rhIL-2 / Dongbao Enterprise Group - LARVOL DELTA

Effect of transcutaneous electrical acupoint stimulation on postoperative gastrointestinal dysfunction following laparoscopic urological surgery: a protocol for a randomised, controlled trial. (PubMed, BMJ Open) - P=N/A | "The results of the study will be disseminated through a variety of channels, including peer-reviewed open-access publications, scientific conferences and targeted communications with patient organisations, healthcare providers and the broader public. NCT07133620."

Clinical protocol • Journal • Anesthesia • Oncology • Urology • IL10 • IL6 • MIR10B • MLN

Investigation into the Influence of Secondary Suction within FLACS on the Postoperative Ocular Surface and Associated Mechanisms. (PubMed, J Cataract Refract Surg) - "Secondary suction in FLACS may worsen early-stage postoperative dry eye, but it recovers in 1 month. Key risk factors for secondary suction include smaller corneal diameter and significant ocular movement, which inform targeted prevention strategies to reduce secondary suction incidence."

Journal • Cataract • Dry Eye Disease • Ocular Inflammation • Ophthalmology • Psychiatry • IL6

The effect of an intravenous analgesic pump with esketamine on postoperative pain and postpartum depression in women with cesarean section. (PubMed, Am J Transl Res) - "Esketamine-based postoperative analgesia for cesarean section effectively reduces perioperative pain, alleviates postpartum depression, mitigates inflammatory and stress responses, and has certain neuroprotective effects. Its safety profile supports its potential for broader clinical use."

Journal • CNS Disorders • Depression • Oncology • Pain • Postpartum Depression • Psychiatry • BDNF • IL6 • TNFA

Xiapyrroles A-F: N-Alkylpyrrole Alkaloids from the Marine-Derived Actinomycete Streptomyces xiamenensis 1310KO-148. (PubMed, J Nat Prod) - "However, 1 dose-dependently suppressed the LPS-induced production of NO (IC50 = 29.5 μM) and interleukin-6 (IL-6) (IC50 = 10.9 μM). Compound 1 exhibited no potential cytotoxicity against six solid cancer cell lines and eight blood cancer cell lines at a concentration of 30 μM."

Journal • Hematological Malignancies • Oncology • Solid Tumor • IL6

A Single-Center, Phase II, Randomized, Controlled Clinical Study Evaluating Injectable Thymofaxine (Nitazan) in Combination with Injectable Human Interleukin-2 (Deruson) for the Treatment of Lymphopenia in Patients with Malignant Hematologic Neoplasms (ChiCTR) - P2 | N=45 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Xiamen University; The First Affiliated Hospital of Xiamen University

Combination therapy • Lymphopenia • New P2 trial • Hematological Disorders • Hematological Malignancies • Oncology • CD4

Impact of Polyonchobothrium magnum on health and gut microbial ecology of African catfish (Clarias gariepinus): Insights from morphological, molecular, and microbiological analyses. (PubMed, J Fish Dis) - "Cetobacterium somerae was prevalent in non-infected fish, while infected fish harboured Aeromonas fluvialis, Plesiomonas shigelloides, and Gallaecimonas xiamenensis. Overall, P. magnum disrupted the immune status and gut microbiota of the host, thereby impacting its health."

Journal • Infectious Disease • IL1B • NFKB1

Thymalfasin and Recombinant Human IL-2 Injections in Treating Lymphocytopenia for Patients With Malignant Hematological Tumors (clinicaltrials.gov) - P2 | N=50 | Recruiting | Sponsor: The First Affiliated Hospital of Xiamen University

Lymphopenia • New P2 trial • Hematological Disorders • Hematological Malignancies • Oncology

Effect of modified ShengYangYiwei decoction on painless gastroscopy and gastrointestinal and immune function in gastric cancer patients. (PubMed, World J Gastrointest Endosc) - "The preoperative use of modified ShengYangYiwei decoction can optimize the anesthesia program during painless gastroscopy, improve the gastrointestinal function of patients after the operation, reduce the occurrence of examination-related complications."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Hypotension • Oncology • Pain • Solid Tumor • CD4 • CD8 • IL6 • TNFA

Anti-Inflammatory Activity of Phenylethanoids from Acanthus ilicifolius var. xiamenensis. (PubMed, J Med Food) - "Phenylethanoids 9 and 10 increased the expression of interleukin-10 and endothelial nitric oxide synthase. Therefore, compounds 9 and 10 showed anti-inflammatory activity by regulation of NF-κB and JAK/STAT signaling pathways."

Journal • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • IL10 • RELA • STAT3

Study on the correlation between dietary N-glycolylneuraminic acid intake and chronic inflammation state of body (PubMed, Zhonghua Yu Fang Yi Xue Za Zhi) - "Spearman correlation analysis showed that the intake level of Neu5Gc was positively correlated with serum anti-Neu5Gc antibody, CRP and IL-6 levels, with r values about 0.222, 0.102 and 0.126, respectively (all P values <0.05). Dietary Neu5Gc intake is mainly from red meat and liquid dairy products, and its intake level is positively correlated with chronic inflammatory state of body."

Journal • Immunology • Inflammation