thyroxine / Generic mfg. - LARVOL DELTA

Polypharmacy and patterns of medication use in the final year of life among people living with dementia in Canada: A case-control study. (PubMed, J Int Med Res) - "The most common medications dispensed in the last year of life were furosemide, levothyroxine sodium, salbutamol, and vitamin B12.ConclusionsCommunity-dwelling older adults with dementia had the highest rates of polypharmacy and hyperpolypharmacy across all time periods assessed. Medications most frequently dispensed in the last year of life did not change in ways that would be expected if deprescribing recommendations were being followed. This suggests that prescribing and deprescribing at the end of life are potential areas for pharmacist support and involvement."

Journal • Retrospective data • Alzheimer's Disease • CNS Disorders • Dementia

Ramadan fasting and thyroid function: a narrative review of physiological adaptation and clinical management. (PubMed, J Diabetes Metab Disord) - "Ramadan fasting is usually safe from a thyroid perspective in healthy individuals and most stable hypothyroid patients, but biochemical monitoring and individualized counseling are recommended. Controlled studies in hyperthyroidism and trials evaluating alternative levothyroxine regimens are needed."

Clinical • Journal • Review • Endocrine Disorders

Early initiation of thyroid hormone therapy versus watchful waiting or delayed treatment or no treatment in subclinical hypothyroidism: A systematic review and meta-analysis protocol. (PubMed, F1000Res) - "The certainty of the evidence will be ascertained through "GRADE (Grading of Recommendations, Assessment, Development, and Evaluation)". The SRMA can inform the framing of clinical guidelines for SCH management for all population groups and also intends to bring out gaps in the existing literature for future studies.PROSPERO ID: CRD420251270021 (Date: 08 February 2026)."

Journal • Retrospective data • Endocrine Disorders

PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF DRUG ABSORPTION FOLLOWING ENDOSCOPIC SLEEVE GASTROPLASTY (UEGW 2026) - "Drug-specific models for acetaminophen, levothyroxine, and metoprolol succinate were constructed and validated using previously published pharmacokinetic profiles in non-surgical and bariatric populations. Physiological alterations following ESG may lead to drug-specific changes in the pharmacokinetics of orally administered medications. PBPK modeling highlights delayed gastric emptying as the dominant factor influencing drug absorption, with potential clinical implications for drug efficacy and safety. This study provides a mechanistically informed framework for anticipating pharmacokinetic changes following ESG and highlights key areas for future clinical investigation."

PK/PD data • Genetic Disorders • Obesity

WHEN THE OESOPHAGUS LIES: A THYROID IN DISGUISE - A CASE REPORT (UEGW 2026) - "Patient has hypothyroidism and was on long term levothyroxine.Radiological findings: A low‑dose CT identified a 4cm posterior mediastinal mass...MDT review concluded that, given CKD, asthma, and benign histology, thoracic oesophageal resection posed unacceptable risk. A conservative surveillance strategy with thyroid function tests and repeat imaging at 12 months was adopted.Conclusion & learning points:1) Slow withdrawal: The proximal oesophagus is a high‑miss zone; deliberate inspection is essential.2) Radiological correlation: Secondary ectopic foci can shift the differential toward benign developmental anomalies.3) EUS‑FNB utility: Core tissue enables definitive diagnosis of rare mediastinal masses, avoiding unnecessary surgical morbidity."

Case report • Clinical • Asthma • Chronic Kidney Disease • Endocrine Disorders • Immunology • Respiratory Diseases • Solid Tumor • NKX2-1

SUSTAINED OFF-TREATMENT REMISSION AFTER NIVOLUMAB DISCONTINUATION FOR IMMUNE-RELATED HYPOTHYROIDISM IN TWICE-RECURRENT GASTRIC CANCER WITH SYNCHRONOUS MSS/MSI-HIGH DUAL HISTOLOGY (UEGW 2026) - "As recurrent lesions were not biopsied, the clonal origin of each relapse—MSS, MSI-High, or both—remained undetermined. Surveillance continued with contrast-enhanced CT and upper gastrointestinal endoscopy.Outcome: With long-term off-treatment follow-up after the final nivolumab dose, the patient remains free of a third recurrence on levothyroxine monotherapy alone.Points to be discussed: durable off-treatment disease control after forced ICI discontinuation for irAE in twice-recurrent gastric cancer; clinical decision-making in molecularly heterogeneous tumors where the relapse-driving clone cannot be histologically confirmed; the optimal duration of checkpoint inhibition when complete response is followed by serious irAEs."

Clinical • MSI-H • Endocrine Disorders • Gastric Cancer • Oncology • Pneumonia • Solid Tumor • HER-2

Long-term thyroid outcomes and survival in hyperthyroid cats treated with radioiodine: association with overt and subclinical hypothyroidism and levothyroxine treatment. (PubMed, J Vet Intern Med) - "Thyroid status after radioiodine treatment is dynamic. Subclinical hypothyroidism frequently resolves, whereas untreated persistent hypothyroidism is associated with shorter survival. Long-term monitoring of thyroid and renal function is critical in managing radioiodine-treated cats."

Journal • Endocrine Disorders

Comparative Effects of Photobiomodulation Therapy Versus Conventional Antioxidant Supplementation on Serum Glutathione Levels in Euthyroid Chronic Autoimmune Thyroiditis: A Prospective Open-Label Interventional Clinical Trial. (PubMed, Antioxidants (Basel)) - "Thyroid-directed PBM was associated with improved systemic GSH status and favorable changes in thyroid autoimmunity, thyroid function parameters, and thyroid volume compared with selenium plus vitamin D supplementation in treatment-naïve euthyroid women with CAT. These findings suggest that modulation of oxidative stress may represent one potential biological pathway underlying the observed effects of PBM. Larger randomized controlled studies with longer follow-up are required to confirm these findings and define the clinical role of PBM in autoimmune thyroid disease."

Journal • Endocrine Disorders • Immunology

Acute Coronary Syndrome with Non-ST-Elevation Myocardial Infarction and Refractory Unstable Ventricular Tachycardia Complicated by Severe Acute Kidney and Liver Injury in Myxedema Crisis: A Case Report. (PubMed, Res Heart Yield Transl Med) - "The patient has been on routine follow-up for almost 1 year with levothyroxine (50 μg once daily) and has recently demonstrated good left ventricular function (ejection fraction=50%) and good functional capacity on an exercise test. Clinicians should consider hypothyroidism crisis in the differential diagnosis for myocardial infarction, heart failure, and lethal arrhythmia, and treatment should be initiated immediately."

Journal • Acute Coronary Syndrome • Acute Kidney Injury • Anorexia • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Fatigue • Heart Failure • Hepatology • Hypotension • Liver Failure • Myocardial Infarction • Nephrology • Pain • Pulmonary Disease • Renal Disease • Ventricular Tachycardia

Adrenocortical Carcinoma: An Exceptional Survival Span Across a Tailored Management. (PubMed, Diagnostics (Basel)) - "In the meantime, she continued levothyroxine replacement (50 to 75 µg/day) for mitotane-induced primary hypothyroidism. This case highlights an exceptional survival span across two decades with an ailment with a generally poor prognosis. Another particular aspect involves a complex multi-segmental resection, which requires a highly skilled surgical team; only a limited number of cases have previously been published, and, to the best of our knowledge, there is no previous data with respect to a third intervention after 15 years of surviving with ACC."

Journal • Adrenal Cortex Carcinoma • Cushing’s Disease • Endocrine Disorders • Genito-urinary Cancer • Infectious Disease • Nephrology • Novel Coronavirus Disease • Oncology • Renal Disease • Solid Tumor

A Rare Case of Olmesartan-Associated Enteropathy Mimicking Autoimmune Enteropathy (ACG 2026) - "Home medications included Olmesartan, aspirin, atorvastatin, levothyroxine, and metoprolol...Gastric biopsy (left) demonstrates marked chronic active gastritis with lamina propria expansion by mixed inflammatory infiltrates, increased intraepithelial lymphocytes, and focal cryptitis. Duodenal biopsy (right) demonstrates partial villous blunting, increased intraepithelial lymphocytosis, lamina propria inflammation, and focal acute cryptitis, consistent with a sprue-like enteropathy pattern."

Clinical • Cardiovascular • Celiac Disease • Cognitive Disorders • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • GAST

Severe Transaminitis as a Misleading Presenting Feature of Myxedema Coma (ACG 2026) - "IV hydrocortisone and levothyroxine were initiated for presumed myxedema coma with ICU transfer. Figure: Axial contrast-enhanced CT of the abdomen at the level of the liver and stomach. Arrow indicates thickening of the gastric wall, one of several sites of luminal wall thickening (also involving the distal esophagus and ascending colon) attributable to hypothyroidism-induced gastrointestinal dysmotility and myxedematous mucosal edema."

Cardiovascular • Endocrine Disorders • Gastrointestinal Disorder • Hepatology • Hypotension • Immunology • Liver Failure • Pruritus

Immune Checkpoint InhibitorâInduced Severe Hypothyroidism Mimicking Hepatic Encephalopathy (ACG 2026) - "Case Description/ A 64-year-old man with cirrhosis from metabolic dysfunction and alcohol-related liver disease and multifocal unresectable HCC on tremelimumab-durvalumab presented with one week of progressive confusion, disorientation, and hypoactivity...The patient demonstrated marked improvement in mental status while continuing lactulose and rifaximin...Individualized approaches, including IV levothyroxine when enteral absorption is unreliable, may be critical to recovery. Generative AI was used in the development and editing of this abstract."

Checkpoint inhibition • CNS Disorders • Endocrine Cancer • Endocrine Disorders • Fibrosis • Hepatic Encephalopathy • Hepatocellular Cancer • Hepatology • Immunology • Liver Cirrhosis • Metabolic Disorders • Oncology • Solid Tumor

Serial CT-Guided Nonoperative Resolution of Partial Transverse Colon Volvulus in a Patient With Profound Hypothyroidism (ACG 2026) - "TSH was 113 with free T4 0.20 from levothyroxine nonadherence...Initial CT abdomen/pelvis: Dilated upstream transverse colon (43.8 mm) with abrupt transition zone Figure: Figure 2. Repeat CT after 1 month: Resolved volvulus with colonic redundancy"

Clinical • Constipation • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Head and Neck Cancer • Lung Cancer • Solid Tumor

Triple Autoimmune Diagnosis at First Encounter: Concurrent Presentation of Primary Biliary Cholangitis, Sjögren's Syndrome, and Hashimoto's Thyroiditis (ACG 2026) - "Shared immunopathogenic mechanisms, including molecular mimicry, cross-reactive autoantibodies, and HLA associations, reinforce that PBC exists within a broader systemic autoimmune spectrum. This case underscores the importance of comprehensive inpatient autoimmune screening when PBC is first suspected, enabling timely initiation of ursodeoxycholic acid, levothyroxine, and sicca symptom management, while facilitating early transplant referral in advanced disease."

Endocrine Disorders • Fibrosis • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Primary Biliary Cholangitis • Sjogren's Syndrome • Xerostomia

When Constipation Is Not Just Constipation: Severe Hypothyroidism Causing Adynamic Ileus (ACG 2026) - "Intravenous levothyroxine was initiated with gradual biochemical improvement...A) Coronal view. B) Axial view."

Atrial Fibrillation • Cardiovascular • Constipation • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Septic Shock

Suspected Ampalaya-Induced Acute Pancreatitis and Hepatitis in a 70-Year-Old Woman: A Case Report (ACG 2026) - "Although generally regarded as safe, its potential for hepatotoxic or pancreatic injury remains poorly characterized, with only one previously documented case of pancreatitis associated with concurrent pazopanib therapy...Current medications included alendronate 70 mg weekly, apixaban 2.5 mg twice a day, cholecalciferol 2000 unit daily, fish oil 1000 mg daily, levothyroxine 112 mcg daily, magnesium glycinate 240 mg daily, rosuvastatin 5 mg daily...This case suggests a probable association between ampalaya ingestion and acute pancreatitis with concomitant hepatocellular injury. Given the widespread use of Momordica charantia for diabetes management, clinicians should maintain a high index of suspicion for herbal-supplement induced pancreatic and hepatic toxicity when more common etiologies have been excluded."

Case report • Clinical • Diabetes • Gastroenterology • Hepatology • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Pancreatitis • Type 2 Diabetes Mellitus

Small Intestinal Bacterial Overgrowth in Hypothyroidism and Its Impact on Levothyroxine Absorption: A Systematic Review and Meta-Analysis (ACG 2026) - "Seven studies (745 hypothyroid patients; 2,599 controls; Newcastle-Ottawa Scale 8-9/9, all low risk) were included. Hypothyroid subjects had nearly 3-fold higher SIBO odds than euthyroid controls (OR 2.98; 95% CI 2.05-4.33; I²=25.9%; p< 0.001). The pregnancy subgroup (4 studies; n=1,073) was homogeneous (OR 2.87; 95% CI 2.26-3.63; I²=0%; p< 0.001); hypothyroid pregnant women had higher rates of hypertensive disorders (p=0.046) and lower neonatal birth weight, with SIBO inversely correlated with birth weight (r=-0.46; p< 0.001)."

Retrospective data • Review • Endocrine Disorders • Hypertension

EUS-Guided Lumen-Apposing Metallic Stent Placement for Partial Reversal of Roux-en-Y Gastric Bypass for Treatment of Severe Malnutrition (ACG 2026) - "At follow-up, her weight has stabilized with improving micronutrient levels and normalization of levothyroxine dosing...Further studies are needed to evaluate long-term efficacy and safety, including how long the LAMS should remain in place to create a permanent anastomosis. Figure: Lumen opposing metal stent connecting gastric pouch and excluded stomach"

Bariatric surgery • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Obesity • Short Bowel Syndrome

Dapsone-Induced Acute Pancreatitis: A Rare but Important Consideration in Drug-Induced Pancreatic Injury (ACG 2026) - "Medication review identified atorvastatin, pantoprazole, levothyroxine, and dapsone, with initiation 5 years prior for DH. This case adds to the growing body of reported cases, reinforcing ddx inclusion of drug-induced AP despite absence of causation-level evidence in patients on dapsone, although further studies are needed to evaluate pathogenesis and instigation regarding specific drug-related AP. Figure: Axial view of diffuse pancreatic edema and distended loops of bowel Figure: Coronal view of diffuse edema surrounding pancreas and hepatogastric structures"

Acute Kidney Injury • Barrett Esophagus • Celiac Disease • Dermatitis • Dyslipidemia • Endocrine Disorders • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hypertriglyceridemia • Immunology • Metabolic Disorders • Nephrology • Pancreatitis • Renal Disease

Effects of levo-thyroxine titration in thyroid cancer patients with lenvatinib-induced TSH increase: a real-life study. (ETA 2026) - "LEN induced a significant increase in TSH levels. Increasing doses of LT4 were required to stabilize TSH levels; however, they were not sufficient to maintain TSH below the target threshold or to restore fT3 levels. These findings, along with the increased risk of disease progression observed in patients requiring higher LT4 increase, suggest that restoring TSH levels through increasing LT4 doses may not be a cost-effective strategy in these patients."

Clinical • Oncology • Solid Tumor • Thyroid Gland Carcinoma

Pituitary Stalk Enlargement With Panhypopituitarism and Arginine Vasopressin Deficiency in Lung Adenocarcinoma: Metastatic Infundibular Disease or Paraneoplastic Hypophysitis? (PubMed, Cureus) - "The patient was initiated on hydrocortisone and levothyroxine replacement therapy...The patient showed subsequent clinical improvement with desmopressin. Serum prolactin was mildly elevated, likely reflecting both pituitary stalk infiltration and concomitant metoclopramide therapy. This case discusses an exceptionally rare presentation of lung adenocarcinoma with isolated pituitary stalk infiltration, panhypopituitarism, and AVP-D before exposure to immune checkpoint inhibitors. Clinicians should be aware of this unusual manifestation, as prompt hormone replacement can significantly reduce morbidity and improve patient outcomes."

Journal • Endocrine Disorders • Growth Hormone Deficiency • Lung Adenocarcinoma • Lung Cancer • Metabolic Disorders • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • PRL

Assessment of the Musculoskeletal Axis and Body Composition Parameters in Women with Controlled Thyroid Dysfunction: A Cross-Sectional Study. (PubMed, Metabolites) - " These preliminary results indicate no detectable deterioration in musculoskeletal and functional parameters in women with managed thyroid dysfunction. However, due to the small sample size of the hypothyroidism subgroup and low statistical power, these findings cannot establish physiological equivalence and must be interpreted with caution, as they do not confirm a direct protective effect of levothyroxine therapy against muscle mass decline."

Journal • Observational data • Endocrine Disorders • Musculoskeletal Diseases • Sarcopenia • BDNF • GDF15

Association of Vitamin D Levels and Systemic Inflammation in Patients with Hashimoto's Thyroiditis. (PubMed, Diseases) - "Participants were categorized as Vitamin D deficient (<20 ng/mL) or non-deficient (≥20 ng/mL), with HT patients further stratified as euthyroid, hypothyroid, or levothyroxine-treated... These findings should therefore be considered exploratory and hypothesis-generating. Nevertheless, the observed Vitamin D status-specific patterns suggest that the relationship with inflammatory profiles in HT may differ according to Vitamin D status and warrant validation in prospective and mechanistic studies."

Journal • Endocrine Disorders • Inflammation • CCL11 • CCL20 • IL17C

Thyroid Disorders during Pregnancy and Puerperal Periods: A Narrative Review. (PubMed, Z Geburtshilfe Neonatol) - "Evidence indicates that the benefit of levothyroxine therapy is mainly observed when the maternal thyroid-stimulating hormone level exceeds 4.0 mU/L and treatment is initiated early in pregnancy...There is no clear consensus in the literature regarding the diagnosis and management of thyroid disorders during the pregnancy-puerperal cycle. Therefore, screening and care strategies should be expanded and adapted to local contexts in order to optimize maternal and fetal outcomes, while respecting regional epidemiological and laboratory characteristics."

Journal • Endocrine Disorders • Gynecology • Obstetrics