tobramycin topical / Generic mfg. - LARVOL DELTA

Safety of topical tobramycin powder during operative treatment of fractures. (PubMed, J Antimicrob Chemother) - P3 | "A single dose of 1200 mg tobramycin powder administered locally during fracture fixation of the tibia does not lead to nephrotoxic serum levels or long-term changes to renal function."

Journal • Acute Kidney Injury • Infectious Disease • Musculoskeletal Diseases • Nephrology • Orthopedics • Renal Disease

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA (clinicaltrials.gov) - P3 | N=1550 | Active, not recruiting | Sponsor: Major Extremity Trauma Research Consortium | Recruiting ➔ Active, not recruiting | Trial completion date: Dec 2026 ➔ Sep 2025

Enrollment closed • Trial completion date • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Case review: canalicular laceration reconstruction with silicone self-retaining stent (SOE 2025) - "In both cases, treatment included eyelid repair and canalicular reconstruction with a Masterka stent, followed by postoperative care with dexamethasone eyedrops, tobramycin ointment, and oral antibiotics.We reported successful healing and preservation of eyelid function in both cases. This highlights the efficacy of using Masterka stents for canalicular reconstruction, demonstrating promising clinical outcomes beyond its primary indication for nasolacrimal duct obstruction."

Clinical • Review • Ophthalmology

Mycobacterium chelonae Keratitis following Keratorefractive Lenticule Extraction: Highlighting Diagnostic and Treatment Complexities. (PubMed, Case Rep Ophthalmol) - "She was using topical tobramycin drops four times per day, which was changed to ciprofloxacin drops. Vision deteriorated to hand movements, but an emergency keratoplasty was avoided. This is the third reported case serving to highlight the diagnostic and treatment challenges associated with postoperative keratitis involving nontuberculous mycobacteria."

Journal • Achromatopsia • Infectious Disease • Keratitis • Nontuberculous Mycobacterial Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Respiratory Diseases • Transplantation

Rose Bengal Photodynamic Antimicrobial Therapy as an Adjunct Treatment for Pseudomonas aeruginosa Infectious Necrotizing Scleritis. (PubMed, Photodiagnosis Photodyn Ther) - "All patients received a standardized regimen of oral fluoroquinolone, topical tobramycin, and ciprofloxacin/moxifloxacin. None of the patients required enucleation. Conclusion RB-PDAT is a feasible option to halt the progression of infectious necrotizing scleritis caused by Pseudomonas aeruginosa, especially in cases of impending perforation."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Scleritis

A Sneaky Culprit: Secondary Infectious Keratitis Due to Brevundimonas diminuta. (PubMed, Eye Contact Lens) - "To our knowledge, this is the second reported culture-positive case of secondary infectious keratitis with B. diminuta, highlighting its rarity and potential for delayed identification. The atypical response to initial therapy underscores the importance of repeat cultures and corneal biopsy in persistent cases. This case contributes to the growing understanding of rare ocular pathogens, advocating for a vigilant clinical approach."

Journal • Infectious Disease • Inflammation • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures At High Risk of Infection: TOBRA (clinicaltrials.gov) - P3 | N=1900 | Recruiting | Sponsor: Major Extremity Trauma Research Consortium | Trial completion date: Mar 2026 ➔ Dec 2026 | Trial primary completion date: Mar 2025 ➔ Jun 2025

Trial completion date • Trial primary completion date • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Practice preference and evidence analysis on topical use of tobramycin powder in lumbar spine surgery: A Multi-National AO spine survey with systematic review of the literature. (PubMed, World Neurosurg X) - "Topical Tobramycin is not the commonly preferred topical antibiotic to prevent SSI among spine surgeons worldwide. There is a lack of sufficient evidence to support the routine use of topical tobramycin in lumbar spine surgery."

Journal • Review • Surgery • Infectious Disease • Orthopedics

Rose Bengal Photodynamic Antimicrobial Therapy as Adjunct Therapy for Pseudomonas Necrotizing Scleritis (AAO 2024) - "All patients received a standardized regimen of oral fourth-generation fluoroquinolone, topical tobramycin and ciprofloxacin. The patient with pan-resistant PA required treatment with topical imipenem. Conclusion RB-PDAT is a feasible option to halt the progression of infectious necrotizing scleritis caused by Pseudomonas, especially in cases of impending perforation."

Keratitis • Ocular Inflammation • Ophthalmology • Scleritis

Corneal Deposits Following Combined Gatifloxacin and Prednisolone Therapy Post-Keratoplasty: A Report of a Rare Case. (PubMed, Cureus) - "Management included corneal scrapping and transition to topical tobramycin and propylene glycol eye drops, resulting in the resolution of deposits and improvement in vision. This case underscores the importance of vigilant monitoring and judicious use of topical medications to mitigate adverse effects in high-risk ophthalmic patients undergoing corneal procedures."

Journal • Ophthalmology • Transplantation

Topical use of tobramycin: A possible innovative treatment of severe skin chronic ulcers. (PubMed, Exp Dermatol) - No abstract available

Journal

Acute dacryocystitis secondary to Burkholderia cepacia and Sphingomonas paucimobilis mixed infection: A novel case report. (PubMed, Saudi J Ophthalmol) - "She was on oral Amoxicillin/clavulanic acid, oral Nitroimidazole antimicrobial and topical Tobramycin from elsewhere. We have changed the antibiotic to oral Trimethoprim/ Sulfamethoxazole as it showed positive sensitivity to the pathogens based on the sensitivity chart. Second follow-up appointment patient's condition improved."

Journal • Infectious Disease • Ocular Infections • Ophthalmology • Pain

Misdiagnosed as Fungal Keratitis: Herpes Simplex Virus-1 Keratitis Confirmed by Next-Generation Sequencing. (PubMed, Surg Infect (Larchmt)) - "Voriconazole 100 mg orally daily, topical tobramycin and 1% voriconazole were initiated empirically right away. HSV-1 keratitis with atypical clinical presentation can be easily misdiagnosed. This case report emphasizes the importance of NGS in diagnosing the pathogens of keratitis."

Biomarker • Journal • Next-generation sequencing • Herpes Simplex • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Transplantation

Impact of pH modification of the empirically used tobramycin ophthalmic solution on MIC90 concentration in tears and aqueous humor of donkeys (Equus asinus). (PubMed, BMC Vet Res) - "Adjustment of the pH of the commercial tobramycin ophthalmic solution, empirically used by veterinarians to treat donkeys' ophthalmic infections at a pH of 8.26, isotonic with the donkeys' tears pH, resulting in higher concentrations of tobramycin in tears and aqueous humor for a longer time."

Journal • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA (clinicaltrials.gov) - P3 | N=1900 | Recruiting | Sponsor: Major Extremity Trauma Research Consortium | Trial completion date: May 2025 ➔ Mar 2026 | Trial primary completion date: Sep 2024 ➔ Mar 2025

Trial completion date • Trial primary completion date • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Cultivated corneal stromal keratocyte injection improves corneal clarity in lumican knockout mouse (ARVO 2024) - "Topical tobramycin and dexamethasone were given 4 times/day for 7 days postoperatively. Injection of cultivated CSKs improved the corneal clarity in the developed haze of Lum-KO mice. The improvement was likely due to the partial recovery of the proteoglycans, which also resulted in the restoration of the corneal thickness in the mice. Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand."

Preclinical • Stroma • Corneal Abrasion • Ophthalmology • BGN • DCN • LUM

The Effect of Vancomycin and Tobramycin Local Antibiotic Powder on Surgical Site Infections after Open Treatment of Fracture: A Retrospective Propensity-Matched Analysis. (PubMed, J Orthop Trauma) - "The use of vancomycin and tobramycin local antibiotic powder lowered the rate of deep SSIs after open treatment of fractures on propensity-matched analysis."

Journal • Retrospective data • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA (clinicaltrials.gov) - P3 | N=1900 | Recruiting | Sponsor: Major Extremity Trauma Research Consortium | Trial completion date: May 2024 ➔ May 2025 | Trial primary completion date: Sep 2023 ➔ Sep 2024

Trial completion date • Trial primary completion date • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Antibiotic Use in Adult Spine Deformity Surgery: Results From the AO Spine Surveillance of the Management of Patients With Adult Spine Deformity. (PubMed, Global Spine J) - "The present survey identifies a trend towards systemic and topical antibiotic prophylaxis primarily targeted at gram positive pathogens. The use of topical tobramycin, proposedly effective against gram negative infections, remains uncommon. There is a lack of consensus in the selection of perioperative antibiotic prophylaxis, thus a prospective study of the rates of infection with each strategy would be useful to inform guidelines."

Journal • Surgery • Infectious Disease

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA (clinicaltrials.gov) - P3 | N=1900 | Recruiting | Sponsor: Major Extremity Trauma Research Consortium | Trial primary completion date: May 2023 ➔ Sep 2023

Trial primary completion date • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Clinical Characteristics and Prognosis of Pediatric Phthirus pubis Coinfestation of the Eyelashes and Scalp Hairs. (PubMed, Am J Trop Med Hyg) - "Treatment included eyelash and scalp hair trimming to the root (100%) and mechanical removal of the parasites (100%), in addition to topical tobramycin eye ointment (100%) and phenothrin shampoo (80%)...Sexually transmitted diseases should be ruled out for patients with P. pubis infestation. Untreated or persistent cases may lead to several serious infections."

Journal • Conjunctivitis • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pediatrics

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial (clinicaltrials.gov) - P4 | N=484 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences | Initiation date: Mar 2023 ➔ Jun 2023

Trial initiation date • Infectious Disease • Inflammation • Musculoskeletal Diseases • Orthopedics

ACANTHAMOEBA AND PSEUDOMONAS CO-INFECTION FOLLOWING CATARACT SURGERY (ESCRS-WM 2023) - "Patient was started on empirical broad spectrum topical treatment of moxifloxacin, tobramycin ointment, and fortified vancomycin eye drops...Multiple difficulties and obstacles were faced to provide the optimal medical management for this patient due to high cost of medical interventions and drug unavailability in the Lebanese pharmaceutical market. The economic crisis in Lebanon and consequent decline in medical sanitary and sterilization standards in some peripheral medical centers should not be taken lightly in order to prevent further emergence of threatening and resilient infections as the one fore mentioned."

Surgery • Cataract • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

CASE REPORT: “ARCHIPELAGO KERATITIS”, AN UNUSUAL VARIANT OF RECURRENT HERPETIC KERATITIS (ESCRS-WM 2023) - "The patient was initially on topical tobramycin and ciprofloxacin treatment... ApK is an atypical form of Herpesviridae keratitis, which must be known to ophthalmologists, to avoid diagnostic delays and the resulting corneal scarring. Topical ciclosporin can be useful to avoid corticosteroid-dependent recurrence."

Clinical • Corneal Abrasion • Keratitis • Ocular Inflammation • Ophthalmology

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial (clinicaltrials.gov) - P4 | N=484 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences | Initiation date: Dec 2022 ➔ Mar 2023

Trial initiation date • Infectious Disease • Inflammation • Musculoskeletal Diseases • Orthopedics