serratiopeptidase / Generic mfg. - LARVOL DELTA

Effect of Occlusal Reduction on Post-operative Pain in Diabetic and Non-diabetic Patients With Symptomatic Apical Periodontitis in a Single Visit: An In Vivo Study. (PubMed, Cureus) - "Both diabetic and non-diabetic groups showed significant pain reduction over 72 hours, with the most substantial decrease within the first 48 hours. The pain patterns were comparable between groups except at 1 hour, where non-diabetics reported higher pain."

Journal • Preclinical • Dental Disorders • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Pain • Periodontitis

Nodule Formation Associated With Botulinum Neurotoxin Type A Injections: Potential Triggers in 23 Patients. (PubMed, Plast Reconstr Surg Glob Open) - "Management strategies implemented included oral antibiotics, oral serratiopeptidase, topical or systemic steroids, and oral antihistamines...The potential association between this complication and the COVID-19 vaccination warrants further investigation. It is important to counsel patients about the benign nature of these complications."

Journal • Immunology • Infectious Disease • Novel Coronavirus Disease

Tuberculoma of deep peroneal nerve- a rare case report. (PubMed, Indian J Tuberc) - "Patient developed diffuse swelling of right lower limb 5 years ago, for which he was treated with NSAIDs & serratiopeptidase by a local practitioner for 2 weeks after which he noticed tiny swellings on lower half of right shin & right foot which grew in size gradually &became painful since 2 months...Tuberculomas of peripheral nerves are rare. Final diagnosis comes from histopathology that reveals caseous necrosis surrounded by epitheloid histiocytes with or without granulomas Nerve exploration, lesion resection, and ATT results in good neurological recovery."

Journal • Brain Cancer • Infectious Disease • Oncology • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Evaluating the Combined Effect of Oral Premedications on Inferior Alveolar Nerve Block Effectiveness (clinicaltrials.gov) - P3 | N=96 | Completed | Sponsor: Zahoor khan

New P3 trial • Dental Disorders

Statistical optimization of process variables for enhanced serratiopeptidase production from soil Serratia marcescens VS56. (PubMed, Sci Rep) - "SDS-PAGE analysis revealed the molecular weight of the purified enzyme to be approximately 60 kDa. This study successfully established a robust strategy for enhanced production and efficient purification of serratiopeptidase from S. marcescens VS56, offering potential for industrial and pharmaceutical applications."

Journal • Immunology • Otorhinolaryngology • Pain • Respiratory Diseases • Rheumatology • Sinusitis

Evaluating the efficacy of curcumin plus serratiopeptidase formulation in inflammatory acne: a quasi-experimental study. (PubMed, Drugs Context) - "Conventional therapies (topical benzoyl peroxide, retinoids, antibiotics and oral isotretinoin) are effective but limited by antibiotic resistance and side effects...They were allocated to standard therapy alone (topical regimen: benzoyl peroxide 5% and adapalene 0.1% gel; oral doxycycline 100 mg once daily) or standard therapy plus a daily curcumin (500 mg) + serratiopeptidase (10 mg) supplement (adjunctive therapy)...This novel combination targets inflammatory pathways and could reduce reliance on prolonged antibiotics. Larger, longer-term studies are recommended to confirm these findings and evaluate effects on relapse and scarring."

Journal • Acne Vulgaris • Dermatology

Optimization of Serratiopeptidase Production from Serratia marcescens SP6 Using Sequential Strategy of Experimental Designs. (PubMed, Curr Microbiol) - "An overall increase of 10.16-fold in the enzyme production was thus achieved from the unoptimized condition. The findings from this sequential optimization method of enzyme synthesis demonstrated the applicability of the predicted optimum conditions for sustainable large-scale serratiopeptidase production from Serratia marcescens SP6."

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Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases. (PubMed, Pharmaceutics) - "Generally, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying anti-rheumatic drugs (DMARDs), antihistamines, biologics, and colchicine are used as pharmacological agents in the management of inflammatory diseases...Most natural anti-inflammatory enzymes belong to the oxidoreductase class, including catalase and superoxide dismutase, as well as hydrolases such as trypsin, chymotrypsin, nattokinase, bromelain, papain, serratiopeptidase, collagenase, hyaluronidase, and lysozyme...This review provides a comprehensive overview of both natural and engineered enzymes, along with their formulations, used as anti-inflammatory therapeutics. It highlights improvements in stability, efficacy, and specificity, as well as minimized immunogenicity, while discussing their mechanisms of action and clinical applications and potential future developments in enzyme-based biomedical therapeutics."

Journal • Review • Cardiovascular • CNS Disorders • Immunology • Inflammation • Metabolic Disorders • Oncology • CAT

Enhanced Antibacterial and Anti-Inflammatory Efficiency of Serratiopeptidase Immobilized on CMC-Silver Nanoparticles. (PubMed, J Basic Microbiol) - "Reusability data demonstrated 50% of initial activity was retained after seven successive cycles. Thereby, it is concluded that incorporation of serratiopeptidase onto CMC-AgNPs presented enhanced effects at lower concentrations with improved anti-inflammatory activity."

Journal • Infectious Disease

Natural serine proteases and their applications in combating amyloid formation. (PubMed, ADMET DMPK) - "We have searched for related articles using the search engines Google Scholar, PubMed, and Scopus for the past 10 years, selected the relevant articles, and written the outcomes and benefits of protease using the medical topic "serine protease" and the following text phrases -keratinase, lumbrokinase, serratiopeptidase, nattokinase...Specifically, serine proteases are a group of enzymes that can be consumed orally and are stable in our gastrointestinal tract. In this review, we discussed the role of different serine proteases in amyloid aggregate inhibition and their potential application in treating amyloidosis."

Journal • Review • Alzheimer's Disease • Amyloidosis • CNS Disorders • Dementia • Diabetes • Gastrointestinal Disorder • Metabolic Disorders • Movement Disorders • Parkinson's Disease • Type 2 Diabetes Mellitus

An Analysis of Cost Variation Among Drugs Available in the Indian Market for the Treatment of Chronic Bone-Related Ailments. (PubMed, Cureus) - "This cost minimization study, the first to the best of our knowledge in the field of chronic musculoskeletal ailments, indicates the usefulness of JA drugs in reducing the patient's financial costs for most drugs."

Journal • Back Pain • Gout • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Osteoarthritis • Osteoporosis • Pain • Rheumatoid Arthritis • Rheumatology

Bioconjugation of Serratiopeptidase with Titanium Oxide Nanoparticles: Improving Stability and Antibacterial Properties. (PubMed, J Funct Biomater) - "This study successfully developed a serratiopeptidase-TiO2 bioconjugate with enhanced enzymatic stability and antibacterial properties. The improved antibacterial activity of the immobilized enzyme presents a promising approach for developing new tools to combat antimicrobial resistance, with potential applications in healthcare, food safety, and environmental protection."

Journal • Targeted Protein Degradation

Serratiopeptidase exhibits antibiofilm activity through the proteolytic function of N-terminal domain and versatile function of the C-terminal domain. (PubMed, Biochim Biophys Acta Proteins Proteom) - "In our investigation, we have been able to analyze the antibiofilm action of serratiopeptidase in detail. Obtained results conclude that while N-terminally located proteolytic domain of serratiopeptidase conventionally acts against biofilms by hydrolytic activity, the C-terminal domain regulates or prevents biofilm formation by yet unknown mechanism in addition to its known function as an c-terminal located calcium modulated internal chaperone ensuring the proper folding and secretion of the molecule. The study's findings give new evidence that the Crtx domain plays a significant role in antibiofilm action. The proteolytic Ncat domain breaks down pre-formed biofilms. The C-terminal domain, on the other hand, acts as an inhibitor of biofilm formation by regulating or preventing biofilm development."

Journal • Targeted Protein Degradation

Nanosized Complexes of the Proteolytic Enzyme Serratiopeptidase with Cationic Block Copolymer Micelles Enhance the Proliferation and Migration of Human Cells. (PubMed, Pharmaceutics) - "It was found that SER retained its proteolytic activity after immobilization in polymeric carriers. Moreover, the complexes have a concentration-dependent enhancing effect on the proliferation and migration of human keratinocyte HaCaT and gingival fibroblast HGF cells."

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ADVANCES AND CHALLENGES IN SERRATIOPEPTIDASE TOPICAL FORMULATION. (PubMed, Ann Pharm Fr) - "Serratiopeptidase topical formulations could be more effective than nonsteroidal anti-inflammatory medications in treating local inflammation. This article reviews studies on various topical formulations."

Journal • Review • Gastrointestinal Disorder • Inflammation • Pain

Bioprospecting of serratiopeptidase-producing bacteria from different sources. (PubMed, Front Microbiol) - "The study hence contributed successfully to isolating, screening, and identifying a potent producer for serratiopeptidase from an environmental source. This inherent advantage of the strain will undoubtedly contribute much to the coco comm commercial production of serratiopeptidase in the near future."

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Does serratiopeptidase prevent thoracic surgery in patients of hydropneumothorax of tubercular aetiology? (PubMed, Lung India) - No abstract available

Journal • Surgery • Respiratory Diseases

Calcium-induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form. (PubMed, FEBS J) - "For efficient secretion and to minimize intracellular toxicity, the enzyme needs to be in an unfolded extended form. The calcium-rich extracellular environment favors the folding and processing of zymogen into mature serratiopeptidase, i.e., the holo-form required by S. marcescens to establish infections and survive in different environmental niches."

Journal • Infectious Disease

Purification, functional characterization and enhanced production of serratiopeptidase from S. marcescens MES-4: An endophyte isolated from Morus rubra. (PubMed, J Biotechnol) - "Kinetic studies revealed Vmax and Km values of 33,333U/mL and 1.66mg/mL, respectively. Further, optimized conditions for the production of serratiopeptidase by Taguchi design led to the productivity of 87U/mL/h with 87.9 fold enhanced production as compared to the previous conditions."

Journal • Pain

Comparison of the Efficacy of Corticosteroids With Enzymatic Agents in the Postoperative Sequelae for Lower Third Molar Surgery: A Prospective Study. (PubMed, Cureus) - "All patients were prescribed a combination drug of aceclofenac 100 mg and paracetamol 325 mg twice daily as a standard analgesic. Conclusion It can be concluded that the use of prednisolone postoperatively following surgical removal of the mandibular third molar provided better relief with regard to pain, trismus, and swelling compared to the enzymatic agents. Among enzymatic agents, a combination of trypsin, chymotrypsin, bromelain, rutoside, and papain was better in reducing pain, trismus, and swelling than serratiopeptidase drug."

Journal • Surgery • Inflammation • Pain

Functional Hydrogels for Delivery of the Proteolytic Enzyme Serratiopeptidase. (PubMed, Gels) - "The release profile of SER and the effects of the enzyme on healthy skin cells were assessed. The results showed that the hydrogel carrier could provide the complete release of the loaded enzyme."

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Scale-Up of the Fermentation Process for the Production and Purification of Serratiopeptidase Using Silkworm Pupae as a Substrate. (PubMed, Methods Protoc) - "Afterward, the retentate was purified using strong anion exchange chromatography and ultrafiltration, yielding a 19.94 ± 3.07% recovery and a purification factor of 1.59 ± 0.31. In conclusion, waste from the sericulture industry can be used for serratiopeptidase production."

Journal • Pain

An up-to-date review of biomedical applications of serratiopeptidase and its biobetter derivatives as a multi-potential metalloprotease. (PubMed, Arch Microbiol) - "Novel functional serratiopeptidases with shorter length and higher stability have seemingly created a hope for using this enzyme as a more effective therapeutic enzyme. This review explains the structural properties and functional aspects of serratiopeptidase, its main characteristics and properties, pre-clinical and clinical applications of the enzyme, improved qualities of the modified forms, different formulations of the enzyme, and the potential future developments."

Journal • Review • Diabetes • Immunology • Metabolic Disorders • Oncology • Pain • Rheumatology

Preparation and Physicochemical Characterization of Hyaluronic Acid-Lysine Nanogels Containing Serratiopeptidase to Control Biofilm Formation. (PubMed, Sci Rep) - "The time-kill assay showed that both forms of SRP-loaded HA-Lys nanogel and blank HA-Lys nanogel showed significant antimicrobial activity against examined bacteria in comparison to the free enzyme. The obtained results demonstrated improved anti-biofilm efficacy and down regulation of tested biofilm genes for both SRP-loaded HA-Lys nanogel 100% and blank HA-Lys nanogel 100% compared to SRP 100%."

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Different levels of single-strain probiotic (Bacillus subtilis) with proteolytic enzyme (serratiopeptidase) can be used as an alternative to antibiotic growth promoters in broiler. (PubMed, Poult Sci) - "In conclusion, the supplementation of B. subtilis with serratiopeptidase as a growth promoter in broiler chicks significantly improved the overall performance, and intestinal health and reduced microbial load contributing to optimizing the performance of broiler chickens. The greatest improvement was observed in the P200 group fed with B. subtilis as a probiotic and serratiopeptidase enzyme (200 mg:30 mg)."

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