sulfadoxine/pyrimethamine / Generic mfg. - LARVOL DELTA

Predictors of Optimal Uptake of Intermittent Preventive Treatment in Pregnancy (IPTp3+) in Nigeria: Survey-Weighted Regression and Exploratory Machine-Learning Analysis of the 2021 Nigeria Malaria Indicator Survey. (PubMed, Niger Med J) - "Malaria in pregnancy remains a public health challenge in Nigeria despite the effectiveness of intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP)...The exploratory machine-learning models showed modest predictive performance. Strengthening ANC access and improving IPTp delivery remain important priorities."

Journal • Infectious Disease • Malaria

Investigating the role of a non-synonymous mutation at dhfr codon 50 in maintaining sulphadoxine-pyrimethamine resistance in Plasmodium falciparum: a modelling study. (PubMed, Lancet Microbe) - "Our findings suggest that fitness-enhancing mutations should be considered when interpreting the emergence of novel resistance patterns; however, this hypothesis requires further empirical validation."

Journal • Infectious Disease • Malaria • DHFR

Perennial Malaria Chemoprevention (PMC) in Côte d'Ivoire (clinicaltrials.gov) - P=N/A | N=1381 | Completed | Sponsor: London School of Hygiene and Tropical Medicine | Active, not recruiting ➔ Completed | Trial completion date: Sep 2025 ➔ Dec 2025

Trial completion • Trial completion date • Anemia • Hematological Disorders • Infectious Disease • Malaria

Perennial Malaria Chemoprevention (PMC) in Cameroon (clinicaltrials.gov) - P=N/A | N=2138 | Completed | Sponsor: London School of Hygiene and Tropical Medicine | Active, not recruiting ➔ Completed | Trial completion date: Sep 2025 ➔ Dec 2025

Trial completion • Trial completion date • Anemia • Hematological Disorders • Infectious Disease • Malaria

Multiple local PfDHFR I164L haplotype expansions drive Plasmodium falciparum antifolate resistance in Uganda. (PubMed, Nat Commun) - "Mutations in the Plasmodium falciparum genes, pfdhfr and pfdhps, drive antifolate resistance and threaten malaria control in regions where sulfadoxine-pyrimethamine (SP) is the primary chemoprevention strategy...Using identity-by-descent, haplotype structure, and extended haplotype homozygosity analyses, we show that PfDHFR I164L is present on multiple haplotype backgrounds and undergoes localised expansions, without detectable signatures of recent positive selection at all but one site. Our results suggest that the evolution of antifolate resistance, driven by PfDHFR I164L, is spatially heterogeneous and complex in regions that primarily use SP chemoprevention programmes."

Journal • Infectious Disease • Malaria

Spatio-temporal trends of the prevalence of Plasmodium falciparum antimalarial drug resistance markers across sub-Saharan Africa from 2010 to 2024: a systematic review and meta-analysis. (PubMed, BMC Infect Dis) - "Overall, the temporal and regional patterns of antimalarial drug resistance molecular markers across sub-Saharan Africa underscore the need for sustained molecular surveillance tailored to local epidemiological trends of resistance markers."

Clinical • Journal • Retrospective data • Review • Infectious Disease • ABCB1

Avian malaria: an in-depth overview on its biology, epidemiology, pathogenesis, clinical features, economic impacts, diagnostic, treatment and control strategies. (PubMed, J Parasit Dis) - "Treatment options are limited, typically involving antimalarial drugs such as chloroquine phosphate, primaquine phosphate, mefloquine, sulfachloropyrazine, sulfaquinoxaline, Trimethoprim, and Pyrimethamine-sulfadoxine combination along with supportive care and environmental management. This review synthesizes current knowledge on the epidemiology, transmission dynamics, and ecological consequences of avian malaria, with the goal of informing conservation and management strategies. The online version contains supplementary material available at https://doi.org/10.1007/s12639-025-01887-z."

HEOR • Journal • Review • Hematological Disorders • Infectious Disease • Malaria

Understanding the Dimensions of Caregiver-Perceived Seasonal Malaria Chemoprevention Delivery Quality in Nigeria: A Structural Equation Modeling Analysis of Door-to-Door Seasonal Malaria Chemoprevention. (PubMed, Am J Trop Med Hyg) - "Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (AQ) has been implemented in Africa since 2012 to prevent malaria among children ages 3 to 59 months old. Structural equation modeling showed that perceived SMC delivery quality had significant direct effects on all three outcomes, with indirect effects significant only for days 2 and 3 AQ adherence. Findings highlight that improving and monitoring caregiver-perceived SMC delivery quality is essential to sustaining SMC effectiveness and suggest the need for strengthened distributor training and community engagement."

Journal • Infectious Disease • Malaria

Phytochemical synergy in artemisia annua herbal tea against malaria: a systematic review of its efficacy and safety in the context of emerging Pfkelch13 resistance. (PubMed, Infect Dis Poverty) - "Whole-plant A. annua herbal tea achieves reproducible early parasitological clearance and preserves the multi-target pharmacological substrate whose pre-clinical resistance-modulation profile (three-fold slower resistance emergence in Pfkelch13-mutant murine lines) is biologically coherent with a Pfkelch13-modulating effect, although this effect has not yet been clinically reproduced in Pfkelch13-endemic African settings. The ≥ 84-percentage-point day-28 cure-rate gap between directly-reported A. annua monotherapy and the African ACT benchmark band frames the present-day clinical use of A. annua infusion as a complementary or adjourning intervention rather than a replacement for ACT. This positioning is preserved while Pfkelch13-stratified randomised trials, vulnerable-population safety studies, and population-scale molecular resistance surveillance are designed and executed."

Journal • Review • Infectious Disease • Malaria

Factors associated with the uptake of intermittent preventive treatment of malaria in pregnancy in Nambale Sub-County Hospital, Kenya. (PubMed, Matern Health Neonatol Perinatol) - "A sub-optimal IPTp-SP 3 utilization (60%) way below WHO target of 80%. ≥4ANC attendance and first IPTp-SP uptake at 14-17 gestation weeks were independently associated with optimal utilization of IPTp. Pregnant women attending ANC at the facility should ensure that they attend ANC at least four times and take at least three doses of IPTp for maximum protection against malaria in pregnancy."

Journal • Infectious Disease • Malaria

Effect of sulfadoxine-pyrimethamine resistance on birthweight and parasite persistence among women receiving intermittent preventive treatment for malaria in pregnancy in Northern Uganda: a directed acyclic graph-guided analysis. (PubMed, Clin Microbiol Infect) - "Resistant haplotypes affected neither birthweight nor persistence. However, birthweight was significantly inferior among primigravidae despite SP-IPTp, and post-infection dosing was associated with increased risk of persistence."

Journal • Infectious Disease • Malaria • DHFR

Causes of mortality and severe morbidity in young children in Sierra Leone: a prospective cohort study. (PubMed, Lancet Glob Health) - P3 | "This study shows that despite major investments and implementation efforts, mortality in infants and young children in Sierra Leone remains high and predominantly caused by preventable infections. These findings highlight the substantial unfinished agenda in global health and the urgent need for more effective tools and strategies."

Journal • Infectious Disease • Malaria • Pneumonia • Respiratory Diseases • Septic Shock

Knowledge, attitudes, and behavioural intentions toward IPTp-SP use among pregnant women in rural Nigeria: A theory of reasoned action approach. (PubMed, Malariaworld J) - "The WHO-recommended intermittent preventive treatment using sulphadoxine-pyrimethamine (IPTp-SP) helps to prevent MiP, but its uptake is low in Nigeria...These women have their own will and are not necessarily pressured by social norms. Intentions may not translate to actual practice or use if structural barriers are not eliminated."

Journal • Infectious Disease • Malaria

An orally available PfPKG inhibitor blocks Plasmodium's infection of the liver. (PubMed, PLoS Pathog) - "The compound retains activity against field isolates resistant to chloroquine, mefloquine, cycloguanil, sulfadoxine and pyrimethamine, suggesting low likelihood of cross-resistance to existing antimalarials. While selectivity profiling identified off-target activity against human kinases, structural modeling provides a clear path for optimization. These results establish PfPKG inhibitors as promising candidates for chemoprevention and support further preclinical development of the RUPB-61 chemotype."

Journal • Infectious Disease • Malaria

Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi (clinicaltrials.gov) - P4 | N=788 | Completed | Sponsor: Liverpool School of Tropical Medicine | Active, not recruiting ➔ Completed

Trial completion • Anemia • Hematological Disorders • Infectious Disease • Malaria

Impact of directly observed treatment and extended age range of seasonal malaria chemoprevention with sulfadoxine-pyrimethamine plus amodiaquine in Burkina Faso: a three-group, open-label, cluster-randomised, controlled trial. (PubMed, Lancet Infect Dis) - P=N/A | "We observed no significant difference in parasite prevalence between programmatic SMC and SMC delivered through DOT in children younger than 5 years. Extending SMC to children aged 5-9 years reduced parasite carriage and incidence of clinical malaria in this age group. Although these findings support extending the SMC age range to older children, potential logistical and financial barriers need to be examined."

Journal • Infectious Disease • Malaria

Malaria in Pregnancy Across Sub-Saharan Africa: A Scoping Review of Prevalence, Risk Factors, and Preventive Interventions. (PubMed, Int J Infect Dis) - "Scaling proven interventions is critical, but innovations are required to address persistent gaps. Priorities include evaluating alternative chemoprevention, expanding adolescent-focused antenatal services, and integrating malaria prevention with HIV programs. Further research gaps remain in implementation science for c-IPTp, adolescent ANC uptake, and understanding climate-related shifts in malaria transmission and pregnancy outcomes."

Journal • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Malaria

Metabolomics reveals potentiated metabolic perturbations induced by antimalarial drug combinations against Plasmodium falciparum in vitro. (PubMed, Exp Parasitol) - "An integrated metabolomic and pharmacological analysis was performed on P. falciparum parasites exposed to chloroquine (CQ), pyrimethamine (PY), sulfadoxine (SD), and their combinations (SDPY and SDCQ). The distinct metabolic perturbations observed with drug combinations suggest enhanced pathway-level responses that may contribute to improved antiplasmodial activity and inform future combination strategies. These findings provide a mechanistic foundation for guiding antimalarial combination policies, optimizing therapeutic regimens, and strengthening rational drug-design strategies."

Journal • Preclinical • Infectious Disease • Metabolic Disorders

Regional Patterns and Temporal Trends of Pfdhfr and Pfdhps Markers of Antifolate Resistance in Plasmodium falciparum in East and West Africa, 2010-2025: A Systematic Review. (PubMed, Acta Trop) - "Sulfadoxine-pyrimethamine (SP) remains central to malaria chemoprevention through intermittent preventive treatment in pregnancy, intermittent preventive treatment in infancy, and seasonal malaria chemoprevention, despite widespread resistance in Plasmodium falciparum...Temporal analyses showed persistently high prevalence of the major markers across East African intervals, whereas in West Africa Pfdhfr mutations and A437G remained moderate to high over time but K540E stayed low. These findings show marked regional heterogeneity in the genetic architecture of SP resistance and may support region-specific molecular surveillance and interpretation of SP-resistance risk."

Journal • Review • Infectious Disease • Malaria

Optimizing intermittent preventive treatment for malaria in pregnancy: protocol for phase IV randomized controlled trial of sulphadoxine-pyrimethamine, dihydroartemisinin-piperaquine, and combination therapy in Northern Nigeria. (PubMed, BMC Pregnancy Childbirth) - "This trial will generate robust clinical, molecular, pharmacokinetic, and immunological evidence regarding alternative IPTp strategies in an area with emerging SP resistance. By integrating parasitological, maternal, placental, and neonatal outcomes, the study seeks to determine whether DP alone or in combination with SP provides clinically meaningful advantages over the current standard of care."

Journal • P4 data • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Malaria

Efficacy of Dihydroartemisinin-piperaquine to Prevent Malaria and Complication-related Malaria during Pregnancy Compared to Sulfadoxine-pyrimethamine: A Systematic Review, Meta-analysis, and Meta-regression. (PubMed, Epidemiol Infect) - No abstract available

Journal • Retrospective data • Review • Infectious Disease • Malaria

Drug resistance gene polymorphisms of Plasmodium falciparum clinical isolates from Kinshasa, Democratic Republic of the Congo. (PubMed, Trop Med Health) - "Established K13 propeller-mediated ART partial resistance was not evident in Kinshasa at the time of sampling. However, diverse non-k13 candidate variants and persistent partner-drug and antifolate resistance markers support expanded molecular surveillance combined with clinical and ex vivo phenotypic monitoring."

Journal • Infectious Disease • Malaria • ABCB1 • ABCB4 • CORO • DHFR

The Persistence of High Maternal Anaemia and Low Birthweight Despite Declining Malaria Transmission and Prevalence in Ghana. (PubMed, Pathogens) - "Intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (aOR 0.65) remained protective despite booking parasitaemia being non-significant...Persistent anaemia and LBW reflect nutritional depletion, structural poverty, and increased malaria vulnerability under declining transmission. Pre-conception nutrition, social protection, and sub-microscopic malaria surveillance must complement clinic care."

Journal • Anemia • Hematological Disorders • Infectious Disease • Malaria

"No culture stops me from taking tablets": Exploring community-level factors influencing pregnant women's IPTp-SP uptake in Nigeria. (PubMed, PLOS Glob Public Health) - "The World Health Organization (WHO)-recommended intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp-SP) helps to prevent MiP...For this study's sample, descriptive norms were more critical. Most women emphasized their will to make health decisions and prioritized their health and their babies, defying the long-standing social norms that militate against women's health-seeking behaviour."

Journal • Infectious Disease • Malaria • Women's Health

Molecular surveillance of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine among pregnant women attending antenatal clinics in Bobo-Dioulasso, Burkina Faso. (PubMed, Parasite) - "The relatively high prevalence of SP resistance markers indicates sustained drug pressure in this setting. Although SP appears to remain effective for intermittent preventive treatment in pregnancy, continued molecular surveillance is warranted to inform malaria control policies."

Journal • Hematological Disorders • Infectious Disease • Malaria