levomepromazine / Generic mfg. - LARVOL DELTA

Association between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure: a retrospective study on two cohorts from Norway and the UK. (PubMed, Lancet Psychiatry) - "CYP2D6 PM status was consistently associated with increased risk of venlafaxine treatment failure in two large, real-life cohorts, suggesting that pre-emptive genotyping could facilitate personalised venlafaxine therapy."

Journal • Observational data • Retrospective data • CNS Disorders • Depression • Major Depressive Disorder • Psychiatry • CYP2C19

Receptor Contribution Reallocation After Removal of Literature-Derived Weights: A Secondary Sensitivity Analysis of the Integrated Ki-DDD-TWAS Pipeline for Antipsychotic Lipid-Trait Prioritization. (PubMed, Cureus) - "The model most strongly under-ranked paliperidone versus the supplied 12-drug comparator, while ziprasidone rose under uniform weighting. Removing HRH1 produced the largest rank shifts, particularly for levomepromazine, promazine, and acepromazine...The framework supports dual reporting of clinically anchored weighted and discovery-oriented uniform models as an internal sensitivity strategy only. It is not externally validated, does not predict patient-level outcomes, and should not be interpreted as estimating clinical metabolic risk or establishing receptor-level causality."

Journal • CNS Disorders • Diabetes • Dyslipidemia • Genetic Disorders • Metabolic Disorders • Obesity • ADRB2 • DRD2 • HTR2A • SLC6A4

Medication for subcutaneous administration: Microbiological and physicochemical stability of drug formulations prepared in advance and stored in syringes. (PubMed, Palliat Care Soc Pract) - "Standardised methods of medication preparation were followed for morphine, midazolam, metoclopramide, hyoscine butylbromide, levomepromazine, haloperidol, ondansetron, fentanyl, ketorolac and dexamethasone, as well as drug mixtures (morphine + midazolam and midazolam + levomepromazine). Formulations aseptically prepared and stored in syringes are microbiologically and physicochemically stable for 12 weeks in the cases of almost all drugs studied, the exception being metoclopramide (which was stable up to week 3). These findings suggest that such formulations show stability characteristics consistent with suitability for SC administration of drugs in palliative home care."

Journal • Palliative care

Rebound mania following abrupt discontinuation of oxcarbazepine in bipolar I disorder: a case report (CINP 2026) - "The patient was discharged on valproic acid, risperidone, levomepromazine, lorazepam, and scheduled maintenance ECT. This case illustrates a temporal association between abrupt oxcarbazepine discontinuation and the onset of severe rebound mania in a patient with bipolar I disorder. It emphasizes the need for careful tapering and close clinical monitoring when discontinuing mood stabilizers, even when evidence for rebound phenomena with a specific medication is limited. Clinicians should remain vigilant to the risk of rapid relapse following treatment cessation and consider proactive strategies to prevent severe mood destabilization."

Case report • Clinical • Bipolar Disorder • CNS Disorders • Mental Retardation • Mood Disorders • Psychiatry • Psychomotor Agitation

GUIDELINE-CONGRUENT CARE FOR CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING PROPHYLAXIS: HIGH DOSE METHOTREXATE (MASCC-ISOO 2026) - "The most frequent prophylactic antiemetics prescribed included aprepitant, fosaprepitant, palonosetron and ondansetron. Breakthrough antiemetics included cyclizine, olanzapine, metoclopramide, levomepromazine, lorazepam and subsequent doses of palonosetron and fosaprepitant or aprepitant at appropriate dosage intervals Conclusions Guideline concordant care is fundamental to optimising antiemetic prophylaxis, promoting a standardised prescribing approach that aligns with the emetic potential of the chemotherapy to ultimately improve quality of life. Locally, there is a need to improve assessment/documentation of patient's experiences of CINV and for prospective evaluation of local breakthrough practices."

CINV • Acute Lymphocytic Leukemia • Chemotherapy-Induced Nausea and Vomiting • Hematological Malignancies • Leukemia • Lymphoblastic Lymphoma • Lymphoma

Case Report: Early onset pulmonary embolism following antipsychotic polypharmacy in an acute psychiatric setting. (PubMed, Front Psychiatry) - "Due to acute agitation, the patient received olanzapine, quetiapine, levomepromazine, and lorazepam. This case is notable for the unusually rapid development of VTE, occurring within hours rather than the typically reported days to weeks. It underscores the need for heightened clinical vigilance even in the very early phase of antipsychotic therapy and in patients without risk factors for VTE."

Journal • Cardiovascular • CNS Disorders • Psychiatry • Pulmonary Embolism • Respiratory Diseases • Venous Thromboembolism

Improving end of life prescribing in advanced CKD: A renal-adjusted anticipatory medication orderset (UKKW 2026) - "Midazolam 1mg SC PRN 1 hourly, max 12 doses/24 hrs (agitation) 3...Levomepromazine 2.5mg SC PRN 2 hourly, max 6 doses/24 hrs (nausea and vomiting) The orderset was approved by the local Governance team and Medicines Management Group and became live in March 2024...Morphine sulphate was the most common anticipatory medication prescribed, accounting for 27.3% of all prescriptions...The pre-populated orderset standardised practice, reduced variability across clinicians of different experience levels, and required minimal additional training, thus facilitating rapid adoption on the renal wards. Future efforts will focus on clinician awareness and education, with subsequent data re-analysis to ensure sustainable change is maintained."

Metastases • Chronic Kidney Disease • CNS Disorders • Depression • Palliative care • Renal Disease

Synthetic Tetrahydrocannabinol (THC) is a Safe Adjunct to the Treatment of Postoperative Pain after Arthroscopic Knee Surgery: A Pilot Randomized Safety Trial (AAOS 2026) - "Exclusion criteria included patients under the age of 18, patients unable to provide consent, patients who are pregnant, breastfeeding, or trying to become pregnant, patients with an allergy to any of the study drugs, patients undergoing revision surgery or open surgery, patients with a history of mania, depression, or schizophrenia, patients currently diagnosed with alcohol or drug abuse, patients who cannot or will not abide by the medication regimen, or patients taking any of the following drugs: anticholinergic agents, benzodiazepines, central nervous system depressants, droperidol, hydroxyzine, levomepromazine, methotrimeprazine, monoamine oxidase inhibitors, ritonavir, selective serotonin reuptake inhibitors, sympathomimetics, St...Primary outcome for this pilot study was safety of the test drug with the secondary outcome being pain control and number of opioid tablets (hydrocodone-acetaminophen 5-325mg) consumed at 3 different time intervals: 24 hours, 48 hours,..."

Clinical • Surgery • Addiction (Opioid and Alcohol) • Bipolar Disorder • Depression • Immunology • Orthopedics • Pain • Schizophrenia • Xerostomia

Current Practice of Palliative Sedation in Dutch Nursing Homes. (PubMed, J Am Med Dir Assoc) - "A substantial number of nursing home residents were prescribed midazolam and morphine within 14 days before death. Further research is needed to clarify the indications for initiating these medications, optimizing dosing strategies, and assessing the intended clinical effects."

Journal • Alzheimer's Disease • Anesthesia • CNS Disorders • Dementia • Palliative care

Coprescription of antipsychotics and benzodiazepines at hospital discharge. (PubMed, Encephale) - "Prevalence of CS-AP with BZD is high at discharge from a psychiatric hospital, especially in patients with short hospital stays (≤14 days)."

Journal • Anesthesia • CNS Disorders • Cognitive Disorders • Psychiatry

Demographic and clinical characteristics, practices, and outcomes of continuous palliative sedation: A multi-setting, province-wide retrospective cohort study. (PubMed, Palliat Med) - "The study demonstrated that standardization in the practice of continuous palliative sedation can be achieved across diverse clinical settings."

Journal • Retrospective data • Anesthesia • CNS Disorders • Oncology • Pain • Palliative care

Medication use in Poland for children and adolescents with neurodevelopmental disorders: before, during and after the COVID-19 pandemic - a retrospective pharmacoepidemiological study using national reimbursement data. (PubMed, Front Pharmacol) - "The most substantial increases occurred for sedative and anxiolytic agents (hydroxyzine, diazepam, alprazolam, lorazepam) and antipsychotics (olanzapine, aripiprazole, risperidone, chlorprothixene, haloperidol, levomepromazine), consistent with pandemic related stress, limited access to non-pharmacological care, and possible stockpiling. The COVID-19 pandemic induced broad but temporary increases in pediatric psychotropic drug dispensing, except for ADHD pharmacotherapies, which demonstrated a persistent upward trend. These findings suggest lasting shifts in diagnostic and therapeutic practices and underscore the need for continued monitoring of stimulant use and prescribing appropriateness in pediatric neurodevelopmental care."

Journal • Reimbursement • Retrospective data • US reimbursement • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Infectious Disease • Mental Retardation • Novel Coronavirus Disease • Pediatrics • Psychiatry

Clinical and sociodemographic characterization of Patients with Psychiatric Disorders and Epilepsy admitted to a reference psychiatric hospital (AES 2025) - "Among antiseizure medications, valproate (20.2%), carbamazepine (14.6%), and phenobarbital (12.4%) were most frequently prescribed. The most utilized psychiatric medications were risperidone (18%), haloperidol (15.73%), levomepromazine (9%), and sertraline (9%)... The findings indicate a high prevalence of psychiatric and behavioral comorbidities among institutionalized individuals with epilepsy, emphasizing the significant use of psychoactive substances and aggressive manifestations. The medication profile underscores the necessity for integrated clinical and psychiatric management, highlighting the importance of multidisciplinary approaches to optimize seizure control, reduce complications, and enhance quality of life."

Clinical • Late-breaking abstract • Behavior Disorders • CNS Disorders • Depression • Epilepsy • Insomnia • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia • Sleep Disorder • Suicidal Ideation

Levomepromazine and paroxetine poisoning with wide QRS complex. (PubMed, Clin Toxicol (Phila)) - No abstract available

Journal

Prescribing patterns of antipsychotic monotherapy and polypharmacy in patients with psychotic disorders (ECNP 2025) - "Among monotherapy patients, olanzapine was most frequently prescribed (33.3%), followed by risperidone and haloperidol (both 18.2%), quetiapine (15.2%), aripiprazole (9.1%), and clozapine (6.1%)...Less frequently prescribed in polytherapy were aripiprazole (10.4%), risperidone (7.3%), levomepromazine and zuclopenthixol (both 6.3%), fluphenazine (4.2%), and amisulpride and sulpiride (both 1.0%)... Despite guideline recommendations that advocate for antipsychotic monotherapy whenever possible [1,3], this study found that polypharmacy remains prevalent in clinical practice. Olanzapine emerged as the most common choice in monotherapy regimens, while haloperidol and promazine were more frequently used in polytherapy. Clozapine, despite its well-established role in treatment-resistant schizophrenia, was more commonly prescribed as part of combination therapy (16.7%) than as monotherapy (6.1%)."

Clinical • Monotherapy • CNS Disorders • Psychiatry • Schizophrenia

Generalized bullous fixed pigmented erythema mimicking toxic epidermal necrolysis: About two-cases (EADV 2025) - "Case 2: A 51-year-old man, with a history of schizophrenia treated with levomepromazine and diazepam for 10 years, presented with generalized erosions that developed within 24 hours after taking omeprazole. The drugs most frequently implicated in FPE include nonsteroidal anti-inflammatory drugs (such as etoricoxib), antibiotics (sulfonamides, tetracyclines), anticonvulsants, and, more rarely, proton pump inhibitors (omeprazole). This warrants heightened vigilance when prescribing these medications, especially in cases of recurrent lesions at the same sites."

Clinical • CNS Disorders • Dermatology • Psychiatry • Schizophrenia • Steven-Johnson Syndrome

WITHDRAWAL OF NON-INVASIVE ASSISTED VENTILATION IN PATIENTS WITH MOTOR NEURONE DISEASE (PACTALS 2025) - "All three patients were commenced on a Syringe Driver with morphine, midazolam and levomepromazine in preparation of the NIV withdrawal. NIV withdrawal in patients with MND can be safely and effectively carried out. Communication and support of the patient's family are also important parts of the process. However, current practices vary, and uniform Practice Guidelines would be invaluable."

Clinical • Non-invasive • Amyotrophic Lateral Sclerosis • Palliative care • Respiratory Diseases

Phenothiazine Derivatives and Their Impact on the Apoptosis Processes: A Review. (PubMed, J Appl Toxicol) - "Chlorpromazine, fluphenazine, levomepromazine, mepazine, perphenazine, promazine, promethazine, thioridazine, trifluoperazine, and trifluoperazine analog (3dc) more often induce apoptosis in cancer cell lines, human hepatocytes, and lymphocytes, and the final effect depends on the type and concentration of drug used, the type of cell line, and the methodology used. The obtained results allow for a better understanding of the biological action of phenothiazine derivatives and will help reposition this group of drugs to cancer treatment, resulting in faster, safer, easier, and cheaper therapy."

Journal • Review • Bipolar Disorder • CNS Disorders • Mood Disorders • Oncology • Psychiatry • Schizophrenia

Sexual dysfunctions related to use of antipsychotics: A protocol for a systematic review and meta-analysis. (PubMed, PLoS One) - "The antipsychotic medications of interest are amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, chlorpromazine, clopenthixol, clozapine, droperidol, flupenthixol, fluphenazine, haloperidol, iloperidone, levomepromazine, loxapine, lurasidone, molindone, olanzapine, paliperidone, penfluridol, perphenazine, perazine, pimozide, prochlorperazine, quetiapine, risperidone, sertindole, sulpiride, thiothixene, thioridazine, trifluoperazine, ziprasidone, zuclopenthixol and zotepine. The Cochrane Risk of Bias tool and RoB 2.0 will be used to assess the risk of bias in studies. We will evaluate the quality of the evidence contributing to network estimates for the primary outcomes using the GRADE framework, and key factors that may affect the observed effects will be analysed for consistency across studies."

Journal • Retrospective data • CNS Disorders • Sexual Disorders • PRL

Cotard's Syndrome in a Patient With Paranoid Schizophrenia: A Case Report of a Type I Presentation. (PubMed, Cureus) - "The patient was successfully treated with haloperidol, diazepam, and levomepromazine. This case demonstrates the importance of identifying Cotard's condition in non-depressed, schizophrenic individuals, as prompt management can improve outcomes."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Palliative sedation in Sweden: specialised palliative care nationwide survey. (PubMed, BMJ Support Palliat Care) - "PS is more common in Sweden today than 20 years ago, 10% compared to 1%. The vast majority received midazolam as a sedative."

Journal • Anesthesia • Palliative care

Therapeutic drug monitoring for antipsychotic medication to estimate drug adherence in Japanese patients with psychiatric disorders (CINP-AsCNP 2025) - " Patients who diagnosed with psychiatric disorders, including schizophrenia (SCZ), bipolar disorder, or major depressive disorder, at the Department of Psychiatry, Gifu University Hospital and prescribed antipsychotics (haloperidol, levomepromazine, aripiprazole, paliperidone, risperidone, olanzapine, and/or quetiapine) were enrolled between August 2021 and October 2023...Factor analysis was done by using factors possibly influencing adherence such as sex, age, diagnosis, number of drugs, antipsychotic dosage [calculated as chlorpromazine (CP) equivalents] and the use of concomitant drugs including antiparkinsonian drugs, antidepressants, benzodiazepines, and mood stabilizers... Consistent with previous reports, the better adherence rate determined by TDM for antipsychotics in Japanese patients was mostly same. Our results revealed that the concomitant medications contributed to improved adherence of antipsychotic medications with relatively high intensity treatment of..."

Adherence • Clinical • Drug adherence • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry • Schizophrenia

"Is this sedation?" - a Group Delphi process to define cut-off doses and dosing intervals for potentially sedating drugs in palliative care. (PubMed, BMC Palliat Care) - "This study for the first time provides evidence- and expert consensus-based data to support clinical judgements regarding sedating effects of a range of potentially sedating drugs commonly used in palliative care."

Journal • Anesthesia • Palliative care

Determination of multiple psychostimulants and antipsychotics in postmortem dried blood spot samples by liquid chromatography-tandem mass spectrometry. (PubMed, Leg Med (Tokyo)) - "To test our novel analytical method we used liquid chromatography coupled with electrospray ionization-tandem mass spectrometry to quantify two psychostimulants (amphetamine, methamphetamine) and eight antipsychotics (chlorpromazine, haloperidol, levomepromazine, aripiprazole, clozapine, quetiapine, risperidone, and paliperidone) in cadaveric DBS samples. Comparison with our general practice method (known as QuEChERS) showed good positive correlations of the quantifiable concentrations of all drugs. In addition, for all drugs, the concentrations obtained by the DBS method were almost well coincident with those obtained by the QuEChERS method."

Journal • CNS Disorders

Austrian physicians’ knowledge of palliative care, assisted suicide, and palliative sedation: An exploratory study (OeGHO-AHOP 2025) - "Regarding PST, PC physicians more frequently adhered to guidelines and used midazolam (97.8% vs. 77.6%, p<0.001), propofol (56.2% vs. 38.1%, p=0.009), and levomepromazine (23.6% vs. 11.2%, p=0.016). Overall, Austrian physicians demonstrate insufficient knowledge of AS and PST, highlighting the need for increased education on the principles of palliative care to ensure informed practice after the legalization of AS. Nevertheless, PC physicians in Austria show superior adherence to guidelines in the management of life-limiting illnesses, PST and AS compared to non-PC physicians, highlighting the importance of specialized palliative care training."

Anesthesia • Cardiovascular • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Heart Failure • Hepatology • Immunology • Palliative care • Respiratory Diseases