papaverine / Generic mfg. - LARVOL DELTA

Intravenous Papaverine for Term Prelabor Rupture of Membranes (clinicaltrials.gov) - P=N/A | N=200 | Recruiting | Sponsor: Wolfson Medical Center

New trial

A single-arm phase II study of papaverine for refractory paclitaxel-induced peripheral neuropathy (ESMO 2026) - No abstract available

P2 data • Oncology

Larval taste exposure creates compound-specific behavioral modifications in adult Drosophila melanogaster. (PubMed, iScience) - "We find that larval dietary exposure to papaverine, a bitter alkaloid, attenuates feeding avoidance of papaverine in adult flies...We identify contributions of larval bitter taste function, taste projection populations, and the cyclic AMP (cAMP)-phosphodiesterase dunce in supporting this behavioral modification. Together, our findings suggest that developmental experiences with bitter compounds can change taste-mediated behaviors through defined sensory and neural circuit components."

Journal

The impact of obesity and obstructive sleep apnea on vascular hemodynamics in men under 40: a 15-year retrospective cohort study. (PubMed, Sex Med) - "Intracavernosal Trimix (papaverine 30 mg/phentolamine 1 mg/alprostadil 10 mcg per mL) was administered by the attending urologist; a single redose was permitted for absent response (n = 4, 3.8%), of whom only 1 subsequently reached an adequate response...VL was unrelated to BMI or OSA. Objectively measured arterial insufficiency affects a clinically meaningful minority of men under 40 with ED, is associated with OSA independently of BMI, and is not identified by routine laboratory testing or explained by psychological factors."

Journal • Retrospective data • Cardiovascular • Diabetes • Dyslipidemia • Erectile Dysfunction • Genetic Disorders • Hypertension • Metabolic Disorders • Obesity • Obstructive Sleep Apnea • Psychiatry • Respiratory Diseases • Sleep Disorder

Papaverine ameliorates psoriasis-like skin inflammation by regulating immune cell differentiation and RAGE-S100A7 axis in an imiquimod-induced murine model. (PubMed, J Immunol) - "These findings suggest that papaverine ameliorates psoriasis-like symptoms through inhibition of proinflammatory cytokines and suppression of aberrant plasma cell differentiation. In conclusion, papaverine demonstrates therapeutic potential as a candidate for the treatment of psoriasis."

Journal • Preclinical • Dermatitis • Dermatology • Immunology • Inflammation • Oncology • Psoriasis • BCL6 • CD4 • CD8 • IFNG • IL1B • IL22 • IL6 • KRT10 • PRDM1 • SDC1 • XBP1

Pharmacological basis for the traditional use of Myrica salicifolia root extract in gut motility disorders via cholinergic and calcium/PDE modulation. (PubMed, J Tradit Complement Med) - "Further, Ms.Cr caused concentration-dependent (1.0-5.0 mg/mL) relaxation of high K+-induced contractions, similar to papaverine. Preincubated jejunal tissues with Ms.Cr shifted the Ca++ concentration-response curves (CRCs) towards right with suppression of the maximum response, similar to verapamil, thus confirming Ca++ channel blocking activity...sonnei, S. typhimurium and ESβL (extended-spectrum beta-lactamase)-producing E. coli. Thus, this research provides a solid foundation for the therapeutic uses of M. salicifolia in gut motility-related disorders."

Journal

Successful Use of Catheter-Directed Intra-Arterial Papaverine for Refractory Mesenteric Vasospasm in a Patient with Total Artificial Heart: A Novel Salvage Strategy in Post-TAH Vasoplegia (AHA 2026) - "Abstract is embargoed at this time."

Clinical • Cardiovascular

Current Evidence on the Management of Non-occlusive Mesenteric Ischemia: A Comprehensive Narrative Review. (PubMed, Cureus) - "Catheter-directed intra-arterial vasodilator therapy with papaverine may improve mesenteric perfusion in carefully selected patients without established bowel infarction, although supporting evidence remains predominantly observational...Despite recent advances in critical care, imaging, and endovascular techniques, the available evidence remains limited by small retrospective studies and considerable heterogeneity. Early recognition, multidisciplinary management, and standardized institutional treatment pathways are likely to represent the most effective strategies for improving outcomes, while prospective multicenter studies are needed to establish evidence-based management algorithms and optimize patient selection for emerging therapeutic interventions."

Journal • Review • Cardiovascular • Cognitive Disorders • Critical care • Gastrointestinal Disorder

A Dose Escalation Study of Papaverine As a Selective Hypoxic Radiosensitizer for Lung Stereotactic Body Radiation Therapy (SBRT) In the Treatment of Early-Stage Non-Small Cell Lung Cancer (NSCLC) and Other Malignancies (ASTRO 2026) - No abstract available

Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

A Rare Cause of Intraoperative Cardiac Instability: Suspected Systemic Papaverine Overdose During Coronary Artery Bypass Grafting (ASA 2026) - "Over the next hour, rhythm and hemodynamics normalized. Systemic papaverine overdose was suspected given the timing, BIMA grafting, small body size, associated arrhythmia and hypotension."

Cardiovascular • Hypotension • Ventricular Tachycardia

Domino reaction sequence to bioactive isoquinoline derivatives using 1,4-oxazinones and benzyne precursors | Poster Board #1637 (ACS-Fall 2026) - "This poster explores the reactivity of oxazinones with benzyne intermediates to provide access to isoquinoline derivatives. Fundamental studies and applications of this method towards bioactive isoquinolines including papaverine and moxaverine are also described."

Standardized femoral artery cannulation and ischemia-prevention protocol for minimally invasive cardiac surgery. (PubMed, JTCVS Tech) - "A >50% decrease in regional oxygen saturation triggered a stepwise protocol: increased cardiopulmonary bypass flow, topical papaverine hydrochloride solution, and, if unresolved, distal perfusion via a 6-Fr sheath...Multivariate analysis identified smaller femoral artery diameter and low ejection fraction as independent risk factors for regional oxygen saturation decrease. A standardized patient-selection strategy combined with a femoral artery-cannulation technique and a structured ischemia-prevention protocol effectively prevented clinically significant limb ischemia without the need for distal perfusion in this cohort."

Journal • Cardiovascular

Transient Bilateral Fixed Dilated Pupils Following Papaverine Use During Intracranial Microvascular Decompression: A Case Report. (PubMed, Cureus) - "Papaverine may induce transient mydriasis mimicking signs of devastating neurological injury. Awareness of this phenomenon is critical for anesthesiologists, neurosurgeons, and critical care teams to avoid unnecessary interventions and guide appropriate postoperative decision-making."

Journal • Anesthesia • CNS Disorders • Critical care • Ophthalmology • Vascular Neurology

Discovery and validation of programmed cell death-associated key biomarker genes in ischemic stroke via ssGSEA/WGCNA and LASSO-SVM-RFE. (PubMed, Front Mol Biosci) - "Enrichr/DSigDB prioritization and docking highlighted papaverine (CREBBP) and trichostatin A (ANTXR2) as plausible leads. An integrative network-ML framework delineated a peripheral-blood pan-PCD-related transcriptional pattern in IS and prioritized three biomarkers with consistent diagnostic performance and a neutrophil-skewed immune context. The exploratory pathway-gene-drug framework proposed here nominates testable compounds and provides a basis for prospective multi-cohort validation and mechanistic studies."

Biomarker • Journal • Cardiovascular • Inflammation • Ischemic stroke • CREBBP

Synthesis of functionalized, 13-alkyl-substituted coralyne derivatives and investigation of their interactions with duplex and abasic site-containing DNA. (PubMed, Beilstein J Org Chem) - "In particular, the alkylation of the benzylic position in papaverine and subsequent cyclization by treatment with acetic anhydride in sulfuric acid led to the synthesis of a coralyne derivative with an alkoxyamine-functionalized linker attached at position C13. Firstly, it was demonstrated with a resembling model compound that the alkylation of the coralyne scaffold does not influence the DNA-binding properties. Furthermore, it was shown that the alkoxyamine function can be readily released from a Boc-protected precursor and that the corresponding coralyne-alkoxyamine conjugate can operate as a ligand for AP-DNA and as inhibitor of enzymatic repair of abasic sites."

Journal

The Role of Papaverine in the Molecular and Biomechanical Mechanisms of Cervical Ripening: A Narrative Review. (PubMed, Int J Mol Sci) - "In particular, smooth muscle relaxation and cyclic nucleotide-dependent signaling may reduce functional cervical resistance and facilitate cervical dilatation despite the predominantly anti-inflammatory molecular profile of PPV. Although this mechanistic framework remains hypothetical, it provides a biologically plausible explanation for the apparent discrepancy between the molecular and clinical effects of papaverine and highlights priorities for future experimental and clinical research."

Journal • Review • Inflammation • Obstetrics

Clarifying the Role of Papaverine in Perineal Protection During Vaginal Delivery. (PubMed, Int Urogynecol J) - No abstract available

Journal

Cangfudaotan Decoction Improves Endometrial Receptivity in Polycystic Ovary Syndrome Rats: A Network Pharmacology-Based Study on the mTOR Pathway. (PubMed, Curr Pharm Des) - "Through chemical profiling and network pharmacology, this study shows that CFD alleviates metabolic and hormonal dysfunction in PCOS while improving endometrial receptivity, possibly by modulating the mTOR signaling pathway in endometrial tissue."

Journal • Preclinical • Polyendocrine Metabolic Ovarian Syndrome • HOXA10 • IL1B • IL6 • TNFA

Nerve Sparing Clitoroplasty via a Ventral Approach in a Child With Congenital Adrenal Hyperplasia: A Case Report and Review of the Surgical Technique. (PubMed, Cureus) - "Magnification loupes, meticulous dissection, and intraoperative papaverine irrigation minimise the risk of vasospasm and neurovascular injury. Multidisciplinary care and community-level awareness are essential for timely intervention."

Journal • Congenital Adrenal Hyperplasia • Endocrine Disorders

Anterior cerebral artery side-to-side bypass and aneurysm trapping: Technical nuances and a contingency-based revascularization strategy. (PubMed, Acta Neurochir (Wien)) - "This approach integrates technical refinement in side-to-side bypass with pragmatic contingency planning, enabling tailored revascularization based on intraoperative anatomical and technical feasibility."

Journal • Cardiovascular

Papaverine and Sublingual Microcirculation in Septic Shock (clinicaltrials.gov) - P=N/A | N=20 | Not yet recruiting | Sponsor: First Affiliated Hospital of Wannan Medical College

New trial • Septic Shock

Intraoperative optimization of radiocephalic arteriovenous fistula surgery with contemporary techniques. (PubMed, Ann Vasc Surg) - "The optimized RCAVF procedure enhances intraoperative flow and early maturation rates, with the most notable effects in the initial postoperative months. Further research is needed to determine the long-term benefits and cost-effectiveness."

Journal • Cardiovascular

Papaverine for Prevention of Perineal Trauma (clinicaltrials.gov) - P=N/A | N=412 | Not yet recruiting | Sponsor: Dr Raneen Abu Shqara

New trial • Obstetrics

Clinical outcomes following fractional flow reserve-guided revascularization using nicorandil versus conventional hyperemic agents: insights from the J-PRIDE Registry. (PubMed, Cardiovasc Interv Ther) - "This study aimed to compare clinical outcomes following FFR-guided strategy using nicorandil versus conventional hyperemic agents, such as adenosine or papaverine. A significant interaction was observed only between the effect of nicorandil on TVF and hemodialysis (P for interaction = 0.028). The 1-year TVF rate was comparable between the nicorandil and non-nicorandil groups, supporting the clinical applicability of nicorandil for FFR measurement in clinical practice."

Clinical data • Journal • Cardiovascular • Coronary Artery Disease • Myocardial Infarction

Ophthalmic and retinal artery occlusion associated with caudate nucleus infarction in an adolescent: a case report. (PubMed, J Med Case Rep) - "Ophthalmic and retinal artery occlusion is an ophthalmologic emergency and deserves more aggressive treatment in adolescents. Caudate nucleus infarction is also an emergency that impairs health. In this adolescent case, the concurrent occurrence of these two events was rare, but the causal relationship remains unproven. Further etiological clarification is needed. More attention should be paid to the general condition of adolescents, and provide comprehensive assessments, treatment, and follow-ups."

Journal • Cardiovascular • Immunology • Infectious Disease • Ischemic stroke • Ocular Inflammation • Ophthalmology • Pain