levomepromazine / Generic mfg. - LARVOL DELTA

Improving end of life prescribing in advanced CKD: A renal-adjusted anticipatory medication orderset (UKKW 2026) - "Midazolam 1mg SC PRN 1 hourly, max 12 doses/24 hrs (agitation) 3...Levomepromazine 2.5mg SC PRN 2 hourly, max 6 doses/24 hrs (nausea and vomiting) The orderset was approved by the local Governance team and Medicines Management Group and became live in March 2024...Morphine sulphate was the most common anticipatory medication prescribed, accounting for 27.3% of all prescriptions...The pre-populated orderset standardised practice, reduced variability across clinicians of different experience levels, and required minimal additional training, thus facilitating rapid adoption on the renal wards. Future efforts will focus on clinician awareness and education, with subsequent data re-analysis to ensure sustainable change is maintained."

Metastases • Chronic Kidney Disease • CNS Disorders • Depression • Palliative care • Renal Disease

Synthetic Tetrahydrocannabinol (THC) is a Safe Adjunct to the Treatment of Postoperative Pain after Arthroscopic Knee Surgery: A Pilot Randomized Safety Trial (AAOS 2026) - "Exclusion criteria included patients under the age of 18, patients unable to provide consent, patients who are pregnant, breastfeeding, or trying to become pregnant, patients with an allergy to any of the study drugs, patients undergoing revision surgery or open surgery, patients with a history of mania, depression, or schizophrenia, patients currently diagnosed with alcohol or drug abuse, patients who cannot or will not abide by the medication regimen, or patients taking any of the following drugs: anticholinergic agents, benzodiazepines, central nervous system depressants, droperidol, hydroxyzine, levomepromazine, methotrimeprazine, monoamine oxidase inhibitors, ritonavir, selective serotonin reuptake inhibitors, sympathomimetics, St...Primary outcome for this pilot study was safety of the test drug with the secondary outcome being pain control and number of opioid tablets (hydrocodone-acetaminophen 5-325mg) consumed at 3 different time intervals: 24 hours, 48 hours,..."

Clinical • Surgery • Addiction (Opioid and Alcohol) • Bipolar Disorder • Depression • Immunology • Orthopedics • Pain • Schizophrenia • Xerostomia

Current Practice of Palliative Sedation in Dutch Nursing Homes. (PubMed, J Am Med Dir Assoc) - "A substantial number of nursing home residents were prescribed midazolam and morphine within 14 days before death. Further research is needed to clarify the indications for initiating these medications, optimizing dosing strategies, and assessing the intended clinical effects."

Journal • Alzheimer's Disease • Anesthesia • CNS Disorders • Dementia • Palliative care

Coprescription of antipsychotics and benzodiazepines at hospital discharge. (PubMed, Encephale) - "Prevalence of CS-AP with BZD is high at discharge from a psychiatric hospital, especially in patients with short hospital stays (≤14 days)."

Journal • Anesthesia • CNS Disorders • Cognitive Disorders • Psychiatry

Demographic and clinical characteristics, practices, and outcomes of continuous palliative sedation: A multi-setting, province-wide retrospective cohort study. (PubMed, Palliat Med) - "The study demonstrated that standardization in the practice of continuous palliative sedation can be achieved across diverse clinical settings."

Journal • Retrospective data • Anesthesia • CNS Disorders • Oncology • Pain • Palliative care

Medication use in Poland for children and adolescents with neurodevelopmental disorders: before, during and after the COVID-19 pandemic - a retrospective pharmacoepidemiological study using national reimbursement data. (PubMed, Front Pharmacol) - "The most substantial increases occurred for sedative and anxiolytic agents (hydroxyzine, diazepam, alprazolam, lorazepam) and antipsychotics (olanzapine, aripiprazole, risperidone, chlorprothixene, haloperidol, levomepromazine), consistent with pandemic related stress, limited access to non-pharmacological care, and possible stockpiling. The COVID-19 pandemic induced broad but temporary increases in pediatric psychotropic drug dispensing, except for ADHD pharmacotherapies, which demonstrated a persistent upward trend. These findings suggest lasting shifts in diagnostic and therapeutic practices and underscore the need for continued monitoring of stimulant use and prescribing appropriateness in pediatric neurodevelopmental care."

Journal • Reimbursement • Retrospective data • US reimbursement • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Infectious Disease • Mental Retardation • Novel Coronavirus Disease • Pediatrics • Psychiatry

Clinical and sociodemographic characterization of Patients with Psychiatric Disorders and Epilepsy admitted to a reference psychiatric hospital (AES 2025) - "Among antiseizure medications, valproate (20.2%), carbamazepine (14.6%), and phenobarbital (12.4%) were most frequently prescribed. The most utilized psychiatric medications were risperidone (18%), haloperidol (15.73%), levomepromazine (9%), and sertraline (9%)... The findings indicate a high prevalence of psychiatric and behavioral comorbidities among institutionalized individuals with epilepsy, emphasizing the significant use of psychoactive substances and aggressive manifestations. The medication profile underscores the necessity for integrated clinical and psychiatric management, highlighting the importance of multidisciplinary approaches to optimize seizure control, reduce complications, and enhance quality of life."

Clinical • Late-breaking abstract • Behavior Disorders • CNS Disorders • Depression • Epilepsy • Insomnia • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia • Sleep Disorder • Suicidal Ideation

Levomepromazine and paroxetine poisoning with wide QRS complex. (PubMed, Clin Toxicol (Phila)) - No abstract available

Journal

Prescribing patterns of antipsychotic monotherapy and polypharmacy in patients with psychotic disorders (ECNP 2025) - "Among monotherapy patients, olanzapine was most frequently prescribed (33.3%), followed by risperidone and haloperidol (both 18.2%), quetiapine (15.2%), aripiprazole (9.1%), and clozapine (6.1%)...Less frequently prescribed in polytherapy were aripiprazole (10.4%), risperidone (7.3%), levomepromazine and zuclopenthixol (both 6.3%), fluphenazine (4.2%), and amisulpride and sulpiride (both 1.0%)... Despite guideline recommendations that advocate for antipsychotic monotherapy whenever possible [1,3], this study found that polypharmacy remains prevalent in clinical practice. Olanzapine emerged as the most common choice in monotherapy regimens, while haloperidol and promazine were more frequently used in polytherapy. Clozapine, despite its well-established role in treatment-resistant schizophrenia, was more commonly prescribed as part of combination therapy (16.7%) than as monotherapy (6.1%)."

Clinical • Monotherapy • CNS Disorders • Psychiatry • Schizophrenia

Generalized bullous fixed pigmented erythema mimicking toxic epidermal necrolysis: About two-cases (EADV 2025) - "Case 2: A 51-year-old man, with a history of schizophrenia treated with levomepromazine and diazepam for 10 years, presented with generalized erosions that developed within 24 hours after taking omeprazole. The drugs most frequently implicated in FPE include nonsteroidal anti-inflammatory drugs (such as etoricoxib), antibiotics (sulfonamides, tetracyclines), anticonvulsants, and, more rarely, proton pump inhibitors (omeprazole). This warrants heightened vigilance when prescribing these medications, especially in cases of recurrent lesions at the same sites."

Clinical • CNS Disorders • Dermatology • Psychiatry • Schizophrenia • Steven-Johnson Syndrome

WITHDRAWAL OF NON-INVASIVE ASSISTED VENTILATION IN PATIENTS WITH MOTOR NEURONE DISEASE (PACTALS 2025) - "All three patients were commenced on a Syringe Driver with morphine, midazolam and levomepromazine in preparation of the NIV withdrawal. NIV withdrawal in patients with MND can be safely and effectively carried out. Communication and support of the patient's family are also important parts of the process. However, current practices vary, and uniform Practice Guidelines would be invaluable."

Clinical • Non-invasive • Amyotrophic Lateral Sclerosis • Palliative care • Respiratory Diseases

Phenothiazine Derivatives and Their Impact on the Apoptosis Processes: A Review. (PubMed, J Appl Toxicol) - "Chlorpromazine, fluphenazine, levomepromazine, mepazine, perphenazine, promazine, promethazine, thioridazine, trifluoperazine, and trifluoperazine analog (3dc) more often induce apoptosis in cancer cell lines, human hepatocytes, and lymphocytes, and the final effect depends on the type and concentration of drug used, the type of cell line, and the methodology used. The obtained results allow for a better understanding of the biological action of phenothiazine derivatives and will help reposition this group of drugs to cancer treatment, resulting in faster, safer, easier, and cheaper therapy."

Journal • Review • Bipolar Disorder • CNS Disorders • Mood Disorders • Oncology • Psychiatry • Schizophrenia

Sexual dysfunctions related to use of antipsychotics: A protocol for a systematic review and meta-analysis. (PubMed, PLoS One) - "The antipsychotic medications of interest are amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, chlorpromazine, clopenthixol, clozapine, droperidol, flupenthixol, fluphenazine, haloperidol, iloperidone, levomepromazine, loxapine, lurasidone, molindone, olanzapine, paliperidone, penfluridol, perphenazine, perazine, pimozide, prochlorperazine, quetiapine, risperidone, sertindole, sulpiride, thiothixene, thioridazine, trifluoperazine, ziprasidone, zuclopenthixol and zotepine. The Cochrane Risk of Bias tool and RoB 2.0 will be used to assess the risk of bias in studies. We will evaluate the quality of the evidence contributing to network estimates for the primary outcomes using the GRADE framework, and key factors that may affect the observed effects will be analysed for consistency across studies."

Journal • Retrospective data • CNS Disorders • Sexual Disorders • PRL

Cotard's Syndrome in a Patient With Paranoid Schizophrenia: A Case Report of a Type I Presentation. (PubMed, Cureus) - "The patient was successfully treated with haloperidol, diazepam, and levomepromazine. This case demonstrates the importance of identifying Cotard's condition in non-depressed, schizophrenic individuals, as prompt management can improve outcomes."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Palliative sedation in Sweden: specialised palliative care nationwide survey. (PubMed, BMJ Support Palliat Care) - "PS is more common in Sweden today than 20 years ago, 10% compared to 1%. The vast majority received midazolam as a sedative."

Journal • Anesthesia • Palliative care

Therapeutic drug monitoring for antipsychotic medication to estimate drug adherence in Japanese patients with psychiatric disorders (CINP-AsCNP 2025) - " Patients who diagnosed with psychiatric disorders, including schizophrenia (SCZ), bipolar disorder, or major depressive disorder, at the Department of Psychiatry, Gifu University Hospital and prescribed antipsychotics (haloperidol, levomepromazine, aripiprazole, paliperidone, risperidone, olanzapine, and/or quetiapine) were enrolled between August 2021 and October 2023...Factor analysis was done by using factors possibly influencing adherence such as sex, age, diagnosis, number of drugs, antipsychotic dosage [calculated as chlorpromazine (CP) equivalents] and the use of concomitant drugs including antiparkinsonian drugs, antidepressants, benzodiazepines, and mood stabilizers... Consistent with previous reports, the better adherence rate determined by TDM for antipsychotics in Japanese patients was mostly same. Our results revealed that the concomitant medications contributed to improved adherence of antipsychotic medications with relatively high intensity treatment of..."

Adherence • Clinical • Drug adherence • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry • Schizophrenia

"Is this sedation?" - a Group Delphi process to define cut-off doses and dosing intervals for potentially sedating drugs in palliative care. (PubMed, BMC Palliat Care) - "This study for the first time provides evidence- and expert consensus-based data to support clinical judgements regarding sedating effects of a range of potentially sedating drugs commonly used in palliative care."

Journal • Anesthesia • Palliative care

Determination of multiple psychostimulants and antipsychotics in postmortem dried blood spot samples by liquid chromatography-tandem mass spectrometry. (PubMed, Leg Med (Tokyo)) - "To test our novel analytical method we used liquid chromatography coupled with electrospray ionization-tandem mass spectrometry to quantify two psychostimulants (amphetamine, methamphetamine) and eight antipsychotics (chlorpromazine, haloperidol, levomepromazine, aripiprazole, clozapine, quetiapine, risperidone, and paliperidone) in cadaveric DBS samples. Comparison with our general practice method (known as QuEChERS) showed good positive correlations of the quantifiable concentrations of all drugs. In addition, for all drugs, the concentrations obtained by the DBS method were almost well coincident with those obtained by the QuEChERS method."

Journal • CNS Disorders

Austrian physicians’ knowledge of palliative care, assisted suicide, and palliative sedation: An exploratory study (OeGHO-AHOP 2025) - "Regarding PST, PC physicians more frequently adhered to guidelines and used midazolam (97.8% vs. 77.6%, p<0.001), propofol (56.2% vs. 38.1%, p=0.009), and levomepromazine (23.6% vs. 11.2%, p=0.016). Overall, Austrian physicians demonstrate insufficient knowledge of AS and PST, highlighting the need for increased education on the principles of palliative care to ensure informed practice after the legalization of AS. Nevertheless, PC physicians in Austria show superior adherence to guidelines in the management of life-limiting illnesses, PST and AS compared to non-PC physicians, highlighting the importance of specialized palliative care training."

Anesthesia • Cardiovascular • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Heart Failure • Hepatology • Immunology • Palliative care • Respiratory Diseases

Frequency and predictors of palliative sedation among patients with cancer who died in a specialist inpatient palliative care unit: a retrospective study. (PubMed, BMC Palliat Care) - "A total of 38% of patients with cancer receiving specialized palliative care required PS before death. Patients who received PS were younger, had a longer hospital stay, were more likely to have their spouse be their primary caregiver, were better informed and had more advance directives. 28% of sedated patients required more than one drug, which was associated with a longer PS, the maintenance of parental hydration during PS and the initiation of PS with levomepromazine instead of midazolam."

Journal • Retrospective data • Anesthesia • CNS Disorders • Mood Disorders • Oncology • Palliative care • Psychiatry

Phenobarbital for inpatient palliative sedation-a clinical audit. (PubMed, BMJ Support Palliat Care) - "Phenobarbital appears to be an effective medication for PST. However, inconsistencies in dosing, concurrent sedative medication use and standardised protocols highlight areas for improvement in clinical guidelines."

Journal • Anesthesia • CNS Disorders • Palliative care

Evaluating physicians' knowledge of assisted suicide and palliative sedation therapy in Austria : An exploratory survey study. (PubMed, Wien Klin Wochenschr) - "Overall, Austrian physicians demonstrate insufficient knowledge of AS and PST, underlining the need for enhanced education on PC principles to ensure informed practice post-AS legalization. Nonetheless, PC physicians in Austria demonstrate superior adherence to guidelines in managing life-limiting conditions, PST and AS compared to non-PC physicians, highlighting the importance of specialized PC education."

Journal • Anesthesia • Palliative care

Response to amoxicillin and perampanel in infantile Alexander disease. (PubMed, Epilepsia Open) - "Although there is no treatment, mild symptomatic improvement has been reported in one case of adult Alexander treated with ceftriaxone, given its interaction with the mutant glial fibrillary acid protein (GFAP) responsible for the disease's pathogenesis...Since irritability had worsened and had not responded to levomepromazine, treatment with amoxicillin (80 mg/kg/day) was attempted to modulate glutamate levels...The patient had frequent daily seizures which did not respond to valproate, clonazepam, or phenobarbital...However, doctors believe that drugs like amoxicillin and perampanel could be promising treatments for managing symptoms of Alexander disease and other similar brain conditions in the future, especially where excess glutamate plays a role in the damage. This case suggests that these treatments may help control irritability and seizures, offering hope for better management of this challenging disease."

Journal • CNS Disorders • Epilepsy • Gastroenterology • Gastroesophageal Reflux Disease • Rare Diseases • Vascular Neurology • Ventriculomegaly • GFAP

THE HISTORY OF MEDICAL CARE OF PATIENTS WITH MENTAL ILLNESS BY EXAMPLE OF THE OLDEST PSYCHIATRIC HOSPITAL IN POLAND (WPA 2024) - "The first psychiatric drugs administered to treat were: morphine (till 1914), bromine salts(1857), chloral hydrate(1869) and scopolamine(1880)...The first neuroleptic drugs - chlorpromazine and reserpine – have been used since 1956...New antidepressant drugs were first administered in 1992 and new antipsychotic drugs (clopenthixol, stelazine, sulpiride, levomepromazine) were in use from 1991.ConclusionsRegional Psychiatric Hospital for Neurologically and Mentally Ill Patients celebrates its 169th founding anniversary this year. Each year thousands of patients are being treated there according to the latest psychiatric recommendations."

Clinical • Alzheimer's Disease • CNS Disorders • Dementia • Depression • Psychiatry • Schizophrenia

An extended substrate spectrum of the proton organic cation antiporter and relation to other cation transporters. (PubMed, Basic Clin Pharmacol Toxicol) - "They included antidepressants (like tranylcypromine or nortriptyline), antipsychotics (like levomepromazine) and local anaesthetics. The substrate overlap between the H+/OC antiporter and OCTN1, OCTN2 or OCT3 was minimal, indicating that the latter three are not the proteins underlying the H+/OC antiporter activity. Overall, about 50% of positively charged drugs may be substrates of the antiporter, which may be the most important membrane transport protein for many drugs."

Journal • Anesthesia • CNS Disorders