atenolol / Generic mfg. - LARVOL DELTA

Comparison of low- and high-pressure balloon valvuloplasty in dogs with severe pulmonary valve stenosis. (PubMed, J Vet Cardiol) - "No significant difference between LP and HP catheters was observed in PS severity reduction or myocardial injury. High-pressure catheters offer no added benefit over LP catheters for treating severe PS in dogs without annular hypoplasia."

Journal • TNNI3

Warm autoimmune hemolytic anemia following epstein-barr virus reactivation: An uncommon clinical association (ASH 2025) - "His only medications were atenolol and atorvastatin, and he denied use of herbal supplements or over-the-counter drugs... Warm AIHA is most commonly idiopathic but can also occur secondary to various conditions, including rheumatologic diseases (e.g., systemic lupus erythematosus), chronic lymphoblastic leukemia, non-Hodgkin's lymphoma, certain medications (e.g., cephalosporins, piperacillin), and infections...Initial corticosteroid therapy varies widely during the first 72 hours, ranging from 1–2 mg/kg of prednisone every 8–12 hours to high-dose intravenous methylprednisolone (250–1000 mg/day)...In cases refractory to steroids, additional therapies such as mycophenolate mofetil or sirolimus may be considered. This case highlights a rare presentation of warm AIHA likely triggered by EBV reactivation, an association that is infrequently reported in the literature."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Chronic Lymphocytic Leukemia • Cytomegalovirus Infection • Dyslipidemia • Epstein-Barr Virus Infections • Hematological Malignancies • Hepatology • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Leukemia • Lupus • Lymphoma • Non-Hodgkin’s Lymphoma • Pulmonary Disease • Rheumatology • Systemic Lupus Erythematosus • HP

Exploring the link between osteoporosis and stroke risk: An exploratory study based on 2017-2018 NHANES clinical data and bioinformatics analysis. (PubMed, PLoS One) - "There is a significant positive correlation between Osteoporosis and stroke risk. LILRA5, HNRNPL and AGBL3 could be key genes common to both diseases, and Cyclopenthiazide, Neostigmine bromide, and R-atenolol could be potential drugs for intervention."

Clinical data • Journal • Cardiovascular • Osteoporosis • Rheumatology

Bullous Fixed Drug Eruption Associated With Atenolol: A Rare Dermatological Reaction With Mucosal Involvement. (PubMed, Am J Dermatopathol) - "Atenolol is a selective β-1 blocker, widely used, which rarely causes bullous skin reactions, including drug-induced pemphigoid, erythema multiforme, and BFDE. We also discuss the classic dermatopathology of FDE and its bullous variant."

Journal • Dermatology • Dermatopathology • Immunology • Pain

HEART-BEAT: Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease (clinicaltrials.gov) - P2/3 | N=350 | Not yet recruiting | Sponsor: Gødstrup Hospital

New P2/3 trial • Cardiovascular • Coronary Artery Disease • Heart Failure

Beta-Blockers as Potential Adjuvants in Melanoma Treatment. (PubMed, Toxics) - "The effects of non-selective β-blockers (carvedilol and propranolol), β1 selective blockers (atenolol and metoprolol) and antineoplastics drugs (cisplatin and 5-fluorouracil) on the A375 melanoma cell line were studied, individually and in combined exposures, by assessing cell viability over a 72 h period. Metoprolol and carvedilol exhibited synergistic interactions with cisplatin at specific concentrations. Overall, the data highlight the concentration-dependent nature of mixture effects and support the potential application of β-blockers melanoma treatment."

Journal • Genetic Disorders • Melanoma • Oncology • Skin Cancer • Solid Tumor

A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction. (PubMed, Drug Deliv) - "Model integrity was assessed via transepithelial electrical resistance (TEER) and efflux functionality using control drugs (atenolol, digoxin). These results position the LLC-PK1-MOCK/MDR1 model as a reliable surrogate tool for early CNS drug screening, enabling rapid prioritization of candidates based on BBB penetration potential. Its integration into preclinical workflows promises to accelerate the development of therapeutics for neurological disorders."

Journal • CNS Disorders • ABCB1

Effects of antihypertensives on the degradation behavior of AZ31 alloy in in-vitro environment. (PubMed, Sci Rep) - "Effects of seven antihypertensives of Losartan Kalicum(LK), Atenolol(ATEN), Nifedipine(NF), Hydrochlorothiazide(HCTZ), Valsartan(VLA), Furosemide(FUR) and Captopril(CAP) have been investigated on the degradation behavior of AZ31 alloy in simulated body fluid (Hank's solution). The surface analysis reveals that the addition of LK, NF and HCTZ can reduce degradation rate by promoting the growth of hydroxyapatite, increasing the protection effect of corrosion film formed. The present results may enhance the corrosion resistance of Mg-based orthopedic implants."

Journal • Preclinical • Orthopedics

Assessing performance of atenolol removal from contaminated water using zero-valent iron impregnated apricot stone biochar. (PubMed, J Contam Hydrol) - "Reusability tests showed a retention of 73.2 % removal efficiency after five cycles, highlighting the material's considerable stability. These findings underscore the potential of ZVI/ASB-800 as a cost-effective and sustainable sorbent for pharmaceutical pollutant removal, leveraging agricultural waste for environmental remediation."

Journal

A QSPR study of coronary artery disease drugs using eccentricity-based indices. (PubMed, Sci Rep) - "This study advances QSPR modeling by using eccentricity-based graphical invariants, specifically designed to enhance the predictive accuracy for physicochemical properties of drugs used to treat coronary artery disease, including atorvastatin, simvastatin, rosuvastatin, aspirin, clopidogrel, metoprolol, atenolol, enalapril, lisinopril, amlodipine, diltiazem, nitroglycerin, isosorbide dinitrate, ranolazine, gemfibrozil, and fenofibrate. The experimental values were compared with forecasted data, revealing a strong correlation between them. This demonstrates the reliability of our regression models in assessing these vital physicochemical parameters."

Journal • Cardiovascular • Coronary Artery Disease

Polypharmacy Screen of the Thiazide-Sensitive Sodium Chloride Cotransporter (NCC) (KIDNEY WEEK 2025) - "10 compounds were selected for further study: atenolol, furosemide, bendroflumethiazide, dapagliflozin, empagliflozin, labetalol, ramiprilat, metolazone, amlodipine and indapamide. Conclusion Potentially significant interactions between the site of known NCC inhibition and three compounds known to exert diuretic effects (dapagliflozin, empagliflozin and furosemide) have been identified in this computational screening study. A selection of docked conformations from a virtual polypharmacy screen of NCC."

Cardiovascular • Hypertension

Over-the-Counter and Under-the-Radar: A Tubular Cover-Up for a Covert Interstitial Agent (KIDNEY WEEK 2025) - "He was prescribed gabapentin, tramadol, rosuvastatin, aspirin, baclofen, valsartan, amlodipine, and atenolol; he also reported use of esomeprazole and ibuprofen as-need for reflux and back pain. While biopsy is still the gold standard for diagnosing AIN, it remains invasive, carries procedural risks, and can be delayed itself due to unforeseen factors. High-clinical suspicion for AIN remains crucial; and continued reaserch on non-invasive tests for reliable detection of AIN is paramount to improve the current quality of management."

Acute Kidney Injury • Back Pain • Eosinophilia • Inflammation • Musculoskeletal Pain • Nephrology • Renal Disease

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol (clinicaltrials.gov) - P=N/A | N=817337 | Completed | Sponsor: Brigham and Women's Hospital | Active, not recruiting ➔ Completed

Trial completion • Alzheimer's Disease • Cardiovascular • CNS Disorders • Hypertension

Forward osmosis followed by reverse osmosis for the removal of contaminants of emerging concern using a CO2-responsive draw agent. (PubMed, J Hazard Mater) - "An artificial solution containing six common CECs was investigated: ciprofloxacin, atenolol, trimethoprim, sulfamethoxazole, acetaminophen, and carbamazepine. Over multiple filtration cycles, the removal efficiencies ranged from 90 to > 99 %, demonstrating that FORO using a CO2-responsive draw agent is an effective filtration method for removing CECs from an aqueous solution."

Journal

The impact of blood pressure variability on cardiovascular and renal outcomes in patients with and without diabetes: insights from the Anglo-Scandinavian Cardiac Outcomes Trial. (PubMed, J Hypertens) - "Long-term BPV is a critical cardiovascular and renal risk factor in individuals with diabetes and should be incorporated into risk assessment where feasible. On the basis of available evidence, long-acting calcium channel blockers should be incorporated into treatment strategies to improve cardiovascular outcomes."

Clinical • Journal • Cardiovascular • Coronary Artery Disease • Diabetes • Heart Failure • Metabolic Disorders • Myocardial Infarction • Renal Disease

Electrospun Maltodextrin Fibers for Efficient Removal of Nanoparticles, Atenolol, and Crystal Violet: Preparation and Characterization. (PubMed, ACS Omega) - "The combination with lysine proved to be the most effective for gold nanoparticle removal, while cysteine-modified GLU2 fibers achieved up to 98% removal of crystal violet. These findings highlight the potential of amino acid-modified maltodextrin electrospun mats as effective adsorbents for water remediation."

Journal

Visible-Light Optical Coherence Tomography Reveals Atenolol-Induced Vascular Remodeling in the Mouse Eye (AHA 2025) - "Compared to the retina, the more pronounced changes observed in limbal vessels may reflect regional differences in adrenergic regulation. Moreover, the degree of limbal remodeling showed a weak but measurable correlation with blood pressure reduction (R2 = 0.35), suggesting that anterior segment vessels may serve as a noninvasive marker of individual responsiveness to systemic beta-blocker therapy."

Preclinical • Cardiovascular • Hypertension

Tachycardia-induced Cardiomyopathy from Incessant Atrial Tachycardia in a Teenager with Severe Pectus Excavatum (AHA 2025) - "Initial medical therapy with ivabradine, flecainide, and atenolol led to rate control and subsequent improvement in left ventricular function but failed to terminate the arrhythmia...Postoperatively, left ventricular function normalized, but AT persisted despite continued escalation to ivabradine, sotalol, and flecainide...The p wave morphology on electrocardiogram, left atrial deformity on echocardiogram, and intracardiac activation map of the AT focus in this case, support cardiac compression as the mechanism for AT. These findings suggest the potential for sustained atrial remodeling with subsequent arrhythmia in the context of PE and underscores the importance of cardiac screening in asymptomatic adolescents with severe chest wall deformities."

Cardiomyopathy • Cardiovascular • Pediatrics

Apical Hypertrophic Cardiomyopathy: Diagnostic Challenges in a Patient with Hypertension and Obstructive Sleep Apnea. (PubMed, Am J Case Rep) - "His medical history included longstanding hypertension managed with atenolol and enalapril, and untreated OSA. CONCLUSIONS ApHCM should be considered in patients with dyspnea, hypertension, and OSA when giant precordial T-wave inversions are present. ECG and MRI confirming apical hypertrophy without outflow obstruction guide medical therapy, not septal reduction, and prioritize blood pressure optimization, OSA treatment, ambulatory rhythm monitoring, and structured follow-up to mitigate adverse outcomes."

Journal • Cardiomyopathy • Cardiovascular • Hypertension • Hypertrophic Cardiomyopathy • Obstructive Sleep Apnea • Pain • Pulmonary Disease • Respiratory Diseases • Sleep Disorder

Cerebrospinal fluid proteomic analysis of long-term antihypertensive treatment with amlodipine and atenolol in hypertensive rats. (PubMed, Sci Rep) - "A comparison of the two antihypertensive treatments revealed alterations in pathways associated with cell adhesion, central nervous system development, and vascular development. These findings show that hypertension and long-term treatment with antihypertensive medications elicit distinct effects on the CSF proteome."

Journal • Preclinical • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Hypertension • Inflammation • AHSG • APOE • CHI3L1

DISTINGUISHING FAMILIAL HYPOKALEMIC PERIODIC PARALYSIS FROM OTHER CAUSES OF HYPOKALEMIA: A CASE REPORT AND REVIEW OF DIFFERENTIAL DIAGNOSES (CHEST 2025) - "His medications include acetazolamide, spironolactone, and atenolol. HypoPP is an unusual musculoskeletal disorder that requires differentiation from diseases that may present similar symptoms. Suspicion heavily relies on clinical history and exclusion of secondary causes with genetic evaluation for confirmation. Management includes potassium replacement, lifestyle modifications, and prophylactic therapies to prevent episodes."

Case report • Clinical • Review • Cardiovascular • Endocrine Disorders • Metabolic Disorders • Musculoskeletal Diseases • Nephrology • CACNA1S

A Novel Stability-Indicating HPLC Method with Kinetics Study for the Concurrent Analysis of Anti-Hypertensive Drug Combination of Atenolol and Indapamide. (PubMed, Drug Metab Bioanal Lett) - "The developed stability-indicating HPLC method successfully identified and quantified atenolol and indapamide in the presence of degradation products. It offered high specificity, precision, and robustness, making it ideal for routine pharmaceutical analysis. The method distinguished between the active drugs and degradation products under various stress conditions, ensuring the long-term stability and efficacy of atenolol and indapamide formulations. These findings can significantly contribute to pharmaceutical quality control, ensuring drugs' safety and effectiveness."

Journal • Cardiovascular • Hypertension

Nonsurgical Management of Drug-induced Gingival Enlargement in a Young Adolescent with Chronic Kidney Disease: A Case Report. (PubMed, Int J Clin Pediatr Dent) - "This case reports a 13-year-old female with chronic kidney disease and hypertension who was under the medication of atenolol and amlodipine for 5 years...The management included counseling, oral hygiene maintenance, full-arch scaling, and transition to alternate antihypertensive clonidine; the patient was reverted back to amlodipine after 1 month due to inadequate blood pressure control with clonidine...Non-surgical Management of Drug-induced Gingival Enlargement in a Young Adolescent with Chronic Kidney Disease: A Case Report. Int J Clin Pediatr Dent 2025;18(9):1164-1167."

Journal • Cardiovascular • Chronic Kidney Disease • Hypertension • Inflammation • Nephrology • Pediatrics • Renal Disease

BETA-BLOCKERS ARE ASSOCIATED WITH LOWER RISK OF PANCREATIC CANCER IN PATIENTS WITH TYPE 2 DIABETES: A POPULATION-BASED COHORT STUDY (UEGW 2025) - "Primary exposure was beta-blocker use (e.g., acebutotlol, atenolol, bisoprolol, carvedilol, celiprolol, esmolol, labetalol, metoprolol, nadolol, nebivolol, pindolol, propranolol, and sotalol)...Adjusted hazard ratios (aHRs) were derived from multivariable Cox models adjusting for 31 covariates: age, sex, smoking status, alcohol use disorder, body index mass, glycemic control (in terms of time-weighted mean HbA1c), pancreatitis, cholangitis, colectomy, Charlson's comorbidity index, metabolic and cardiovascular comorbidities, and concomitant medications (aspirin, non-steroidal anti-inflammatory drugs, statins, and other antidiabetics)... Beta-blocker use was associated with a lowered risk of PC among patients with newly diagnosed T2D, in a dose- and duration-dependent manner."

Clinical • Addiction (Opioid and Alcohol) • Diabetes • Gastrointestinal Disorder • Hepatology • Metabolic Disorders • Oncology • Pancreatic Cancer • Pancreatitis • Solid Tumor • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

Removal and persistence of pharmaceuticals in Induced River Bank Filtration system in low-flow regime. (PubMed, Sci Total Environ) - "Surface water PhACs concentrations remained low and stable (generally lower than 10 ng/L), yet groundwater showed significant variability (from few to one hundred ng/L), with Ibuprofen, Clarithromycin and Diclofenac reaching levels up to 100 times higher, likely due to retardation processes. While Atenolol, Naproxen, and Metformin were rapidly removed, Ibuprofen, Carbamazepine, and Sulfamethoxazole remained detectable at the drinking water well (at about 1 ng/L concentration), likely due to low microbial uptake at low concentrations...The Serchio River IRBF system proved effective at reducing PhACs presence in drinking water well below 0.1 μg/L, highlighting its value as an energy-efficient treatment method. To ensure safe use of IRBF, future research must integrate geochemical, and metabolite tracking information, along with a proactive approach to designing degradable PhACs, hence, reducing the need on downstream treatment systems."

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