplanin, tigecycline, daptomycin, rifampicin, and quinupristin/dalfopristin...Continuous integrated One Health surveillance is essential to monitor the emergence and dissemination of these resistance phenotypes. The AMR profiles observed in companion animals further support the need for integrated One Health surveillance, combining veterinary, human, and environmental data to better understand the emergence and dissemination of..."

Journal

Virulence Gene Profile and Antimicrobial Susceptibility of Staphylococcus aureus Clinical Isolates from the United Arab Emirates. (PubMed, Microorganisms) - "Resistance was highest for ampicillin and penicillin (86% each), while full susceptibility (100%) was retained for vancomycin, linezolid, daptomycin, teicoplanin, rifampin, Synercid, and trimethoprim. mecA carriage was significantly associated with resistance to amoxicillin, clavulanate, ampicillin, imipenem, penicillin, oxacillin, azithromycin, erythromycin, and ciprofloxacin (p < 0.05). This study provides the first integrated molecular characterization of key S. aureus virulence determinants, along with a comprehensive antimicrobial susceptibility profile in the UAE. The high PVL prevalence and substantial MRSA burden highlight the need for structured regional surveillance and antimicrobial stewardship, while retained susceptibility to last-resort agents offer actionable guidance for empirical therapy."

Journal • Infectious Disease • Septic Shock

Real-World Patterns of Delayed Cutaneous Adverse Reactions to Antimicrobial Therapy in Children: A Case Series and FAERS Analysis Across Age Groups. (PubMed, Antibiotics (Basel)) - "FAERS analysis identified 97 delayed rash reports, associated with prolonged treatment duration, frequent polytherapy, and higher reporting rates for vancomycin, teicoplanin, and beta-lactam combination regimens. Improved recognition of these reactions may facilitate appropriate clinical management, support more informed prescribing decisions, and reduce inappropriate antibiotic allergy labeling. Further studies are needed to validate these findings and refine risk-based management strategies in pediatric patients."

Journal • Real-world evidence • Allergy • Immunology • Pediatrics

Chiral and achiral analysis of amino acids in the rumen of steers under different diets (ACS-Fall 2026) - "Enantiomeric separations were then performed using teicoplanin- and quinine-based chiral stationary phases. Due to sample complexity and the number of analytes, chiral analysis was carried out using a two-dimensional automated heart-cutting LC method, enabling selective transfer and determination of amino acid enantiomeric ratios. The results indicate clear diet-related variations in both achiral and chiral amino acid profiles in the rumen."

Prosthetic joint infection by Corynebacterium striatum: a case report on a rare and emerging pathogen. (PubMed, Indian J Med Microbiol) - "The isolate was susceptible to glycopeptides and linezolid. The patient received intravenous teicoplanin and revision surgery, highlighting the clinical significance of repeated isolation from deep specimens."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Pain

Longitudinal Changes in Clonal Distribution and Fluoroquinolone Resistance of Ocular MRSA. (PubMed, Biomed J) - "Ocular MRSA infections in Taiwan demonstrate longitudinal changes in clonal distribution, characterized by declining CC59 and increasing CC8, and a concurrent increase in fluoroquinolone-resistant CC8. This evolution may compromise fluoroquinolone-based empirical therapy, a cornerstone of first-line treatment for ocular infections, and highlights the importance of continued molecular surveillance."

Journal • Infectious Disease • Ocular Infections • Ophthalmology

PLATO-3: TDM-optimized Teicoplanin Dosing Versus Standard of Care (clinicaltrials.gov) - P4 | N=54 | Terminated | Sponsor: Radboud University Medical Center | Active, not recruiting ➔ Terminated; The intervention was deemed futile the intervention group, as TDM was not needed in patients with a 12mg/kg dose. In consultation with the METC and biostatistics it was decided to terminate the study early.

Head-to-Head • Trial termination • Infectious Disease

Clostridium saudiense bacteremia: case report and literature review of C.celatum group infections. (PubMed, Anaerobe) - "C. celatum group infections are rare and require a multidisciplinary approach for optimal management. 16S rDNA sequencing has proven essential for accurate identification. Further research is needed to better understand the pathogenic role of these bacteria and to establish optimal therapeutic strategies."

Journal • Review • Infectious Disease

Identification of Siderophores With Unexpected Antibacterial Properties From Actinoplanes teichomyceticus. (PubMed, Chembiochem) - "Actinoplanes teichomyceticus is a well-established producer of bioactive secondary metabolites, including the glycopeptide antibiotic teicoplanin...Synthetic C7 and C9 acyl-desferrioxamine analogs showed enhanced antibacterial activity upon Al3+ chelation, indicating a metal-dependent bioactivity. These findings reveal an unexpected antibacterial role for ferrioxamine-type siderophores produced by A. teichomyceticus, extending their function beyond iron acquisition, possibly through a "Trojan horse" (or "Trojan metal") mechanism."

Journal • Infectious Disease

Factors affecting the initial serum concentration of teicoplanin in pediatric patients: A single-center retrospective analysis. (PubMed, J Pediatric Infect Dis Soc) - "Clinical conditions, such as FN and BMT, which cause an increase in eGFR, may affect the initial Ctrough in pediatric patients. Moreover, a higher LD was well-tolerated. When determining the LD, clinical conditions must be considered."

Journal • Retrospective data • Bone Marrow Transplantation • Febrile Neutropenia • Hematological Disorders • Infectious Disease • Neutropenia • Pediatrics • Transplantation

Detection of the VanA and VanB Gene in Clinical Isolates of Vancomycin-Resistant Enterococci. (PubMed, J Coll Physicians Surg Pak) - "The presence of VRE and the vanA gene among clinical isolates in a tertiary care setting underscores the need for stringent surveillance and effective infection control practices."

Journal • Infectious Disease

Microbiological spectrum of septic arthritis: Diagnostic insights and clinical implications. (PubMed, Indian J Med Microbiol) - "Staphylococcus aureus was the most common pathogen isolated (9, 28.12 %) and all were susceptible to clindamycin, vancomycin, teicoplanin and linezolid. Although uncommon, anaerobes and Mycobacterium tuberculosis should be considered. Antibiotic sensitivity testing remains crucial for guiding the right antimicrobial therapy."

Journal • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Orthopedics • Pulmonary Disease • Respiratory Diseases • Rheumatology • Tuberculosis