Moxduo IV (morphine/oxycodone) / QRxPharma, Aoxing - LARVOL DELTA

The evaluation of NT-proCNP, C-reactive protein and serum amyloid A protein concentration in patients with multiple myeloma undergoing stem cell transplantation. (PubMed) - Leuk Res - "We showed positive correlation between NT-proCNP levels and absolute neutrophil and platelets count in patients after ASCT. NT-proCNP can be useful parameter to assess effectiveness of treatment and monitoring of hematopoetic recovery time in patients with MM after stem cell transplantations."

Journal • Biosimilar • Hematological Malignancies • Leukemia • Multiple Myeloma • Oncology

The conversion ratio from intravenous hydromorphone to oral opioids in cancer patients. (PubMed, J Pain Symptom Manage) - "Our study found that 1 mg of IV hydromorphone is equivalent to 2.5 mg of oral hydromorphone and 11.46 mg of MEDD. Hydromorphone at doses ≥ 30 mg/day may require a lower ORR to other opioids."

Journal • Biosimilar • Demo Pain • Oncology • Oral Cancer • Pain

Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle. (PubMed) - J Vet Med Sci - "In conclusion, the results of the present study indicate that DF and AAP are rapidly absorbed from the forestomach of cattle. Therefore, the appropriate efficacies of these drugs may be achieved via their oral administration, even in cattle."

Journal • Biosimilar

QRXPharma stops work on pain drug (The Australian) - "QRXPharma, has announced it is stopping work on the development of its pain medication [Moxduo]...the decision came after US regulators baulked at approving its drug in May. 'The management team has...made a recommendation to the Board to halt all further development of the Moxduo IR, CR and IV programs'."

Discontinued • Pain

Phase I study of PF-03446962, a fully human monoclonal antibody against activin receptor-like kinase 1 in patients with hepatocellular carcinoma. (PubMed) - Ann Oncol - "The observed safety, tolerability, pharmacokinetic profile, and clinical activity support further evaluation of PF-03446962 in patients with hepatocellular carcinoma and other solid malignancies, as single agent or in combination with other antiangiogenic, chemotherapeutic or immunotherapeutic agents."

Biomarker • Journal • Biosimilar • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology

Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT. (PubMed) - Int J Reprod Biomed (Yazd) - "our result showed in normal IVF patients with normal endometrial thickness, the intrauterine infusion of G-CSF did not improve pregnancy outcomes."

Journal • Biosimilar • Endometrial Cancer • Endometriosis • Gene Therapies • Renal Disease

Effectiveness of pericardial lavage with or without tranexamic acid in cardiac surgery patients receiving intravenous tranexamic acid: a randomized controlled trial. (PubMed) - Eur J Cardiothorac Surg - "Pericardial lavage, with or without TA, does not result in a statistically significant difference in the 12-h postoperative blood loss in cardiac surgery patients receiving intravenous TA administration. Pericardial lavage with saline, with or without TA, should not be a part of a blood conservation strategy."

Journal • Biosimilar

From a Suspect Victim to the Holmes: The Unexpected Value of a Home-Made Mobile Chemotherapy Medication Administration System. (PubMed) - Stud Health Technol Inform - "Our newly hospital-wide implemented home-made mobile chemotherapy medication support system, which has released our nurses from the traditional heavy 2-nurse-double-checking loading, was unexpectedly used to protect our nurses from being suspected in a recent event of over delivery of infusion. The outcome turned us to reexamine the device maintenance and test protocols."

Journal • Biosimilar

Intravenous and Oral Contrast vs Intravenous Contrast Alone Computed Tomography for the Visualization of Appendix and Diagnosis of Appendicitis in Adult Emergency Department Patients. (PubMed) - Can Assoc Radiol J - "Our findings suggest that reader confidence in visualizing the appendix improved with addition of oral contrast as compared to IV contrast alone. One- and 3-hour oral regimens have a similar diagnostic performance in diagnosing appendicitis."

Journal • Biosimilar • Immunology • Pain

Factors Affecting Difficult Peripheral Intravenous Cannulation in Adults: A Prospective Observational Study. (PubMed) - J Clin Nurs - "These results can help nurses to recognise risk factors for difficult IV access and pay appropriate attention when attempting a venepuncture to preserve patients' peripheral veins."

Journal • Biosimilar • Oncology

In vivo efficacy, toxicity and biodistribution of ultra-long circulating desferrioxamine based polymeric iron chelator. (PubMed) - Biomaterials - "Since ULC-DFO has improved iron removal properties, longer plasma retention time and possesses excellent biocompatibility, it represents a polymer conjugate with high clinical utility in comparison to DFO for the treatment of transfusion dependent iron overload. More importantly, ULC-DFO is anticipated to reduce the requirement for prolonged subcutaneous infusion of DFO."

Journal • Biosimilar • Gene Therapies • Myelodysplastic Syndrome • Oncology

Impact of elemental diet on early recovery after laparoscopic colectomy: findings of a randomized controlled trial. (PubMed) - Surg Today - "The perioperative ingestion of ED by patients undergoing laparoscopic colectomy is safe and can reduce the postoperative hospital stay by supporting the acceleration of oral intake."

Journal • Biosimilar • Pain

Intravenous administration of adipose tissue-derived stem cells enhances nerve healing and promotes BDNF expression via the TrkB signaling in a rat stroke model. (PubMed) - Neuropsychiatr Dis Treat - "However, K252a administration reversed the ADSCs-induced elevation of BDNF, TrkB, and Bcl-2 and reduction of Bax protein in MCAO rats. ADSCs promote BDNF expression via the TrkB signaling and improve functional neurological recovery in stroke rats."

Journal • Biosimilar

One-Step Detection of Major Lipid Components in Sub-microliter Volumes of Unpurified Liposome and Cell Suspensions. (PubMed) - Anal Chem - "This method has been tested on liposomes (containing phosphatidylcholine and phosphatidylglycerol) and four types of animal/human cells, i.e. mouse macrophages (RAW 264.7), human breast cancer cells (T47D and Hs578T), and mouse pre-adipocyte cells (3T3-L1). We suggest that HDC-ESI-MS can be used in quality control analyses of bioparticle suspensions in the fields of biotechnology, molecular biology, drug discovery, and cosmetics."

Journal • Biosimilar • Breast Cancer • Oncology • Triple Negative Breast Cancer

Role of Macrophage (M1 and M2) in Titanium-Dioxide Nanoparticle-Induced Oxidative Stress and Inflammatory Response in Rat. (PubMed) - Appl Biochem Biotechnol - "The M1-induced inflammatory response was found to cause DNA and chromosomal damage resulting apoptosis induction via upregulation of Bax/Bcl-2 ratio and subsequent loss of mitochondrial membrane potential and cyto c release in splenocytes. The TNP-led inflammatory response also causes damage at different tissue levels."

Journal • Biosimilar

Influence of Distance to Scene on Time to Thrombolysis in a Specialized Stroke Ambulance. (PubMed) - Stroke - "In a metropolitan area such as Berlin, time benefits justify a specialized stroke ambulance service up to a mean travel time of 18 minutes from base station."

Journal • Biosimilar • Reperfusion Injury