FA-relaxin (BMS-986259) / BMS - LARVOL DELTA

A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function (clinicaltrials.gov) - P1; N=30; Completed; Sponsor: Bristol-Myers Squibb; Active, not recruiting ➔ Completed; N=48 ➔ 30; Trial completion date: Feb 2021 ➔ Jul 2021; Trial primary completion date: Feb 2021 ➔ Jul 2021

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Renal Disease

Study of the Safety of BMS-986259 in Participants With Post-Acute Decompensated Heart Failure (clinicaltrials.gov) - P2; N=25; Completed; Sponsor: Bristol-Myers Squibb; Trial primary completion date: Apr 2022 ➔ Jul 2021; Recruiting ➔ Completed; N=72 ➔ 25; Trial completion date: Apr 2022 ➔ Jul 2021

Clinical • Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Cardiovascular • Congestive Heart Failure • Heart Failure

An Ascending Dose Study of BMS-986259 to Study Safety in Healthy Participants (clinicaltrials.gov) - P1; N=132; Completed; Sponsor: Bristol-Myers Squibb; Active, not recruiting ➔ Completed

Trial completion

Study of the Safety of BMS-986259 in Participants With Post-Acute Decompensated Heart Failure (clinicaltrials.gov) - P2; N=72; Recruiting; Sponsor: Bristol-Myers Squibb; Not yet recruiting ➔ Recruiting; Trial completion date: Jul 2021 ➔ Apr 2022; Trial primary completion date: Jul 2021 ➔ Apr 2022

Clinical • Enrollment open • Trial completion date • Trial primary completion date • Cardiovascular • Congestive Heart Failure • Heart Failure

A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function (clinicaltrials.gov) - P1; N=48; Active, not recruiting; Sponsor: Bristol-Myers Squibb; Trial completion date: Jun 2020 ➔ Feb 2021; Trial primary completion date: Jun 2020 ➔ Feb 2021

Clinical • Trial completion date • Trial primary completion date • Renal Disease

Study of the safety of BMS-986259 in participants with post-acute decompensated heart failure (clinicaltrialsregister.eu) - P2; N=72; Ongoing; Sponsor: Bristol-Myers Squibb International Corporation

Clinical • New P2 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function (clinicaltrials.gov) - P1; N=48; Active, not recruiting; Sponsor: Bristol-Myers Squibb; Recruiting ➔ Active, not recruiting

Clinical • Enrollment closed • Chronic Kidney Disease • Renal Disease

An Ascending Dose Study of BMS-986259 to Study Safety in Healthy Participants (clinicaltrials.gov) - P1; N=78; Active, not recruiting; Sponsor: Bristol-Myers Squibb; N=116 ➔ 78; Trial completion date: May 2020 ➔ Aug 2020; Trial primary completion date: May 2020 ➔ Aug 2020

Clinical • Enrollment change • Trial completion date • Trial primary completion date

Study of the Safety of BMS-986259 in Participants With Post-acute Decompensated Heart Failure (clinicaltrials.gov) - P2; N=72; Not yet recruiting; Sponsor: Bristol-Myers Squibb

Clinical • New P2 trial

An Ascending Dose Study of BMS-986259 to Study Safety in Healthy Participants (clinicaltrials.gov) - P1; N=116; Active, not recruiting; Sponsor: Bristol-Myers Squibb; Recruiting ➔ Active, not recruiting

Clinical • Enrollment closed

A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function (clinicaltrials.gov) - P1; N=48; Recruiting; Sponsor: Bristol-Myers Squibb; Not yet recruiting ➔ Recruiting

Clinical • Enrollment open

A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function (clinicaltrials.gov) - P1; N=48; Not yet recruiting; Sponsor: Bristol-Myers Squibb

Clinical • New P1 trial