JJH201601 / Jebel Pharm - LARVOL DELTA

Antitumor effects of the novel docetaxel derivative JJH201601 in glioma: targeting ribosome biogenesis and enhancing temozolomide sensitivity. (PubMed, J Transl Med) - "JJH201601 exhibited anti-glioma activity by suppressing proliferation, promoting apoptosis, affecting ribosome biogenesis-related signaling, and disrupting cell cycle regulation. Its combination with TMZ and selected cell cycle inhibitors showed enhanced inhibitory effects in preclinical glioma models. However, current in vivo evidence is restricted to a subcutaneous xenografts, further orthotopic intracranial glioma studies with pharmacokinetic profiling and comprehensive safety assessments are required to confirm its efficacy for resistant glioma."

Journal • Brain Cancer • Glioma • Oncology • Solid Tumor • CDC7 • CDK2 • MCM2 • RPL13