gene silencing oligonucleotide / Aceragen - LARVOL DELTA

Management of hepatitis B virus coinfection in people with human immunodeficiency virus: Current guidelines, challenges, and future perspectives in Japan. (PubMed, J Infect Chemother) - "PWH without HBV immunity should receive HBV vaccines, but their low seroprotection rates often pose a challenge to the use of novel ART with no HBV activity, such as long-acting injections. New vaccines and treatment options under development, including toll-like receptor agonists and gene-silencing oligonucleotide agents, are warranted to improve the management of HBV coinfection in PWH."

Journal • Review • Hepatitis B • Human Immunodeficiency Virus • Infectious Disease • Inflammation

GSOCS-LULCC: A Global dataset of Soil Organic Carbon Stock dynamics following Land Use and Land Cover Change. (PubMed, Sci Data) - "Compiled from 912 peer-reviewed articles up to December 2025, this dataset spans five major land uses (cropland, grassland, forest, plantation and savanna) yielding 8,748 harmonized records from 1,967 sites across various sampling depths. GSOCS-LULCC serves as a vital resource for evaluating the global effects of LULCC on SOCS and identifying the primary environmental factors driving carbon stock variations across different ecosystem transitions."

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Modular nucleic acid-based construct for delivery of immunostimulatory agonists and oncogene-silencing oligonucleotides in tumours. (PubMed, Nat Biomed Eng) - "Aptamer-antisense chimeras achieve selective knockdown of the oncogenic Kirsten rat sarcoma viral oncogene homologue transcript in pancreatic cancer through RNase H-mediated degradation of its messenger RNA, suppressing tumour growth without transfection reagents. These findings establish circular functional molecular flare as a chemically programmable approach for engineering targeted nucleic acid therapeutics with improved stability, specificity and efficacy in extrahepatic disease models."

Journal • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor • KRAS

Chemical evolution of ASO-like DNAzymes for effective and extended gene silencing in cells. (PubMed, Nucleic Acids Res) - "Another promising class of gene-silencing oligonucleotides is RNA-cleaving nucleic acid enzymes, which offer the potential for allele-specific RNA inhibition with greater precision than ASOs and siRNAs...RACE (rapid amplification of cDNA ends) polymerase chain reaction and Sanger sequencing confirmed precise, site-specific mRNA transcript cleavage with minimal RNase H activation in cells. By merging ASO structural and pharmacokinetic advantages with DNAzyme catalytic versatility, these ASO-like 10-23 variants offer a promising new class of potent gene-silencing agents, representing a significant step toward therapeutic DNAzyme development."

Journal • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • MYC

Injection of Ortho-Functionalized Tetrafluorinated Azobenzene-Containing siRNAs into Japanese Medaka Embryos for Photocontrolled Gene Silencing. (PubMed, Curr Protoc) - "To the best of our knowledge, this marks the first reversible control of a gene-silencing oligonucleotide within an in vivo system...Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Medaka maintenance and embryo collection Basic Protocol 2: Injection of stage-two one-cell medaka embryos Basic Protocol 3: Evaluation of the F-siRNA gene-silencing ability through light activation and inactivation using blue and green light by measuring enhanced green fluorescent protein fluorescence."

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GSOOA-1DDRSN: Network traffic anomaly detection based on deep residual shrinkage networks. (PubMed, Heliyon) - "Additionally, it reduces the time computation costs by 20 % and 30 % on these datasets. Furthermore, compared to other models, GSOOA-1DDRSN offers superior classification accuracy and effectively reduces the number of features."

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GSOligo: an in-silico discovery and detection tool of bacteria from metagenomic reads (ECCMID 2023) - No abstract available

"gsorry last tweet was garbled, check out "Life's Simple 7" at www.heart.or" (,@dnorthfelt)

GSOAP: A tool for visualisation of gene set over-representation analysis. (PubMed, Bioinformatics) - "Here, we propose a visual exploration of the GSOA results by showing the relationships among the enriched instances; while highlighting important instance attributes, such as significance, closeness (centrality) and clustering. GSOAP is implemented as an R package and is available at https://github.com/tomastokar/gsoap."

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"GSO has been used by @AdamGreenbaumMD @DeeDeeWangMD et al I think" (,@cardiacpolymath)

"GSO Announces Opening of San Francisco and Toronto Offices https://t.co/VkTSV4TuBT" (,@NewsFromBW)

Azobenzene-containing photoresponsive siRNAs (ACS-Sp 2019) - "siRNAs are gene-silencing oligonucleotides that have an important role in biotechnology and as modern therapeutics...Cell transfection of an inactive siRNazo. The siRNAzos can be reversibly activated and inactivated with visible light and UV light, respectively, in cell culture, thus enabling an event where timed gene-silencing via siRNAzo can be controlled."