sulfadoxine/pyrimethamine / Generic mfg. - LARVOL DELTA

Molecular epidemiology of Plasmodium falciparum drug resistance and vaccine targets in high-transmission settings in Africa. (PubMed, Sci Rep) - "We identified high frequencies of dhfr-IRNI (90%) and dhps-SGKAA (45%) haplotypes, consistent with molecular markers of sulfadoxine-pyrimethamine (SP) resistance...The chloroquine-resistant Pfcrt-76T allele persisted at ~ 25% frequency, suggesting both sustained resistant lineages and a potential re-expansion of chloroquine-susceptible parasites...In parallel, polymorphisms within immunogenic domains of csp, the target of recently approved R21/Matrix-M vaccines were predicted to affect protein stability, though their functional consequences require experimental validation. Geographic analyses revealed localized clustering of resistance haplotypes, particularly in Kano and Yobe, reflecting heterogeneous selection pressures across transmission settings. Together, these findings establish a genomic surveillance framework for real-time monitoring of antimalarial resistance and vaccine-target polymorphisms in high-burden regions, with direct implications for evidence-based..."

Journal • Infectious Disease • Malaria • ABCB1 • DHFR

Wealth-based inequalities in the uptake of three or more doses of intermittent preventive treatment in pregnancy in West Africa, 2015-2021. (PubMed, Malar J) - "Wealth-based inequalities continue to hinder IPTp-SP3 uptake in West Africa. Addressing these disparities require targeted equity-driven strategies to improve coverage among pregnant women and towards achieving the objectives of SDG 3."

Journal • Hematological Disorders • Infectious Disease • Malaria

Spatial heterogeneities in women's adherence to sulfadoxine pyrimethamine prophylaxis in Tanzania: Findings from the 2022 TDHS-MIS. (PubMed, IJID Reg) - "The Northern, Southern, Lake, and Eastern zones show higher coverage, while Zanzibar lags substantially behind. Factors such as place of residence, education, maternal age, wealth status, and parity are key determinants, underscoring the need for carefully designed, geographically targeted interventions to improve SP/Fansidar adherence in the most affected zones."

Journal • Infectious Disease • Malaria

Comparative effect of chemoprevention in malaria infection during pregnancy: A network meta-analysis. (PubMed, Br J Clin Pharmacol) - "The findings suggest that there is moderate certainty of evidence of the effect of IPTp-SP monthly single dose on maternal parasitaemia and anaemia. Future research should include a head-to-head comparison with adequate samples and evaluate the effectiveness, safety, operational feasibility and cost-effectiveness of IPTp for SP, DP, azithromycin and other potential antimalarials as either monotherapy or combination therapy. Information from endemic regions outside Africa, such as Asia and Latin America, is recommended."

Journal • Retrospective data • Review • Hematological Disorders • Infectious Disease • Malaria

Factors associated with intermittent preventive treatment (IPTp-SP) use for malaria during pregnancy in Somalia: a multilevel analysis of the 2020 demographic and health survey. (PubMed, Malar J) - "The overall reported use of SP/Fansidar in Somalia is critically low, indicative of significant gaps in maternal healthcare delivery and falling far short of WHO coverage goals. This is fundamentally driven by the very low overall ANC attendance rate (31.0%) and further exacerbated by paradoxical findings, such as lower reported SP use among those who do attend, despite higher ANC attendance, which suggest severe systemic barriers and potential issues with service quality or SP availability. Interventions are needed to improve both initial access to ANC and the quality of ANC delivery, ensure SP availability and administration during visits, address regional inequities, and strengthen the health system to protect pregnant women and newborns from malaria."

Journal • Infectious Disease • Malaria

Comparative effects of antimalarial drugs on oxidative phosphorylation, mitochondrial dynamics and mitophagy in Plasmodium berghei-infected mice. (PubMed, Toxicol Rep) - "Thirty-five Swiss-mice (18 ± 3 g) were infected intraperitoneally with chloroquine resistant (ANKA) strain of Plasmodium berghei and treated orally and once daily with (10 mg/kg) dose of Amodiaquine artesunate (AA), Artemether-Lemefantrine (AL), Sulfadoxine- pyrimethamine (SP) and Artesunate (ART), On day 6, animals were sacrificed and livers were removed. Significant down-regulation in the expressions of PINK 1 by SP, FUNDC1 by AA and AL, DNM1L by ART, PGC-1α by AA, AL, and ART, and prohibitins 1 and 2 by AA and AL similar to the infected control were observed. This study showed that host mitochondria respond differently to antimalarial drugs."

Journal • Preclinical • Infectious Disease • MFN2

Cost-effectiveness of intermittent preventive therapy and insecticide-treated bed nets for malaria prevention among pregnant women in Jos North, Plateau State, Nigeria. (PubMed, Malar J) - "This study demonstrates that IPTp-SP/ITN is a cost-effective intervention for preventing malaria during pregnancy. However, its cost-effectiveness is influenced by integration into ANC services, adherence to ITN use, and funding mechanisms. Policymakers should consider optimizing funding and service delivery models to improve intervention efficiency and sustainability. Further research incorporating household-level costs and long-term economic impacts is recommended."

HEOR • Journal • Hematological Disorders • Infectious Disease • Malaria

Initiating community intermittent preventive treatment of malaria in pregnancy in Senegal: qualitative evaluation of stakeholder acceptability and experience. (PubMed, Malar J) - "The study identifies and addresses challenges to optimal deployment of c-IPTp in Senegal. Continued efforts to overcome these challenges will be crucial in realising the full potential of c-IPTp to improve maternal and child health outcomes in malaria-endemic regions."

Journal • Infectious Disease • Malaria

Inequalities in the use of three-dose of intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine among women in Sierra Leone, 2008-2019. (PubMed, Malar J) - "Despite the overall improvement in IPTp-SP coverage and the decreasing economic, educational and place of residence-related inequalities, continued provincial-level disparities indicate the necessity of tailoring interventions to address provincial-specific barriers. To achieve universal and equitable coverage of IPTp-SP, the study recommends a multifaceted approach that combines strengthening the health system, targeted behaviour change communication and addressing social determinants of health."

Journal • Infectious Disease • Malaria

Recurrent Plasmodium falciparum parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda. (PubMed, medRxiv) - "Intermittent preventive treatment with monthly sulfadoxine-pyrimethamine (IPTp-SP) is recommended during pregnancy in malaria-endemic countries...Infection with mutant parasites was associated with non-significant increases in risks of recrudescence. IPTp-SP had poor preventive efficacy and selected for increased drug resistance, questioning the value of this intervention."

Journal • Infectious Disease • Malaria • DHFR

Rethinking a hybrid malaria chemoprevention delivery strategy for children in sub-perennial settings: a modelling study integrating age- and seasonally-targeted delivery. (PubMed, Malar J) - "Substantially increased public health benefits might be achieved by adding seasonally-targeted chemoprevention to current PMC in sub-perennial malaria transmission settings. Effectiveness-implementation studies will be crucial to generate empirical evidence of public health impact including on the disease burden averted, safety, and cost-effectiveness of the hybrid approach. Such studies should also explore determinants of implementation success including operational feasibility, coverage, and acceptability of proposed dosing strategies to inform deployment decisions."

Journal • Infectious Disease • Malaria

Beyond malaria: can intermittent preventive treatment with sulphadoxine-pyrimethamine reduce the number of small vulnerable newborns globally? (PubMed, Lancet Glob Health) - "Refining our understanding of the pathways underlying the protective efficacy of sulphadoxine-pyrimethamine will require mechanistic studies and placebo-controlled randomised trials of IPTp-SP in non-malarious settings. These studies will be crucial to confirm whether sulphadoxine-pyrimethamine could be considered for reducing the risk of SVNs in settings with high prevalence of SVNs and little or no malaria transmission."

Journal • Review • Infectious Disease • Malaria • Nephrology

Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi (clinicaltrials.gov) - P4 | N=1000 | Active, not recruiting | Sponsor: Liverpool School of Tropical Medicine | Recruiting ➔ Active, not recruiting

Enrollment closed • Anemia • Hematological Disorders • Infectious Disease • Malaria

A scoping review of antimalarial drug resistance markers in Kenya (1987-2022): toward a National Surveillance Framework and Data Repository. (PubMed, Malar J) - "Tracking the molecular markers of resistance emerged as a valuable tool over 60 years ago, following the identification of sulfadoxine-pyrimethamine (SP) genetic resistance markers, dhfr and dhps...MDR1 codons 86 and 1246, also genetic markers of chloroquine resistance have shown a full reversion to the wildtype, that was rising since 1994 in the Coast and 2003 in Western Kenya...The compilation and standardization of over 100 studies provides a high-level, structured overview of when and where resistance markers have been surveyed. This establishes a foundational national repository to support strategic surveillance planning by the Kenya NMCP."

Journal • Review • Infectious Disease • ABCB1 • DHFR

Parasite clearance and protection from Plasmodium falciparum infection (PCPI): a two-arm, parallel, double-blinded, placebo-controlled, randomised trial of presumptive sulfadoxine-pyrimethamine versus artesunate monotherapy among asymptomatic children 3-5 years of age in Zambia. (PubMed, BMC Infect Dis) - P3 | "We will report unblinded results including: (i) time-to-parasite clearance among SP recipients who were positive on day 0 by qPCR and measured to day 63; (ii) mean duration of SP protection against infection, and (iii) mean duration of symptom-free status among SP recipients who were parasite free on day 0 by qPCR. Our conclusions will reflect on the utility of WHO's new malaria chemoprevention efficacy study protocol with its follow-up to day 28 versus day 63."

Journal • Monotherapy • Infectious Disease • Malaria

ASPIRE Trial: Effects of metronidazole plus intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine or dihydroartemisinin-piperaquine on adverse pregnancy outcomes and curable sexually transmitted infections in a double-blind . (ASTMH 2025) - "Neither SP-MTZ nor DP-MTZ was superior to SP for protection against adverse pregnancy outcomes. DP-MTZ was superior to SP and SP-MTZ against malaria , whereas SP-containing regimens were better at reducing curable of sexually transmitted infections."

Adverse events • Clinical • Infectious Disease • Malaria • Vaginitis

WITHDRAWN Understanding cohort retention: findings from a seasonal malaria chemoprevention efficacy study in Niassa, Mozambique (ASTMH 2025) - "This analysis utilised data from a CPES in which a cohort of children were prospectively recruited in four communities, underwent a baseline assessment, received a three-day course of sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) and were followed up for up to 28 days to monitor incidence of malaria infection. There was substantial attrition in the study. Dropout rates varied across study communities, suggesting the influence of individual and contextual factors."

Clinical • Infectious Disease • Malaria

WITHDRAWN Integrating evidence from novel chemoprevention trials to estimate protective efficacy of sulfadoxine-pyrimethamine against malaria parasites across different sub-Saharan Africa resistance profiles (ASTMH 2025) - "Drug resistance data from various published data sources will be used to extrapolate our findings on genotype-specific protective efficacy across sub-Saharan Africa (SSA). We will present an updated map of SP chemoprevention efficacy at the subnational level across SSA, contributing to the broader evidence base and allowing PMC strategies to be tailored to individual settings based on their epidemiology and drug resistance profile."

Clinical • Infectious Disease • Malaria

WITHDRAWN Assessing spatial and temporal trends in seasonal malaria chemoprevention coverage and other key indicators, and identifying factors associated with the trends in Nampula Province, Mozambique. (ASTMH 2025) - "In 2020, a mid-term review of Mozambique's Malaria Strategic Plan recommended the adoption of seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) to accelerate malaria control. Conversely, children whose caregivers had limited SMC knowledge had lower odds of receiving Day 1 SPAQ compared with those of more knowledgeable caregivers (Odds ratio, 0.68 [95% CI: 0.47- 0.98]). Future interventions should focus on strengthening caregiver engagement and refining distribution strategies, especially in underperforming districts."

Infectious Disease • Malaria

Effect of malaria chemoprevention for school-age children across transmission archetypes: a modelling study. (PubMed, Lancet Glob Health) - "Our model suggests that adding IPT of school-age children to current control tools could decrease malaria burden in this group and reduce P falciparum transmission."

Journal • Hematological Disorders • Infectious Disease • Malaria • FPR2

Pharmacometric evaluation of sulfadoxine-pyrimethamine- amodiaquine and dihydroartemisinin-piperaquine seasonal malaria chemoprevention in northern Uganda. (PubMed, Clin Infect Dis) - "SPAQ SMC had low clinical and parasitological chemopreventive efficacy in Northern Uganda whereas dihydroartemisinin-piperaquine was effective."

Journal • Infectious Disease • Malaria

Is Seasonal Malaria Chemoprevention with Sulfadoxine-Pyrimethamine/Amodiaquine Appropriate in East Africa? (PubMed, Clin Infect Dis) - No abstract available

Journal • Infectious Disease • Malaria

Malaria in Children with Sickle Cell Anaemia in Areas with Low, Moderate and High Transmission in Uganda (ASH 2023) - "Cohort 1 were SCA aged 3-9 years, enrolled in the hydroxyurea therapy for neurological and cognitive protection in Uganda (BRAINSAFE II) trial at Mulago Hospital, a low transmission area, while cohort 2 and 3 aged 6 months to 15 years, were enrolled in the dihydroartemisinin-piperaquine (DP) or sulphadoxine-pyrimethamine (SP) for the chemoprevention of malaria in SCA (CHEMCHA) trial at Jinja Hospital (moderate transmission) and Kitgum Hospital (high transmission). Malaria incidence remains high among Ugandan children with SCA, and differs by transmission patterns. Prevention strategies should be strengthened, especially in high transmission areas."

Clinical • Anemia • Hematological Disorders • Infectious Disease • Malaria • Sickle Cell Disease

Parasitological efficacy of seasonal malaria chemoprevention in Nampula, northern Mozambique. (PubMed, Trans R Soc Trop Med Hyg) - "In Nampula, northern Mozambique, amodiaquine had low parasitological efficacy and sulphadoxine and pyrimethamine did not contribute significantly to chemoprevention."

Journal • Infectious Disease • Malaria

Association between adequacy of antenatal care and uptake of intermittent preventive treatment of malaria in pregnancy among women in Ghana. (PubMed, Malar J) - "Receipt of adequate ANC services is positively associated with the uptake of at least three doses of IPTp-SP. This association is independent of potential confounders. These findings highlight the need for targeted interventions to improve access to and the quality of ANC services, thereby increasing the uptake of IPTp-SP during pregnancy."

Journal • Infectious Disease • Malaria