S 3304 / Shionogi - LARVOL DELTA

S4502: Common Problems in the Newborn Nursery and Beyond (Repeats from S3304) (AAP-NCE 2024) - "This interactive, case-based session will review common issues that arise in newborns with an emphasis on pathophysiology, diagnosis, management, and outcomes. Faculty will provide succinct explanations and visual illustrations."

Unveiling the bioinformatic genes and their involved regulatory mechanisms in type 2 diabetes combined with osteoarthritis. (PubMed, Front Immunol) - "The Receiver Operating characteristic (ROC) analysis demonstrated the significant diagnostic potential of MMP9 and ANGPTL4.Moreover, we identified raloxifene, ezetimibe, and S-3304 as promising agents for patients with both T2D and OA. This study uncovers the shared signaling pathways, biomarkers, potential therapeutics, and diagnostic models for individuals suffering from both T2D and OA. These findings not only present novel perspectives on the complex interplay between T2D and OA but also hold significant promise for improving the clinical management and prognosis of patients with this concurrent condition."

Biomarker • Journal • Diabetes • Immunology • Metabolic Disorders • Osteoarthritis • Pain • Rheumatology • Type 2 Diabetes Mellitus • MMP9

Identification of key genes in colorectal cancer diagnosis by co-expression analysis weighted gene co-expression network analysis. (PubMed, Comput Biol Med) - "Taken together, the results of the current study indicated that seven hub genes including COL1A2, COL5A1, COL5A2, SERPINH1, MMP9, SPARC, and COL1A1 which were upregulated in CRC could be used as a diagnostic and progression biomarker of CRC. On the other hand, miR-940 which targets SERPINH1 could be used as a potential biomarker of CRC. More ever, Andecaliximab, Carboxylated glucosamine, Marimastat, Tozuleristide, S-3304, Incyclinide, Curcumin, Prinomastat, Demethylwedelolactone, Bevacizumab, Ocriplasmin , and Collagenase clostridium histolyticum were introduced as therapeutic agents for CRC which their therapeutic potential should be evaluated experimentally."

Journal • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • COL1A1 • COL1A2 • COL5A1 • COL5A2 • MMP9 • SERPINH1

miR-6742-5p regulates the invasion and migration of lung adenocarcinoma cells via mediating FGF8/ERK12/MMP9/MMP2 signaling pathway. (PubMed, Aging (Albany NY)) - "We conclude that miR-6742-5p might be a regulator of LUAD progression by targeting FGF8/ERK1/2/MMPs signaling pathway, which provides a novel therapeutic target for LUAD."

Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • MAPK1 • MMP2 • MMP9