NA-184
/ NeurAegis
- LARVOL DELTA
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March 07, 2024
Identification and neuroprotective properties of NA-184, a calpain-2 inhibitor.
(PubMed, Pharmacol Res Perspect)
- "Like NA-112, NA-184 inhibited TBI-induced calpain-2 activation and cell death in mice and rats, both male and females. Pharmacokinetic and pharmacodynamic analyses indicated that NA-184 exhibited properties, including stability in plasma and liver and blood-brain barrier permeability, that make it a good clinical candidate for the treatment of TBI."
Journal • CNS Disorders • Vascular Neurology • CAPN1 • CAPN2
October 10, 2022
Identification and properties of NA-184, a selective calpain-2 inhibitor, and its use for TBI treatment
(Neuroscience 2022)
- "Grant #BA170606. “Optimization of a selective calpain-2 inhibitor for prolonged field care in Traumatic Brain Injury”."
CNS Disorders • Vascular Neurology
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