WX-UK1 / RedHill, Heidelberg Pharma - LARVOL DELTA

Combined Antitumor Effect of the Serine Protease Urokinase Inhibitor Upamostat and the Sphingosine Kinase 2 Inhibitor Opaganib on Cholangiocarcinoma Patient-Derived Xenografts. (PubMed, Cancers (Basel)) - "Mouse weights and PAX165 tumor volumes were measured. Tumor volumes in the upamostat, opaganib, and upamostat plus opaganib groups were significantly decreased compared to the control group."

Journal • Biliary Cancer • Cholangiocarcinoma • Gastrointestinal Cancer • Oncology • Solid Tumor • PRSS1 • PRSS3 • SPHK1 • SPHK2

Upamostat: a serine protease inhibitor for antiviral, gastrointestinal and anticancer indications. (PubMed, Expert Opin Investig Drugs) - "Upamostat is an orally bioavailable prodrug of WX-UK1, which is most active against trypsins and closely related enzymes. Upamostat is an orally bioavailable serine protease inhibitor with an excellent safety profile and favorable pharmacokinetic properties. It has demonstrated preliminary evidence of efficacy against COVID-19 and nonclinical data suggest potential applicability against other viral illnesses, gastrointestinal diseases and cancer."

Journal • Review • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Hepatology • Infectious Disease • Novel Coronavirus Disease • Oncology • Pancreatic Cancer • Respiratory Diseases • Solid Tumor

MECHANISTIC EFFECTS OF UPAMOSTAT AND OPAGANIB IN CHOLANGIOCARCINOMA CELL LINES (AASLD 2022) - "Upamostat and its active metabolite WX-UK1 have been shown to inhibit serine proteases. Upamostat and opaganib in combination have significant inhibitory effects on both CCA cell migration and viability in vitro which may prevent tumor progression. Both drugs have an established clinical safety profile and may be effective in targeted treatment of CCA patients."

Preclinical • Biliary Cancer • Breast Cancer • Cholangiocarcinoma • Gastrointestinal Cancer • Genito-urinary Cancer • Hepatology • HER2 Breast Cancer • Liver Cancer • Oncology • Pancreatic Cancer • Prostate Cancer • Solid Tumor • HER-2