betahistine / Generic mfg. - LARVOL DELTA

A national survey of the diagnosis and management of Ménière's disease among ENT consultants, UK. (PubMed, Ann R Coll Surg Engl) - "Our survey revealed wide disparities in the diagnosis and management of MD by ENT consultants in the UK, and AAO-HNS guidelines were not universally used. We propose developing greater consensus and intend to conduct a similar international survey to gather a broader perspective."

Journal • Otorhinolaryngology

Is Vitamin D Deficiency a Cause of Refractory Benign Paroxysmal Positional Vertigo (BPPV)? (PubMed, Otolaryngol Pol) - "Instead, malegender, comorbidities (notably hypertension), and betahistine use were identified asrisk factors for requiring multiple maneuvers. The study raises questions about therole of vitamin D in BPPV pathophysiology and suggests that other clinical factorsmay have a greater influence on treatment outcomes."

Journal • Retrospective data • Cardiovascular • Hypertension • Otorhinolaryngology • Vertigo

Phantom earthquake syndrome presenting with chronic dizziness after an earthquake: A case report. (PubMed, Medicine (Baltimore)) - "This case contributes to diagnose phantom earthquake syndrome as a psychosomatic response to disaster which highlights the significance of further history-taking and non-pharmacological treatments like exercise and vestibular rehabilitation for alleviating symptoms."

Journal • Hematological Disorders • Mood Disorders • Ophthalmology • Pain • Psychiatry

Pro-histaminergic drug restores balance, promotes microgliogenesis and modulates neuroinflammation after vestibular injury. (PubMed, Eur J Pharmacol) - "For this purpose, we used a histamine analog, betahistine dihydrochloride (BD), which increases histamine synthesis and release in the VN through its histamine H3 autoreceptor antagonistic properties...BD also prioritizes the differentiation of neoformed cells towards a microglia phenotype. These results, which need to be confirmed and further investigated by identifying the histaminergic receptors responsible for this effect, may lead to new therapeutic targets in vestibular pathology."

Journal • Inflammation • Otorhinolaryngology

Impact of vestibular rehabilitation therapy on quality of life and cognitive function in individuals with chronic dizziness or vertigo. (PubMed, Eur Arch Otorhinolaryngol) - "VRT combined with medication significantly improves cognitive function and quality of life in individuals with chronic dizziness or vertigo. These findings suggest that VRT not only addresses physical symptoms but also enhances cognitive performance, highlighting its potential as a comprehensive therapeutic approach."

HEOR • Journal • Alzheimer's Disease • Cognitive Disorders • Otorhinolaryngology • Vertigo

Misdiagnosis of spinocerebellar ataxia type 3 as persistent postural-perceptual dizziness: A case report. (PubMed, Medicine (Baltimore)) - "Detailed neuro-otological and neuro-ophthalmological evaluations are helpful for the diagnosis of patients with suspected cerebellar ataxia."

Journal • Ataxia • CNS Disorders • Movement Disorders • Ophthalmology • Otorhinolaryngology

Effectiveness of betahistine as an add-on therapy to epley maneuver for benign paroxysmal positional vertigo: A systematic review and meta-analysis. (PubMed, World J Otorhinolaryngol Head Neck Surg) - "Combining betahistine with Epley maneuver could improve the outcomes of BPPV in the long term. However, clinical trials with longer follow-up periods are needed to unravel its efficacy."

Journal • Retrospective data • Review • Otorhinolaryngology • Vertigo

Comparative analysis of efficacy, safety, and cost-effectiveness of betahistine alone, caroverine alone, and caroverine plus ginkgo biloba in moderate tinnitus. (PubMed, Indian J Pharmacol) - "Caroverine and ginkgo biloba combination therapy was the most effective in reducing the handicap of moderate tinnitus."

Clinical • HEOR • Journal • Observational data • Otorhinolaryngology

World-wide survey on the treatment of peripheral vestibular disorders. (PubMed, Front Neurol) - "MD: 85% pharmacotherapy, namely 65% betahistine, 21% diuretics, 20% steroids, 16% antiemetics, 14% gentamicin; 37% surgery. This study shows in particular that certain drugs are often used despite low or very low evidence. Namely in AUVP, MD and VP well-designed controlled trials with clinically meaningful endpoints are needed."

Journal • Otorhinolaryngology • Vertigo

Comments on: The Utility of Betahistine Dihydrochloride, a Structural Analog of Histamine, in Clozapine-Associated Daytime Sedation: A Case Series. (PubMed, Indian J Psychol Med) - No abstract available

Journal • Anesthesia

Clinical efficacy of Fu's subcutaneous needling based on "multi-joint muscle spiral balance chain" theory for cervical vertigo and its effect on blood flow velocity of vertebral artery (PubMed, Zhongguo Zhen Jiu) - "Fu's subcutaneous needling based on the "multi-joint muscle spiral balance chain" theory can effectively alleviate the vertigo and neck pain, and improve the blood flow velocity of vertebral artery in CV patients, and has a long-term therapeutic effect."

Clinical • Journal • Musculoskeletal Pain • Otorhinolaryngology • Pain • Vertigo

Gastroprotective Effects of Betahistine Against an Indomethacin-Induced Gastric Mucosal Ulcer in Rats: The Role of CINC-2α Gene. (PubMed, Med J Islam Repub Iran) - "In this experiment, rats were divided into four groups; the control group received no treatment, group 2 was treated with indomethacin at a dose of 25 mg/kg, group 3 pre-treated with famotidine at a dose of 50 mg/kg, and group 4 pre-treated with betahistine (as a reference drug) at a dose of 50 mg/kg. Betahistine for five days before administrating indomethacin reduced the ulcer index and downregulated the expression of CINC-2α significantly. Overall, pre-treatment with betahistine protects against the gastric damage induced by indomethacin by lowering the expression of CINC-2ɑ."

Journal • Preclinical • Peptic Ulcer

den Hartogh, Govert. What Kind of Death: The Ethics of Determining One's Own Death. New York/London: Routledge, 2023. 402 pp. USD $ 128.00 (hardcover); USD $ 43.99 (paper); USD $ 43.99 (Ebook). ISBN 978-1-032-24796-0. (PubMed, Theor Med Bioeth) - No abstract available

Journal

Which Canal BPPV Should be Checked for Residual Disease after 1 Week? (PubMed, Ear Nose Throat J) - "Materials and A comprehensive investigation was conducted to determine the effect of the affected canal, sociodemographic data, body mass index, hospital admission time, systemic disease history, betahistine use, and previous otologic vertigo history on the residual BPPV rate...We recommend that patients be called for follow-up after 1 week, especially in cases of anterior canal involvement and bilateral involvement. These findings provide valuable insights for the management of BPPV."

Journal • Residual disease • Genetic Disorders • Otorhinolaryngology • Vertigo

The Utility of Betahistine Dihydrochloride, a Structural Analog of Histamine, in Clozapine-associated Daytime Sedation: A Case Series. (PubMed, Indian J Psychol Med) - No abstract available

Journal • Anesthesia

Effect of betahistine on pro-inflammatory cytokine expression in autoimmune inner ear disease and Meniere's disease patients. (PubMed, Laryngoscope Investig Otolaryngol) - "We observe that betahistine abrogates salt-induced IL-1β expression, suggesting an additional treatment option for AIED and MD patients with inflammatory mediated disease. Level 4."

Journal • Immunology • Otorhinolaryngology • Vertigo • IL1B • IL6

Trousseau syndrome with recurrent cerebral infarction as the first oneset in a gastrointestinal malignant tumor patient: A case report. (PubMed, Medicine (Baltimore)) - "Currently, TS has a complex and varied clinical presentation and is relatively difficult to diagnose, especially in patients with an unknown tumor history. Focus should be placed on patients with recurrent cerebral infarctions and increased D-dimer levels, and anticoagulation may be an effective treatment for patients with TS."

Journal • Cardiovascular • CNS Disorders • Gastrointestinal Cancer • Gastrointestinal Disorder • Hematological Disorders • Oncology • Pulmonary Embolism • Respiratory Diseases • Solid Tumor

An International Survey of the Diagnosis and Management of Ménière's Disease Amongst Otolaryngology Consultants. (PubMed, J Int Adv Otol) - "Cinnarizine was the first-line treatment for acute attacks followed by betahistine...Our survey revealed disparities in the diagnosis of MD and its management, like the results of our previously conducted UK survey. This suggests the need for an international consensus regarding the diagnosis and subsequent management strategies for this disease."

Journal • Otorhinolaryngology

Signal detection of drugs associated with obstructive and central sleep apnoea. (PubMed, Sleep Med) - "In this signal detection study, we found that opioids, benzodiazepines (but not Z-drugs) and myorelaxing agents are associated with the onset or aggravation of SA. Moreover, a new safety signal for antivertigo preparations such as betahistine emerged and needs to be further explored."

Journal • Otorhinolaryngology • Respiratory Diseases • Sleep Apnea • Sleep Disorder

Atypical cutaneous mycobacterial infection caused by M. avium (EADV 2024) - "She has history of systemic treatment with corticosteroids, methotrexate and hydroxychloroquine for the underlying rheumatoid arthritis and betahistine for multiple sclerosis...Systemic treatment with Rifampicin 600 mg daily for 2 months in a roll with good therapeutic results... The cutaneous atypical mycobacterial infection which was considered in our patient is very rare base of the cause and infection transmission. The prompt diagnosis and multidisciplinary approach are crucial for optimal patient outcomes. Long-term management strategies for imunosupressed patients with new onset of skin lesions should be under suspicion of atypical mycobacterial infection."

Cardiovascular • CNS Disorders • Constipation • Dermatology • Fatigue • Gastroenterology • Gastrointestinal Disorder • Herpes Zoster • Immunology • Infectious Disease • Inflammatory Arthritis • Multiple Sclerosis • Pain • Pulmonary Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Tuberculosis • Varicella Zoster

Betahistine's Neuroprotective Actions against Lipopolysaccharide-Induced Neurotoxicity: Insights from Experimental and Computational Studies. (PubMed, Brain Sci) - "Molecular modeling studies revealed that BHTE effectively binds to key enzymes involved in neuroinflammation and apoptosis (AChE, COX-2, and caspase-3), with binding free energies between 4 and 5 kcal/mol, interacting with critical residues. These findings underscore BHTE's multifaceted neuroprotective effects against LPS-induced neurotoxicity, offering potential therapeutic avenues for managing neuroinflammation and related neurodegenerative disorders."

IO biomarker • Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • Metabolic Disorders • Pain • BCL2 • CASP3 • CAT • IL10 • IL6 • TGFB1 • TNFA

Pharmacological intervention of behavioural traits and brain histopathology of prenatal valproic acid-induced mouse model of autism. (PubMed, PLoS One) - "Therefore, the aim of this study was to evaluate the neuro-behavioural effects of Betahistine, an H3R antagonist, and Donepezil, an acetylcholinesterase inhibitor on Swiss albino mouse model of autism...The behavioural Y-Maze test exhibits significant improvement (p <0.01) on the short term memory of the test subjects upon administration of lower dose of Betahistine along with MAO-B inhibitor Rasagiline once compared with the NC1 group (VPA-exposed mice)...The effects found are dose dependent. The findings suggest that H3R might be a viable target for the treatment of ASD."

Journal • Preclinical • Alzheimer's Disease • Autism Spectrum Disorder • Cognitive Disorders • Genetic Disorders • Mood Disorders • Pain • Psychiatry

Acupuncture for Residual Dizziness After Successful Repositioning Maneuvers in Patients with Benign Paroxysmal Positional Vertigo: Study Protocol for a Randomized Noninferiority Trial. (PubMed, Med Acupunct) - "Although oral betahistine is a common clinical treatment for RD, some patients may discontinue this medication due to adverse effects...Ethics approval was obtained from the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, with permission number 2023-095-KY. Written informed consent was obtained from the enrolled patients."

Head-to-Head • Journal • CNS Disorders • Otorhinolaryngology • Vertigo

Current status and influencing factors of prophylactic use of proton pump inhibitors in internal medicine inpatients receiving glucocorticoid therapy. (PubMed, Front Pharmacol) - "Multiple logistic regression analysis showed that age ≥80 years [OR = 7.009, 95% CI (1.424, 34.495), p = 0.017], history of gastroesophageal reflux disease (GERD) [OR = 2.047, 95% CI (1.338, 3.133), p = 0.001], low platelet count [OR = 0.997, 95% CI (0.994, 0.999), p = 0.004], number of concomitant diseases [OR = 1.104, 95% CI (1.056, 1.153), p < 0.001], junior doctors [OR = 1.755, 95% CI (1.248, 2.468), p = 0.001], glucocorticoid dose (higher than 50 mg, measured by methylprednisolone) [OR = 2.455, 95% CI (1.371, 4.395), p = 0.003], antiplatelet agents [OR = 2.567, 95% CI (1.456, 4.524), p = 0.001], immunosuppressants [OR = 1.477, 95% CI (1.014, 2.153), p = 0.042], and betahistine [OR = 5.503, 95% CI (1.124, 26.950), p = 0.035] were associated with more prophylactic use of PPIs. The prophylactic use of PPIs in internal medicine inpatients receiving glucocorticoid therapy is common in China. Clinical pharmacists will take targeted measures to promote the..."

Journal • Gastroenterology • Gastroesophageal Reflux Disease • Thrombocytopenia

Vertigo and pancreatic malabsorption (AGW-GESA 2024) - "Particle positioning manoeuvres (Epley or Sermont) can be used although recurrences are frequent; and medication can be tried for the acute clinical situation (antihistamines, and/or benzodiazepines, and/or anti-emetics) or for recurrent episodes (betahistine and/or prochlorperazine) although there seems to be no evidence of these drugs' long-term efficacy.Case Reports: Both husband & wife from a rural setting incidentally mentioned improvement in vertigo following management of pancreatic exocrine insufficiency (PEI). The manoeuvres or medications mentioned above were not utilised. All patients revealed prolonged symptomatic and objective improvement of Vertigo with management of malabsorption associated with PEI."

Otorhinolaryngology • Vertigo