serratiopeptidase / Generic mfg. - LARVOL DELTA

Efficacy of high-dose serrapeptase (serratiopeptidase) in inflammation among orthopedic trauma patients. (PubMed, J Med Life) - "Adverse events were mild and comparable between groups, with no serious events reported. Adjunctive serrapeptase (serratiopeptidase; DANZ-N 30 mg) was associated with lower pain scores and fewer clinical signs of inflammation in orthopedic trauma patients."

Journal • Observational data • Inflammation • Musculoskeletal Diseases • Orthopedics • Pain

Elucidation of the biochemical properties of a partially purified Serratia marcescens SP6 serratiopeptidase with anti-biofilm efficacy. (PubMed, 3 Biotech) - "These results highlight the enzyme's potential role in biofilm inhibition and suggest its possible use as an adjunct therapeutic agent alongside conventional antimicrobials to combat biofilm-associated infections. The online version contains supplementary material available at https://doi.org/10.1007/s13205-026-05063-9."

Journal • Infectious Disease

EOSVDPIAEAETCH: Efficacy of Oral Serratiopaptidase Vs Dexamethasone on Post-Operative Inflammation After Exodontia. An Experience at Tertiary Care Hospital Karachi Pakistan. (clinicaltrials.gov) - P=N/A | N=110 | Completed | Sponsor: Kharadar General Hospital

New trial • Inflammation • Pain

Management of Traumatic Penile Degloving Injury in a Resource-Constrained Setting: A Case Report and Literature Review. (PubMed, Clin Case Rep) - "The postoperative course was completed by a superficial bacterial infection on day 3, which resolved with oral linezolid and adjunctive serratiopeptidases. Follow-up confirmed that vascular supply, normal sensation, unimpaired voiding, and preserved sexual function. This case demonstrates that in resource-limited settings, meticulous assessment to confirm tissue viability enables conservative surgical management with excellent outcomes, avoiding the need for advanced techniques or grafts."

Journal • Infectious Disease

The activity of niosomal serratiopeptidase enzyme in combination with palmitoleic acid in rats with insulin-resistant polycystic ovarian syndrome. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "PCOS was induced in groups 2-6 using letrozole plus a high-fat diet for 30 days, followed by 30 days of the respective treatments, after which body and ovarian weights, ovarian cysts, and histological and biochemical parameters were assessed. In contrast, the combination of niosomal serratiopeptidase and palmitoleic acid produced the greatest effects, significantly improving metabolic, hormonal, and ovarian parameters toward near-normal levels (p < 0.05-0.0001). These preclinical findings suggest that niosomal serratiopeptidase combined with palmitoleic acid may represent a potential supportive therapeutic approach for PCOS; however, further clinical validation is warranted before any translational conclusions can be drawn."

Journal • Preclinical • Polyendocrine Metabolic Ovarian Syndrome

Exploring the bioactive potential of green synthesized silver nanoparticles coated serratiopeptidase and chalcone derivatives. (PubMed, Discov Nano) - "These findings suggest that chalcone derivatives represent a promising class of therapeutic agents, with potential application in the management of inflammation-related disorders and warrant further in-depth pharmacological and clinical investigations."

Journal • Inflammation • Pain

Structure-guided engineering of serratiopeptidase using constant-pH molecular dynamics and site-directed mutagenesis to improve pH-dependent functional resilience. (PubMed, Biochim Biophys Acta Proteins Proteom) - "A small improvement in the retained caseinolytic activity was also observed under acidic pH levels. This research demonstrated that the importance of rational design strategies in the selection of the mutation site which might influence the functional resilience of serratiopeptidase under different pH levels."

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Production, optimization, and purification of serratiopeptidase from Bacillus siamensis found in marine sediments. (PubMed, Front Microbiol) - "Serratiopeptidase produced from marine Bacillus siamensis was found to be highly stable and effective. The findings of this study support the potential of this anti-inflammatory protein as a potent candidate for therapeutic and industrial applications."

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Effectiveness of Serratiopeptidase After Mandibular Third Molar Surgery (clinicaltrials.gov) - P=N/A | N=110 | Completed | Sponsor: Sharif Medical Research Center

New trial

Heterologous expression, purification and functional characterization of recombinant serratiopeptidase from Serratia marcescens AD-W2. (PubMed, World J Microbiol Biotechnol) - "The recombinant serratiopeptidase demonstrated comparable anti-inflammatory activity to the commercially available serratiopeptidase, inhibiting nitric oxide release and pro-inflammatory cytokine production in LPS-stimulated murine macrophage cell line RAW 264.7. The study reveals that the recombinant serratiopeptidase produced in E. coli K12 holds promising source of safe and effective anti-inflammatory agent."

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CESE-3M: A Comparison of Recovery After Impacted Wisdom Tooth Removal (clinicaltrials.gov) - P3 | N=24 | Completed | Sponsor: University of Science and Technology, Yemen

New P3 trial

Effect of Occlusal Reduction on Post-operative Pain in Diabetic and Non-diabetic Patients With Symptomatic Apical Periodontitis in a Single Visit: An In Vivo Study. (PubMed, Cureus) - "Both diabetic and non-diabetic groups showed significant pain reduction over 72 hours, with the most substantial decrease within the first 48 hours. The pain patterns were comparable between groups except at 1 hour, where non-diabetics reported higher pain."

Journal • Preclinical • Dental Disorders • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Pain • Periodontitis

Nodule Formation Associated With Botulinum Neurotoxin Type A Injections: Potential Triggers in 23 Patients. (PubMed, Plast Reconstr Surg Glob Open) - "Management strategies implemented included oral antibiotics, oral serratiopeptidase, topical or systemic steroids, and oral antihistamines...The potential association between this complication and the COVID-19 vaccination warrants further investigation. It is important to counsel patients about the benign nature of these complications."

Journal • Immunology • Infectious Disease • Novel Coronavirus Disease

Tuberculoma of deep peroneal nerve- a rare case report. (PubMed, Indian J Tuberc) - "Patient developed diffuse swelling of right lower limb 5 years ago, for which he was treated with NSAIDs & serratiopeptidase by a local practitioner for 2 weeks after which he noticed tiny swellings on lower half of right shin & right foot which grew in size gradually &became painful since 2 months...Tuberculomas of peripheral nerves are rare. Final diagnosis comes from histopathology that reveals caseous necrosis surrounded by epitheloid histiocytes with or without granulomas Nerve exploration, lesion resection, and ATT results in good neurological recovery."

Journal • Brain Cancer • Infectious Disease • Oncology • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Evaluating the Combined Effect of Oral Premedications on Inferior Alveolar Nerve Block Effectiveness (clinicaltrials.gov) - P3 | N=96 | Completed | Sponsor: Zahoor khan

New P3 trial • Dental Disorders

Statistical optimization of process variables for enhanced serratiopeptidase production from soil Serratia marcescens VS56. (PubMed, Sci Rep) - "SDS-PAGE analysis revealed the molecular weight of the purified enzyme to be approximately 60 kDa. This study successfully established a robust strategy for enhanced production and efficient purification of serratiopeptidase from S. marcescens VS56, offering potential for industrial and pharmaceutical applications."

Journal • Immunology • Otorhinolaryngology • Pain • Respiratory Diseases • Rheumatology • Sinusitis

Evaluating the efficacy of curcumin plus serratiopeptidase formulation in inflammatory acne: a quasi-experimental study. (PubMed, Drugs Context) - "Conventional therapies (topical benzoyl peroxide, retinoids, antibiotics and oral isotretinoin) are effective but limited by antibiotic resistance and side effects...They were allocated to standard therapy alone (topical regimen: benzoyl peroxide 5% and adapalene 0.1% gel; oral doxycycline 100 mg once daily) or standard therapy plus a daily curcumin (500 mg) + serratiopeptidase (10 mg) supplement (adjunctive therapy)...This novel combination targets inflammatory pathways and could reduce reliance on prolonged antibiotics. Larger, longer-term studies are recommended to confirm these findings and evaluate effects on relapse and scarring."

Journal • Acne Vulgaris • Dermatology

Optimization of Serratiopeptidase Production from Serratia marcescens SP6 Using Sequential Strategy of Experimental Designs. (PubMed, Curr Microbiol) - "An overall increase of 10.16-fold in the enzyme production was thus achieved from the unoptimized condition. The findings from this sequential optimization method of enzyme synthesis demonstrated the applicability of the predicted optimum conditions for sustainable large-scale serratiopeptidase production from Serratia marcescens SP6."

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Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases. (PubMed, Pharmaceutics) - "Generally, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying anti-rheumatic drugs (DMARDs), antihistamines, biologics, and colchicine are used as pharmacological agents in the management of inflammatory diseases...Most natural anti-inflammatory enzymes belong to the oxidoreductase class, including catalase and superoxide dismutase, as well as hydrolases such as trypsin, chymotrypsin, nattokinase, bromelain, papain, serratiopeptidase, collagenase, hyaluronidase, and lysozyme...This review provides a comprehensive overview of both natural and engineered enzymes, along with their formulations, used as anti-inflammatory therapeutics. It highlights improvements in stability, efficacy, and specificity, as well as minimized immunogenicity, while discussing their mechanisms of action and clinical applications and potential future developments in enzyme-based biomedical therapeutics."

Journal • Review • Cardiovascular • CNS Disorders • Immunology • Inflammation • Metabolic Disorders • Oncology • CAT

Enhanced Antibacterial and Anti-Inflammatory Efficiency of Serratiopeptidase Immobilized on CMC-Silver Nanoparticles. (PubMed, J Basic Microbiol) - "Reusability data demonstrated 50% of initial activity was retained after seven successive cycles. Thereby, it is concluded that incorporation of serratiopeptidase onto CMC-AgNPs presented enhanced effects at lower concentrations with improved anti-inflammatory activity."

Journal • Infectious Disease

Natural serine proteases and their applications in combating amyloid formation. (PubMed, ADMET DMPK) - "We have searched for related articles using the search engines Google Scholar, PubMed, and Scopus for the past 10 years, selected the relevant articles, and written the outcomes and benefits of protease using the medical topic "serine protease" and the following text phrases -keratinase, lumbrokinase, serratiopeptidase, nattokinase...Specifically, serine proteases are a group of enzymes that can be consumed orally and are stable in our gastrointestinal tract. In this review, we discussed the role of different serine proteases in amyloid aggregate inhibition and their potential application in treating amyloidosis."

Journal • Review • Alzheimer's Disease • Amyloidosis • CNS Disorders • Dementia • Diabetes • Gastrointestinal Disorder • Metabolic Disorders • Movement Disorders • Parkinson's Disease • Type 2 Diabetes Mellitus

An Analysis of Cost Variation Among Drugs Available in the Indian Market for the Treatment of Chronic Bone-Related Ailments. (PubMed, Cureus) - "This cost minimization study, the first to the best of our knowledge in the field of chronic musculoskeletal ailments, indicates the usefulness of JA drugs in reducing the patient's financial costs for most drugs."

Journal • Back Pain • Gout • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Osteoarthritis • Osteoporosis • Pain • Rheumatoid Arthritis • Rheumatology

Bioconjugation of Serratiopeptidase with Titanium Oxide Nanoparticles: Improving Stability and Antibacterial Properties. (PubMed, J Funct Biomater) - "This study successfully developed a serratiopeptidase-TiO2 bioconjugate with enhanced enzymatic stability and antibacterial properties. The improved antibacterial activity of the immobilized enzyme presents a promising approach for developing new tools to combat antimicrobial resistance, with potential applications in healthcare, food safety, and environmental protection."

Journal • Targeted Protein Degradation

Serratiopeptidase exhibits antibiofilm activity through the proteolytic function of N-terminal domain and versatile function of the C-terminal domain. (PubMed, Biochim Biophys Acta Proteins Proteom) - "In our investigation, we have been able to analyze the antibiofilm action of serratiopeptidase in detail. Obtained results conclude that while N-terminally located proteolytic domain of serratiopeptidase conventionally acts against biofilms by hydrolytic activity, the C-terminal domain regulates or prevents biofilm formation by yet unknown mechanism in addition to its known function as an c-terminal located calcium modulated internal chaperone ensuring the proper folding and secretion of the molecule. The study's findings give new evidence that the Crtx domain plays a significant role in antibiofilm action. The proteolytic Ncat domain breaks down pre-formed biofilms. The C-terminal domain, on the other hand, acts as an inhibitor of biofilm formation by regulating or preventing biofilm development."

Journal • Targeted Protein Degradation

Nanosized Complexes of the Proteolytic Enzyme Serratiopeptidase with Cationic Block Copolymer Micelles Enhance the Proliferation and Migration of Human Cells. (PubMed, Pharmaceutics) - "It was found that SER retained its proteolytic activity after immobilization in polymeric carriers. Moreover, the complexes have a concentration-dependent enhancing effect on the proliferation and migration of human keratinocyte HaCaT and gingival fibroblast HGF cells."

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