betahistine / Generic mfg. - LARVOL DELTA

Surgical Trends and Severity Implications of Migraine in Patients with Meniere's Disease: A Multicenter Study (AAO-HNSF 2026) - "Acetazolamide/betahistine use was higher across cohorts (RR=2.73, 1.55, 1.36, 1.12; all p≤0.006). In MD, comorbid migraines is linked to greater long-term medical, intratympanic, and rehabilitative therapy use without sustained increases in surgery, suggesting higher ongoing symptom burden rather than worse procedural outcomes."

Clinical • CNS Disorders • Migraine • Otorhinolaryngology

Idiopathic Sudden Sensorineural Hearing Loss : Role of Different Treatment Modalities --prospective Interventional Cohort Study (AAO-HNSF 2026) - "Group A: ITS +AV (antiviral)+BH (Betahistine as vasodilator).Group B: CS (Oral Corticosteroid)- Prednisolone 1mg/kg body weight with tapering dose for 3 weeks. Group C: ITS (Intratympanic steroid) 0.3 ml Injection Dexamethasone by intratympanic route with 26 gauze spinal needle with bi-weekly doses of 6 injections... The ITS group showed the most significant improvement in hearing loss with complete recovery in 60% patients. The ITS+AV+BH group showed considerable improvement, oral corticosteroid group showed least improvement"

Clinical • Otorhinolaryngology

Lateral Semicircular Canal Occlusion in Patients with Refractory Meniere's Disease. (PubMed, J Int Adv Otol) - "Lateral semicircular canal occlusion seems to be an effective surgical option for patients with refractory Meniere's disease."

Journal • Anesthesia • Otorhinolaryngology • Vertigo

An Eco-Friendly N-Doped Carbon Quantum Dot-Based Fluorimetric Assay for Sensitive Betahistine Quantitation in Pharmaceuticals and Biological Fluids. (PubMed, Luminescence) - "Notably, the procedure operates entirely in distilled water, requiring minimal reagents with a short incubation time, highlighting its simplicity and practicality. The greenness and sustainability of the developed method were quantitatively evaluated and confirmed using the carbon footprint reduction index (CaFRI), the newly developed Nanomaterials Assessment Tool (NAT), and an integrated NQS-SAMI assessment."

Journal

Influence of physicians and surgeons on Leeuwenhoek’s observations on crystal formation (ACS-Fall 2026) - "The medics included Reinier de Graaf, Johannes (Jan) Swammerdam, Cornelis 's-Gravesande, Johan Ham, Govert Bidloo, and Lambert van Velthuysen...He also sketched out what he saw, although he knew his drawing skills were poor, a common point of self-criticism he related in his correspondence. Examples of his observations, including illustrations and relevant comments from the various editors of his collected letters, will be presented."

Gout • Inflammatory Arthritis

Innovations in conservative and surgical therapy for Ménière's disease-narrative review. (PubMed, Front Neurol) - "Clinical trial reports evaluating the efficacy of new oral treatment-ebselen were included. Preliminary report describing treating patients with MD and migaine with rimegepant was analyzed. Novel strategies to improve betahistine bioavailability were also reviewed...At the same time, these innovative therapeutic approaches provide valuable insights into the underlying pathophysiological mechanisms of the disease and may stimulate further research into its etiology. A better understanding of disease etiology is essential for developing causal treatments."

Journal • Review • Otorhinolaryngology • Vertigo

A 12-week study on the effects of betahistine (an H₃ antagonist/H₁ agonist) on cognitive functions in schizophrenia patients treated with olanzapine. (PubMed, Exp Clin Psychopharmacol) - "Betahistine was well-tolerated. This study explores betahistine as an adjunctive treatment for cognitive impairment in schizophrenia, with potential implications for improving cognitive outcomes and informing future treatment strategies."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia

Effect of Betahistine on Daytime Sedation and Metabolic Parameters in Patients with Schizophrenia on Second-generation Antipsychotics. (PubMed, Indian J Psychol Med) - "Changes in daytime sedation will be assessed using ESS scores at each follow-up at 2, 4, and 6 weeks. Changes in metabolic parameters will be assessed using blood investigations and body measurements at baseline and 6 weeks."

Journal • Anesthesia • CNS Disorders • Metabolic Disorders • Psychiatry • Schizophrenia

Sustainable fluorescence quenching approach for betahistine analysis: greenness evaluation. (PubMed, Sci Rep) - "The method was successfully applied to commercial tablets without interference from excipients, and results showed no significant difference compared with a reported spectrophotometric method. Owing to its simplicity, sensitivity, and exclusive use of aqueous media, the procedure is well-suited for routine pharmaceutical quality control."

Journal

Intratympanic Application of Betahistine for Menière Disease-An Animal Study on Safety and Diffusion to the Inner Ear. (PubMed, Otol Neurotol) - "This preclinical study demonstrated that IT-administered betahistine diffuses dose-dependently into the inner ear and is safe pertaining to cochlear and vestibular function and inner ear microstructures. Higher intracochlear concentration can be achieved by this route of application. This opens the option for a novel treatment for patients with Menière disease."

Journal • Otorhinolaryngology

Intervention Outcomes for Meniere's Disease: An Umbrella Review. (PubMed, Laryngoscope) - "Intratympanic gentamicin provides the strongest vertigo control but is backed by low-quality evidence and risks hearing loss. Conservative treatments like intratympanic steroids and betahistine show modest benefit with mixed evidence. Adjunctive options like acupuncture require cautious interpretation due to low-quality evidence. Surgical and device-based options demonstrate variable effectiveness, highlighting the need for individualized, symptom-driven care and further high-quality trials."

Journal • Review • Otorhinolaryngology • Vertigo

Suicidality associated with betahistine: A rare case report and systematic review of histaminergic drug-induced depression. (PubMed, Medicine (Baltimore)) - "This case emphasizes the need for clinicians and pharmacists to move beyond the cognitive bias that only psychotropic drugs carry a significant suicide risk. Vigilance for potential neuropsychiatric adverse reactions, such as depression and suicidality, should be maintained for all drug classes, particularly for non-psychotropic agents acting on histamine receptors. Timely recognition and drug discontinuation are crucial to ensure patient safety."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Psychiatry • Suicidal Ideation

Betahistine for residual dizziness after canalith repositioning in benign paroxysmal positional vertigo: a systematic review of randomized controlled trials. (PubMed, Front Pharmacol) - "Further adequately powered trials with standardized RD definitions, comparable outcomes, longer follow-up, and objective vestibular assessments are needed to clarify its clinical role. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261339853."

Journal • Review • Otorhinolaryngology • Vertigo

Efficacy of Vestibular Rehabilitation Therapy on Benign Paroxysmal Positional Vertigo After Repositioning: Improvement of Vestibular Symptoms and Vertigo Disability. (PubMed, Otol Neurotol) - "VRT significantly improves residual symptoms in BPPV after repositioning. Subtype-specific differences exist between pc-BPPV and hc-BPPV in early VRT efficacy and functional recovery dimensions, providing evidence for precision rehabilitation classification."

Journal • Otorhinolaryngology • Vertigo

Vertigo-unsolved Mystery (Meniere's Disease) Care Redefined: Insights from a Tertiary Care Center. (PubMed, Ann Afr Med) - "A regimen combining betahistine with diuretics offers a reliable, non-invasive, and effective approach to managing Meniere's disease. This protocol provides substantial vertigo control and hearing stabilization, and may be adopted as a first-line strategy before considering surgical options."

Journal • Otorhinolaryngology • Vertigo

Prevalence and direct costs of vestibular disease in France - matched case-control study results from the 2022 and 2023 french health data system. (PubMed, Cost Eff Resour Alloc) - "Vestibular disorders are common and associated with significant excess healthcare costs. Standardizing diagnostic and therapeutic pathways may reduce expenditures and improve care quality."

Journal • Otorhinolaryngology • Vertigo

DART-TINN: DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury (clinicaltrials.gov) - P2 | N=20 | Enrolling by invitation | Sponsor: Leading Edge Clinic | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Infectious Disease • Novel Coronavirus Disease • Otorhinolaryngology

The efficacy and cerebral hemodynamics mechanisms of acupuncture on the posterior circulation ischemic stroke with vertigo: study protocol for a multicenter, randomized, controlled trial. (PubMed, Front Neurol) - P1 | "Manual and sham acupuncture will be administered five times weekly for 3 weeks (30 min/session), while the western medication group will receive oral betahistine mesilate tablets three times daily, 5 days per week, for 3 weeks...This research aims to offer novel insights into acupuncture as a potential therapeutic approach for vertigo following PCIS. [chictr.org.cn], identifier [ChiCTR2400087030]."

Journal • Cardiovascular • Ischemic stroke • Mood Disorders • Otorhinolaryngology • Psychiatry • Vertigo

DART-TINN: DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury (clinicaltrials.gov) - P2 | N=20 | Not yet recruiting | Sponsor: Leading Edge Clinic

New P2 trial • Infectious Disease • Novel Coronavirus Disease • Otorhinolaryngology

A Positive-Controlled Study on the Efficacy and Safety of Phencynonate Hydrochloride Tablets in Treating Patients with Acute Vertigo (ChiCTR) - P4 | N=72 | Sponsor: Xuanwu Hospital Capital Medical University; Xuanwu Hospital Capital Medical University

New P4 trial • Otorhinolaryngology • Vertigo

Brief commentary on the 2023 Cochrane review on betahistine therapy in Meniere's disease (PubMed, HNO) - No abstract available

Journal • Otorhinolaryngology

Effects and central mechanisms of acupuncture for post-stroke vascular vertigo: study protocol of a multicenter, randomized, sham-controlled trial. (PubMed, Front Neurol) - "Following the induction period, the drug group will receive betahistine mesilate tablets orally, the acupuncture group will receive needling at Baihui (GV20), Fengchi (GB20), Wangu (GB12), and Taichong (LR3), and the sham acupuncture group will receive superficial needling at non-acupoints combined with blunt needle...The findings will be disseminated through publications, conferences, and briefs to professional organizations. http://itmctr.ccebtcm.org.cn, identifier ITMCTR2025001283."

Journal • Cardiovascular • Mood Disorders • Otorhinolaryngology • Psychiatry • Vertigo

Betahistine attenuates vestibular stimulation-induced mitochondrial damage and neuroinflammation in Deiters' neurons. (PubMed, Neurosci Lett) - "Furthermore, betahistine attenuated neuroinflammation, as evidenced by the state of microglia and astrocytes. These results clarify the mechanism of vestibular-induced damage to the Deiters nucleus and identify betahistine as a potential therapeutic agent for neurodegenerative diseases and ischemia."

Journal • Cardiovascular • CNS Disorders • Inflammation • Otorhinolaryngology • Vertigo

Ménière's Disease: Treatment Options, Dietary Restrictions, and Lifestyle Modifications. (PubMed, J Pharm Bioallied Sci) - "This review aims to review treatments and studies for Ménière's disease (MD) and the impact of dietary restrictions and lifestyle changes on MD symptoms."

Journal • Review • Otorhinolaryngology • Vertigo

Atypical posterior canal benign paroxysmal positional vertigo mimicking anterior canal involvement: a case series and review of the literature. (PubMed, J Med Case Rep) - "Atypical posterior semicircular canal benign paroxysmal positional vertigo can closely mimic anterior canal benign paroxysmal positional vertigo. Recognition of nystagmus transformation following repositioning maneuvers, supported by video-oculography, is essential for accurate diagnosis and optimal management."

Journal • Ophthalmology • Otorhinolaryngology • Vertigo