betahistine / Generic mfg. - LARVOL DELTA

Investigation of the Binding Characteristics of Agonists and Various Antagonists Targeting Histamine 1 Receptor. (PubMed, Pharm Res) - "These mechanistic insights into H1R ligand binding provide a structural foundation for the rational design of targeted therapies with improved selectivity and efficacy against allergic disorders."

Journal • Allergy

Effectiveness of Ryokeijutsukanto in the Treatment of Benign Paroxysmal Positional Vertigo (BPPV). (PubMed, Cureus) - "Forty-eight BPPV patients were divided into three groups: Group A (BD method only, N=8), Group B (BD method + Kampo, N=11), and Group C (BD method + betahistine 36 mg, N=29)...Results Positional nystagmus resolution occurred in 38.3 ± 34.5 days (Group A), 30 ± 30.2 days (Group B), and 20.8 ± 21.4 days (Group C), with no statistically significant differences between groups. Subjective improvements were observed in 55% (6/11) of patients in Group B. Conclusions While ryokeijutsukanto did not significantly impact nystagmus resolution times, it enhanced subjective outcomes and adherence, suggesting its potential as an adjunctive therapy in BPPV management."

Journal • Ophthalmology • Otorhinolaryngology • Vertigo

Comparing Oral Lumbrokinase DLBS1033 and Betahistine Mesylate in Benign Paroxysmal Positional Vertigo (clinicaltrials.gov) - P4 | N=44 | Completed | Sponsor: Universitas Sebelas Maret

HEOR • New P4 trial • Otorhinolaryngology • Vertigo

The effect of betahistine on weight-related and metabolic measures in patients with schizophrenia treated with olanzapine and risperidone. (PubMed, J Psychopharmacol) - "The addition of betahistine appears to be well tolerated and positively influences anthropometric indices. These findings suggest that betahistine may help mitigate some of the metabolic side effects of drugs for psychosis, although further research is needed to confirm these effects and to explore the optimal dosage."

Journal • CNS Disorders • Metabolic Disorders • Psychiatry • Schizophrenia

Recent Trends in Ménière's Disease Management in India: Results from the DIRECTION Cross-sectional Online Survey. (PubMed, Indian J Public Health) - "Vertigo and dizziness are the most common symptoms of MD, and the disease is generally detected during its middle stage. Patient counseling and education, being one of the most important aspects in disease management, must be promoted."

Journal • Infectious Disease • Novel Coronavirus Disease • Otorhinolaryngology • Vertigo

Efficacy and Safety of Histamine H3 Receptor Antagonist/Inverse Agonist Including Betahistine for Schizophrenia: A Systematic Review and Meta-Analysis. (PubMed, Neuropsychopharmacol Rep) - "Some H3R-ANTs/H3R-IAs might provide benefit for the treatment of cognitive symptoms and depressive symptoms in individuals afflicted with schizophrenia."

Clinical • Journal • Retrospective data • Review • CNS Disorders • Insomnia • Psychiatry • Schizophrenia • Sleep Disorder

Challenges in Diagnosing Opsoclonus-Myoclonus Syndrome in Adults. (PubMed, Cureus) - "She received betahistine and ondansetron as symptomatic treatment and was diagnosed with OMS. A month before her presentation, she had been seen by the General Practitioner, was treated with antiemetics, and was referred to ENT. This case illustrates the importance of awareness of OMS in avoiding delay in diagnosis."

Journal • Immunology • Movement Disorders • Oncology

Anti-vertigo drug prescribing for patients with vestibular symptoms in primary care. (PubMed, BJGP Open) - "AVD prescriptions, including long-term prescriptions, are common among patients with a wide array of vestibular symptoms and disorders, despite limited evidence. Management of vestibular symptoms by GPs can be improved by reducing these potentially inappropriate prescriptions."

Journal • Otorhinolaryngology • Vertigo

A national survey of the diagnosis and management of Ménière's disease among ENT consultants, UK. (PubMed, Ann R Coll Surg Engl) - "Our survey revealed wide disparities in the diagnosis and management of MD by ENT consultants in the UK, and AAO-HNS guidelines were not universally used. We propose developing greater consensus and intend to conduct a similar international survey to gather a broader perspective."

Journal • Otorhinolaryngology

Is Vitamin D Deficiency a Cause of Refractory Benign Paroxysmal Positional Vertigo (BPPV)? (PubMed, Otolaryngol Pol) - "Instead, malegender, comorbidities (notably hypertension), and betahistine use were identified asrisk factors for requiring multiple maneuvers. The study raises questions about therole of vitamin D in BPPV pathophysiology and suggests that other clinical factorsmay have a greater influence on treatment outcomes."

Journal • Retrospective data • Cardiovascular • Hypertension • Otorhinolaryngology • Vertigo

Phantom earthquake syndrome presenting with chronic dizziness after an earthquake: A case report. (PubMed, Medicine (Baltimore)) - "This case contributes to diagnose phantom earthquake syndrome as a psychosomatic response to disaster which highlights the significance of further history-taking and non-pharmacological treatments like exercise and vestibular rehabilitation for alleviating symptoms."

Journal • Hematological Disorders • Mood Disorders • Ophthalmology • Pain • Psychiatry

Pro-histaminergic drug restores balance, promotes microgliogenesis and modulates neuroinflammation after vestibular injury. (PubMed, Eur J Pharmacol) - "For this purpose, we used a histamine analog, betahistine dihydrochloride (BD), which increases histamine synthesis and release in the VN through its histamine H3 autoreceptor antagonistic properties...BD also prioritizes the differentiation of neoformed cells towards a microglia phenotype. These results, which need to be confirmed and further investigated by identifying the histaminergic receptors responsible for this effect, may lead to new therapeutic targets in vestibular pathology."

Journal • Inflammation • Otorhinolaryngology

Impact of vestibular rehabilitation therapy on quality of life and cognitive function in individuals with chronic dizziness or vertigo. (PubMed, Eur Arch Otorhinolaryngol) - "VRT combined with medication significantly improves cognitive function and quality of life in individuals with chronic dizziness or vertigo. These findings suggest that VRT not only addresses physical symptoms but also enhances cognitive performance, highlighting its potential as a comprehensive therapeutic approach."

HEOR • Journal • Alzheimer's Disease • Cognitive Disorders • Otorhinolaryngology • Vertigo

Misdiagnosis of spinocerebellar ataxia type 3 as persistent postural-perceptual dizziness: A case report. (PubMed, Medicine (Baltimore)) - "Detailed neuro-otological and neuro-ophthalmological evaluations are helpful for the diagnosis of patients with suspected cerebellar ataxia."

Journal • Ataxia • CNS Disorders • Movement Disorders • Ophthalmology • Otorhinolaryngology

Effectiveness of betahistine as an add-on therapy to epley maneuver for benign paroxysmal positional vertigo: A systematic review and meta-analysis. (PubMed, World J Otorhinolaryngol Head Neck Surg) - "Combining betahistine with Epley maneuver could improve the outcomes of BPPV in the long term. However, clinical trials with longer follow-up periods are needed to unravel its efficacy."

Journal • Retrospective data • Review • Otorhinolaryngology • Vertigo

Comparative analysis of efficacy, safety, and cost-effectiveness of betahistine alone, caroverine alone, and caroverine plus ginkgo biloba in moderate tinnitus. (PubMed, Indian J Pharmacol) - "Caroverine and ginkgo biloba combination therapy was the most effective in reducing the handicap of moderate tinnitus."

Clinical • HEOR • Journal • Observational data • Otorhinolaryngology

World-wide survey on the treatment of peripheral vestibular disorders. (PubMed, Front Neurol) - "MD: 85% pharmacotherapy, namely 65% betahistine, 21% diuretics, 20% steroids, 16% antiemetics, 14% gentamicin; 37% surgery. This study shows in particular that certain drugs are often used despite low or very low evidence. Namely in AUVP, MD and VP well-designed controlled trials with clinically meaningful endpoints are needed."

Journal • Otorhinolaryngology • Vertigo

Comments on: The Utility of Betahistine Dihydrochloride, a Structural Analog of Histamine, in Clozapine-Associated Daytime Sedation: A Case Series. (PubMed, Indian J Psychol Med) - No abstract available

Journal • Anesthesia

Clinical efficacy of Fu's subcutaneous needling based on "multi-joint muscle spiral balance chain" theory for cervical vertigo and its effect on blood flow velocity of vertebral artery (PubMed, Zhongguo Zhen Jiu) - "Fu's subcutaneous needling based on the "multi-joint muscle spiral balance chain" theory can effectively alleviate the vertigo and neck pain, and improve the blood flow velocity of vertebral artery in CV patients, and has a long-term therapeutic effect."

Clinical • Journal • Musculoskeletal Pain • Otorhinolaryngology • Pain • Vertigo

Gastroprotective Effects of Betahistine Against an Indomethacin-Induced Gastric Mucosal Ulcer in Rats: The Role of CINC-2α Gene. (PubMed, Med J Islam Repub Iran) - "In this experiment, rats were divided into four groups; the control group received no treatment, group 2 was treated with indomethacin at a dose of 25 mg/kg, group 3 pre-treated with famotidine at a dose of 50 mg/kg, and group 4 pre-treated with betahistine (as a reference drug) at a dose of 50 mg/kg. Betahistine for five days before administrating indomethacin reduced the ulcer index and downregulated the expression of CINC-2α significantly. Overall, pre-treatment with betahistine protects against the gastric damage induced by indomethacin by lowering the expression of CINC-2ɑ."

Journal • Preclinical • Peptic Ulcer

den Hartogh, Govert. What Kind of Death: The Ethics of Determining One's Own Death. New York/London: Routledge, 2023. 402 pp. USD $ 128.00 (hardcover); USD $ 43.99 (paper); USD $ 43.99 (Ebook). ISBN 978-1-032-24796-0. (PubMed, Theor Med Bioeth) - No abstract available

Journal

Which Canal BPPV Should be Checked for Residual Disease after 1 Week? (PubMed, Ear Nose Throat J) - "Materials and A comprehensive investigation was conducted to determine the effect of the affected canal, sociodemographic data, body mass index, hospital admission time, systemic disease history, betahistine use, and previous otologic vertigo history on the residual BPPV rate...We recommend that patients be called for follow-up after 1 week, especially in cases of anterior canal involvement and bilateral involvement. These findings provide valuable insights for the management of BPPV."

Journal • Residual disease • Genetic Disorders • Otorhinolaryngology • Vertigo

The Utility of Betahistine Dihydrochloride, a Structural Analog of Histamine, in Clozapine-associated Daytime Sedation: A Case Series. (PubMed, Indian J Psychol Med) - No abstract available

Journal • Anesthesia

Effect of betahistine on pro-inflammatory cytokine expression in autoimmune inner ear disease and Meniere's disease patients. (PubMed, Laryngoscope Investig Otolaryngol) - "We observe that betahistine abrogates salt-induced IL-1β expression, suggesting an additional treatment option for AIED and MD patients with inflammatory mediated disease. Level 4."

Journal • Immunology • Otorhinolaryngology • Vertigo • IL1B • IL6

Trousseau syndrome with recurrent cerebral infarction as the first oneset in a gastrointestinal malignant tumor patient: A case report. (PubMed, Medicine (Baltimore)) - "Currently, TS has a complex and varied clinical presentation and is relatively difficult to diagnose, especially in patients with an unknown tumor history. Focus should be placed on patients with recurrent cerebral infarctions and increased D-dimer levels, and anticoagulation may be an effective treatment for patients with TS."

Journal • Cardiovascular • CNS Disorders • Gastrointestinal Cancer • Gastrointestinal Disorder • Hematological Disorders • Oncology • Pulmonary Embolism • Respiratory Diseases • Solid Tumor