Panretin (alitretinoin topical) / Eisai - LARVOL DELTA

Acitretin for the treatment of Kaposi Sarcoma: case report and review of the literature. (EADV 2024) - "Case Presentation: A 66-year-old woman with a history of seronegative rheumatoid arthritis currently treated with tofacitinib, methotrexate, and folic acid, presented with a several-month history of asymptomatic cutaneous lesions. We present a case of iatrogenic KS successfully treated with oral acitretin, showcasing the potential benefits of systemic retinoids in this vascular neoplasm."

Case report • Clinical • Review • Epstein-Barr Virus Infections • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammatory Arthritis • Kaposi Sarcoma • Oncology • Rheumatoid Arthritis • Rheumatology • Sarcoma • Solid Tumor

Kaposi Sarcoma Associated with Tofacitinib Use in a Patient with Rheumatoid Arthritis. (PubMed, R I Med J (2013)) - "The purple-red Kaposi sarcoma nodules decreased 50% in size after 4 months and resolved at 1 year off the tofacitinib and initiation of alitretinoin gel. As the use of immunomodulators and biologics continues to expand, awareness of this association is important for prompt diagnosis and management."

Journal • Human Immunodeficiency Virus • Immune Modulation • Immunology • Infectious Disease • Inflammatory Arthritis • Kaposi Sarcoma • Oncology • Rheumatoid Arthritis • Rheumatology • Sarcoma • Solid Tumor • Transplantation

Treatments for AIDS/HIV-related Kaposi sarcoma: A systematic review of the literature. (PubMed, Int J Dermatol) - "The evidence of efficacy of any particular intervention is overall varied and there was insufficient evidence to recommend any particular intervention. We have provided an overview of treatments for KS but larger studies need to be carried out to verify the efficacy of treatment options reported in the literature."

Journal • Review • Dermatology • Human Immunodeficiency Virus • Infectious Disease • Kaposi Sarcoma • Oncology • Pain • Sarcoma • Solid Tumor

Systematic Review of Topical Treatments for Kaposi Sarcoma (AAD 2022) - "These include topical diphencyprone (DPCP), all-trans-retinoic-acid, rapamycin and bleomycin-dimethylsulfoxide (BLM-DMSO) which achieved variable response rates but have not been widely studied. Topical timolol, imiquimod and alitretinoin demonstrated positive response for limited cutaneous KS and the treatments were well tolerated. These three topical treatment modalities could be considered by clinicians to make informed treatment decisions about cutaneous KS."

Review • Human Immunodeficiency Virus • Infectious Disease • Kaposi Sarcoma • Oncology • Sarcoma • Solid Tumor