levetiracetam / Generic mfg. - LARVOL DELTA

ZTTK Syndrome Expanding the Cardiac Phenotype: A Case of Shone's Complex With a Novel SON Variant and Focused Review of the Cardiac Manifestations in ZTTK Syndrome. (PubMed, Case Rep Genet) - "Her epilepsy is well controlled with levetiracetam monotherapy...The literature review did not reveal an increased association between epilepsy in ZTTK patients and that in congenital heart disease compared with ZTTK patients without congenital heart disease, supporting the previous findings that SON is likely to be involved in multiple critical biological processes. Mitochondrial dysfunction was implicated in previous reports of loss-of-function SON variants and supported by the cardiac phenotype in previously reported cases."

Journal • Cardiovascular • CNS Disorders • Developmental Disorders • Epilepsy • Heart Failure • Metabolic Disorders • Psychiatry

Clinical utility and tolerability of ketamine as adjunctive rescue therapy for refractory neonatal status epilepticus: a case report of a late preterm infant with multifocal hemorrhagic brain injury. (PubMed, Front Pediatr) - "Although phenobarbital remains the recommended first-line antiseizure medication (ASM), followed by agents such as phenytoin or levetiracetam, seizure control is not always achieved. Continuous EEG monitoring remains essential for evaluating treatment response. Prospective neonatal studies are needed to define the optimal timing, dosing strategies, efficacy, and long-term safety of ketamine in RNSE."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Hematological Disorders • Vascular Neurology

Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma. (PubMed, Nat Med) - "This effect is independent of action on SV2A, the chief mechanism by which levetiracetam functions to prevent and treat seizures. Taken together, these findings indicate a promising approach to target GABAergic synapses in DMG and suggest that use of levetiracetam in DMG should be further studied in future prospective clinical studies."

Journal • Brain Cancer • CNS Disorders • Diffuse Midline Glioma • Epilepsy • Glioma • High Grade Glioma • Oncology • Pediatrics • Solid Tumor

Management Guidelines for the Treatment of Pediatric Brain Tumor-Associated Seizure: A Modified Delphi Consensus Report. (PubMed, Ann Child Neurol Soc) - "Respondents universally agreed to start a patient on anti-seizure medication (ASM) only after their first seizure, with levetiracetam as the first-line and lacosamide or oxcarbazepine as the second-line. Finally, the presence of cortical dysplasia or mesial temporal sclerosis should prompt an upfront epilepsy surgery evaluation. This study yielded guidelines for pediatric brain tumor-related epilepsy established from the opinions of child neurologists specializing in the care of these patients."

Journal • Brain Cancer • CNS Disorders • Epilepsy • Oncology • Pediatrics • Solid Tumor

Posterior reversible encephalopathy syndrome following eclampsia in a primigravida at 35 weeks of gestation: A case report. (PubMed, Radiol Case Rep) - "She underwent emergency lower-segment cesarean section (LSCS) for delivery of a live neonate, with a second intraoperative seizure controlled with intravenous diazepam and magnesium sulfate. She was treated with intravenous magnesium sulfate, antihypertensive therapy, and levetiracetam, with complete clinical recovery and radiological resolution on follow-up imaging. This case highlights eclamptic PRES as a cause of postoperative cortical visual loss and illustrates how the combination of T2/FLAIR signal change with preserved diffusion on MRI distinguishes reversible vasogenic edema from ischemic injury, supporting prompt, targeted management even in resource-limited settings."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Gynecology • Hypertension • Pain • Pulmonary Disease • Renal Disease

Volumetric Microsampling for Patient-Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review. (PubMed, J Clin Pharmacol) - "Fixed conversion factors performed well for lacosamide and levetiracetam but were less reliable for lamotrigine at high concentrations. Several analyte-matrix combinations, including cefepime, vancomycin, meropenem, paclitaxel, abiraterone, and mitotane, did not consistently meet agreement criteria. Volumetric microsampling can support patient-centered drug monitoring when validated for the specific analyte, matrix, device, and clinical application. Future research should prioritize drug-specific optimization, multicenter validation, standardized conversion reporting, and integration with MIPD platforms."

Journal • Review

RHABDOMYOLYSIS AFTER REINITIATION OF LEVETIRACETAM IN THE INTENSIVE CARE UNIT (CHEST 2026) - No abstract available

Critical care

LEVETIRACETAM-INDUCED STEVENS-JOHNSON SYNDROME PROGRESSING TO TOXIC EPIDERMAL NECROLYSIS IN A PATIENT WITH SEVERE SYSTEMIC LUPUS ERYTHEMATOSUS (CHEST 2026) - No abstract available

Clinical • Immunology • Inflammatory Arthritis • Lupus • Steven-Johnson Syndrome • Systemic Lupus Erythematosus

Transient Postoperative Myoclonus Following Hypothermic Circulatory Arrest. (PubMed, Ochsner J) - "The patient was treated with intravenous levetiracetam and calcium supplementation...This case demonstrates a transient form of postoperative myoclonus distinct from Lance-Adams syndrome. Recognition of atypical movement disorders after hypothermic circulatory arrest may help clinicians avoid unnecessary escalation of therapy and provide reassurance regarding the potential for complete recovery."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Endocrine Disorders • Epilepsy • Metabolic Disorders • Movement Disorders

Trends in Use of Antiseizure Medicines in Women With Epilepsy in Pregnancy During 2018-2023 in an Irish Maternity Hospital: A Cohort Study. (PubMed, Obstet Gynecol Int) - "Levetiracetam (60.1%) and lamotrigine (31.5%) were most frequently used overall. Zonisamide use decreased significantly (-0.395, p = 0.029), although this finding should be interpreted cautiously given the small number of exposures (n = 13)...ASMs with safer pregnancy profile were most frequently used in WWE in pregnancy. Additional data are needed to further assess trends and outcomes and to determine the place of newer generation ASMs in WWE in pregnancy."

Journal • CNS Disorders • Epilepsy

Potential Role of CYP3A4 in Determining In Vivo Exposure to Cannabidiol (CBD) and its Active Metabolite 7-OH-CBD: Evidence from an In Vitro Study. (PubMed, Eur J Drug Metab Pharmacokinet) - "ASMs with CYP3A4-inhibitory potential may alter systemic exposure to both CBD and its active metabolite, 7-OH-CBD, as demonstrated in vitro. However, co-administration of CBD with CYP3A4-substrate ASMs or CYP2C19 inhibitors is predicted to result in only modest increases in CBD exposure."

Journal • Preclinical • CNS Disorders • Epilepsy • CYP2C19 • CYP2C9 • CYP3A4

Investigating the influence of anti-seizure medications on aperiodic EEG activity. (PubMed, Clin Neurophysiol) - "Aperiodic EEG measures may provide a non-invasive approach for characterising ASM-related neurophysiological effects and may help elucidate how distinct pharmacological mechanisms influence large-scale cortical activity."

Journal • CNS Disorders • Epilepsy

Continuous-Flow Synthesis of Antiepileptic Drugs: Process Intensification, Sustainability Metrics, and Scalable Manufacturing. (PubMed, ACS Omega) - "The review will examine examples of recent advances in continuous-flow processing of major molecules, including pregabalin, levetiracetam, lacosamide, and brivaracetam. In addition, the review will discuss the obstacles preventing a complete transition to an automated, environmentally friendly, and continuous-flow process for producing AEDs."

Journal • Review

Phenotype-driven response to sodium channel blockers in neonatal and infantile genetic epilepsies with tonic seizures. (PubMed, Seizure) - "SCBs are safe and highly effective in early-onset genetic epilepsies with tonic seizures, particularly in self-limited phenotypes. Recognition of tonic seizure semiology may guide early, phenotype-driven treatment decisions while awaiting genetic results."

Clinical • Journal • CNS Disorders • Epilepsy

Tocilizumab Prophylaxis Following Axicabtagene Ciloleucel in Relapsed or Refractory Large B-cell Lymphoma. (PubMed, Transplant Cell Ther) - "Based on these findings, prophylactic tocilizumab is not recommended to prevent CAR T-cell-related adverse events, and beneficial effects of prophylactic levetiracetam remain uncertain in patients with R/R LBCL."

Journal • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • IL6R

JNJ-42153605, a mGluR2 PAM, potentiates levetiracetam treatments of TBI to mitigate subsequent tau aggregation in a larval zebrafish model. (PubMed, Exp Neurol) - "Thus, LEV and JNJ-42153605 applied briefly after TBI offer a potent polypharmacy approach, at least in our preclinical animal model, to tackle the later tau aggregation and neurodegeneration that follows from TBI neurotrauma. These results warrant further investigation, including testing in mammalian TBI models with longer disease course and more conventional markers of tau pathology."

Journal • CNS Disorders • Dementia • Epilepsy • Vascular Neurology

Systematic Review of Pharmacologic Treatment for Migraine Prevention in Adults: Report of the AAN Guidelines Subcommittee and the American Headache Society. (PubMed, Headache) - "This SR provides a comprehensive synthesis of evidence on pharmacologic migraine prevention in adults. High- and moderate-confidence findings confirm the efficacy of several established and newer preventive therapies and demonstrate improvements in patient-reported outcomes across multiple validated measures. These conclusions informed the development of evidence-based recommendations, presented in a companion publication, to guide clinicians in selecting preventive medications for adults with episodic and chronic migraine."

Journal • CNS Disorders • Migraine • Pain

Systematic Review of Pharmacologic Treatment for Migraine Prevention in Adults: Report of the AAN Guidelines Subcommittee and the American Headache Society. (PubMed, Neurology) - "This SR provides a comprehensive synthesis of evidence on pharmacologic migraine prevention in adults. High- and moderate-confidence findings confirm the efficacy of several established and newer preventive therapies and demonstrate improvements in patient-reported outcomes across multiple validated measures. These conclusions informed the development of evidence-based recommendations, presented in a companion publication, to guide clinicians in selecting preventive medications for adults with episodic and chronic migraine."

Journal • Review • CNS Disorders • Migraine • Pain

Mapping the evidence-practice gap in pediatric post-traumatic seizures and post-traumatic epilepsy: A national practice-pattern survey of pediatric neurologists. (PubMed, Epilepsy Res) - "Pediatric PTS/PTE management in Türkiye shows strong convergence in drug selection but substantial variation in duration and follow-up decisions, reflecting persistent pediatric evidence gaps and highlighting the need for pediatric-specific guidelines and national consensus initiatives."

Journal • CNS Disorders • Epilepsy • Pediatrics • Vascular Neurology

Thrombotic event occurrence in patients treated with concurrent apixaban and levetiracetam (SNO 2026) - No abstract available

Clinical

Antiseizure medication in patients with brain metastases and epilepsy: efficacy of first-line levetiracetam versus valproic acid (SNO 2026) - No abstract available

Clinical • CNS Disorders • Epilepsy • Solid Tumor

Early-onset maculopapular eruption with palmoplantar desquamation following intravenous levetiracetam. (PubMed, Epileptic Disord) - No abstract available

Journal • CNS Disorders • Epilepsy

Epilepsy Is Part of the CNS Phenotype in Classic Infantile Pompe Disease. (PubMed, Neurol Genet) - "Levetiracetam was most frequently used as antiseizure medication...Our findings suggest a potential increased frequency of seizures in classic infantile Pompe disease in comparison with unaffected children, occurring predominantly after the age of 7, and that epilepsy is part of the CNS phenotype. The risk of seizures should be evaluated during follow-up in long-term survivors with classic infantile Pompe disease."

Journal • Cardiomyopathy • Cardiovascular • CNS Disorders • Epilepsy • Hypertrophic Cardiomyopathy • Infectious Disease • Pompe Disease • NEFL

Development of a prediction model for levetiracetam plasma concentration in children with epilepsy based on pharmacokinetic characteristics: A comparison of multiple linear regression and complex algorithms (PubMed, Zhong Nan Da Xue Xue Bao Yi Xue Ban) - "After incorporating dose, body weight, renal function, concomitant medications, and routine laboratory indicators, the principal predictable information regarding steady-state trough concentrations of LEV in children with epilepsy could be adequately captured by a multiple linear regression model. Its overall predictive performance, error stability, and clinical interpretability were not inferior to those of complex machine-learning models. The daily weight-normalized dose was the key determinant of steady-state trough LEV concentration, while renal function, albumin, serum potassium, and certain concomitant antiseizure medications further explained individual differences in LEV concentrations. Nevertheless, unexplained interindividual variability remained, potentially owing to factors such as medication adherence and developmental maturation. The model results may provide supportive information for the interpretation of TDM findings and dose adjustment, but their..."

Clinical • Journal • PK/PD data • Retrospective data • CNS Disorders • Epilepsy • Hematological Disorders

An Observational Study of the Effect of Concomitant Levetiracetam on Apixaban Concentrations in a Hospital Cohort. (PubMed, Clin Transl Sci) - "Apixaban minimum and maximum concentrations (Cmin and Cmax) were compared using descriptive statistics in R. While the median Cmin and Cmax appear to be marginally elevated, there were no apparent differences relative to apixaban alone. These findings suggest no apparent interaction of levetiracetam and support the current lack of labeled warning of concomitant apixaban dosing."

Journal • Observational data • Cardiovascular