SC-002 / AbbVie - LARVOL DELTA

Molecular Characterization of Clostridium botulinum Isolates from Sichuan Province, China (1990-2024). (PubMed, Foodborne Pathog Dis) - "All strains belonging to Group I (SC001, SC002, SC003, SC006, and SC009) were assigned to five totally different recognized ST types (ST-2 to ST-51). In addition, analysis of BoNTs subtypes demonstrated that the types of BoNTs causing botulism in Sichuan were mainly types A, B, and E. Among them, some rare subtypes of BoNT reported for the first time in China, such as BoNT/B4, BoNT/E12, and BoNT/A5(B3), and no specific subtypes were predominant in the botulism incidents. This study is critical for disease surveillance and early warning systems, while also providing a basis for food safety regulation, clinical diagnosis, and treatment in the future."

Journal

Complete genome sequence analysis of Edwardsiella tarda SC002 from hatchlings of Siamese crocodile. (PubMed, Front Vet Sci) - "Pan-genome and comparative genome analyses of the complete sequenced genomes confirmed their evolutionary relationships. The present study confirmed that E. tarda SC002 is a potential pathogen bearing a bulk amount of antibiotic resistance, virulence, and pathogenic genes and its open pan-genome may enhance its host range in the future."

Journal • Infectious Disease

Cosmosporasides F-H, three new sugar alcohol conjugated acyclic sesquiterpenes from a Fusarium oxysporum fungus. (PubMed, Nat Prod Res) - "Three new sugar alcohol conjugated acyclic sesquiterpenes, cosmosporasides F-H (1-3), were isolated from the fermented cultures of Fusarium oxysporum SC0002. Their structures were elucidated by extensive analysis of spectroscopic data, including H-C long-range coupling constants (J). Their antibacterial, cytotoxic and anti-inflammatory activities were evaluated."

Journal

SC-002 in patients with relapsed or refractory small cell lung cancer and large cell neuroendocrine carcinoma: Phase 1 study. (PubMed, Lung Cancer) - "SC-002 treatment was associated with systemic toxicity and limited efficacy."

Clinical • Journal • P1 data • Lung Cancer • Neuroendocrine Tumor • Oncology • Small Cell Lung Cancer • Solid Tumor • Thoracic Cancer