RG7863 / Roche - LARVOL DELTA

Safety, tolerability, pharmacokinetics and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers. (PubMed, Clin Transl Sci) - "Single RO6870868 doses activated components of the TLR innate immune system in a dose-dependent manner with adequate safety and tolerability. Single-dose data in healthy volunteers are useful to evaluate safety, PK and PD activity of TLR7 agonists and help to guide dose and regimen selection for further trials in patients with chronic hepatitis B."

Clinical • Journal • PK/PD data • Hepatitis B • Hepatology • Infectious Disease

Mobile Messaging Support Versus Usual Care for People With Type 2 Diabetes on Glycemic Control: Protocol for a Multicenter Randomized Controlled Trial. (PubMed, JMIR Res Protoc) - "The knowledge gained from this study will have wide applications and advance the evidence base for effectiveness of mobile phone-based, brief text messaging on clinical outcomes and in large-scale, operational settings. It will provide evidence for cost-effectiveness and acceptability that will further inform policy development and decision making. We will work with a wide network that includes patients, clinicians, academics, industry, and policy makers to help us identify opportunities for informing people about the work and raise awareness of what is being developed and studied."

Clinical • Journal