Veltassa (patiromer)
/ CSL Behring
- LARVOL DELTA
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November 22, 2025
PAT-CHINA-303: Trial Evaluating the Efficacy and Safety of Patiromer in Chinese Subjects
(clinicaltrials.gov)
- P3 | N=262 | Active, not recruiting | Sponsor: Vifor Fresenius Medical Care Renal Pharma | Recruiting ➔ Active, not recruiting
Enrollment closed • Chronic Kidney Disease • Nephrology • Renal Disease
November 14, 2025
Managing Hyperkalemia in Heart Failure Patients: A Systematic Review.
(PubMed, Cardiol Rev)
- "For chronic management, newer potassium-binding agents such as patiromer and sodium zirconium cyclosilicate offer improved safety and efficacy compared with traditional resins, enabling the continuation and up-titration of renin-angiotensin-aldosterone system inhibitors. These therapies support optimal neurohormonal blockade, improve adherence, and reduce morbidity and mortality in heart failure."
Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Nephrology • Renal Disease
October 18, 2025
Changes in Albuminuria (ACR) in Patients with Hyperkalemic (HK) CKD Taking Patiromer (PAT) and RAAS Inhibitors (RAASi)
(KIDNEY WEEK 2025)
- "Cohorts 1 & 2 (TIP n=61; LTMP n=48) received guideline-directed medical therapy with losartan 100 mg daily, with or without spironolactone and treated with PAT. Given the observational nature of these analyses & the variability in patient populations, further studies are needed to confirm these results & clarify their clinical significance. Figure: Median ACR changes in OPAL-HK (Part A) and AMETHYST-DN studies"
Clinical • Chronic Kidney Disease • Diabetes • Metabolic Disorders • Renal Disease
August 15, 2025
Hyperkalemia in the Time of Zirconium and Patiromer
(KIDNEY WEEK 2025)
- "This session provides the latest clinical guidance to help make sense of all these changes. Learning Objective(s) Identify the diagnostic pathways to determine the etiology of hyperkalemia Explain the role of potassium binders in the treatment of hyperkalemia Explain the role of potassium control in CKD treatment Describe the treatment of acute hyperkalemia in the modern era"
Chronic Kidney Disease
November 11, 2025
Strategies for hyperkalemia management in dialysis patients: A systematic review.
(PubMed, Open Med (Wars))
- "The aim of this systematic review is to evaluate current therapeutic strategies for hyperkalemia in dialysis patients, including diuretics, ion-exchange resins, and newer agents such as sodium zirconium cyclosilicate (SZC)...New therapies like SZC and patiromer demonstrated efficacy in maintaining safe potassium levels...Hyperkalemia management in dialysis patients benefits from an integrated approach combining pharmacologic treatment, tailored nutrition, and close monitoring. Novel interventions and evolving dietary guidelines may improve safety, effectiveness, and quality of life in this vulnerable population."
Journal • Review • Chronic Kidney Disease • Nephrology • Renal Disease
November 11, 2025
The Economic Burden of Parkinson's Disease in the Netherlands: From Societal Impact to Investments in Health Solutions
(ISPOR-EU 2025)
- "In the Netherlands, the aging population is expected to drive a substantial increase in PD prevalence, from 67,000 in 2022 to nearly 105,000 by 2040, intensifying pressure on the healthcare system and informal care networks... PD poses a growing societal and economic burden in the Netherlands, with major impacts beyond the healthcare sector. Future research should focus on understanding key cost drivers and explore strategies to mitigate the projected burden. Topics such as integrated care, toxin exposure prevention and lifestyle interventions will be crucial."
HEOR • CNS Disorders • Movement Disorders • Parkinson's Disease
November 03, 2025
Net clinical benefit of patiromer for acute hyperkalemia: a post-hoc analysis of the reduce trial.
(PubMed, Ann Med)
- "NCB for PAT over SOC was numerically superior at 2 h (-0.05 vs 0.43; p = 0.108), 4 h (0.11 vs 0.73; p = 0.097), and 6 h (0.64 vs 1.60; p = 0.094) post-intervention. NCB captures the clinical benefit of binders, while accounting for the confounding effect of other potassium-lowering agents."
Clinical • Journal • Retrospective data
October 14, 2025
Impact of Potassium-Binders on the Interpretation of Bone Mineral Density Following Kidney Transplantation.
(PubMed, Clin Transplant)
- "The potassium lowering drug sodium zirconium cyclosilicate (Lokelma) is radiopaque and therefore acts as a confounder on DXA interpretations in kidney transplant recipients. Patiromer (PAT, Veltassa) has no such effect."
Journal • Gastrointestinal Disorder • Transplantation
September 27, 2025
Colossal and tunable dielectric tunability in domain-engineered barium strontium titanate.
(PubMed, Nat Commun)
- "Using phenomenological modeling, film growth, and characterization, we show that devices consisting of domain-wall-rich Ba0.8Sr0.2TiO3 films close to a polar-domain-variant phase boundary exhibit colossal dielectric tunability of 100:1 (99%) at a voltage (electric field) of ~15 V (750 kV/cm), resulting in a tunability-quality factor product figure of merit that rises to nearly 105, two orders of magnitude higher than the best previous reported values. Remarkably, varying the amplitude of alternating-current bias enables modulation of this tunability by 50%, owing to domain-wall motion. These results suggest that domain engineering is a powerful approach for achieving excellent modulation of functional properties in ferroelectric films."
Journal
September 09, 2025
Differences in Efficacy Among New and Old Potassium Binders in Dialysis Patients: A Systematic Review and Meta-Analysis.
(PubMed, G Ital Nefrol)
- "Newer potassium binders, patiromer and sodium zirconium cyclosilicate (SZC), offer improved tolerability compared to older agents. The lack of sufficient RCTs, especially those directly comparing newer binders, highlights a significant knowledge gap. Further studies are needed to evaluate long-term outcomes, including quality of life and cardiovascular effects, and to directly compare the efficacy and safety of different potassium binders in this population."
Clinical • Journal • Retrospective data • Review • Cardiovascular
September 05, 2025
PRINCE: Patiromer and Diet/hrQoL in Chronic Dialysis
(clinicaltrials.gov)
- P3 | N=40 | Recruiting | Sponsor: Mario Negri Institute for Pharmacological Research | Not yet recruiting ➔ Recruiting
Enrollment open • HEOR • Chronic Kidney Disease • Nephrology • Renal Disease
July 18, 2025
PRINCE: Patiromer and Diet/hrQoL in Chronic Dialysis
(clinicaltrials.gov)
- P3 | N=40 | Not yet recruiting | Sponsor: Mario Negri Institute for Pharmacological Research | Trial completion date: Feb 2026 ➔ Jul 2026 | Trial primary completion date: Feb 2026 ➔ Jul 2026
HEOR • Trial completion date • Trial primary completion date • Chronic Kidney Disease • Nephrology • Renal Disease
July 25, 2025
KBindER: Comparison of Potassium Binders in the ER
(clinicaltrials.gov)
- P4 | N=37 | Terminated | Sponsor: University of California, Irvine | N=120 ➔ 37 | Trial completion date: Dec 2025 ➔ Jan 2025 | Recruiting ➔ Terminated | Trial primary completion date: Jul 2025 ➔ Jan 2025; Low enrollment rate
Enrollment change • Trial completion date • Trial primary completion date • Trial termination
August 11, 2025
Management of patients with heart failure at high risk of hyperkalaemia: The CARE-HK in HF registry.
(PubMed, Eur J Heart Fail)
- P | "In this contemporary multinational prospective registry of patients with HF at high risk for hyperkalaemia, hyperkalaemic events were common but infrequently associated with RASi/MRA modification or potassium binder use. Fewer than one in three patients received optimal RASi/MRA therapy for the majority of follow-up, and hyperkalaemic events were associated with higher risk of adverse clinical outcomes."
Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease
August 22, 2025
Hyperkalemia in Heart Failure with Reduced Ejection Fraction: Implications and Management.
(PubMed, Heart Fail Rev)
- "This review explores the complex interplay between hyperkalemia and the use of guideline-directed medical therapies (GDMT), such as renin-angiotensin-aldosterone system inhibitors (RAASi) and steroidal mineralocorticoid receptor antagonists (sMRAs), including spironolactone and eplerenone, which are currently recommended in guidelines for improving outcomes in heart failure with reduced ejection fraction (HFrEF)...This review emphasizes the importance of regular potassium monitoring, the potential benefits of combining therapies such as sodium-glucose cotransporter 2 (SGLT2) inhibitors with RAASi to reduce the risk of hyperkalemia, and the emergence of the newer non-steroidal MRA (nsMRA), finerenone, which may have a lower risk of hyperkalemia. Additionally, potassium binders such as patiromer and sodium zirconium cyclosilicate (SZC) are highlighted for their role in managing and preventing hyperkalemia, allowing patients to continue optimal RAASi and MRA therapy without..."
Journal • Review • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Nephrology • Renal Disease
July 29, 2025
Comparison of Three Potassium Binders in Patients With Acute Hyperkalemia.
(PubMed, Cureus)
- "SPS and SZC were superior to patiromer in lowering serum potassium levels in patients with acute hyperkalemia, with no significant difference between SPS and SZC. Considering the established safety concerns associated with SPS, SZC may be the preferred binder for managing acute hyperkalemia in the inpatient setting."
Journal • Cardiovascular • Chronic Kidney Disease • Nephrology • Renal Disease
June 19, 2025
Novel Drugs and Hyperkalemia: Risks and Solutions: Electrolyte Disorders in CKD and the Elderly: Clinical Challenges and Emerging Solutions
(KSN 2025)
- "Recently, finerenone, a non-steroidal mineralocorticoid receptor antagonist has become available to treat patients with type 2 diabetes...Sacubitril/valsartan, a new pharmacological class of angiotensin receptor neprilysin inhibitor, is beneficial to heart failure through blocking the degradation of natriuretic peptides and inhibiting renin-angiotensin-aldosterone system (RAAS) activation which also relate to the pathophysiologic mechanisms of chronic kidney disease...Patiromer and sodium zirconium cyclosilicate (SZC) are newer options for hyperkalemia treatment...Recent randomized clinical trials have shown that SZC effectively lowers serum potassium and maintains normokalemia in most hyperkalemic patients. It is likely these newer oral potassium-binding agents will help change how patients with hyperkalemia are treated in regards to sudden and chronic medical conditions."
Clinical • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Nephrology • Type 2 Diabetes Mellitus
July 03, 2025
Hyperkalemia in Hemodialysis: Use of Sodium Zirconium Cyclosilicate - A Single-center Experience
(PubMed, G Ital Nefrol)
- "Recently, two new medications have been introduced for chronic potassium control: Patiromer and Sodium Zirconium Cyclosilicate, the latter approved for use in haemodialysis. We conducted an observational study at our dialysis unit on 28 chronic haemodialysis patients, where after detecting hyperkalaemia, therapy with Sodium Zirconium Cyclosilicate was initiated. We evaluated the potassium levels over time, changes in home treatments, and the drug's tolerability."
Journal • Observational data • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Nephrology • Renal Disease
July 03, 2025
Changes in natriuretic peptide levels following patiromer-enabled optimization of medical therapy in heart failure: A post hoc analysis of the DIAMOND study.
(PubMed, Eur J Heart Fail)
- "In this post-hoc analysis of DIAMOND, patients with HFrEF and elevated (>1000 ng/ml) NT-proBNP at screening experienced clinically meaningful NT-proBNP reductions following a RAASi optimization strategy that included patiromer during the run-in phase, with no significant differences observed between patiromer and placebo groups during the randomized withdrawal phase."
Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure
July 01, 2025
Pathology of Melanoma: New Concepts (2025 Update).
(PubMed, Dermatol Clin)
- "The American Cancer Society estimates that nearly 105,000 new cases of invasive melanoma of the skin and over 107,000 new cases of melanoma in situ will be diagnosed in the United States in 2025...Among this population, overall 5 year survival rates have improved from 82% in 1975 to 1997 to 94% in 2014 to 2020. As expected, disease that is only local at diagnosis confers an excellent greater than 99% 5 year survival, whereas melanoma that has metastasized regionally or distant confers only a 75% or 35% 5 year survival, respectively."
Journal • Review • Melanoma • Oncology • Solid Tumor
April 15, 2025
Real-World Effectiveness of Patiromer Among Hemodialysis (HD) Patients Prescribed Various Treatment Schedules Over a One-Year Follow-Up
(ERA 2025)
- "In a real-world analysis of adult, prevalent HD patients, various treatment schedules were prescribed for PAT, although the most common was once a day with 8.4 g per packet. All treatment schedule groups had a decrease in mean sK, an increase in the percent of patients achieving < 5.5 mEq/L and a decrease in patients receiving at least one treatment with 1K dialysate bath."
Clinical • Real-world • Real-world effectiveness • Real-world evidence
June 09, 2025
Outcomes and Resource Utilization in Hyperkalemic Emergency Department Patients Treated With Patiromer or Sodium Zirconium Cyclosilicate.
(PubMed, J Am Coll Emerg Physicians Open)
- "Patients receiving patiromer had lower in-hospital mortality. Patients receiving SZC had lower 30-day all-cause and hyperkalemia-related hospitalization risks."
HEOR • Journal
May 28, 2025
Guideline-Recommended Disease-Modifying Therapies for Patients with Cardiorenal Disease: A Call-to-Action Narrative Review.
(PubMed, Adv Ther)
- "Hyperkalemia can be managed and optimal RASi dosing can be continued by using novel potassium binders, such as sodium zirconium cyclosilicate or patiromer. In doing so, the guideline targets achievement of the "quadruple aim" of GDMT in CKD, i.e., enabling optimal use of RASi and SGLT2i in most patients, along with nonsteroidal mineralocorticoid receptor antagonists, and glucagon-like peptide-1 receptor agonists in diabetic kidney disease. This manuscript constitutes a call to action to raise awareness of the growing clinical and economic burdens of CKD and to promote a united approach to the early detection and optimal treatment of CKD through stricter adherence to GDMT."
Journal • Review • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Gastrointestinal Disorder • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus
February 24, 2025
Practice Patterns of Potassium-binding Agent Use for Severe Acute Hyperkalemia in Intensive Care Units
(ATS 2025)
- " Using PINC AI Healthcase Database, we identified adults (age ≥18) with severe hyperkalemia (serum potassium ≥6.0 mmol/L) admitted to ICUs May 2018 - September 2022 and received any of three potassium-binding agents: Sodium polystyrene sulfate (SPS; Kayexalate®), sodium zirconium cyclosilicate (SZC; Lokelma®), or patiromer. Few ICU patients with severe acute hyperkalemia received a potassium-binding agent on presentation, but if used, there was significant variation between hospitals in the choice of agent. We theorize this may be partly explained by the high cost of new potassium-binding agents relative to SPS. Notably, the use of new potassium-binding agents increased although no comparative effectiveness clinical trials have been completed to date."
Cardiovascular • Critical care • Nephrology • Renal Disease
May 12, 2025
Economic Evaluation of Patiromer in Patients with Concomitant Heart Failure and Chronic Kidney Disease in Italy.
(PubMed, Pharmacoecon Open)
- "Applying DIAMOND data, patiromer is deemed to be cost-effective at a willingness-to pay threshold of €40,000 per QALY gained in Italy."
HEOR • Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease
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