Ocufen (flurbiprofen ophthalmic solution) / AbbVie - LARVOL DELTA

Quality by Design (QbD)-Based Development of a Self-Nanoemulsifying Drug Delivery System for the Ocular Delivery of Flurbiprofen. (PubMed, Pharmaceutics) - " Therefore, the formulation of a flurbiprofen-loaded SNEDDS (FLU-SNE) was successfully optimized using the QbD approach. The optimized FLU-SNE exhibited excellent stability and enhanced permeability, suggesting its potential effectiveness in treating various ocular inflammations, including uveitis and cystoid macular edema."

Journal • Inflammation • Macular Edema • Ocular Inflammation • Ophthalmology • Uveitis

High Molecular Weight Hyaluronic Acid/Trehalose/Sacha Inchi Oil Drops In Post-Cataract Dry Eye Symptoms (ESCRS 2024) - "The combination of hyaluronic acid/trehalose/sacha inchi oil drops proved highly effective in relieving symptoms of dry eye following cataract surgery. While both groups experienced reduction in OSDI scores post operatively, certainly given the overall visual acuity gain after cataract removal, it's noteworthy that the group receiving hyaluronic acid/trehalose/sacha inchi oil drops exhibited a more significant enhancement. Cataract surgery is an effective procedure to improve visual acuity."

Cataract • Dry Eye Disease • Ophthalmology

Advancing ophthalmic delivery of flurbiprofen via synergistic chiral resolution and ion-pairing strategies. (PubMed, Asian J Pharm Sci) - "Flurbiprofen (FB), a nonsteroidal anti-inflammatory drug, is widely employed in treating ocular inflammation owing to its remarkable anti-inflammatory effects. In comparison to Ocufen®, S-FBTMA demonstrated significantly higher in vivo anti-inflammatory activity and lower ocular irritability (such as conjunctival congestion and tingling). The findings from this research highlight the potential of chiral separation and ion-pair enhanced permeation techniques in providing pharmaceutical enterprises focused on drug development with a valuable avenue for improving therapeutic outcomes."

Journal • Inflammation • Ocular Inflammation • Ophthalmology

Smallest unit of maximal entropy as novel experimental criterion for parametric characterization of middle- and high-entropy materials. (PubMed, Phys Chem Chem Phys) - "Here we show a simplified limited area calculation approach for assessing the entropy of mixing using a CoCuFeNi model nanoalloy. Based on our calculations we propose a new parametric entropy-based criterion, which defines critical scale parameter transition from the maximal entropy state to the entropy-depleted state of the system. The criterion could be used for generalized mechanistic assessment of the effect of the entropy of mixing on the characteristics of the materials with multiple principal elements and for the development and characterization of existing and new middle- and high-entropy materials with both simple single-, and more complex, multiple-sublattice structures."

Journal

Ideal plasticity and shape memory of nanolamellar high-entropy alloys. (PubMed, Sci Adv) - "Here, we construct nanolamellar AlCoCuFeNi HEAs with alternating high- and low-Al concentration layers and explore their mechanical properties using a combination of molecular dynamic simulation and density functional theory calculation...Unexpectedly, this ideal plasticity is fully reversible upon unloading, leading to a remarkable shape memory effect. Our work highlights the importance of nanolamellar structures in controlling the mechanical and functional properties of HEAs and presents a fascinating route for the design of HEAs for both functional and structural applications."

Journal

Parametric Drug Release Optimization of Anti-Inflammatory Drugs by Gold Nanoparticles for Topically Applied Ocular Therapy. (PubMed, Int J Mol Sci) - "Gold nanoparticles showed an ability to release different molecules, whether hydrophobic or hydrophilic, in passive or active drug release environments. Based on these preliminary results, gold nanoparticles could represent a promising drug delivery system for ketorolac and flurbiprofen when topically applied through eye drops."

Journal • Ocular Inflammation • Ophthalmology

Synthesis and effect of CoCuFeNi high entropy alloy nanoparticles on seed germination, plant growth, and microorganisms inactivation activity. (PubMed, Environ Sci Pollut Res Int) - "The use of suspension of CoCuFeNi HEA-NPs for plant irrigating together with ordinary water showed positive results in plant biostimulation, which resulted in the plant height up to 12% for watercress and up to 50% for oil radish. CoCuFeNi HEA-NPs showed nice inactivation activity for Pseudomonas aeruginosa that was comparable for the use of Tetracycline."

Journal

Construction and Evaluation of Hyaluronic Acid-Coated Flurbiprofen-Layered Double Hydroxide Ocular Drug Delivery System. (PubMed, AAPS PharmSciTech) - "The fluorescent substance-fluoresce isothiocyanate (FITC) was substituted for FB intercalation in LDH for in vitro tissue imaging study of rabbits, whose results stated clearly that FITC-LDH and HA-FITC-LDH could both prolong the precorneal residence time of drugs, and HA-FITC-LDH could increase the corneal permeability of the drug to a certain extent. To sum up, HA-FB-LDH, which can overcome the shortcomings of low bioavailability of traditional eye drops to a certain degree, is a safe and effective ophthalmic drug delivery system."

Journal • Ophthalmology

γ-Cyclodextrin-based polypseudorotaxane hydrogels for ophthalmic delivery of flurbiprofen to treat anterior uveitis. (PubMed, Carbohydr Polym) - "Additionally, the safety of hydrogels was confirmed by cytotoxicity and ocular irritation studies. In all, the present study demonstrates a friendly non-invasive strategy based on γ-CD-based polypseudorotaxane hydrogels for ocular drug delivery."

Journal • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis

A Systematic Review of Flurbiprofen 8.75 mg Dose and Risk of Haemorrhagic Events. (PubMed, Front Pharmacol) - "Counts were low across all studies and results comparing flurbiprofen and placebo treatment arms were non-significant. However, scarcity of studies and low certainty of evidence for the outcome of haemorrhagic events limits the conclusions of this systematic review."

Journal • Review • Otorhinolaryngology

Simultaneously enhancing the ultimate strength and ductility of high-entropy alloys via short-range ordering. (PubMed, Nat Commun) - "Here, we investigate a CoCuFeNiPd high-entropy alloy (HEA), using a combination of Monte Carlo method, molecular dynamic simulation, and density-functional theory calculation...The SRO-induced composite microstructure consists of three categories of clusters: face-center-cubic-preferred (FCCP) clusters, indifferent clusters, and body-center-cubic-preferred (BCCP) clusters, with the indifferent clusters playing the role of the matrix, the FCCP clusters serving as hard fillers to enhance the strength, while the BCCP clusters acting as soft fillers to increase the ductility. Our work highlights the importance of SRO in influencing the mechanical properties of HEAs and presents a fascinating route for designing HEAs to achieve superior mechanical properties."

Journal

Formulation and Evaluation of Thermosensitive Flurbiprofen In Situ Nano Gel for the Ocular Delivery. (PubMed, J Biomater Sci Polym Ed) - "Greater concentration of drug in aqueous humor was due to its improved saturation solubility of the drug, and amplified residence time was attributed to the formation of gel matrix-embedded nanoparticles. This demonstrated that in situ nano gels (NIGF3) comprehending aqueous solutions of 0.3% w/v concentrations of Carbopol 934 with Pluronic F 127 may ominously persist the residence time and mend bioavailability of a water-insoluble drug."

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Optimizing Ophthalmic Delivery of a Poorly Water Soluble Drug from an Aqueous In situ gelling system. (PubMed, Eur J Pharm Biopharm) - "The percentage of drug permeation through the cornea was 55% in 300 min whereas the marketed non gelling eye drop formulation containing FBP sodium showed only 37% permeation. The data presented here, revealed that not only could a poorly soluble drug be complexed with cyclodextrin and loaded into an in situ gelling system without interfering with the gelation, but also permeability the of the drug improved."

Journal • Ophthalmology

ineye® - an ocular insert for simultaneous but distinct release profiles of moxifloxacin and flurbiprofen for ocular surgery prophylaxis (ARVO 2020) - "In the present study it was demonstrated that a single ineye® can replace two bottles of eye-drops on preventing inflammation and infection before and after an ocular surgery.ineye® is a new ocular device that can release two drugs for several weeks at distinct rates, making it a very promising technology for overcome the low efficacy of eye drops and to improve patients' adherence to the treatment of ocular diseases. This small spherical, pearl-like ocular insert will be placed behind the eyelid and as it is made of highly biocompatible materials it will not interfere with vision and will not cause any discomfort or foreign-body sensation.This technology has a patent pending application in different countries, including the US, for the release of drugs and other active biomolecules for ocular surgery prophylaxis, glaucoma, dry eye and other diseases."