NA-184 / NeurAegis - LARVOL DELTA

Identification and neuroprotective properties of NA-184, a calpain-2 inhibitor. (PubMed, Pharmacol Res Perspect) - "Like NA-112, NA-184 inhibited TBI-induced calpain-2 activation and cell death in mice and rats, both male and females. Pharmacokinetic and pharmacodynamic analyses indicated that NA-184 exhibited properties, including stability in plasma and liver and blood-brain barrier permeability, that make it a good clinical candidate for the treatment of TBI."

Journal • CNS Disorders • Vascular Neurology • CAPN1 • CAPN2

Identification and properties of NA-184, a selective calpain-2 inhibitor, and its use for TBI treatment (Neuroscience 2022) - "Grant #BA170606. “Optimization of a selective calpain-2 inhibitor for prolonged field care in Traumatic Brain Injury”."

CNS Disorders • Vascular Neurology