Fibrocaps (fibrinogen and thrombin) / Mallinckrodt - LARVOL DELTA

Uncovering Fibrocapsa japonica (Raphidophyceae) in South America: First Taxonomic and Toxicological Insights from Argentinean Coastal Waters. (PubMed, Toxins (Basel)) - "No brevetoxins (PbTx-1, -2, -3, -6, -7, -8, -9, -10, BTX-B1 and BTX-B2) were detected by LC-MS/MS, suggesting that the cytotoxicity may be linked to the production of reactive oxygen species (ROS), polyunsaturated fatty acids (PUFAs), or hemolytic compounds, as previously hypothesized in the literature. These findings offer novel insights into the toxic potential of F. japonica in South America and underscore the need for further research to elucidate the mechanisms underlying its ichthyotoxic effect."

Journal

Evolutionary Dynamics and Lateral Gene Transfer in Raphidophyceae Plastid Genomes. (PubMed, Front Plant Sci) - "In contrast, the marine species Fibrocapsa japonica contains the largest IR region and overall plastid genome for any raphidophyte examined thus far, mainly due to the presence of four large gene-poor regions and foreign DNA...A group II intron in the F. japonica psbB gene also appears to be derived by LGT. Our results provide important insights into the evolutionary history of raphidophyte plastid genomes via LGT from the plastids and plasmid DNAs of diatoms."

Journal • Gene Therapies

Scleral communication between Glaucoma drainage device capsule and the suprachoroidal space simulating amelanotic choroidal melanoma. (PubMed, Arq Bras Oftalmol) - "The ultrasound exam visualized the patient's implanted superotemporal justabulbar drainage device, which revealed a transscleral communication from the plate fibrocapsular's draining space to the suprachoroidal space (fistula)...The patient's recovery progressed well, and he regained a visual acuity of 20/70 (0.55 LogMAR). To the best of our knowledge, this is the first case report of this condition."

Journal • Choroidal Melanomas • Glaucoma • Immunology • Melanoma • Ocular Melanoma • Oncology • Ophthalmology • Retinal Disorders • Solid Tumor

Diverse harmful microalgal community assemblages in the Johor Strait and the environmental effects on its community dynamics. (PubMed, Harmful Algae) - "The most common and abundant HAB taxa in the strait (frequency of occurrence >70%) comprised Heterosigma akashiwo, Fibrocapsa japonica, Pseudo-nitzschia pungens, Dinophysis spp., Gymnodinium catenatum, Alexandrium leei, and A. tamiyavanichii...Different HAB taxa, constitute various functional types, occupied and prevailed in different environmental niches across space and time, leading to diverse community assemblages and population density. This study adds to the current understandings of HAB dynamics and provides a robust overview of temporal-spatial changes in HAB community assemblages along the environmental gradients in a tropical eutrophic coastal ecosystem."

Journal • Immunology

Preliminary exploration on the application of hydrogel from acellular porcine adipose tissue to assist lipofilling (PubMed, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi) - "For in vivo study, grafts of all groups had intact fibrocapsule...As the volume ratio of HAPA gradually increased, the survival of transplanted adipose tissue also increased, but the volume retention rate decreased gradually. 30%HAPA was considered the relative optimal volume ratio for its superior adipose tissue survival and volume retation rate."

Journal • Preclinical • Fibrosis • Immunology • Transplantation • CD31 • PLIN2

Safety and Efficacy Study of Raplixa™ (Fibrin Sealant [Human]) to Treat Surgical Bleeding in Children (clinicaltrials.gov) - P2; N=87; Active, not recruiting; Sponsor: Mallinckrodt; Recruiting ➔ Active, not recruiting

Enrollment closed • Biosimilar

Safety and Efficacy Study of Raplixa™ (Fibrin Sealant [Human]) to Treat Surgical Bleeding in Children (clinicaltrials.gov) - P2; N=55; Terminated; Sponsor: Mallinckrodt; N=87 ➔ 55; Active, not recruiting ➔ Terminated; Non-safety device related issues

Clinical • Enrollment change • Trial termination

Feeding by the heterotrophic nanoflagellate Katablepharis remigera on algal prey and its nationwide distribution in Korea. (PubMed, Harmful Algae) - "...Among 25 potential algal prey tested, K. remigera fed on only H. akashiwo and C. subsalsa; however, it did not feed on a diatom, a prymnesiophyte, a prasinophyte, cryptophytes, dinoflagellates, Mesodinium rubrum, a mixotrophic ciliate, and another raphidophyte Fibrocapsa japonica...occurred in 2000-2017, K. remigera was detected. Thus, the abundance of K. remigera may increase during red tides caused by H. akashiwo and Chattonella spp."

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