dexamethasone/neomycin/polymyxin B / Generic mfg. - LARVOL DELTA

Spectral Medical Completes Tigris Trial Enrollment (GlobeNewswire) - "Spectral Medical Inc...announced the completion of full enrollment in the Company’s Tigris trial, a Phase 3 follow-on study evaluating the use of Polymyxin B Hemoperfusion ('PMX') in a randomized controlled trial of adults treated for endotoxic septic shock."

Enrollment closed • Septic Shock

Optimizing Ocular Outcomes: A Dual-armed Study for Periorbital Burn Management (clinicaltrials.gov) - P1 | N=10 | Not yet recruiting | Sponsor: Virginia Commonwealth University | Trial completion date: Oct 2026 ➔ Jan 2027 | Trial primary completion date: Aug 2026 ➔ Nov 2026

Trial completion date • Trial primary completion date • Thermal Injury

Spectral Medical Provides February Tigris Trial Update (GlobeNewswire) - "152 patients enrolled to date; Six patients enrolled in February...Estimate a further four to seven patients (given the enrollment randomization scheme) to reach 150 evaluable patients; Addresses the six patients randomized into the PMX arm that did not receive the treatment Enrollment of 100 patients in the PMX arm and 50 patients in the standard-of-care arm who receive the assigned treatment is important for PMX regulatory review with respect to safety analysis and secondary analyses; Project full enrollment closer to the end of March 2025."

Enrollment status • Septic Shock

Temporary tectonic posterior corneal lamellar graft without Descemet's stripping for ab-interno sealing of large corneal perforation in severe dry eyes. (PubMed, BMJ Case Rep) - "A patient with Sjogren's syndrome presented with filamentary keratitis and was inappropriately prescribed G. Maxitrol (Novartis, USA) along with lubricants...This graft was kept in situ for 3 months before removal. The melt and perforation self-healed with a scar, and 9 months after the original surgery, the patient's vision improved to 6/9 with a scleral contact lens."

Journal • Dry Eye Disease • Immunology • Keratitis • Ocular Inflammation • Ophthalmology • Sjogren's Syndrome

Optimizing Ocular Outcomes: A Dual-armed Study for Periorbital Burn Management (clinicaltrials.gov) - P1 | N=10 | Not yet recruiting | Sponsor: Virginia Commonwealth University | Initiation date: Nov 2024 ➔ Feb 2025

Trial initiation date • Thermal Injury

Optimizing Ocular Outcomes: A Dual-armed Study for Periorbital Burn Management (clinicaltrials.gov) - P1 | N=10 | Not yet recruiting | Sponsor: Virginia Commonwealth University | Phase classification: P=N/A ➔ P1 | Initiation date: Aug 2024 ➔ Nov 2024

Phase classification • Trial initiation date • Thermal Injury

Successful 5-FU Ointment Application in a Patient With SLE (AAO 2024) - "While initially responsive to Maxitrol ointment, the dermal irregularities, particularly noticeable on the right upper lid, persisted...Due to the chronic nature of the rash, a conservative approach was chosen. The patient underwent a 2-week treatment with 5-fluorouracil ointment, resulting in complete resolution."

Clinical • Dry Eye Disease • Ocular Inflammation • Ophthalmology

Disparities in Treatment Patterns for Pediatric Patients with Chalazion by Age, Gender, and Race/Ethnicity (ARVO 2024) - "Medications in the search strategy were Fluorometholone, Tobradex, Maxitrol, Blephamide, and Erythromycin. We identify racial/ethnic disparities in the prevalence and treatment of chalazia in pediatric patients 2-18 y/o. Compared to Caucasian children, Hispanic children had the highest odds of having chalazia and lowest odds of obtaining only surgery, while Asian children had the highest odds of receiving only prescription drug management without any surgery. Further investigation is warranted to understand the root causes of the observed disparities in the prevalence and treatment of chalazion."

Clinical • Ophthalmology

Limbal Autograft, Symblepharon Removal And Cleaning After A Unilateral Chemical Burning. (ESCRS 2023) - "We altered the therapy from Maxitrol 0/2 to Autologous serum 0/4, Dexamytrex oint 0/1 ands tb Vibramycin 100mg...The cornea is clear (patch amniotic membrane above) and visual acuity is counting fingers at 60cm Conclusion/Take home message: It is very important to sustain limbal stem cells for the transparency of the cornea and a normal eye function after a chemical burn as soon as possible. Thus, a later penetrating keratoplasty procedure may be averted."

Ophthalmology

Case report: orbital compartment syndrome in the setting of periorbital necrotizing fasciitis (SOE 2023) - "Intravenous vancomycin and ceftazidime, acetazolamide, brimonidine, and Maxitrol ointment were given to prevent infection and IOP elevation.The next morning, erythema surrounded the left eye with increasing swelling and pain. Ice packs and intravenous solumedrol were provided to relieve inflammation...Patient was admitted to the intensive care unit for management of sepsis and transferred for surgical debridement upon stabilization. This rare clinical presentation of orbital compartment syndrome secondary to S. pyogenes necrotizing fasciitis, including disease course and therapeutic management, represents an important consideration for clinicians when developing differential diagnoses. _x000D_ _x000D_ _x000D_"

Clinical • Ocular Infections • Ocular Inflammation • Ophthalmology

RING INFILTRATES ON THE FIRST POSTOPERATIVE DAY AFTER CORNEAL COLLAGEN CROSSLINKING. (ESCRS-WM 2023) - "Because the patient had G6PD deficiency, he was started on Maxitrol eyedrops four times per day (fluoroquinolones are contraindicated)...Conclusion / Take home message: Aggressive infectious keratitis uncommonly presents on postoperative day one and other entities should be kept in mind and addressed initially. However, keeping in mind an infectious etiology is essential to prevent progression with further complications."

Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

TOPICAL NSAID INDUCED CORNEAL MELT: A CASE REPORT (ESCRS-WM 2023) - "She was commenced on topical Maxitrol (dexamethasone, polymyxin B sulphate, neomycin sulphate) and Acular (Ketorolac) QDS post-operatively. This case highlights the importance of awareness of the major side effect of topical NSAIDs. It is essential to identify patient cohorts at risk pre-operatively to avoid adverse outcomes, particularly those with pre-existing ocular surface disease."

Clinical • Corneal Abrasion • Ophthalmology

Intraocular Pressure Elevation Following the Use of Topical Dexamethasone Ointment After Squint Surgery. (PubMed, J West Afr Coll Surg) - "All patients were administered Maxitrol® ointment postoperatively...Elevated intraocular pressure with the use of topical dexamethasone ointment after squint surgery was common in this study and majority of the patients had significant elevation in intraocular pressure. Close monitoring of the intraocular pressure of black patients, especially children, on topical steroid medication after squint surgery is strongly recommended."

Journal • Ophthalmology • Strabismus

Acute exudative serous macular detachment with intraretinal oedema following uncomplicated phacoemulsification cataract surgery. (PubMed, BMJ Case Rep) - "The findings were presumed to be caused by cefuroxime toxicity despite a standard intraoperative dose of 1 mg/0.1 mL injected into the anterior chamber. This patient was treated with topical prednisolone 1%, ketorolac 0.5% and chloramphenicol 0.5% in place of the standard Maxitrol (dexamethasone 0.1% with neomycin) prescribed as a postoperative regimen in our unit. There was complete resolution of the retinal changes with restoration of normal vision at 3-week follow-up."

Journal • Cataract • Ophthalmology

Acute iris toxicity following bilateral gel stent implantation with mitomycin-C and intracameral moxifloxacin January consultation #1. (PubMed, J Cataract Refract Surg) - "Intracameral moxifloxacin was injected at the time of surgery, and moxifloxacin and Maxitrol eyedrops were used in the postoperative period. Please include whether ab interno or ab externo and open or closed conjunctival approach to be used and mention antifibrosis dosing and method of administration. Finally, what would be your approach for managing this patient's severe photophobia, in the setting of her moderate open-angle glaucoma?"

Journal • Cataract • Fibrosis • Glaucoma • Ophthalmology

Safety and Efficacy of Maxitrol in Pediatric Age Group Below Two Years With Adenoid Hypertrophy: A Retrospective Cohort Study. (PubMed, Cureus) - "Conclusion In this small sample, the use of Maxitrol® in the pediatric age group below two years with adenoid hypertrophy was safe and effective in relieving nasal symptoms; however, eventually, surgery was needed in most of our patients. Suppression of growth and eye complications were not reported in any of our patients during the follow-up time."

Journal • Retrospective data • Obstructive Sleep Apnea • Pediatrics • Respiratory Diseases • Sleep Disorder

Colon Cancer: Diet As Prevention [Google translation] - "Other studies put carbohydrates in the dock: in particular, published in November 2012 by another young researcher, Jeffrey Meyerhardt...has shown that carbohydrate consumption influences the risk of falls in patients with advanced colon cancer: people who consume more carbohydrates during the post-operative period are there is a triple risk of relapse compared to those who consume at least..."

Systemic detectability of dexamethasone and prednisolone after eye drop application in horses. (PubMed, Equine Vet J) - "Dexamethasone and prednisolone eye drops can induce detectable drug levels in serum and urine samples of horses after a 14-day treatment plan. This can lead to a positive doping result. All samples tested negative (below LOD of the analytical method) for dexamethasone one day and for prednisolone one week after treatment cessation."

Journal

[VIRTUAL] Potential Long-Term Sequelae of Herpes Simplex Virus: A Case of Unilateral Lipid Keratopathy and Neurotrophic Ulcer (AAOPT 2020) - "For neurotrophic ulcer 6 months later, pt was initially treated with Besivance 0.6% QID OD. After 1 week follow-up, tx with fluoroquinolone was discontinued due to allergic reaction, and the pt was placed on Maxitrol 0.1% gtts QID OD...Other tx for LK and neurotrophic ulcer secondary to HSV include:LK:- Topical or oral acyclovir & topical steroids- Subconjunctival &/or intracorneal bevacizumab injections- Argon Laser- Verteporfin Photodynamic Therapy- Penetrating KeratoplastyNeurotrophic Ulcer:- Copious preservative-free artificial tears & antibiotic gtts/ung- Bandage CL or Amniotic membrane- Topical steroids (with caution)- Autologous Serum- Incomplete Tarsorrhaphy- PO Doxycycline &/or ascorbic acid Conclusion LK & Neurotrophic ulcer are two possible long-term sequelae of HSV. It is important to consider the case hx and clinical signs when making these diagnoses. Various methods of tx for these conditions are available."

Clinical • Achromatopsia • Astigmatism • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

[VIRTUAL] Surgical Intervention and Anisometropia in an Infant with Dacryocystocele (AAOPT 2020) - "Enlargement of bony nasolacrimal canal due to the cystic lesion.Debris within the cystic lesion show restrictive diffusion possibly related to proteinaceous contentLesion of left lacrimal sac measures approximately 15 X 13 X 12 mmOrbits: mild mass effect upon anterior-inferior aspect of the left lobe due to cystic lesion External photos: Elevated cystic lesion at left nasolacrimal region. Displacement of inferior lid margin superiorly Differential Diagnosis Primary: Dermoid cystOthers: Hemangioma, Encephalocele, Rhabdomyosarcoma Diagnosis and Discussion DacryocystocelePresents at birth or within the first few days of lifeUnilateral > bilateral Signs/symptomsInfant preferring mouth breathing over nasal breathingNasal breathing common in infancy to allow breathing during feedingsCystic mass present inferior to medial canthus with bluish discoloration of overlying skinMucopurulent discharge on palpation Etiology:Obstruction of Rosenmuller valve..."

Astigmatism • Ophthalmology

[VIRTUAL] Contact Lens Management in an Infant with Bilateral Aphakia: A Case Report (AAOPT 2020) - "Abstract A 7 month old infant presents to clinic for an aphakic contact lens (CL) fitting status post cataract extraction of both eyes. Case History Patient demographics: 7 month old femaleChief complaint: aphakic CL fitting for both eyesOcular history: Nonsenile cataracts OU, diagnosed at 6 months of ageMedications:OD: Maxitrol BID, Cyclogyl BIDOS: Maxitrol TID, Cyclogyl BIDSurgical History:Cataract extraction with anterior vitrectomy OD/OS Pertinent Findings Anterior SegmentConjunctiva/Sclera: 1+ Subconjunctival hemorrhage OUCornea: Sutures in place OULens: aphakic OUVisual Fixation: FFM OD/OSCL FittingGP lens made of Menicon Z material using Dyna Intralimbal designTrials: BC/Diameter/Power and ObservationsOD: 7.00/10.4/+21.50: Moderate central clearance, 1 mm bubble, moderate peripheral clearance, centered, adequate movement, over-refraction= -3.00 DTrial dispensed to the parent after CL education and successful I&R training in office.OS:..."

Clinical • Cataract • Glaucoma • Ophthalmology

[VIRTUAL] Looking Through Glass: A Not So Traumatic Experience (AAOPT 2020) - "AS OCT confirmed subepithelial hyper-reflective opacity. Treatment, Management Initial visit: Pred Forte q2h and Atropine bid OS only.2-day follow-up: improved symptoms but stable AC, continue Pred Forte q2h, taper Atropine qd, add Maxitrol qhs OS only.Next follow-up in 5 days. The forward movement of glass, as in this case, is likely caused by anatomical phenomenon. Conclusion Cases of ocular trauma involving glass require careful examination of the anterior segment with appropriate ancillary testing. This is especially true in cases with a late presentation, during which the wound may have healed and the patient remains asymptomatic due to the inert properties of the material."

Achromatopsia • Corneal Abrasion • Ocular Inflammation • Ophthalmology • Uveitis

[VIRTUAL] Ocular Surface Management of Stevens-Johnson Syndrome with Scleral lenses (AAOPT 2020) - "Medications include Maxitrol suspension 1 drop twice daily, over the counter artificial tears and ointment at bed time as needed, as well as birth control pills. Pertinent Findings The patient wore older scleral lenses to the exam due to discomfort from the most recent lenses...Management of patients with SJS involves keeping eyes lubricated, epilating abnormal eyelashes regularly, and treating with topical medications as necessary. Patients experience significant relief of debilitating dry eye symptoms and can also benefit from greater quality of vision with scleral lenses."

Conjunctivitis • Dry Eye Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

[VIRTUAL] Unusual Manifestation of Bilateral Dendritiform Keratitis (AAOPT 2020) - "She had an exam with an optometrist on the day the symptoms started and was prescribed Maxitrol drops QID. After the condition worsened at the one day follow up, prednisolone acetate was discontinued, and the patient was prescribed 1 gram valacyclovir PO TID for 14 days. Conclusion Viral keratoconjunctivitis can be difficult to differentiate when the signs do not fit the typical disease characteristics. Best practice requires applying the treatment most likely to improve the situation, and to follow up appropriately."

Conjunctivitis • Dry Eye Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

[VIRTUAL] Management of a Tide POD Chemical Burn (AAOPT 2020) - "A combination ointment such as Maxitrol can be used in these cases, however, Erythromycin ointment and a topical steroid such as Pred Forte 1% is preferred...Cyclopentolate can be prescribed to manage ocular pain as well as oral pain medications...Prompt management of inflammation, pain and infection is pertinent to visual prognosis. Long-term management should include comprehensive evaluations ruling out neovascularization, limbal stem cell deficiency and glaucoma."

Cataract • Conjunctivitis • Corneal Abrasion • Glaucoma • Ocular Inflammation • Ophthalmology