VV169
/ Vyriad
- LARVOL DELTA
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December 16, 2025
Lead in vivo CAR T candidate VV169
(Businesswire)
- "100% of mice treated with a single intravenous injection of therapy cleared OPM-2 tumors completely within 28 days. This response held true for all dose levels, including the lowest dose tested. The mice remained tumor-free 84 days post-treatment and successfully resisted tumor re-challenge; The treatment was well tolerated. Analysis of cytokines confirmed the absence of a severe cytokine storm. While IFNγ was elevated during T-cell expansion, inflammatory markers, such as IL-6, TNFα and GM-CSF, were barely detectable....Vyriad is continuing preclinical work for the development of VV169 and plans to begin a clinical trial in the U.S. in 2026."
New trial • Preclinical • Multiple Myeloma
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