betahistine / Generic mfg. - LARVOL DELTA

Maternal Betahistine Exposure and Pregnancy Outcomes: A Retrospective Cohort Study. (PubMed, Cureus) - "However, the small sample size and retrospective nature of the data warrant caution in result interpretation and do not confirm its safety for use in pregnant women. Avoidance of unnecessary medication during pregnancy is advisable whenever possible."

Journal • Retrospective data • Gastroenterology

Hyperbaric oxygen therapy as salvage treatment for post-traumatic sudden sensorineural hearing loss: a case report. (PubMed, Diving Hyperb Med) - "He was treated with corticosteroids and betahistine for an acute audiovestibular loss with resolution of the vestibular symptoms...The patient started treatment with hyperbaric oxygen therapy with complete resolution of the hearing loss after 11 sessions. This case identifies potential benefit from salvage hyperbaric oxygen therapy in the treatment of sudden sensorineural hearing loss of traumatic etiology."

Journal • Musculoskeletal Diseases • Orthopedics • Otorhinolaryngology

Sex and age differences in the management of dizziness/vertigo in primary care: a retrospective population-based study. (PubMed, BMC Prim Care) - "There is a predominance of nonspecific diagnoses in PC, primarily affecting women who receive more treatments and neurology referrals for nonspecific diagnoses. For specific diagnoses, no differences in resource usage were observed between sexes."

Journal • Retrospective data • Otorhinolaryngology • Vertigo

Bioequivalence and safety evaluation of Betahistine hydrochloride tablets: a randomized, open - label, crossover study. (PubMed, Expert Opin Drug Metab Toxicol) - "Test formulation is bioequivalent and well-tolerated to reference, supporting interchangeability. Limitations: small single-center sample, healthy subjects."

Journal

Vestibular schwannoma presenting as vestibular neuritis-like attack during the COVID-19 pandemic: A case report. (PubMed, Medicine (Baltimore)) - "VS can present with acute vestibular syndrome resembling vestibular neuritis, even in the absence of auditory symptoms. Comprehensive neurotological evaluation and high-resolution magnetic resonance imaging are crucial for differential diagnosis and management."

Journal • Brain Cancer • Infectious Disease • Novel Coronavirus Disease • Oncology • Ophthalmology • Otorhinolaryngology • Solid Tumor • Vertigo

A randomized controlled trial of electronic balance assistant combined with pharmacotherapy for vestibular rehabilitation in patients with acute peripheral vestibular injury (PubMed, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) - "Control group (conventional drug treatment): Patients received medication treatment for 2 weeks, including betahistine mesilate tablets, vitamin B1 tablets, methylcobalamin tablets, ginkgo biloba tablets, diphenhydramine hydrochloride injection (within 3 days of onset), metoclopramide hydrochloride injection, and glucocorticoids. After treatment, the visual, vestibular, and visual dependence scores of both groups significantly increased compared with those before treatment (all P<0.05); moreover, the post-treatment visual, vestibular, and visual dependence scores of the experimental group were significantly higher than those of the control group (all P<0.05). Compared with medication-only treatment, the combination of an electronic balance aid and medication for the treatment and rehabilitation training of patients with acute peripheral vestibular injury can significantly improve the therapeutic effect in the short term."

Clinical • Journal • Otorhinolaryngology • Vertigo

Analysis of Benign Paroxysmal Positional Vertigo Cases in the Posterior Canal at a Tertiary Care Facility. (PubMed, J Pharm Bioallied Sci) - "The present study aims to evaluate the prevalence of posterior canal benign paroxysmal positional vertigo (BPPV) among all vertigo cases in a tertiary care hospital in India and assess the treatment outcomes of the Epley maneuver combined with Betahistine...The gender distribution was balanced, and trauma-related BPPV was observed in a few cases. The findings bolster the effectiveness of the Epley maneuver as a primary treatment and highlight the need for further research into combined treatments and long-term outcomes, including vestibular rehabilitation for refractory cases."

Journal • Mood Disorders • Otorhinolaryngology • Vertigo

Letter to the Editor in Response to "Efficacy and Safety of Histamine H3 Receptor Antagonist/Inverse Agonist Including Betahistine for Schizophrenia: A Systematic Review and Meta-Analysis" by Nishii et al. (PubMed, Neuropsychopharmacol Rep) - No abstract available

Journal • Retrospective data • CNS Disorders • Psychiatry • Schizophrenia

Secondary Reinforcement of the Round Window to Treat Residual Hyperacusis in Patients With Superior Semicircular Canal Dehiscence Syndrome. (PubMed, Otol Neurotol) - "Patients with hyperacusis symptoms demonstrated resolution of their symptoms after RWR in the operated ear. Careful patient selection is required, and patients need to be informed about the potential for postoperative hearing loss as part of informed decision-making."

Journal • Otorhinolaryngology

Efficacy and Safety of the Cinnarizine/Dimenhydrinate Combination versus Betahistine in the Treatment of Vertigo: A Systematic Literature Review. (PubMed, Acta Otorrinolaringol Esp (Engl Ed)) - "Overall, the fixed low-dose combination demonstrated superior clinical efficacy from the first week of treatment, along with a more favourable tolerability and safety profile. These results support its preferential use in the management of acute vestibular syndrome."

Journal • Review • Otorhinolaryngology • Vertigo

Combination Lorcaserin and Betahistine Treatment Improves Cognitive Dysfunction and Dopaminergic Neuron Activity in a Rat Model of Diet-Induced Obesity. (PubMed, Brain Sci) - "Lorcaserin and betahistine co-treatment significantly increased the number of spontaneously active dopaminergic neurons of obese animals. These results demonstrate the potential of combination lorcaserin-betahistine treatment to reverse obesity-related cognitive deficits, possibly through enhancement of mesocortical dopaminergic neuron activity."

Journal • Preclinical • Cognitive Disorders • Genetic Disorders • Obesity

Structural Brain Abnormalities, Diagnostic Approaches, and Treatment Strategies in Vertigo: A Case-Control Study. (PubMed, Neurol Int) - P | "Treatments included lifestyle modifications, physical therapy (e.g., Epley maneuver), and pharmacological therapies such as betahistine...A multidisciplinary treatment approach is recommended. Trial Registration: This study was registered in ClinicalTrials.gov with the trial registration number NCT06848712 on 22 February 2025."

Journal • Atherosclerosis • Cardiovascular • Ischemic stroke • Musculoskeletal Diseases • Otorhinolaryngology • Pain • Respiratory Diseases • Sinusitis • Vertigo

Late-Onset Autosomal Recessive Dystrophic Epidermolysis Bullosa: A Case Report (EADV 2025) - "Materials & A 73-year-old female patient with a 3-day history of widespread skin eruption and pruritus that started after a seven-day use of betahistine dihydrochloride 24 mg, oral vitamin D3, and Ginkgo biloba prescribed for tinnitus...The patient received oral methylprednisolone, and eroded lesions were treated topically... The absence of symptoms in the patient's parents and the presence in both the patient and her siblings confirm autosomal recessive inheritance, with both parents likely being carriers. The late-onset presentation in this patient is noteworthy, as it may reflect a milder phenotype associated with this specific mutation. The triggering of symptoms following medication use, absence of oral mucosal involvement, and overlapping drug eruption contribute to the atypical clinical presentation of this patient."

Case report • Clinical • Dermatology • Mood Disorders • Otorhinolaryngology • Pruritus • COL7A1

Idiopathic sudden sensineural hearing loss: demographic data and treatment in ENT practices in Germany (2014-2023). (PubMed, Eur Arch Otorhinolaryngol) - "The results show a stable demographic distribution and an increasing preference for oral corticosteroids in the treatment of ISSNHL. The decrease in the use of pentoxifylline likely reflects contemporaneous changes in guideline recommendations. These findings highlight an increasing need for evidence-based therapies for ISSNHL in clinical practice."

Journal • Infectious Disease • Novel Coronavirus Disease • Otorhinolaryngology

Brain histaminergic system: an emerging target for the treatment of feeding and eating-related disorders. (PubMed, Pharmacol Res) - "Promising results are emerging from clinical trials evaluating the efficacy of betahistine, a drug with a dual pharmacological profile as a weak H1R agonist and potent H3R antagonist, in restoring histaminergic tone and counteracting weight gain and metabolic side effects induced by antipsychotic therapies...In this review, we surveyed the role of brain histamine in the control of eating behavior and energy expenditure. We also described the implications of histamine release in the gut-brain axis and discussed available clinical data regarding the efficacy of histaminergic compounds in eating-related disorders."

Journal • Review • Anorexia • CNS Disorders • Genetic Disorders • Metabolic Disorders • Obesity

Effectiveness of Goreisan in Ménière's Disease. (PubMed, Cureus) - "Goreisan may be an effective and safe treatment option for reducing vertigo frequency in MD patients. However, it does not appear to improve hearing function. Further placebo-controlled studies are needed to confirm its efficacy."

Journal • Otorhinolaryngology • Vertigo

Variations in the Diagnosis and Management of Benign Paroxysmal Positional Vertigo Among Physician Specialties in Saudi Arabia: Influence of Clinical Experience and Case Exposure. (PubMed, Healthcare (Basel)) - "Physicians with 11-15 years of experience and >50 BPPV case exposures consistently showed a greater use of diagnostic maneuvers, repositioning techniques, and guideline-concordant medication use (betahistine 76.67%; p < 0.001)...Greater clinical experience and higher case exposure are associated with improved adherence to evidence-based practices. Targeted educational interventions are needed, particularly in primary care, to enhance guideline implementation."

Journal • Otorhinolaryngology • Vertigo

Comparing Oral Lumbrokinase DLBS1033 and Betahistine Mesylate in Benign Paroxysmal Positional Vertigo (clinicaltrials.gov) - P4 | N=44 | Completed | Sponsor: Universitas Sebelas Maret

HEOR • New P4 trial • Otorhinolaryngology • Vertigo

A Randomized Controlled Trial of Vinpocetine Combined with Betahistine for Residual Dizziness After Posterior Semicircular Canal BPPV Repositioning (ChiCTR) - P1 | N=100 | Not yet recruiting | Sponsor: Yongchuan District People's HospitalnChongqing, China; Yongchuan District People's Hospital Chongqing, China

New P1 trial

Investigation of the Binding Characteristics of Agonists and Various Antagonists Targeting Histamine 1 Receptor. (PubMed, Pharm Res) - "These mechanistic insights into H1R ligand binding provide a structural foundation for the rational design of targeted therapies with improved selectivity and efficacy against allergic disorders."

Journal • Allergy

Effectiveness of Ryokeijutsukanto in the Treatment of Benign Paroxysmal Positional Vertigo (BPPV). (PubMed, Cureus) - "Forty-eight BPPV patients were divided into three groups: Group A (BD method only, N=8), Group B (BD method + Kampo, N=11), and Group C (BD method + betahistine 36 mg, N=29)...Results Positional nystagmus resolution occurred in 38.3 ± 34.5 days (Group A), 30 ± 30.2 days (Group B), and 20.8 ± 21.4 days (Group C), with no statistically significant differences between groups. Subjective improvements were observed in 55% (6/11) of patients in Group B. Conclusions While ryokeijutsukanto did not significantly impact nystagmus resolution times, it enhanced subjective outcomes and adherence, suggesting its potential as an adjunctive therapy in BPPV management."

Journal • Ophthalmology • Otorhinolaryngology • Vertigo

The effect of betahistine on weight-related and metabolic measures in patients with schizophrenia treated with olanzapine and risperidone. (PubMed, J Psychopharmacol) - "The addition of betahistine appears to be well tolerated and positively influences anthropometric indices. These findings suggest that betahistine may help mitigate some of the metabolic side effects of drugs for psychosis, although further research is needed to confirm these effects and to explore the optimal dosage."

Journal • CNS Disorders • Metabolic Disorders • Psychiatry • Schizophrenia

Recent Trends in Ménière's Disease Management in India: Results from the DIRECTION Cross-sectional Online Survey. (PubMed, Indian J Public Health) - "Vertigo and dizziness are the most common symptoms of MD, and the disease is generally detected during its middle stage. Patient counseling and education, being one of the most important aspects in disease management, must be promoted."

Journal • Infectious Disease • Novel Coronavirus Disease • Otorhinolaryngology • Vertigo

Efficacy and Safety of Histamine H3 Receptor Antagonist/Inverse Agonist Including Betahistine for Schizophrenia: A Systematic Review and Meta-Analysis. (PubMed, Neuropsychopharmacol Rep) - "Some H3R-ANTs/H3R-IAs might provide benefit for the treatment of cognitive symptoms and depressive symptoms in individuals afflicted with schizophrenia."

Clinical • Journal • Retrospective data • Review • CNS Disorders • Insomnia • Psychiatry • Schizophrenia • Sleep Disorder

Challenges in Diagnosing Opsoclonus-Myoclonus Syndrome in Adults. (PubMed, Cureus) - "She received betahistine and ondansetron as symptomatic treatment and was diagnosed with OMS. A month before her presentation, she had been seen by the General Practitioner, was treated with antiemetics, and was referred to ENT. This case illustrates the importance of awareness of OMS in avoiding delay in diagnosis."

Journal • Immunology • Movement Disorders • Oncology