Silverzine Tulle (Silver Sulfadiazine) / MinaPharm - LARVOL DELTA

Addition of Copper Chloride and Zinc Chloride to Liquid-Stored Pig Semen Reduces Bacterial Growth Without Impairing Sperm Quality. (PubMed, Int J Mol Sci) - "Separate metal ions (Ag, silver sulfadiazine; Al, aluminum chloride; Zn, zinc chloride; and Cu, and cooper chloride) were added at different concentrations (100 μM, 300 μM, 500 μM, 1 mM, and 10 mM) to seminal doses, which were stored at 17 °C for 48 h. Motility, viability, and the intracellular levels of reactive oxygen species (ROS) were tested to determine their effects on sperm quality maintenance...In spite of this, the inhibition of bacterial growth was not complete, thus suggesting that these two ions could contribute to reducing bacterial growth but should be combined with other strategies, such as a lower storage temperature and a decreased concentration of antibiotics. Further research is warranted to address whether copper and zinc chloride could have a synergistic effect when added together."

Journal

Silver Sulfadiazine With Hyaluronic Acid Versus Silver Sulfadiazine Alone in Partial-Thickness Burns (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Dr Muhammad Naveed Shahzad

New trial • Thermal Injury

The role of negative pressure wound therapy on TGF-β1, MMP-9, α-SMA, and collagen type III in preventing burn contractures in a porcine model. (PubMed, J Plast Reconstr Aesthet Surg) - "NPWT may reduce wound contraction and accelerates re-epithelialization without impairing wound healing, confirmed by modulation of MMP-9, TGFβ1, α-SMA, and COL3, suggesting the potential to minimize contracture scar formation."

Journal • Preclinical • Thermal Injury • MMP9 • TGFB1

Case Report of Wound Treatment with Hyiodine Gel in an Occasional KID Syndrome Patient. (PubMed, J Clin Med) - "Initial outpatient treatment included serial sharp surgical debridement under local anesthesia, combined with topical keratolytics and silver sulfadiazine with hyaluronic acid. Surgical debridement and excision, when combined with targeted dermatological and antimicrobial therapy, can be an effective and safe strategy for managing chronic wounds in KID syndrome. This case highlights the importance of multidisciplinary collaboration and individualized surgical planning in this extremely rare disorder."

Journal • Alopecia • Anesthesia • Atopic Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Psoriasis • Rare Diseases • Vitiligo

Substance-Based Medical Device in Wound Care: Bridging Regulatory Clarity and Therapeutic Innovation. (PubMed, Polymers (Basel)) - "These products often incorporate biopolymers such as hyaluronic acid or chitosan, alone or in combination with antimicrobial agents like silver nanoparticles (AgNPs) or silver sulfadiazine (SSD), offering hydration, tissue protection, and control of microbial burden in both acute and chronic wounds...Through selected examples and case analyses, the review highlights inconsistencies in classification across Member States and underscores the need for a more harmonized, evidence-based, and proportionate regulatory approach. Overall, SBMDs challenge traditional regulatory boundaries and call for a framework capable of accommodating complex, multifunctional products while ensuring patient safety and regulatory coherence."

Journal • Review

Re-Epithelialization Comparison Between Topical Administration of 1% Feracrylum and Silver Sulfadiazine in the Treatment of Deep Dermal Burns in Wistar Rats. (PubMed, Ann Burns Fire Disasters) - "In this animal study, 1FA administration showed improved wound healing and re-epithelialization of the skin after deep dermal burns. These findings may lead to a new therapeutic approach for burn wound healing."

Journal • Preclinical • Anesthesia • Thermal Injury

Innovative Therapeutic Strategies for Chronic Ulcer Healing. (PubMed, Adv Exp Med Biol) - "This study investigates the effects of ascorbic acid, arginine, silver sulfadiazine, and colloidal silver on ulcer healing, aiming to elucidate their role in the restoration of skin integrity...The results of this study contribute to the growing body of evidence supporting alternative and complementary treatments for chronic wound management. By refining clinical protocols and integrating these bioactive agents into standardized treatment regimens, healthcare professionals may improve healing rates, reduce complications, and enhance overall patient care."

Journal

Therapeutic effects of skin repair plus ointment on molecular and morphological changes in burn wounds: A rat model. (PubMed, PLoS One) - "The groups were designated as follows: negative control (burn treated with normal saline), positive control (burn treated with 1% silver sulfadiazine), and tested (burn treated with Remanco cream)...Molecular investigations revealed that the Remanco-treated group demonstrated a significant increase in the levels of two essential growth factors: TGF-beta on day 3 and IGF-1 on day 9, with a p-value less than 0.05. In summary, Remanco cream holds potential for enhancing wound healing in animal models, but further studies are necessary to investigate its potential clinical applications."

Journal • Preclinical • Thermal Injury • IGF1 • TGFB1

Evaluation of in vitro antioxidant activity of chrysin and in vivo wound healing potential of an optimized chrysin emulgel formulation. (PubMed, J Biomater Sci Polym Ed) - "In the excision model, the chrysin emulgel achieved 97.93% wound contraction by day 12 with an epithelization period of 14.83 ± 0.30 days, similar to the standard (98.17%; 14.33 ± 0.42 days). Overall, the optimized chrysin emulgel demonstrated strong antioxidant activity, effective wound healing, and excellent safety, suggesting its potential as a natural alternative to silver sulfadiazine for topical wound management."

Journal • Preclinical

Repurposing amlexanox as a topical anti-inflammatory and antioxidant intervention for diabetic foot ulcers: insights from in-silico and in-vivo studies. (PubMed, Inflammopharmacology) - "Taken together, the present work highlights the mechanisms associated with ALX mediated wound healing in diabetic rats thereby demonstrating its potential as a promising strategy for DFU management."

Journal • Preclinical • Diabetes • Inflammation • Metabolic Disorders • IL1B • IL6 • MMP9 • TNFA

From Vineyard to Hydrogel: Antioxidant, Anti-Inflammatory, and Regenerative Potential of Grape Skin Extract in Diabetic Wound Repair. (PubMed, Pharmaceutics) - "Afterwards, male Wistar rats were divided into four groups: untreated control (NC), silver sulfadiazine-treated (PC), hydrogel without extract (HG), and hydrogel with GSE (HG + GSE)...These outcomes are attributed to the sustained release of bioactive polyphenols such as naringin, caffeic acid, and epicatechin. Overall, this GSE-based hydrogel presents a multifunctional, biocompatible, sustainable, and effective strategy for diabetic wound care."

Journal • Dermatology • Inflammation • IL6 • TNFA

WITHDRAWN Wound healing effect of Ethanolic extract of Newbouldia laevis leaf in Albino Sprague-Dawley rats (ASTMH 2025) - "The 20% ethanolic leaves extract of Newbouldia laevis leaves formulated into cream demonstrated a better potential for wound healing at the end of the study and can be used as an alternative medicine at an optimal concentration for the management and treatment of wounds as1% Silver Sulfadiazine cream. We however recommend further studies of toxicological tests to ensure the complete safety of the extract on humans and on the optimal concentration of the extract with the highest wound healing effect."

Preclinical • Diabetes • Fibrosis • Immunology • Infectious Disease • Malaria • Metabolic Disorders

Assessment of In Vivo Analgesic, Anti-Inflammatory and Wound Healing Properties of Aqueous Leaf Extract of Annona reticulata Linn. (PubMed, ScientificWorldJournal) - "Remarkable wound healing activity was also noted in the test extract in the burn wound model; the observed epithelialisation period for 10% ointment of aqueous extract was 13 ± 0.32 days, whereas the epithelialisation period for standard medication silver sulfadiazine was 14.20 ± 0.38 days. Moreover, probable components responsible for achieving these potentials were identified by utilising GC-MS analytical data."

Journal • Preclinical • Pain

Bioinspired Membranes with Silver Sulfadiazine and Piperine for Enhanced Cutaneous Permeability. (PubMed, ACS Omega) - "For E. coli clinical strains, the addition of PIP enhanced the bactericidal effect of SSD (76% vs 33% reduction), consistent with its reported role as an efflux pump inhibitor. Overall, these multifunctional membranes combine sustained SSD release, improved and reproducible skin permeation, and enhanced antimicrobial efficacy in the evaluated strains, offering a promising platform for advanced wound dressings in burn care and other skin injuries."

Journal

Bacterial cellulose nanofibers fabricated using electrospinning as a wound dressing material. (PubMed, Int J Biol Macromol) - "To further enhance the therapeutic efficacy, the scaffold surface was modified with a gum arabic matrix loaded with silver sulfadiazine, resulting in a dual-functional composite (BCP-LSD) with both antimicrobial and anesthetic properties...Lidocaine exhibited a 29 % burst release in the first 30 min, with complete release achieved within 108 h. These findings underscore the potential of the BCP-LSD nanofiber scaffold as a next-generation wound dressing, offering a synergistic combination of antimicrobial protection, sustained analgesic release, and a bioactive environment favorable for wound healing."

Journal • Anesthesia • Infectious Disease • Pain

Programmed Therapy of Diabetic Foot Ulcers Using a Dual-Responsive Multifunctional Hydrogel Driven by Diatomic Nanoenzymes (ChiCTR) - P=N/A | N=50 | Not yet recruiting | Sponsor: General Hospital of Ningxia Medical University; General Hospital of Ningxia Medical University

New trial

Anti-inflammatory and immunomodulatory effects of camel milk exosomes (CM-Exo) in rat models for burn wound healing. (PubMed, Iran J Basic Med Sci) - "Evaluation of lesion size and histological data indicated a significant reduction in lesion size in the HCM-Exo and 1% silver sulfadiazine cream (Exo+SS) group compared to both the 1% silver sulfadiazine (SS) group and the negative control (Ctrl) group across days 0, 3, 7, and 14. Our study concluded that HCM-Exo significantly accelerated wound healing and reduced inflammatory reactions."

Journal • Preclinical • IL6

Repurposing Metal-Based Therapeutics for Human Metapneumovirus (HMPV): An Integrative Computational Approach. (PubMed, Bioinorg Chem Appl) - "Top-ranked compounds-Auranofin, silver sulfadiazine, and gallium nitrate-exhibited superior binding affinities (ΔG_binding: -68.5 to -62.7 kcal/mol), stable protein-ligand complexes (RMSD: 2.1-2.4 Å), and consistent interaction profiles when benchmarked against known antivirals ribavirin and favipiravir. Furthermore, ADMET predictions revealed acceptable oral bioavailability, low predicted toxicity, and renal clearance profiles, though known risks such as gallium accumulation were acknowledged. This integrative study highlights the potential of repurposed metallodrugs as novel anti-HMPV agents, offering a rational and cost-effective path toward therapeutic advancement."

Journal

Shifting the clinical paradigm: Copper versus silver wound dressings - Where we are and what we are looking for. (PubMed, J Biomater Appl) - "Traditional silver formulations, such as silver sulfadiazine (1%) and silver nitrate (0.5%), demonstrate antimicrobial activity but are limited by cytotoxicity and lack of long-term healing benefits...CODs represent a biologically attractive alternative with dual antimicrobial and regenerative properties. Nonetheless, the current body of evidence is insufficient to declare a paradigm shift in wound healing, and CODs should presently be regarded as promising adjuncts pending validation in high-quality randomized trials."

Journal • Review • Infectious Disease • Thermal Injury • Venous Ulcer

Valorization of Channa striatus waste skin for developing marine collagen peptide based hydrogels for potential wound dressings. (PubMed, RSC Adv) - "The Ch/PVA5-CP2 hydrogel had multiple bioactive properties and antibacterial activity against Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli, anti-inflammatory activity, antioxidant activity and well-balanced mechanical stability and elasticity. In a preliminary seven-day trial on mice, this formulation showed promising results in treating burn wounds compared to commercial burn ointment (silver sulfadiazine 1%), and a negative control, warranting further in vivo studies using the hydrogel."

Journal • Infectious Disease

Development and characterization of injection molded multi drug delivery IUD for women's health therapy against bacterial and viral infections. (PubMed, Drug Dev Ind Pharm) - "Devices were loaded with acyclovir and silver sulfadiazine, with actual drug incorporation measured at ∼2-3% w/w for single or combination formulations. This approach presents a promising, scalable strategy for localized treatment of gynecological infections. Further optimization and in vivo studies are warranted to validate the device's therapeutic effectiveness and regulatory readiness."

Journal • Candidiasis • Infectious Disease • Long-acting Reversible Contraceptives • Vaginitis • Women's Health

The impact of negative pressure wound therapy on epidermal stem cells and keratinocyte growth factor in deep dermal burn injury: An experimental study. (PubMed, Burns) - "The continuous NPWT group demonstrated significantly elevated KGF levels on days 1, 3, and 7, which corresponded to a significant increase in ESC. Further research is warranted to confirm these findings."

Journal • Infectious Disease • Thermal Injury • CK19 • KRT19

Laponite®-Based Smart Hydrogels for Sustained Topical Delivery of Silver Sulfadiazine: A Strategy for the Treatment of Contaminated or Biofilm-Forming Wounds. (PubMed, Pharmaceutics) - " LAP-based hydrogels are promising smart delivery systems for AgSD, combining mechanical robustness, controlled drug release, and effective antibacterial and antibiofilm activities. These findings support their potential use in topical therapies for infected and chronic wounds, particularly where biofilm formation is a challenge."

Journal • Thermal Injury

Multifunctional Metal Oxide-Doped Nanofluorophosphate Glass: A Bioactive Topical Formulation for Ischemic Wound Repair. (PubMed, ACS Biomater Sci Eng) - "In vivo, the MgFP-PPG formulation resulted in 72.5% wound contraction by day 7, compared to 61.3% with silver sulfadiazine and 45.8% in untreated wounds. Histopathological evaluation further revealed greater granulation tissue formation, increased Cluster of Differentiation 34 (CD34) expression, and enhanced VEGF signaling in burn wound models treated with MgFP-PPG and appreciably enhanced the wound healing by promoting cellular proliferation (Ki67). This study presents a promising approach for next-generation ischemic wound healing therapies."

Journal • CD34

Effects of Photobiomodulation Adjunct Therapy via Superpulsed 904 nm Laser in Patients With Second-Degree Burns: Randomized Controlled Clinical Trial. (PubMed, J Biophotonics) - "This randomized, active-controlled trial evaluated the effects of 904 nm superpulsed laser NIR-PBMT as an adjunct to standard care (SOC; 1% silver-sulfadiazine, paraffin-gauze) for second-degree burn patients...These findings indicate that NIR-PBMT is an effective non-invasive adjunct therapy for faster repair of second-degree burns. Further, large-scale trials are needed."

Clinical • Journal • Infectious Disease • Inflammation • Pain • Thermal Injury • CRP