rifampicin / Generic mfg. - LARVOL DELTA

High Levels of Helicobacter pylori Antimicrobial Resistance in Ireland-A Multicentre Study. (PubMed, Microorganisms) - "Antimicrobial susceptibility testing (AST) was performed using Etests for metronidazole, clarithromycin, levofloxacin, amoxicillin, tetracycline and rifampicin and resistance classified using EUCAST guidelines. Clarithromycin-based triple therapy should no longer be used in Ireland in the absence of pre-treatment AST. Resistance to amoxicillin, tetracycline and rifampicin should be monitored closely."

Journal • Infectious Disease

Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence. (PubMed, Pathogens) - "In in vivo studies, sulfadiazine and rifampicin were effective as preventive or early monotherapies for GAE. For AK, the combination of polyhexamethylene biguanide, neomycin, and atropine, as well as voriconazole and nitazoxanide monotherapies, showed the greatest promise. In PAM, azithromycin alone or in combination with amphotericin B emerged as the most promising therapeutic options. Further studies are required to advance the clinical translatability of these findings. To the best of our knowledge, this work provides the first comprehensive and integrated synthesis of repurposable drug candidates against FLA infections."

Journal • Review • CNS Disorders • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Physiologically-Based Pharmacokinetics of Ribociclib Drug-Drug Interactions and Organ Impairment Pharmacokinetics in Early Breast Cancer. (PubMed, Pharmaceuticals (Basel)) - " PBPK modeling predicted that ritonavir or erythromycin (strong and moderate CYP3A4 inhibitors) would increase ribociclib steady-state area under the concentration-time curve (AUC) by 1.84-fold or show no meaningful impact, respectively. Steady-state ribociclib AUC was estimated to decrease by 83% and 74% with rifampicin and efavirenz, strong and moderate CYP3A4 inducers, respectively. Ribociclib was estimated to increase CYP3A4 substrate midazolam exposure by 280%. Mild HI or mild/moderate RI did not show an apparent impact on ribociclib PK. Using relevant data and methodology for EBC patients, this analysis informed the approved ribociclib label of no dose adjustment for EBC patients with concomitant use of a moderate CYP3A inhibitor, any degree of HI, or mild/moderate RI, and a reduced 200 mg dose for patients with concomitant use of a strong CYP3A inhibitor or severe RI."

Journal • PK/PD data • Breast Cancer • Hepatocellular Cancer • Hepatology • HER2 Breast Cancer • HER2 Positive Breast Cancer • Oncology • Renal Disease • Solid Tumor • HER-2

Nontuberculous Mycobacteriosis as a Cause of Cervical Lymphadenopathy: A Retrospective Case Series. (PubMed, Microorganisms) - "NTM infection should be considered in the differential diagnosis of cervical lymphadenopathy. Pathogen detection remains challenging, and antimicrobial therapy alone may be sufficient in selected cases."

Journal • Retrospective data • Infectious Disease • Nontuberculous Mycobacterial Disease • Otorhinolaryngology • Pediatrics • Pulmonary Disease • Respiratory Diseases

One-Month Rifapentine-Isoniazid Regimen Versus Six-Month Isoniazid Monotherapy for Latent Tuberculosis: Experience from a Reference Center. (PubMed, Medicina (Kaunas)) - "A therapeutic switch to rifampicin was required in 16.2% of patients receiving the 6H regimen, whereas no switch was needed in the 1HP group. The 1HP regimen was associated with a higher rate of treatment completion and lower hepatic toxicity with no significant differences in the reported adverse symptoms."

Journal • Monotherapy • Observational data • Retrospective data • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Profile of Priority Antimicrobial-Resistant Pathogens and the Behavior of Multidrug-Resistant Tuberculosis in the Santiago de Cali District, Colombia. (PubMed, Pathogens) - "The expansion of resistance mechanisms suggests sustained selective pressure, underscoring the need for strategies to optimize antibiotics."

Journal • Human Immunodeficiency Virus • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Awareness, Attitudes, and Behavioral Practices of the Population of the Republic of Kazakhstan Regarding Tuberculosis. (PubMed, Healthcare (Basel)) - "The findings show a need for focused educational efforts to boost TB awareness and lessen stigma, especially among internal migrants and the general public. Vulnerable groups, like PLHIV and PWUD, have higher awareness but still encounter major barriers. Improving healthcare workers' knowledge about TB diagnostics is also crucial. Specific communication strategies and policies are needed to improve TB detection, reduce social stigma, and improve healthcare access for at-risk groups in Kazakhstan."

Journal • Human Immunodeficiency Virus • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Use of dried plasma spots to monitor rifampicin concentrations in resource-constrained settings. (PubMed, Int J Tuberc Lung Dis) - "Clinical validation confirmed the need for a correction equation to predict plasma rifampicin concentration from the DPS concentration. The predictive model had a mean bias of 0.27 µg/mL, sensitivity of 93.8%, and specificity of 91.1% for identifying therapeutic concentrations (8-24 µg/mL).CONCLUSIONDPS using Whatman® Grade 1 filter paper is a reliable and cost-effective alternative sampling strategy for TDM of rifampicin, particularly in resource-limited settings.."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Temporal trends in treatment strategies and outcomes of newly diagnosed Mycobacterium avium complex pulmonary disease. (PubMed, Int J Tuberc Lung Dis) - "While the use of rifampicin declined, the use of azithromycin, inhaled or intravenous amikacin, and clofazimine increased over time. The probability of culture conversion progressively improved (Tarone-Ware test, P CONCLUSIONSince 2011, treatment strategies for MAC-PD have evolved toward a more proactive approach, accompanied by a gradual improvement in treatment outcomes.."

Journal • Retrospective data • Pulmonary Disease • Respiratory Diseases

Linezolid-associated adverse events and outcomes in the treatment of multidrug/rifampicin-resistant tuberculosis: A systematic review and meta-analysis of randomized controlled trials. (PubMed, J Infect Public Health) - "Lower-dose (≤600 mg) or shorter-duration (≤9 months) regimens demonstrated improved efficacy than SOC, with comparable tolerability. These findings support linezolid's key role in WHO-recommended regimens, informing safe and more effective TB care globally."

Adverse events • Journal • Retrospective data • Review • Hepatology • Infectious Disease • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Emergence of Rv0678 (mmpR5) Mutations Mediating Resistance to Bedaquiline and Clofazimine in a Liver Transplant Recipient with Rifampicin-Susceptible Tuberculosis: A Case Report. (PubMed, Int J Infect Dis) - "Phenotypic drug susceptibility testing (DST) further confirmed susceptibility to Bdq and Cfz before Bdq exposure and resistance to both drugs after Bdq treatment. This case highlights the critical need for potent combination regimens during Bdq treatment, particularly among immunocompromised patients."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Transplantation • Tuberculosis

Extensively drug-resistant and heat-resistant Enterococcus faecalis and Enterococcus faecium in ready-to-eat meat products. (PubMed, NPJ Sci Food) - "Absolute resistance (100%) of enterococcal isolates was found towards penicillin and imipenem, while 86.7%, 85.6%, and 41.9% were resistant to rifampin, vancomycin, and amoxicillin, respectively. The threat caused by virulent, heat-tolerant, vancomycin-resistant enterococci contaminating meat products highlights the risk associated with these pathogens. This emphasizes the urgent need for preventive measures and global strategies to control these emerging foodborne threats."

Journal

Prevalence of Bedaquiline Resistance among Drug Resistant - Tuberculosis Cases at a Tertiary Healthcare Setting in Metropolitan City of Maharashtra, India. (PubMed, Int J Mycobacteriol) - "BDQ resistance is low but emerging; routine DST, rational drug use, and robust surveillance are vital to preserve BDQ efficacy and ensure effective DR-TB management."

Journal • Observational data • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

The impact of rifampin drug interactions on tuberculosis preventive treatment completion and safety. (PubMed, Int J Tuberc Lung Dis) - "Individuals talking medications with potential DDI had a higher percentage of two or more unscheduled visits (12%) compared to those not taking them (5%) (P = 0.0001).CONCLUSIONIn participants taking medications with potential rifampin DDI, rifampin TPT can be used safely without impacting completion rates. However, additional follow-up visits should be anticipated.."

Clinical • Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

A rare case of nephrotic syndrome and arterial thrombosis following long-term rifampicin therapy. (PubMed, Wien Klin Wochenschr) - "The patient was successfully treated for nephrotoxicity with corticosteroids, diuretics, albumin infusion and antihypertensive agents. We emphasize the need for clinicians to be aware of the risk of rifampicin nephrotoxicity, particularly in patients with pre-existing renal impairment."

Journal • Cardiovascular • Fibrosis • Glomerulonephritis • Hematological Disorders • Immunology • Infectious Disease • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Thrombosis • Tuberculosis

Antimicrobial Resistance in Rhodococcus equi and the Promise of Synergistic Therapies. (PubMed, Antibiotics (Basel)) - "The treatment of R. equi infections in foals relies mainly on the combination of macrolides and rifampin...This review summarizes the current understanding of the molecular factors contributing to antimicrobial resistance in R. equi and assesses new therapeutic approaches aimed at overcoming these challenges. It highlights recent findings on strategies to improve treatment outcomes and manage antimicrobial resistance."

Journal • Review • Infectious Disease • Pneumonia • Respiratory Diseases

Deficiency of the Mycobacterial Lipoarabinomannan Biosynthesis Glycosyltransferase MptC Enhances Antibacterial Immune Response and Rifapicin Antibiotic Susceptibility. (PubMed, Antibiotics (Basel)) - "Mannosyltransferase MptC plays an important role in maintaining cell wall integrity (via LM/LAM synthesis), regulating T cell responses, and influencing antibiotic susceptibility in mycobacteria."

Journal • Infectious Disease • IFNG • IL17A • TNFA

Comparative effectiveness of three linezolid management strategies for peripheral neuropathy during multidrug- or rifampicin-resistant tuberculosis treatment. (PubMed, medRxiv) - "We did not find evidence of a substantial negative impact of immediate modification to linezolid among people who developed mild or moderate peripheral neuropathy in the first six months of an individualized regimen. Our results support the clinical practice of cautiously adjusting linezolid when needed to manage non-severe peripheral neuropathy."

HEOR • Journal • Infectious Disease • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review. (PubMed, Infect Dis Ther) - "Tetracyclines may provide therapeutic options for refractory or MDR-related BJIs, and for suppressive therapy when surgical or antibiotic alternatives are limited. However, available data are heterogeneous and largely observational. Robust prospective studies are needed to clarify their role, particularly for newer agents such as omadacycline and eravacycline."

Journal • Review • Infectious Disease • Inflammation

PET-CT benchmarked detection and 5-year progression of asymptomatic tuberculosis: a longitudinal, prospective cohort study. (PubMed, Lancet Respir Med) - "Most adult asymptomatic contacts diagnosed with tuberculosis over 5 years had baseline radiographically evident disease, not radiographically negative incipient tuberculosis. Although PET-CT is not feasible for routine screening, it provides a highly sensitive reference benchmark for diagnostic development, with chest x-ray CAD performing comparatively well."

Journal • Human Immunodeficiency Virus • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Ultrasound-Responsive Nanoparticles Enable Hydrophobic Antibiotic Release and Deep Penetration for Biofilm Treatment. (PubMed, JACS Au) - "In this study, we present designs of nonporous silica nanoparticles that encapsulate a lipophilic antibiotic, rifampicin, with noncovalent interactions and enable controlled release triggered by Low-Frequency Ultrasound (LFUS)...This work introduces a design paradigm for nonporous nanoparticle agents combined with ultrasound, enabling both temporal and spatial control of drug release in bacterial biofilms. This will open transformative therapeutic approaches for effective localized delivery of drugs that have previously been challenging to deliver."

Journal

Bedaquiline and linezolid resistance in people with rifampicin-resistant tuberculosis in the Western Cape Province of South Africa. (PubMed, Res Sq) - "One in five people with RR/MDR-TB did not have bedaquiline DST done, highlighting care cascade gaps. Despite long treatment and sustained culture positivity, minimal linezolid resistance occurred."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Severe pulmonary Mycobacterium genavense infection in an immunocompetent adult : Diagnostic challenges and successful macrolide-based combination therapy (PubMed, Inn Med (Heidelb)) - "Molecular diagnostics identified M. genavense as the causative pathogen. A 15-month regimen of rifampicin, azithromycin, and ethambutol led to complete clinical and radiological remission."

Journal • Infectious Disease • Nontuberculous Mycobacterial Disease • Oncology • Respiratory Diseases

Distribution of Pathogenic Bacteria and Changes in Drug Resistance of Urinary Tract Infections in Children in Southwest China, 2020-2024. (PubMed, Infect Drug Resist) - "coli showed less than 10% resistance to piperacillin/tazobactam, cefoperazone/sulbactam, amikacin and nitrofurantoin, with resistance to quinolones ranging from 31.3% to 51.5%...pneumoniae showed resistance rates of 13.1% and 16.8% to imipenem and meropenem, respectively, from 2020 to 2024...faecium showed significantly higher resistance rates to the tested drugs than E. faecalis, particularly to ampicillin (95.1-97.4% vs 4.9-8.0%)...MRSA showed a higher level of resistance to penicillin, rifampicin, levofloxacin, clindamycin and erythromycin than methicillin-sensitive strains. Over the past five years, the main pathogenic bacteria responsible for pediatric UTIs in southwestern China were E. coli, E. faecium and E. faecalis. Resistance patterns among major uropathogens revealed diverse trends, and the emergence of multidrug-resistant organisms presents a serious therapeutic challenge that warrants close surveillance."

Journal • Infectious Disease • Nephrology • Pediatrics • Pneumonia

Feline tuberculosis due to Mycobacterium bovis: case series with clinical course, genotyping and therapeutic outcomes from Buenos Aires, Argentina. (PubMed, JFMS Open Rep) - "All cats received a combination therapy of rifampicin, clarithromycin and doxycycline, achieving full recovery in two cases and treatment failure in one. A raw meat diet was identified as a potential source of infection in one case. This report provides a comprehensive clinical, molecular and therapeutic description of feline M bovis infection, emphasizing its zoonotic relevance and the need for One Health collaboration."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Retinal Disorders • Tuberculosis