papaverine / Generic mfg. - LARVOL DELTA

Decreasing hypoxia with mitochondrial inhibition in locally advanced rectal cancer: Phase 1 trial of papaverine in combination with radiation (DINOMITE). (ASCO-GI 2026) - P1 | "Funded by U.S. National Institutes of Health Clinical Trial Registration Number: NCT06834126 The full, final text of this abstract will be available on Jan 05 at 05:00 PM EST."

Combination therapy • Metastases • P1 data • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Rectal Cancer • Solid Tumor

GC-MS/MS and LC-MS/MS Identification of Opium and Tropane Alkaloids in Pottery from Funnel Beaker Culture Sites in South-Eastern Poland. (PubMed, Materials (Basel)) - "Papaverine was identified in three artifacts (N1, N2, G2) using GC-MS/MS, and its presence was independently confirmed in two of these vessels (N1, N2) by LC-MS/MS. In one miniature vessel (D1), trace amounts of tropane alkaloids-scopolamine and presumptive atropine-were detected following derivatization...The analytical results indicate that psychoactive plant derivatives could have been intentionally used and stored in selected FBC vessels, supporting interpretations related to ritual or medicinal practices. The validated procedures developed in this work provide a robust framework for the detection of unstable biomolecular residues in prehistoric ceramics and can be applied to future archaeometric and materials-science research."

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Effect of topical papaverine on parathyroid function preservation after total thyroidectomy: a retrospective cohort study. (PubMed, Front Endocrinol (Lausanne)) - "This method is simple, easy to perform, and has a high safety profile. Future multicenter randomized controlled trials should be conducted to confirm long-term effectiveness and refine the dosing protocol."

Journal • Retrospective data • Endocrine Disorders • Hypoparathyroidism

Trace papaverine analysis in biological samples after preconcentration by UA-D-μ-SPE method using a new magnetic GO-MOF nanocomposite. (PubMed, Sci Rep) - "The novel UA-D-μ-SPE technique, coupled with HPLC-UV detection, not only yields enhanced sensitivity, selectivity, and environmental sustainability but also reduces sample preparation time and operational cost significantly. Incorporation of state-of-the-art nanocomposite sorbents and comprehensive optimization emphasizes the method's potential as a reliable tool for trace-level pharmaceutical analysis in biomedical and clinical research."

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Use of Papaverine to Shorten the Second Stage/Duration of Labor in Pregnant Women After Cervical Ripening by Double-balloon Catheter (clinicaltrials.gov) - P=N/A | N=184 | Recruiting | Sponsor: Hillel Yaffe Medical Center

New trial

When the Gut Mimics the Heart: A Rare Case of Acute Mesenteric Ischemia Masquerading as STEMI in a Young Athlete (ACG 2025) - "Intra-arterial papaverine and aggressive intravenous fluid resuscitation were administered intraoperatively, leading to improved bowel perfusion...NOMI should be considered when hypotension and elevated lactate accompany vague abdominal symptoms, even in young individuals. Prompt recognition, imaging, and intervention can prevent bowel infarction and improve outcomes."

Clinical • Cardiovascular • Coronary Artery Disease • Gastrointestinal Disorder • Hypotension • Myocardial Infarction • Myocardial Ischemia

Salvage of necrotic flap following malignant peripheral nerve sheath tumor excision using multimodal pharmacotherapy: a case report. (PubMed, Front Oncol) - "This case underscores the need for early pathological evaluation of rapidly enlarging skin masses when clinical and imaging findings are discordant. It also demonstrates the successful use of papaverine, Danhong, and enzymatic debridement as a salvage strategy for postoperative flap necrosis."

Journal • Brain Cancer • Neurofibromatosis • Neurofibrosarcoma • Oncology • Pain • Solid Tumor

Effects of Different Centrifugation Parameters on Equilibrium Solubility Measurements. (PubMed, Methods Protoc) - "One such example was papaverine hydrochloride, that showed solubility values 60-70% higher than the reference after centrifugation at 10,000 rpm for 20 min without prior sedimentation. Lower standard deviations were observed with shorter, slower centrifugation, with 5 min and 5000 rpm yielding results closest to the reference values."

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Intraoperative neurophysiological monitoring in surgery for intramedullary spinal cord lesions - workflow, setup and outcomes. (PubMed, Acta Neurochir (Wien)) - "Live data from continuous intraoperative neurophysiological monitoring, expertly interpreted in the OR, could potentially be used to make surgical and anesthesiologic adjustments with the goal of minimizing the risk of negative neurological outcomes. Significant associations were found between decreased or lost IONM signals and poorer sensorimotor function and mMC score at short- and long-term follow-up. Implementation of the IONM workflow is suggested in all intramedullary surgery."

Journal • Retrospective data • Anesthesia • Ependymoma • Oncology • Pain • Solid Tumor

A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids. (PubMed, Adv Sci (Weinh)) - "The titer of papaverine reaches an impressive 2.83 g L-1, demonstrating substantial industrial potential. Overall, this work establishes a paradigm for constructing modular chemoenzymatic platforms that simplify the production of structurally diverse natural and unnatural products for drug development."

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Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer. (PubMed, J Med Chem) - "We have therefore generated additional derivatives which have improved mitochondrial complex 1 inhibition and reduced PDE10A inhibition. Two of these compounds were tested in vivo for radiosensitization of murine EO771 mammary gland tumors and found to be as effective as papaverine with an improved safety profile."

Journal • Breast Cancer • Oncology • Solid Tumor

In vitro and in silico studies of GST-inhibitory and larvicidal activities of alkaloids against Rhipicephalus microplus. (PubMed, Vet Parasitol) - "Colchicine and papaverine show the best GridScocre: -38.09 and -36.09 kcal/mol, respectively. The association of in silico and in vitro techniques allowed the identification of two potential RmGST inhibitors (colchinine and papaverine) capable of interacting in the active site of the enzyme. RmGST inhibitors can be used in association with acaricides for a more effective control of R. microplus reducing parasite resistance."

Journal • Preclinical

Arrhythmia prevention protocol during papaverine administration for invasive coronary functional assessment. (PubMed, Front Cardiovasc Med) - "Ventricular arrhythmias occurred in 1.5% of patients, including four episodes of ventricular fibrillation and two of ventricular tachycardia; all resolved with prompt defibrillation and without hemodynamic compromise. These findings suggest that pre-treatment with lidocaine may enhance the safety of papaverine-induced hyperemia during invasive coronary testing."

Journal • Cardiovascular • Ventricular Tachycardia

Papaverine enhances sperm quality in asthenospermia by reducing oxidative stress and inflammation while regulating the expression of apoptosis-related genes during cryopreservation. (PubMed, Cryobiology) - "However, in the Freeze + Papaverine group, all these factors, except acrosomal integrity, showed significant improvement compared to the Freeze group. This study suggests that treating asthenozoospermic sperm with papaverine before freezing improves post-thaw sperm quality by enhancing motility, viability, plasma membrane integrity, and MMP, while reducing oxidative stress, inflammation, and apoptosis-potentially contributing to improved outcomes in ART."

IO biomarker • Journal • Infertility • Inflammation • Metabolic Disorders • Sexual Disorders • BAX • BCL2 • CASP3 • IL10 • TNFA

Primary Mediastinal Large B-Cell Lymphoma Mimicking Acute Coronary Syndrome: A Case Report (HFSA 2025) - "After administration of vasodilators (nitroglycerin and papaverine), positive dynamics were observed: improved antegrade flow in the LCA (TIMI II), with significant dilation of proximal LAD and Cx segments. Cardiac arrest occurred within 48h of ICU admission, with unsuccessful resuscitation.Post-Mortem Findings: Autopsy confirmed extensive pericardial and myocardial infiltration by a malignant tumour, compressing major vascular structures. Histopathology was consistent with primary mediastinal large B-cell lymphoma with cardiac involvement."

Case report • Clinical • Acute Coronary Syndrome • Angiosarcoma • Atrial Fibrillation • B Cell Lymphoma • Cardiovascular • Cough • Hematological Malignancies • Large B Cell Lymphoma • Lymphoma • Non-Hodgkin’s Lymphoma • Primary Mediastinal Large B-Cell Lymphoma • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Sarcoma • Solid Tumor

Association of Perioperative Vasodilator Therapy and Mortality in Nonocclusive Mesenteric Ischemia. (PubMed, J Surg Res) - "Perioperative vasodilator therapy was associated with reduced mortality in patients undergoing surgery for NOMI. These findings suggest that vasodilator therapy may serve as a beneficial adjunct in the surgical management of NOMI."

Journal • Cardiovascular • Gastrointestinal Disorder

Bronchorelaxant effects of 6-Nitrodopamine in human airway smooth muscle (ERS 2025) - "The effect of 6-ND was measured in isolated bronchial rings pre-contracted with carbachol (CCh) at 70% of maximal contractility and in tissue stimulated by electrical field stimulation (EFS; 3 – 25 Hz) to mimic vagal firing. Data from hASM pre-contracted by CCh were reported as a percentage of the maximal bronchorelaxant effect (Emax) induced by papaverine 100 µM...Conclusions These preliminary findings suggest that 6-ND effectively reduces hASM contractility elicited by parasympathetic activation, highlighting its potential as a bronchorelaxant agent for the treatment of chronic obstructive pulmonary disorders. Further studies with larger sample size are needed to enhance statistical accuracy."

Immunology • Pulmonary Disease • Respiratory Diseases

Harnessing nanotechnology for improving the druggability of opium poppy-derived pharmaceutical benzylisoquinoline alkaloids: A review. (PubMed, Biomed Pharmacother) - "The BIAs predominantly found in opium poppy constitute morphine, noscapine, sanguinarine, papaverine, thebaine, and codeine, with a long history of applications in healing numerous diseases. We also discuss the capability of artificial intelligence (AI), organs-on-a-chip, and carrier-free nanoparticles for toxicity and efficacy assessment and druggability improvement, respectively. Taken together, information present here provides valuable insight into the power of nanoparticles for enriching BIAs and ultimately facilitating their clinical translation."

Journal • Review

Predictors of Digit Replantation and Revascularization Outcomes [WITHDRAWN] (PSTM 2025) - "Post-op aspirin for active smokers increased the success rates of revasc by 86% (OR 25, P=.03). Our analysis included 60 digits (43 patients), with 21 replantations (19 patients) and 39 revascularizations (25 patients). Success rates for replants and revascs were 33.3% and 74.4%, respectively, with an overall success rate of 60%. Time from injury to presentation for replants had a mean time of 2.7 hours for successful replants and 4.9 hours for failures (OR 0.6, P=.04)."

Cardiovascular • CNS Disorders • Psychiatry

Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography (PASS): rationale and design. (PubMed, Stroke Vasc Neurol) - P2 | "RAS was indicated by the presence of at least two of these five signs or by the presence of just one when the operator considered it necessary to administer other spasmolytic agents. NCT05861765."

Journal • Pain

Synthesis and late-stage C-H functionalization of papaverines. (PubMed, Org Biomol Chem) - "Additionally, gram-scale synthesis of papaverine and its functionalized derivatives was successfully accomplished. Furthermore, the photophysical properties of the synthesized functionalized papaverine compounds were thoroughly investigated using absorption and emission spectroscopy."

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Effect of Papaverine Use on Immediate Postoperative Hypoparathyroidism Rates in Total Thyroidectomy (ATA 2025) - "The findings of this study showed that papaverine did not significantly improve the rates of immediate POH. However, this may be secondary to the limited sample size of this study. Future studies with larger sample sizes are needed to confirm these results."

Endocrine Disorders • Hypoparathyroidism • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma

Impact of Vasospasm on the Effects of N-butyl Cyanoacrylate Embolization in Swine Arteries. (PubMed, Interv Radiol (Higashimatsuyama)) - "Arteries in the vasoactive group were constricted by constant venous infusion of vasopressin and an arterial injection of noradrenaline just before embolization and then dilated by arterial injection of papaverine and lidocaine immediately after embolization...The median volume of N-butyl cyanoacrylate used during embolization was significantly lower in the vasoactive group (0.32 mL) than in the control group (0.78 mL) (p = 0.0037). Vasospasm during N-butyl cyanoacrylate embolization increased the recanalization rate of the embolized arteries and reduced the embolization effect in swine."

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Phytochemical richness, antioxidant activity, and molecular diversity in Papaver species from Iran's western and central regions. (PubMed, Front Plant Sci) - "Codeine content peaked in P. hybridum, while papaverine was highest in P. dubium...These findings highlight substantial phytochemical and genetic variation shaped by local environments. As this study focuses on Iranian populations, broader geographic sampling is needed to generalize the patterns observed."

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Investigation of the influence of magnetic fields on the separation of selected substances in reversed-phase column chromatography. (PubMed, Sci Rep) - "For this purpose, the drugs were categorized into three series based on polarity: tramadol (logP 1.34) and heroin (logP 1.58) as the polar series; cocaine (logP 2.3) and noscapine (logP 2.58) as the moderate polarity series; and papaverine (logP 3.00) and ketamine (logP 3.21) as the non-polar series. Other effects of the magnetic field on separation were changes in peak widths and resolutions. The results indicated that drugs with moderate polarity were most influenced by the induced magnetic field."

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