Steglatro (ertugliflozin) / Pfizer, Merck (MSD) - LARVOL DELTA

Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors and Risk of Heart Failure Hospitalization in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PubMed, Cureus) - "This benefit was consistent across most agents, including empagliflozin, canagliflozin, dapagliflozin, and sotagliflozin, while ertugliflozin showed a nonsignificant trend in the same direction. The results demonstrate that SGLT2 inhibitors confer clinically meaningful cardiorenal protection that is recognized to occur through mechanisms largely independent of glucose lowering, reinforcing their role as cornerstone agents in the management of T2DM. These findings highlight the importance of prioritizing SGLT2 inhibitors in contemporary diabetes care to reduce the global burden of heart failure (HF)."

Journal • Retrospective data • Review • Atherosclerosis • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Impact of Ertugliflozin on Cardiac Structure and Function in Patients with ICDs/CRT-Ds Assessed by Echocardiography: A Post Hoc Sub-Analysis of the ERASe Trial. (PubMed, J Clin Med) - "Lower LVEF at baseline was associated with a higher number of ventricular arrhythmias in both treatment groups. In this sub-analysis of the ERASe trial, treatment with ertugliflozin did not improve structural and functional parameters assessed by echocardiography after 52 weeks of treatment compared to placebo despite the significant reduction in arrhythmic burden."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure

Multiscale computational analysis reveals enhanced allosteric modulation of Nav1.5 by dual binding of dapagliflozin and ertugliflozin. (PubMed, Sci Rep) - No abstract available

Journal • NAV1

Attenuation of cerebral ischemia-reperfusion induced neurotoxicity by telmisartan, ertugliflozin, and omaveloxolone through Nrf2/HO-1 pathway modulation: In vivo and in silico insights. (PubMed, Toxicol Rep) - "In silico analysis revealed strong binding through highly negative docking scores of telmisartan and ertugliflozin to Nrf2 negative regulators Keap1 and GSK-3β, supported by stable molecular dynamics simulations, suggesting direct inhibition. In conclusion, omaveloxolone, telmisartan, and ertugliflozin alleviate ischemia-reperfusion induced neurotoxicity via potential Nrf2-mediated antioxidant and anti-inflammatory mechanisms, highlighting their potential preventive role in conditions predisposing to stroke."

Journal • Preclinical • Cardiovascular • CNS Disorders • Diabetes • Hypertension • Metabolic Disorders • Oncology • Reperfusion Injury • Vascular Neurology • HMOX1 • IL6 • KEAP1 • MMP9 • TNFA

Ultrasensitive, green molecularly-imprinted poly(o-phenylenediamine) sensor on pencil graphite for trace ertugliflozin quantification in plasma and tablets. (PubMed, BMC Chem) - "The environmental impact of the proposed method was assessed using the AGREE and GAPI green evaluation tools, which confirmed its environmentally friendly nature. Furthermore, the sensor exhibited high selectivity in the presence of commonly co-formulated drugs, such as sitagliptin and metformin, indicating its potential for pharmaceutical applications."

Journal

Glucagon-like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors Reduce Dementia Risk in Type 2 Diabetes: A Comprehensive Bayesian Network Meta-Analysis (AHA 2025) - "For all-cause dementia versus control according to the SUCRA: albiglutide (RR: 0.03, 95% CrI: 0.00 to 0.08; SUCRA: 94.4%), lixisenatide (RR: 0.08, 95% CrI: 0.00 to 0.20; SUCRA: 93.62%), efpeglenatide (RR: 0.24, 95% CrI: 0.00 to 1.38; SUCRA: 70.09%), canagliflozin (RR: 0.31, 95% CrI: 0.01 to 1.47; SUCRA: 61.81%), semaglutide (RR: 0.50, 95% CrI: 0.03 to 1.98; SUCRA: 50.06%), liraglutide (RR: 2.12, 95% CrI: 0.02 to 9.89; SUCRA: 41.91%), empagliflozin (RR: 0.68, 95% CrI: 0.05 to 2.35; SUCRA: 39.63%), exenatide (RR: 4.13, 95% CrI: 0.02 to 20.28; SUCRA: 35.41%), dulaglutide (RR: 3.38, 95% CrI: 0.03 to 15.72; SUCRA: 32.89%), dapagliflozin (RR: 1.19, 95% CrI: 0.09 to 4.96; SUCRA: 30.37%), ertugliflozin (RR: 6.79, 95% CrI: 0.02 to 29.23; SUCRA: 30.1%), control (SUCRA: 19.67%). GLP-1RAs and SGLT2is reduce dementia risk, with albiglutide and lixisenatide excelling for all-cause dementia, dapagliflozin and ertugliflozin for vascular dementia, and dulaglutide for Alzheimer's...."

Retrospective data • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

SGLT2 Inhibitors in LVAD Patients: A Multi-Center Propensity-Matched Cohort Analysis (AHA 2025) - "Patients were stratified based on exposure to SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin, ertugliflozin) post-implant. In this large real-world analysis, SGLT2 inhibitor use in LVAD patients was associated with markedly reduced 1-year mortality and improved cardiorenal and infectious outcomes. These findings suggest a potential role for SGLT2i in optimizing medical therapy in LVAD recipients, a population not included in pivotal HF trials. This retrospective analysis may be affected by residual confounding despite rigorous matching."

Clinical • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Nephrology • Renal Disease

Impact of diabetes on the effects of SGLT2 inhibitors on kidney outcomes: An updated drug/dose-dependent meta-analysis. (PubMed, Clin Nephrol) - "SGLT2 inhibitors confer renal protection in both diabetic and non-diabetic populations, supporting their use in CKD management across a broad spectrum of patients. However, careful drug selection is warranted in diabetic patients at risk for DKA."

Journal • Retrospective data • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetes • Metabolic Disorders • Nephrology • Renal Disease

The Relationship between Sodium-Glucose Co-Transporter 2 Inhibitors and Erythrocytosis: A Retrospective Review from a Large Urban Center (ASH 2024) - "The most popular SGLT-2 inhibitor was empagliflozin (79.4%) followed by dapagliflozin (8.8%), ertugliflozin (8.8%), and canagliflozin ( 3%). Given the considerable benefit of SGLT2i, further studies could focus on long-term patient monitoring, as the benefits of continuing SGLT2i may outweigh the risks of discontinuation. Additionally, further education should be provided to primary care providers regarding the possibility of erythrocytosis while on SGLT2i to prevent unnecessary workup, especially if the time to peak Hb/HCT levels is around two years, as our study showed."

Retrospective data • Review • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Hematological Disorders • Metabolic Disorders • Nephrology • Obstructive Sleep Apnea • Renal Disease • Respiratory Diseases • Sleep Disorder • Venous Thromboembolism • JAK2

A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study Evaluating the Efficacy and Safety of Fecal Microbiota Capsule Transplantation Combined with Henagliflozin in Patients with Type 2 Diabetic Kidney Disease (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Affiliated Hospital of Southwest Medical University; Affiliated Hospital of Southwest Medical University

New trial • Diabetes • Diabetic Nephropathy • Nephrology • Renal Disease • Transplantation • Type 2 Diabetes Mellitus

Association of SGLT2 Inhibitors with Reduced Mortality and Improved Clinical Outcomes in Patients with Cancer and CKD: A Real-World Propensity-Matched Analysis (KIDNEY WEEK 2025) - "Patients prescribed SGLT2i (dapagliflozin, empagliflozin, canagliflozin, ertugliflozin, sotagliflozin) were matched 1:1 to controls without SGLT2i. Conclusion SGLT2i use in cancer patients with CKD is associated with substantial reductions in mortality and major adverse renal, cardiovascular, and healthcare utilization outcomes, but is linked to a higher hazard of DKA. These findings support SGLT2i therapy as a promising strategy in this vulnerable population, with appropriate DKA risk monitoring."

Clinical • Clinical data • Real-world • Real-world evidence • Acute Kidney Injury • Anemia • Chronic Kidney Disease • Congestive Heart Failure • Diabetic Nephropathy • Fatigue • Heart Failure • Metabolic Disorders • Myocardial Infarction • Nephrology • Oncology • Renal Disease

Impact of SGLT2 Inhibitor Use on Cardiac Allograft Vasculopathy and Other Clinical Outcomes in Heart Transplant Recipients: A Propensity-Matched Real-World Study (AHA 2025) - "Exposure was defined as initiation of SGLT2i therapy within 5 years after transplant (canagliflozin, dapagliflozin, empagliflozin, or ertugliflozin). In this multicenter real-world cohort of heart transplant recipients, SGLT2 inhibitor use was associated with significantly reduced all-cause mortality, rejection and hospitalization, without an increase in transplant rejection. There was no significant increase in CAV. These findings support the potential role of SGLT2i as a safe adjunct in selected post-transplant patients."

Clinical • Clinical data • Real-world • Real-world evidence • Cardiovascular • Immunology • Transplant Rejection • Transplantation

Comparative Risk of Acute Pancreatitis in Hypertriglyceridemia Patients Treated With SGLT2 Inhibitors vs GLP-1 Receptor Agonists: A Propensity-Score Matched Analysis (ACG 2025) - "In propensity-score–matched cohorts of 22,042 patients per arm, the incidence of acutepancreatitis was higher in patients treated with SGLT2 inhibitors compared to GLP-1receptor agonists, acute pancreatitis occurred in 0.349% of the SGLT2 users versus0.263% of the GLP-1 RA(OR 1.33, 95% CI 0.95–1.87; P = 0.10).In a multivariable Cox regression analysis adjusting for individual medications, For SGLT2inhibitors, the adjusted hazard ratios were: canagliflozin (aHR < 0.0001, 95% CI 0–0; P =0.9844), dapagliflozin (aHR 1.22, 95% CI 0.45–3.28; P = 0.6982), empagliflozin (aHR 0.77, 95%CI 0.34–1.73; P = 0.5249), and ertugliflozin (aHR < 0.0001, 95% CI 0–0; P = 0.9954). ForGLP-1 receptor agonists, results included: albiglutide (aHR < 0.0001, 95% CI 0–0; P = 0.9962),dulaglutide (aHR 1.19, 95% CI 0.63–2.25; P = 0.5968), semaglutide (aHR 1.58, 95% CI0.81–3.10; P = 0.1808), liraglutide (aHR 0.59, 95% CI 0.24–1.45; P = 0.2501), and exenatide(aHR 0.30, 95% CI 0.04–2.17; P =..."

Clinical • Cardiovascular • Dyslipidemia • Hypertriglyceridemia • Pancreatitis

ASSESSING MORTALITY IN PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS RECEIVING SGTL-2 INHIBITORS (CHEST 2025) - "Patients had to be diagnosed with IPF and be on maintenance therapy with either pirfenidone or nintedanib...The SGLT2i cohort was composed of patients using one of the following medications: Canagliflozin, Dapagliflozin, Empagliflozin or Ertugliflozin... There was no statistically significant difference observed between comparison groups at 1-, 3- and 5-year follow-up. CLINICAL IMPLICATIONS: While SGLT-2 inhibitors are well established in the management of heart failure and diabetes, with documented mortality benefits, and while several existing in vitro and animal model studies suggest potential antifibrotic effects, this study did not demonstrate a reduction in mortality for IPF patients receiving SGLT-2i therapy. Despite these results, there are several limitations to the study and further investigation may be warranted due to current lack of available options to slow the rate of IPF progression."

Clinical • Cardiovascular • Congestive Heart Failure • Diabetes • Endocrine Disorders • Fibrosis • Heart Failure • Idiopathic Pulmonary Fibrosis • Immunology • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Scleroderma • Systemic Sclerosis

Sodium-Glucose Cotransporter 2 Inhibitors for the Primary Prevention of Systemic Autoimmune Rheumatic Diseases in Patients with Type 2 Diabetes: A Population-Based Target Trial Emulation (ACR Convergence 2025) - "This study aimed to evaluate the effect of treatment with sodium-glucose cotransporter-2 inhibitors (SGLT2i) on the risk of new-onset SARD. This emulated target trial used electronic health records of adults with T2D who initiated either an SGLT2i (canagliflozin, dapagliflozin, empagliflozin, or ertugliflozin) or a DPP4i (alogliptin, saxagliptin, linagliptin, or sitagliptin) between 2016 and 2024 from 101 U.S. healthcare organizations. Treatment with SGLT2i, especially dapagliflozin and empagliflozin, was associated with reduced risks of developing various SARD compared to DPP4i. These findings provide evidence for the broader immunomodulatory effects of SGLT2i. Prospective studies on the roles of SGLT2i in attenuating inflammation and autoimmunity are warranted to validate the finding."

Clinical • Ankylosing Spondylitis • Diabetes • Giant Cell Arteritis • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Metabolic Disorders • Musculoskeletal Pain • Rare Diseases • Rheumatoid Arthritis • Rheumatology • Scleroderma • Seronegative Spondyloarthropathies • Sjogren's Syndrome • Systemic Lupus Erythematosus • Systemic Sclerosis • Type 2 Diabetes Mellitus • Vasculitis

Computational structural studies of SGLT2-related polypharmacy. (PubMed, PLoS One) - "The indication of interactions with several compounds likely to be prescribed alongside SGLT2 inhibitors, such as antibiotics, statins, and antiplatelet agents, warrants further investigation of the potential for polypharmacological complications."

Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Nephrology • Renal Disease • PDZK1IP1

Euglycemic Diabetic Ketoacidosis and Its Prevention in Elective Surgical Patients Taking Sodium-Glucose Linked Transporter 2 Inhibitors: An International Perspective. (PubMed, Arthroplast Today) - "The most commonly recommended preoperative withholding time was 4 days for ertugliflozin and 3 days for all other SGLT-2 inhibitors...There was little consensus between the guidelines, suggesting that this is a poorly understood subject. There is clearly a need for dissemination of the pathophysiological basis for the correct management of surgical patients taking SGLT-2 inhibitors, to avoid EDKA."

Journal • Anesthesia • Diabetes • Metabolic Disorders

SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS WERE ASSOCIATED WITH LOWER RISK OF PANCREATIC CANCER IN METFORMIN-TREATED PATIENTS WITH DIABETES: A TERRITORY-WIDE PROPENSITY SCORE-MATCHED STUDY (UEGW 2025) - "The outcome and exposure of interest was PC and SGLT-2i use (including dapagliflozin, empagliflozin, canagliflozin and ertugliflozin), respectively. SGLT-2i use was associated with a lower risk of PC in a dose- and duration-dependent manner, which was independent of glycemic control, among T2D patients treated with metformin. These findings provide insights into informing the choice of second-line anti-diabetic drug in lowering PC risk in T2D metformin users."

Clinical • Addiction (Opioid and Alcohol) • Diabetes • Gastrointestinal Disorder • Hepatology • Metabolic Disorders • Oncology • Pancreatic Cancer • Pancreatitis • Solid Tumor • Type 2 Diabetes Mellitus

Association Between Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor Use and All-Cause Mortality in Patients With Pulmonary Arterial Hypertension. (PubMed, Cureus) - "SGLT2i use was associated with significant and sustained mortality reduction in PAH patients. A 13% absolute risk reduction at five years highlights the potential for a transformative impact on PAH management. Randomized controlled trials are warranted to confirm these findings and guide clinical practice."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Ertugliflozin ameliorates experimentally-induced colitis in rats by regulating the interplay between M1/M2 macrophage polarization, tight junction proteins, and MicroRNA 155 expression. (PubMed, Int Immunopharmacol) - "Forty-two adult Wistar rats were allocated into seven groups: control, Ertu (10 mg/kg), AA, AA+ Ertu (1, 5, and 10 mg/kg), and AA+ sulfasalazine (Sulfa) (100 mg/kg); all received oral treatments daily for 7 days. Ertu also demonstrated anti-apoptotic effects by reducing BAX meanwhile increasing BCL2. Notably, Ertu (10 mg/kg) exhibited therapeutic effects comparable to the standard treatment, Sulfa, underscoring its potential as a distinctive and valuable option for UC management."

IO biomarker • Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • BCL2 • CD86 • CLDN1 • IL10 • IL1B • MIR155 • MRC1 • OCLN • RELA • TJP1 • TNFA

Exploring the risk of ventricular arrhythmia and sudden cardiac death with SGLT2 inhibitors in heart failure patients: a comprehensive systematic review and bayesian network meta-analysis (ESC-WCC 2025) - "For the primary outcome, the risk of sudden cardiac death (SCD), the interventions were ranked as follows: Empagliflozin ranked highest (HR: 0.70, 95% CrI: 0.40 to 1.14; SUCRA: 73.34%), followed by Canagliflozin (HR: 0.72, 95% CrI: 0.40 to 1.14; SUCRA: 71.55%), Dapagliflozin (HR: 0.73, 95% CrI: 0.48 to 1.06; SUCRA: 69.77%), Ertugliflozin (HR: 1.66, 95% CrI: 0.25 to 5.92; SUCRA: 33.86%), Control (SUCRA: 29.65%), and Sotagliflozin (HR: 1.27, 95% CrI: 0.60 to 2.35; SUCRA: 21.82%). This Bayesian network meta-analysis suggests that SGLT2 inhibitors, particularly Empagliflozin and Canagliflozin, are associated with a lower risk of sudden cardiac death and ventricular arrhythmia in heart failure patients. Bexagliflozin also shows promise for reducing ventricular arrhythmia. Further studies are needed to confirm these findings."

Retrospective data • Review • Cardiovascular • Congestive Heart Failure • Heart Failure

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors in Heart Failure With Preserved Ejection Fraction: A Systematic Review. (PubMed, Cureus) - "A systematic review of randomized controlled trials (RCTs) assessing the effects of SGLT2 inhibitors (empagliflozin, dapagliflozin, sotagliflozin, canagliflozin, and ertugliflozin) in HFpEF patients was conducted. Improvements in KCCQ total symptom scores were observed, indicating enhanced patient-reported outcomes. The renal benefits of SGLT2 inhibitors were evident, with a reduction in kidney disease progression and a marked decrease in cardiovascular-related renal outcomes."

Journal • Review • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Ertugliflozin in Chronic Heart Failure (clinicaltrials.gov) - P2 | N=60 | Recruiting | Sponsor: Yale University | Trial completion date: Jul 2025 ➔ Dec 2025 | Trial primary completion date: Jun 2025 ➔ Dec 2025

Trial completion date • Trial primary completion date • Cardiovascular • Congestive Heart Failure • Heart Failure

Post-Marketing Safety Profile of Ertugliflozin: Insights from a Real-World Pharmacovigilance Analysis based on the FAERS database. (PubMed, Eur J Pharmacol) - "Ertugliflozin is associated with increased risks of metabolic, infectious, and renal adverse events, including some that are potentially life-threatening. Clinicians are advised to monitor ketone levels during the initial treatment period and to assess patients for a history of genital fungal infections prior to initiation. These steps may help mitigate early adverse events in high-risk populations. Further investigation is warranted to clarify causal pathways and inform safer clinical use."

Adverse events • Journal • P4 data • Real-world evidence • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Type 2 Diabetes Mellitus

The effect of Ertugliflozin on blood uric acid in patients with type 2 diabetes: A real-world study. (ChiCTR) - P4 | N=2600 | Recruiting | Sponsor: The first affiliated hostipal of nanchang university; The first affiliated hostipal of nanchang university

New P4 trial • Real-world evidence • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus