Pfs25 VLP- FhCMB / iBio - LARVOL DELTA

Are Antibiotics the Next Class of Psychopharmaceutical Drugs? (ACNP 2016) - "For example, the isoniazid class of antibiotics has been shown to possess monoamine oxidase activity, while tricyclic antidepressants are reported to have antimalarial and anti-leishmanial properties. Methods: The presentation will review the published literature on antibiotic use in PANDAS and PANS, including: a case series documenting improvement in pediatric OCD following open-label antimicrobial treatment (ML Murphy & Pichichero 2002); improvements in symptom severity associated with open-label monthly Bicillin injections (F Falcini et al, 2013); a placebo-controlled trial of penicillin prophylaxis in PANDAS (Garvey et al, 1999); a comparison of azithromycin and pencillin prophylaxis for PANDAS (Snider et al, 2005); and a randomized placebo-controlled trial of cefdinir for recent-onset PANS (TK Murphy et al, 2015). An increasing number of prospective randomized clinical trials support a therapeutic role for beta lactam agents in the management of PANDAS and the use of..

Clinical • Biosimilar • Depression • Immunology

Pharmacokinetics of transfer of azithromycin into the breast milk of African mothers. (PubMed) - Antimicrob Agents Chemother - "The median estimated absolute and relative cumulative infant doses were 4.5 (95% prediction interval 0.6-7.0) mg/kg and 15.7 (95% prediction interval 2.0-27.8) % of maternal dose, respectively, the latter exceeding the recommended 10% safety limit. Although some infants with bacterial infections may benefit from AZI in breast milk, there is a risk of hypertrophic pyloric stenosis with a worst-case number needed to harm of 60 based on the present and available epidemiologic data."

Journal • Biosimilar • Immunology

Microbiological, clinical and molecular findings of non-typhoidal Salmonella bloodstream infections associated with malaria, Oriental Province, Democratic Republic of the Congo. (PubMed) - BMC Infect Dis - "During the peak of an epidemic increase in malaria in the DRC in 2012, a high proportion of multidrug resistant Salmonella Typhimurium and Salmonella Enteritidis were isolated from blood cultures. Overall, the two serovars showed subtle differences in clinical presentation and genetic diversity."

Journal • Biosimilar • Immunology

Late relapse of imported Plasmodium ovale malaria: a case report. (PubMed) - Tunis Med - "This case emphasizes the possibility of relapse of some plasmodial species. It highlights the importance of repeating microscopic examination of blood when the diagnosis of malaria is suspected."

Journal • Biosimilar • Pain

Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries. (PubMed) - "The prevalence of antimicrobial self-medication is high and varies in different communities as well as by social determinants of health and is frequently associated with inappropriate drug use."

Journal • Biosimilar • Immunology • Inflammation

Introducing rapid tests for malaria into the retail sector: what are the unintended consequences? (PubMed) - BMJ Glob Health - P=N/A; "It describes how the test engendered trust in the professional competence of DSVs; was misconstrued by clients and providers as enabling a more definitive diagnosis of disease in general rather than malaria alone; that blood testing made drug shops more attractive places to seek care than they had previously been; was described as shifting treatment-seeking behaviour away from formal health centres and into drug shops; and influenced an increase in sales of medications, particularly antibiotics. NCT01194557; Results."

Journal • Biosimilar

Broad-range potential of Asphodelus microcarpus leaves extract for drug development. (PubMed, BMC Microbiol) - "The overall results provide supportive data on the use of A. microcarpus as antimicrobial agent and a potential source of anti-viral natural products. Data collected set the bases for further studies for the identification of single active components and the development of new pharmaceuticals."

Journal • Biosimilar • CNS Disorders • Oncology • Pain

Inferring genetic interactions from comparative fitness data. (PubMed, Elife) - "We analyzed various genetic systems comprising HIV-1, the malaria-causing parasite Plasmodium vivax, the fungus Aspergillus niger, and the TEM-family of β-lactamase associated with antibiotic resistance. For all systems, our approach revealed higher order interactions among mutations."

Journal • Biosimilar • Gene Therapies

Synthesis and biological evaluation of xenortide derivatives (ACS-Sp 2018) - "...A lesser-known public health threat exists in Neglected Tropical Diseases (NTDs), a category of parasitic diseases that include malaria, sleeping sickness, chagas disease, and leishmaniasis...The central hypothesis of this research is to synthesize, characterize, and biologically evaluate derivatives of xenortide natural products with SAR studies. Work done on these derivatives will potentially lead to the identification of a promising antibacterial and anti-parasitic drug for further biological testing."

Biosimilar

Occurrence patterns of pharmaceutical residues in wastewater, surface water and groundwater of Nairobi and Kisumu city, Kenya. (PubMed) - Chemosphere - "In shallow wells situated next to pit latrines and used for drinking water, the recalcitrant antiretroviral nevirapine was measured at concentrations as high as 1-2 μg L(-1). Overall, distinct pharmaceutical contamination patterns as compared to the Western world can be concluded, which might be a trigger for further research in developing regions."

Journal • Biosimilar • Gene Therapies • Pain

Principles, practices and knowledge of clinicians when assessing febrile children: a qualitative study in Kenya. (PubMed, Malar J) - "Results of this study suggest that since malarial testing has become more widespread, clinicians working in resource-poor environments still face difficulty when evaluating a child with fever, especially when malaria testing is negative. Improving access to additional diagnostics, continuing medical education, and ongoing evaluation and revision of clinical guidelines may lead to more consistent management of febrile illness by providers, and may potentially decrease prescription of unnecessary antibiotics. Additional interventions at the community level may also have an important role in managing febrile illness, however, more studies are needed to identify targets for intervention at both the clinic and community levels."

Journal • Biosimilar

A study of antimicrobial use in children admitted to pediatric medicine ward of a tertiary care hospital. (PubMed) - Indian J Pharmacol - "The profile of antimicrobial use is broadly similar to earlier Indian studies. Apparent overuse of multiple antimicrobials per prescription and the parenteral route requires exploration. Antimicrobials are being used empirically in the absence of policy. ADRs to antimicrobials are occasional and usually mild. The baseline data can serve in situation analysis for antibiotic prescribing guidelines."

Journal • Biosimilar

Isolation of cytotoxic compounds against melanoma cells from Epicoccum nigrum, an endophyte Isolated from Ferula sumbul plant (WCM 2017) - "...Prodigionines are of potent clinical interest because these are reported to have anti fungal, anti bacterial, anti protozoal, anti malarial, immunosuppressive and anti cancer activities... In conclusion, assays in current research using the crude extract and fractions of secondary metabolites of Epicoccum nigrum showed a significant cytotoxic activity against melanoma cells.nThus strain could be further exploited for various applications in pharmaceutical, for its secondary metabolites."

Melanoma • Oncology • Solid Tumor

Pervasive antibiotic misuse in the Cambodian community: antibiotic-seeking behaviour with unrestricted access. (PubMed) - Antimicrob Resist Infect Control - "Pervasive antibiotic misuse was driven by a habitual supplier-seeking behaviour that was enabled by unrestricted access and misconceptions about antibiotics for mild illnesses. Unofficial suppliers must be stopped by supporting existing regulations with tough new laws aimed at outlawing supplies outside registered pharmacies and fining registered pharmacist/owners of these pharmacies for supplying antibiotics without a prescription. Community primary healthcare centres must be strengthened to become the frontline antibiotic prescribers in the community thereby enabling the community's access to inexpensive and appropriate healthcare. Community-based education program should target appropriate health-seeking pathways and the serious consequences of antibiotic misuse."

Journal • Biosimilar • Pain

Human Babesiosis in Southeast China: A Case Report. (PubMed, Int J Infect Dis) - "...Malaria was diagnosed initially after visualizing intraerythrocytic ring shaped parasites in bone marrow and blood smears...The patient recovered from fever and hemolysis, repeated peripheral blood smears showed hemoparasite clearance. Cases of human babesiosis are rarely reported and probably under-diagnosed in China; therefore, improving our understanding of this disease as a newly emerging public health threat is imperative."

Clinical • Journal • Biosimilar • Cardiovascular • Complement-mediated Rare Disorders • Hematological Malignancies • Oncology • Rare Diseases • Venous Thromboembolism

Antibiotic utilization and the role of suspected and diagnosed mosquito borne illness among adults and children with acute febrile illness in Pune, India. (PubMed, Clin Infect Dis) - "Most patients with acute febrile illness in an Indian public hospital setting receive empiric antibiotics. Mosquito-borne disease identification is associated with reduced empiric antibiotic use and faster antibiotic discontinuation."

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