sulfadoxine/pyrimethamine / Generic mfg. - LARVOL DELTA

Nanoscaffold-based 3D human liver spheroids for predictive hepatotoxicity screening of antimalarial compounds from the global health priority box. (PubMed, Parasit Vectors) - "This study demonstrates the translational application of a validated nanoscaffold-based 3D human liver spheroid model for antimalarial drug in vitro hepatotoxicity assessment. By establishing a reference framework from clinically approved antimalarials and applying it to candidate compounds from the MMV GHPB, our platform enabled early classification of hepatotoxicity risk using a human-relevant, non-animal method. The findings support the integration of advanced 3D in vitro systems into antimalarial drug discovery pipelines to improve safety prediction, reduce reliance on animal testing, and accelerate the development of safer, more effective antimalarial therapies."

Journal • Hepatology • Infectious Disease • Liver Failure • Malaria

Effectiveness of intermittent preventive treatment for malaria in pregnancy in an area of high sulfadoxine/pyrimethamine resistance in Northern Uganda: a directed acyclic graph-guided analysis (ESCMID Global 2026) - No abstract available

Infectious Disease • Malaria

Geographical Heterogeneity in Antimalarial Resistance Markers by Genomic Surveillance in Angola, 2023. (PubMed, Am J Trop Med Hyg) - "Efficacy of artemether-lumefantrine has been reported below 90% in two provinces, underscoring the need for routine resistance surveillance...In the southeast, artemisinin partial resistance markers (k13 P574L, P441L) were detected at very low prevalence (35% of samples)...The chloroquine resistance marker crt C72/V73/M74I/N75E/K76T (CVIET) haplotype had a national prevalence of 17.7%, detected in over 48% of samples from the northern sites...Coinfections of P. falciparum and non-falciparum species were rare, with no Plasmodium vivax coinfections detected. These findings highlight the need for continued monitoring to safeguard treatment efficacy, reinforcing the importance of molecular surveillance in malaria control strategies."

Heterogeneity • Journal • Infectious Disease • Malaria • ABCB1 • DHFR

Targeted Genomic Surveillance Unveils Genetic Variations Linked to Regional Malaria Drug Resistance Dynamics in India. (PubMed, Open Forum Infect Dis) - "India's historical policy of artesunate-sulfadoxine-pyrimethamine in central India and artemether-lumefantrine in the Northeast has shaped contrasting resistance profiles. In the Northeast, chloroquine resistance persisted at high frequency (Pfcrt K76T and CVIET haplotype; Pfaat1 S258L), alongside quintuple and sextuple Pfdhfr-Pfdhps haplotypes conferring complete sulfadoxine-pyrimethamine resistance...India's resistance landscape is fragmented, with signals of expanding lumefantrine tolerance and importation or evolution of globally relevant mutations. These findings highlight the importance of integrating molecular genomic surveillance into malaria control policy to monitor and protect ACT effectiveness and advance malaria elimination."

Journal • Infectious Disease • Malaria • ABCB1

Emerging Artemisinin Partial Resistance in Southern Africa. (PubMed, Am J Trop Med Hyg) - "Given past failures to contain chloroquine and sulfadoxine-pyrimethamine resistance, a timely response is critical. We recommend immediate treatment policy shifts, expanded surveillance, and regional coordination to prevent the spread of ART-R. This Perspective calls on global health actors to act decisively while resistance remains geographically limited."

Journal • Infectious Disease • Malaria

Molecular markers of antimalarial drug resistance in pfk13, pfmdr1, pfdhfr, and pfdhps genes of Plasmodium falciparum in a rural municipality in Cubal, Benguela Province, Angola (2022-2023). (PubMed, Malar J) - "This study provides an updated molecular profile of antimalarial resistance in a rural area of Angola. No validated or candidate pfk13 markers of artemisinin resistance were identified. However, the predominance of pfmdr1 haplotypes linked to reduced lumefantrine susceptibility raises concerns regarding AL efficacy. Although SP remains suitable for IPTp, the presence of the "fully resistant" haplotype (IRNGE) of pfdhfr/pfdhps highlight potential risks to long-term effectiveness. These findings reinforce the need for integrated molecular surveillance and periodic therapeutic efficacy studies to guide malaria control policies in rural Angola."

Biomarker • Journal • Infectious Disease • Malaria • ABCB1

Extreme weather events and malaria prevention in pregnancy: a mediation analysis of antenatal care and sulfadoxine-pyrimethamine use in two malaria-endemic counties of Kenya. (PubMed, Malar J) - "Extreme weather events reduced IPTp₃ + uptake primarily through ANC disruption in unadjusted models, with effects concentrated in Kisumu. However, these associations attenuated after adjustment, suggesting the role of underlying socioeconomic and contextual vulnerabilities."

Journal • Hematological Disorders • Infectious Disease • Malaria

Improving malaria chemoprevention coverage in pregnancy: Surveying stakeholder preferences for new product profiles and community-delivery approaches across five African countries. (PubMed, PLOS Glob Public Health) - "Sulfadoxine-pyrimethamine (SP) is the only WHO-recommended option for the intermittent preventive treatment of malaria in pregnancy (IPTp). However, coverage is suboptimal, efficacy is limited in areas of high resistance and SP is contraindicated in the first trimester and women living with HIV receiving cotrimoxazole...Minimizing food-related restrictions and addressing resistance concerns are key priorities, together with safety and tolerability. Long-acting injectable formulations and hybrid delivery models could play a substantial role in improving adherence and uptake."

Journal • Human Immunodeficiency Virus • Infectious Disease • Malaria

Factors influencing the utilisation of malaria preventive services during pregnancy in Ile Ife, Nigeria: a mixed method approach. (PubMed, Malar J) - "Modalities to maintain constant availability of malaria preventive commodities at ANC clinics should be put in place. In addition to the conventional awareness programmes, optimal utilisation of MPS can be achieved through the integration of unconventional healthcare providers such as faith-based and traditional birth attendants into malaria in pregnancy preventive initiatives. Also, educational interventions and continuous health workers training are crucial."

Journal • Infectious Disease • Malaria • Obstetrics

Incidence and trends of adverse drug reactions during seasonal malaria chemoprevention among children: evidence from Ghana's pharmacovigilance database, 2015-2023. (PubMed, Malar J) - "SMC with SPAQ is generally safe in Ghana, though serious ADRs continue to occur. The low reporting rate by healthcare professionals, contrasted with high reporting by caregivers, underscores the need to enhance professional engagement, ensure accurate community reporting, and expand active surveillance during SMC campaigns."

Adverse drug reaction • Adverse events • Journal • Infectious Disease • Malaria

Plasmodium falciparum GTP-cyclohydrolase 1 (Pfgch1) Gene Copy Number Variation and Its Implications in antimalarial resistance from Northeast India. (PubMed, J Vector Borne Dis) - "The present study focuses on the GTP-cyclohydrolase 1 (Pfgch1) gene, a key enzyme in the folate biosynthesis pathway, known to play a role in antimalarial (Sulfadoxine-Pyrimethamine, commonly used in combination therapies) resistance...Further investigation is needed to elucidate the correlation between Pfgch1 amplification and how Pfdhfr/Pfdhps mutations contribute to antimalarial drug resistance in P. falciparum. This research finding may help to detect and mitigate the spread of antifolate-resistant P. falciparum."

Journal • Infectious Disease • Malaria • DHFR • GCH1

Adherence and barriers to key antenatal interventions among pregnant women in an urban district of Ghana: A cross-sectional study. (PubMed, J Public Health Res) - "The uptake of Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment in pregnancy (SP-IPTp) was found to be inadequate among 48.0%, those with adequate SP-IPTp uptake, 58.34% were in their third-trimester gestation, 8.33% were in their first trimester and 85.58% of third-trimester expectant mothers had inadequate uptake of SP-IPTp...For deworming therapy, 94.12% of participants reported that the medication was not administered at ANC. This study makes significant contributions to maternal and child health research and policy by providing empirical evidence on the gaps between the coverage and actual uptake of key antenatal care (ANC) interventions such as SP-IPTp, IFAS, and deworming therapy among pregnant women in Ghana."

Journal • Observational data

Use of antiparasitic drugs in the prevention of congenital toxoplasmosis: systematic review and meta-analysis (PubMed, Med Trop Sante Int) - "In the context of preventing congenital Toxoplasma gondii infection, optimizing the use of antiparasitic molecules, such as spiramycin, pyrimethamine-sulfadiazine combinations, cotrimoxazole, and pyrimethamine-sulfadoxine, during the prenatal period is a significant challenge in limiting maternal-fetal transmission and reducing associated effects. The failure rate of standard anti-toxoplasma treatments can be reduced by addressing several recognized risk factors early on. Each healthcare system must strengthen the monitoring and evaluation of treatment policies for primary infection per pregnancy in order to implement a more appropriate secondary prevention strategy."

Journal • Retrospective data • Review • Infectious Disease

Persistent and Circulating Plasmodium falciparum dhfr and dhps Mutations in Busia County, Western Kenya. (PubMed, Pathogens) - "For decades, intermittent preventive treatment in pregnancy (IPTp), with sulphadoxine-pyrimethamine (SP), has mitigated malaria-associated health risks, but concerns have been raised regarding accumulated Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations on the efficacy of SP...These findings indicate the persistence and circulation of both canonical and non-canonical dhfr and dhps haplotypes in P. falciparum isolates from Busia County. This study highlights the need for continuous molecular and phenotypic surveillance to clarify the functional and epidemiological significance of parasites carrying S108T and I164L mutations, and to inform IPT policy."

Journal • Infectious Disease • Malaria • DHFR

Asymptomatic malaria: a hidden reservoir for the transmission and circulation of artemisinin partial-resistant Plasmodium falciparum in Tanzania. (PubMed, Emerg Microbes Infect) - "Artemether-lumefantrine (AL, 64.7%) was the most commonly used antimalarial in high-transmission areas, whereas sulfadoxine-pyrimethamine (SP, 75.9%) predominated in low-transmission areas. Higher AL use correlated with increased pfmdr1 mutation prevalence in high-transmission regions, while NFD detection in low-transmission areas may reflect gene flow from high-transmission settings. These findings demonstrate that asymptomatic carriers are a substantial hidden reservoir of ART-resistant parasites, emphasizing the importance of integrating molecular surveillance and demographic information on asymptomatic infections into malaria control programs to detect emerging resistance and guide targeted interventions in Tanzania."

Journal • Infectious Disease • Malaria • ABCB1

The Global Landscape of Plasmodium falciparum Drug Resistance Markers, 2005-2025: A Systematic Review and Meta-Analysis. (PubMed, Pathogens) - "High heterogeneity (I2 > 95%) and rising pfk13 since 2012 highlight emerging artemisinin resistance, while persistent pfdhfr/pfdhps mutations show that ongoing sulfadoxine-pyrimethamine (SP) pressure on P. falciparum drug resistance, decreased parasite clearance, and treatment failure remain widespread and evolving in Africa. Integrating molecular surveillance into national malaria programs is essential to guide treatment modalities and support progress toward malaria elimination."

Journal • Retrospective data • Review • Infectious Disease • Malaria • ABCB1

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas. (PubMed, Cochrane Database Syst Rev) - "Malaria prevention: None of the included trials reported primary outcomes. Malaria treatment: People who received folic acid supplementation (alone or with iron) and antifolate antimalarial treatment were less likely to clear malaria parasitaemia (day 3), and had increased treatment failure (days 7, 14, 28). Most of the included trials provided folic acid with doses above the tolerable UL (> 1.0 mg). One trial included folic acid at a dose of 400 μg/d (recommended dose for preventing neural tube defects) and showed little to no difference in parasite clearance or treatment failure."

Clinical • Journal • Review • Infectious Disease • Malaria

Plasmodium falciparum field isolates drug susceptibility in Mali. (PubMed, JAC Antimicrob Resist) - "Parasites were exposed to 14 drugs, including tafenoquine, N-desethyl-amodiaquine, chloroquine, dihydroartemisinin, lumefantrine, pyronaridine, quinine, sulfadoxine, pyrimethamine, amodiaquine, atovaquone, GNF179, KDU691 and cabamiquine. While current frontline therapies remain effective, reduced activity of chemopreventive antimalarials supports the need for continued surveillance to detect early signs of resistance in Mali. The potent activity of next-generation candidates (cabamiquine and GNF179) supports their potential for further clinical development and field deployment."

Journal • Infectious Disease • Malaria

Recurrent Plasmodium falciparum parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda. (PubMed, J Infect Dis) - "IPTp-SP had poor antimalarial preventive efficacy and selected for increased drug resistance, questioning the value of this intervention."

Journal • Infectious Disease • Malaria • DHFR

Impact of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine on sexually transmitted and reproductive tract infections: results from a randomized trial in Uganda. (PubMed, Int J Epidemiol) - "Monthly IPTp-SP may reduce the risk of adverse birth outcomes through its activity against C. trachomatis and GBS, highlighting its potential non-malarial benefits."

Clinical • Journal • Infectious Disease • Malaria • Small for Gestational Age • Vaginitis

Evolving patterns of antimalarial drug resistance markers in symptomatic infections in Kenya, 2013-2022. (PubMed, Parasit Vectors) - "Our findings reveal no WHO-validated k13 mutations up until 2022 and confirm previous findings of a reduction in the Pfcrt resistance genotypes over time. This study underscores the importance of continued molecular surveillance and suggests that resistance may evolve through different pathways in East compared with West Africa and Southeast Asia."

Journal • Infectious Disease • Malaria • DHFR

Integrating group antenatal care into routine services: a registry-based cohort study in Geita, Tanzania. (PubMed, BMC Glob Public Health) - "In routine settings, G-ANC was associated with high ANC attendance, strong uptake of essential interventions, and positive birth outcomes. Integration appears feasible within public systems, though adaptations are needed to promote earlier initiation and alignment with the WHO eight-contact model. Further research should examine costs, feasibility, scalability, and long-term impact."

Journal • Infectious Disease • Malaria

Malaria in pregnancy at the frontline: a delicate balance. (PubMed, Curr Opin Immunol) - "Despite parasite resistance to sulfadoxine-pyrimethamine (SP), it still helps improve birth weight as an intermittent preventive treatment in pregnancy. Dihydroartemisinin-piperaquine, though more effective against parasitemia, does not improve birth outcomes when used alone or in combination with SP. Interventions targeting first-trimester infections, blood-stage parasites, and vaccines that prime defences in primigravidae would be optimal for controlling malaria in pregnancy."

Journal • Review • Infectious Disease • Inflammation • Malaria

MULTIple Doses of IPTi Proposal: a Lifesaving High Yield Intervention (clinicaltrials.gov) - P=N/A | N=94252 | Completed | Sponsor: Barcelona Institute for Global Health | Active, not recruiting ➔ Completed | N=45000 ➔ 94252

Enrollment change • Trial completion • Infectious Disease • Malaria

Prevalence of antimalarial drug resistance molecular markers in Makenene, central Cameroon. (PubMed, Int J Parasitol Drugs Drug Resist) - "The in-depth analysis of genetic mutations associated with antimalarials resistance in this study, notably those with a high prevalence of mutations on the Pfdhfr and Pfdhps genes, highlights the immediate need for proactive strategies to combat resistance in Makenene. Continuous monitoring, including molecular and in vivo surveillance is crucial to uphold the effectiveness of current treatments and, more particularly, artemisinin-based combination therapies, and to enable better decision-making on effective treatment policy in Cameroon and in Africa as a whole."

Biomarker • Journal • Infectious Disease • Malaria • ABCB1