thyroxine / Generic mfg. - LARVOL DELTA

A rare case of gelatinous transformation of the bone marrow secondary to untreated hypothyroidism and congestive heart failure (ASH 2025) - "He was empirically treated with cefepime and azithromycin for presumed sepsis...He was started on levothyroxine 25 mcg, Jardiance 10 mg, and spironolactone 25 mg for HFpEF...Diagnosing GTBM requires a high index of suspicion and exclusion of other pancytopenia causes. Early recognition and treatment of the underlying disorder can reverse both GTBM and associated cytopenias."

Clinical • Aplastic Anemia • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Hematological Malignancies • Human Immunodeficiency Virus • Immunology • Infectious Disease • Pituitary Gland Carcinoma • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • IL2

Nivolumab with doxorubicin, vinblastine, and dacarbazine (NAVD) in older adults with classic Hodgkin lymphoma: Do S1826 results hold up in the real world? (ASH 2025) - "Overall, 15% pts required steroids withresolution of IrAEs in 56% cases, 30% (n=7) pts required continued therapy (levothyroxine in 4 pts,steroids in 3 pts, medical tx for heart failure in 1 pt). In this largest RWS cohort of OAs treated with NAVD we showed comparable response rates, AEs and 1-year survival outcomes to those in the pivotal S1826 trial. Notably, rates of ≥G3 AEs including infections,neuropathy and IrAEs remained low and manageable. Although survival significantly improved withNAVD compared to historical data, outcomes of OAs remained inferior compared to pts <60 yrs."

Clinical • Real-world • Real-world evidence • Cardiovascular • Classical Hodgkin Lymphoma • Congestive Heart Failure • Endocrine Disorders • Febrile Neutropenia • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Hematological Malignancies • Hepatology • Hodgkin Lymphoma • Immunology • Infectious Disease • Inflammatory Arthritis • Lymphoma • Nephrology • Neutropenia • Pneumonia • Renal Disease • Rheumatology • Sarcoidosis

A real-world analysis of safety and outcomes with first line nivolumab in combination with doxorubicin, vinblastine, and dacarbazine (NAVD) in patients with classic Hodgkin lymphoma (cHL) – a multicenter cohort study (ASH 2025) - "S1826 demonstrated a 1-year progression free survival (PFS) of 94% forNAVD compared to 86% for brentuximab vedotin-AVD, which remained durable at 2 years (Herrera et al,NEJM 2024)...Among all pts, 14.4% (n=45) requiredsystemic steroids at any time (intravenous in 4.1%), 3.2% (n=10) require ongoingsteroids/immunosuppression and 8.3% other therapy for an irAE (n=23 levothyroxine, n=1 hemodialysis,n=1 heart failure tx, n=1 insulin).Among all pts, 265 (85%) had an interim PET-CT after 2-4 cycles...Pts treated with NAVD in a large RWS showed comparable response rates and 1-year survival outcomesto those in the pivotal S1826 trial. Most AEs were similar and grade 1-2, but close monitoring of irAEs isnecessary given the potential long-term toxicity of checkpoint inhibitors and potential for ≥G3 irAEs(7.5%) in this young patient population. Our data supports the use of NAVD for 1L advanced stage cHL."

Clinical • Combination therapy • Real-world • Real-world evidence • Cardiovascular • Classical Hodgkin Lymphoma • Congestive Heart Failure • Diabetes • Endocrine Disorders • Febrile Neutropenia • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Hematological Malignancies • Hodgkin Lymphoma • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Lymphoma • Metabolic Disorders • Nephrology • Neutropenia • Pancreatitis • Renal Disease • Rheumatology

Pancytopenia in the context of hypothyroidism and B12 deficiency: A case report and review literature. (PubMed, Caspian J Intern Med) - "The patient showed a rapid and significant hematological response, with all cell lines improving and approaching normal ranges on follow-up, confirming the diagnosis. In this patient, after the diagnosis of hypothyroidism and receiving levothyroxine, we saw a better stability of the improvement of the patient's symptoms and a further improvement in the number of any blood cell lines chiefly platelet which is one of the regulators of the coagulation pathway, and its deficiency increase the risk of bleeding."

Journal • Anorexia • Endocrine Disorders • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology

BG12 Carotenaemia: a persistent orange hue. (PubMed, Br J Dermatol) - "Her medical history is notable for hypothyroidism, managed with a low dose of levothyroxine...It also highlights the need for further investigation into other, perhaps less well-understood, mechanisms contributing to persistent carotenaemia. While benign, the condition can cause cosmetic concern and may warrant dermatological follow-up for reassurance and management guidance."

Journal • Anorexia • Dermatology • Diabetes • Endocrine Disorders • Hepatology • Liver Failure • Metabolic Disorders

Hypopituitarism and Rathke's cleft cyst in 48,XXYY Syndrome: new insights into sex chromosome aneuploidies. (PubMed, Einstein (Sao Paulo)) - "Hormone replacement therapy with prednisone and levothyroxine was initiated, resulting in adequate hormonal replacement. The association between 48,XXYY syndrome and Rathke's cleft cyst raises intriguing questions about the potential links between sex chromosome aneuploidies and pituitary abnormalities. This report emphasizes the need for comprehensive endocrine and structural assessments to optimize patient outcomes by contributing to the limited literature on 48,XXYY syndrome."

Journal • Autism Spectrum Disorder • Endocrine Disorders • Essential Tremor • Genetic Disorders • Movement Disorders

Effect of Autoimmune Thyroid Disease on Pregnancy Outcomes: A Systematic Review and Meta-Analysis. (PubMed, J Clin Med) - "Objective: To assess the association between AITD and adverse pregnancy outcomes and evaluate the effect of levothyroxine (LT4) therapy in high-risk populations...LT4 in high-risk women may reduce miscarriage and preterm birth. Further RCTs should stratify by AITD subtype, antibody titer, and thyroid function, and report perinatal outcomes systematically."

Journal • Retrospective data • Review • Endocrine Disorders • Immunology

THE AMELIORATING EFFECT OF LEVOTHYROXINE ON RETINOL BINDING PROTEIN 4, AND GELSOLIN IN PATIENTS WITH HYPOTHYROIDISM. (PubMed, Georgian Med News) - "In post treatment with levothyroxine their levels were significantly increased as compared to the pretreatment. Levothyroxine marginally restored RBP4 and gelsolin level parallel to improved thyroid hormone levels."

Journal • Endocrine Disorders • GSN • RBP4

A comparative study on L-thyroxine treatment and sesame oil supplementation in experimentally induced hypothyroidism in rats. (PubMed, Front Physiol) - "Adult female Wistar rats (n = 66) were randomly allocated into control, sesame oil-treated euthyroid, propylthiouracil-induced hypothyroid, L-thyroxine-treated hypothyroid, sesame oil-treated hypothyroid, and combined treated hypothyroid groups. Sesame oil has the potential to be utilized as an adjuvant therapy with L-thyroxine to counteract the cardiac and hepatic alterations induced by hypothyroidism. This is supported by its antioxidant, anti-inflammatory, and antisteatotic characteristics."

Journal • Preclinical • Anesthesia • Cardiomyopathy • Cardiovascular • Dyslipidemia • Endocrine Disorders • Fibrosis • Hepatology • Hypertension • Hypotension • Immunology • Metabolic Disorders • IL6 • SCD

A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism (clinicaltrials.gov) - P2 | N=303 | Completed | Sponsor: Neuvosyn Laboratories, LLC | Active, not recruiting ➔ Completed | Trial completion date: Dec 2025 ➔ Sep 2025

Trial completion • Trial completion date • Endocrine Disorders

Effects of Hypopituitarism Due to Sheehan's Syndrome on Bone Mineral Density: A Multicentric Study in Asian Indians. (PubMed, Clin Endocrinol (Oxf)) - "SS is characterized by a high prevalence of multiple pituitary hormone deficiencies, including hypoprolactinaemia. Low BMD is highly prevalent in SS compared to age, and BMI-matched controls. Despite adequate relevant hormone replacement therapy, a longer delay in diagnosing is the major determinant of low BMD in patients with SS."

Journal • Endocrine Disorders • Growth Hormone Deficiency • Osteoporosis • Rheumatology • IGF1

Webb-Dattani syndrome in a 17-year-old girl. (PubMed, Endocrinol Diabetes Metab Case Rep) - "Management included hormone replacement with hydrocortisone, levothyroxine, and desmopressin, as well as fluid regulation and supportive care. Long-term survival, although rare, is possible with coordinated multidisciplinary care addressing endocrine, neurological, renal, and infectious complications. This case underscores the importance of individualized endocrine replacement therapy and caregiver education in managing complex syndromic conditions such as WEDAS."

Journal • Developmental Disorders • Endocrine Disorders • Growth Hormone Deficiency • Infectious Disease • Metabolic Disorders

Progression From Isolated Posterior Pituitary Dysfunction to Combined Anterior Hormone Deficiencies With Pituitary Stalk Enlargement in Suspected Lymphocytic Hypophysitis: A Case Report. (PubMed, Cureus) - "Combined anterior pituitary hormone deficiencies were diagnosed, and replacement therapy with hydrocortisone and levothyroxine was initiated, resulting in symptomatic improvement. This case was considered to represent LYH, showing possible dynamic changes in pituitary function and morphology over time. Administration of pharmacologic-dose steroids or pituitary biopsy should be considered if further progressive pituitary enlargement or new mass effects, such as headache or visual disturbance, become evident."

Journal • Immunology • Inflammation • Metabolic Disorders • Pain • Xerostomia • PRL

Anemia in acromegaly: Prevalence, etiologies, and predictors from a large tertiary center cohort. (PubMed, Pituitary) - "Anemia is a frequent and clinically relevant comorbidity in acromegaly, associated with tumor burden, hypopituitarism, treatment intensity. These findings highlight the need for systematic evaluation of anemia in acromegalic patients and underscore the importance of future prospective studies to clarify its complex pathophysiology."

Journal • Retrospective data • Acromegaly • Anemia • Beta-Thalassemia • Endocrine Disorders • Genetic Disorders • Hematological Disorders • Oncology • Pituitary Gland Carcinoma • IGF1 • SSTR

A Rare Presentation of Myxedema Coma Complicated by Acute Coronary Syndrome Successfully Managed With Oral Levothyroxine. (PubMed, JCEM Case Rep) - "Both myxedema coma and ACS are life-threatening medical emergencies that require a high index of suspicion for timely diagnosis, especially when they occur simultaneously in a single patient. Delayed recognition and intervention significantly increase the risk of mortality."

Journal • Acute Coronary Syndrome • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Hypertension • Pain

Postmarketing pharmacovigilance study of levothyroxine based on FDA adverse event reporting system (FAERS) and Mendelian randomization. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "These findings provide valuable reference information for reducing clinical risks associated with levothyroxine use. Clinicians should be vigilant for these adverse reactions when prescribing levothyroxine."

Adverse events • Journal • P4 data • Celiac Disease • CNS Disorders • Depression • Endocrine Disorders • Gastrointestinal Disorder • Immunology • Metabolic Disorders • Migraine • Musculoskeletal Pain • Pain • Psychiatry

Outcomes of in vitro fertilization for women with thyroid cancer: a case report. (PubMed, BMC Pregnancy Childbirth) - "Thyroid surgery for infertile women complicated with PTC may be deferred after completing COS, embryo transfer, and pregnancy. No adverse effects of PTC on IVF outcomes, obstetrical and neonatal outcomes were observed in this case."

Journal • Preclinical • Gynecology • Infertility • Obstetrics • Oncology • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma

Levothyroxine in euthyroid pregnant women with thyroid peroxidase antibody: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Rev Bras Ginecol Obstet) - "Our subgroup analysis also provides evidence that levothyroxine may have a higher benefit for patients with a history of RPL. CRD42023410433."

Clinical • Journal • Retrospective data • Review

Revealing the genotype-phenotype correlations of congenital hypothyroidism in Yunnan Province, Southwest China. (PubMed, Front Endocrinol (Lausanne)) - "CH patients exhibiting goiter and thyroid dysgenesis required a higher initial levothyroxine (L-T4) dose...Genotype cannot effectively be used to predict CH phenotype and prognosis. Standardized treatment and follow-up are crucial for positive outcomes in CH children."

Journal • Retrospective data • Endocrine Disorders • DUOX2

LESI: Levothyroxine Treatment and IVF Outcomes in Women With Subclinical Hypothyroidism: A Target Trial Emulation (clinicaltrials.gov) - P=N/A | N=900 | Recruiting | Sponsor: Mỹ Đức Hospital

New trial • Endocrine Disorders • Gynecology • Infertility • Sexual Disorders

Influence of levothyroxine supplementation on athletic performance in subclinical hypothyroidism - a review of the literature. (PubMed, Folia Med Cracov) - "Overall, LT4 therapy in sHT shows promise in improving selected physiological parameters, yet evidence for meaningful enhancement of overall exercise capacity or athletic performance remains weak. Until robust, athlete-specific data are available, treatment decisions should continue to follow established clinical criteria rather than anticipated performance gains."

Journal • Review • Cardiovascular • Endocrine Disorders

Total Thyroidectomy and Quality of Life in Patients With Hashimoto Thyroiditis: A Systematic Scoping Review. (PubMed, J Surg Res) - "Total thyroidectomy may improve QoL in a subset of Hashimoto thyroiditis patients who are persistently symptomatic despite being euthyroid on levothyroxine therapy. However, a higher surgical complication rate is possible. Further prospective clinical trials are needed to confirm this observation and determine the mechanism behind the improvement in QoL."

HEOR • Journal • Review • Endocrine Disorders • Hypoparathyroidism • Immunology • Infectious Disease

Occam's Razor or Hickam's Dictum: Delayed Onset of Pembrolizumab-Induced Podocytopathy and Acute Interstitial Nephritis After Cessation of the Drug (KIDNEY WEEK 2025) - "Medications included levothyroxine, duloxetine, and rifaximin. Our patient showed favorable response to prednisone, with marked improvement in both proteinuria and acute kidney injury (AKI). Continued vigilance for AKI and proteinuria is required even after the ICI is stopped."

Acute Kidney Injury • Glomerulonephritis • Nephrology • Renal Disease • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Unknown Primary

Immune checkpoint inhibitor-associated hypothyroidism, macular rash and adrenal insufficiency: case report and review of the literature. (PubMed, BMC Endocr Disord) - "This is a typical case of endocrine irAEs caused by ICIs, and the patient's macular rash may also be related to ICIs. For patients treated with ICIs, preventive monitoring of symptoms of irAEs and related hormones is crucial for timely diagnosis, treatment, and even prevention of endocrine crisis."

Checkpoint inhibition • Journal • Review • Anorexia • Cardiovascular • Endocrine Cancer • Endocrine Disorders • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Fatigue • Heart Failure • Hematological Disorders • Hypoglycemia • Hypotension • Nephrology • Oncology • Renal Disease • Squamous Cell Carcinoma

Impact of thyroid disorders on flow-mediated dilation: a systematic review and meta-analysis. (PubMed, J Endocrinol Invest) - "Hypothyroidism is associated with endothelial impairment, reversible after restoration of euthyroidism, highlighting the importance of appropriate management. Hyperthyroidism, especially subclinical, seems associated with FMD reduction, but larger, well-designed studies are needed."

Journal • Retrospective data • Review • Cardiovascular • Endocrine Disorders