Silverzine Tulle (Silver Sulfadiazine) / MinaPharm - LARVOL DELTA

Repurposing amlexanox as a topical anti-inflammatory and antioxidant intervention for diabetic foot ulcers: insights from in-silico and in-vivo studies. (PubMed, Inflammopharmacology) - "Taken together, the present work highlights the mechanisms associated with ALX mediated wound healing in diabetic rats thereby demonstrating its potential as a promising strategy for DFU management."

Journal • Preclinical • Diabetes • Inflammation • Metabolic Disorders • IL1B • IL6 • MMP9 • TNFA

From Vineyard to Hydrogel: Antioxidant, Anti-Inflammatory, and Regenerative Potential of Grape Skin Extract in Diabetic Wound Repair. (PubMed, Pharmaceutics) - "Afterwards, male Wistar rats were divided into four groups: untreated control (NC), silver sulfadiazine-treated (PC), hydrogel without extract (HG), and hydrogel with GSE (HG + GSE)...These outcomes are attributed to the sustained release of bioactive polyphenols such as naringin, caffeic acid, and epicatechin. Overall, this GSE-based hydrogel presents a multifunctional, biocompatible, sustainable, and effective strategy for diabetic wound care."

Journal • Dermatology • Inflammation • IL6 • TNFA

WITHDRAWN Wound healing effect of Ethanolic extract of Newbouldia laevis leaf in Albino Sprague-Dawley rats (ASTMH 2025) - "The 20% ethanolic leaves extract of Newbouldia laevis leaves formulated into cream demonstrated a better potential for wound healing at the end of the study and can be used as an alternative medicine at an optimal concentration for the management and treatment of wounds as1% Silver Sulfadiazine cream. We however recommend further studies of toxicological tests to ensure the complete safety of the extract on humans and on the optimal concentration of the extract with the highest wound healing effect."

Preclinical • Diabetes • Fibrosis • Immunology • Infectious Disease • Malaria • Metabolic Disorders

Assessment of In Vivo Analgesic, Anti-Inflammatory and Wound Healing Properties of Aqueous Leaf Extract of Annona reticulata Linn. (PubMed, ScientificWorldJournal) - "Remarkable wound healing activity was also noted in the test extract in the burn wound model; the observed epithelialisation period for 10% ointment of aqueous extract was 13 ± 0.32 days, whereas the epithelialisation period for standard medication silver sulfadiazine was 14.20 ± 0.38 days. Moreover, probable components responsible for achieving these potentials were identified by utilising GC-MS analytical data."

Journal • Preclinical • Pain

Bioinspired Membranes with Silver Sulfadiazine and Piperine for Enhanced Cutaneous Permeability. (PubMed, ACS Omega) - "For E. coli clinical strains, the addition of PIP enhanced the bactericidal effect of SSD (76% vs 33% reduction), consistent with its reported role as an efflux pump inhibitor. Overall, these multifunctional membranes combine sustained SSD release, improved and reproducible skin permeation, and enhanced antimicrobial efficacy in the evaluated strains, offering a promising platform for advanced wound dressings in burn care and other skin injuries."

Journal

Bacterial cellulose nanofibers fabricated using electrospinning as a wound dressing material. (PubMed, Int J Biol Macromol) - "To further enhance the therapeutic efficacy, the scaffold surface was modified with a gum arabic matrix loaded with silver sulfadiazine, resulting in a dual-functional composite (BCP-LSD) with both antimicrobial and anesthetic properties...Lidocaine exhibited a 29 % burst release in the first 30 min, with complete release achieved within 108 h. These findings underscore the potential of the BCP-LSD nanofiber scaffold as a next-generation wound dressing, offering a synergistic combination of antimicrobial protection, sustained analgesic release, and a bioactive environment favorable for wound healing."

Journal • Anesthesia • Infectious Disease • Pain

Programmed Therapy of Diabetic Foot Ulcers Using a Dual-Responsive Multifunctional Hydrogel Driven by Diatomic Nanoenzymes (ChiCTR) - P=N/A | N=50 | Not yet recruiting | Sponsor: General Hospital of Ningxia Medical University; General Hospital of Ningxia Medical University

New trial

Anti-inflammatory and immunomodulatory effects of camel milk exosomes (CM-Exo) in rat models for burn wound healing. (PubMed, Iran J Basic Med Sci) - "Evaluation of lesion size and histological data indicated a significant reduction in lesion size in the HCM-Exo and 1% silver sulfadiazine cream (Exo+SS) group compared to both the 1% silver sulfadiazine (SS) group and the negative control (Ctrl) group across days 0, 3, 7, and 14. Our study concluded that HCM-Exo significantly accelerated wound healing and reduced inflammatory reactions."

Journal • Preclinical • IL6

Repurposing Metal-Based Therapeutics for Human Metapneumovirus (HMPV): An Integrative Computational Approach. (PubMed, Bioinorg Chem Appl) - "Top-ranked compounds-Auranofin, silver sulfadiazine, and gallium nitrate-exhibited superior binding affinities (ΔG_binding: -68.5 to -62.7 kcal/mol), stable protein-ligand complexes (RMSD: 2.1-2.4 Å), and consistent interaction profiles when benchmarked against known antivirals ribavirin and favipiravir. Furthermore, ADMET predictions revealed acceptable oral bioavailability, low predicted toxicity, and renal clearance profiles, though known risks such as gallium accumulation were acknowledged. This integrative study highlights the potential of repurposed metallodrugs as novel anti-HMPV agents, offering a rational and cost-effective path toward therapeutic advancement."

Journal

Shifting the clinical paradigm: Copper versus silver wound dressings - Where we are and what we are looking for. (PubMed, J Biomater Appl) - "Traditional silver formulations, such as silver sulfadiazine (1%) and silver nitrate (0.5%), demonstrate antimicrobial activity but are limited by cytotoxicity and lack of long-term healing benefits...CODs represent a biologically attractive alternative with dual antimicrobial and regenerative properties. Nonetheless, the current body of evidence is insufficient to declare a paradigm shift in wound healing, and CODs should presently be regarded as promising adjuncts pending validation in high-quality randomized trials."

Journal • Review • Infectious Disease • Thermal Injury • Venous Ulcer

Valorization of Channa striatus waste skin for developing marine collagen peptide based hydrogels for potential wound dressings. (PubMed, RSC Adv) - "The Ch/PVA5-CP2 hydrogel had multiple bioactive properties and antibacterial activity against Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli, anti-inflammatory activity, antioxidant activity and well-balanced mechanical stability and elasticity. In a preliminary seven-day trial on mice, this formulation showed promising results in treating burn wounds compared to commercial burn ointment (silver sulfadiazine 1%), and a negative control, warranting further in vivo studies using the hydrogel."

Journal • Infectious Disease

Development and characterization of injection molded multi drug delivery IUD for women's health therapy against bacterial and viral infections. (PubMed, Drug Dev Ind Pharm) - "Devices were loaded with acyclovir and silver sulfadiazine, with actual drug incorporation measured at ∼2-3% w/w for single or combination formulations. This approach presents a promising, scalable strategy for localized treatment of gynecological infections. Further optimization and in vivo studies are warranted to validate the device's therapeutic effectiveness and regulatory readiness."

Journal • Candidiasis • Infectious Disease • Long-acting Reversible Contraceptives • Vaginitis • Women's Health

The impact of negative pressure wound therapy on epidermal stem cells and keratinocyte growth factor in deep dermal burn injury: An experimental study. (PubMed, Burns) - "The continuous NPWT group demonstrated significantly elevated KGF levels on days 1, 3, and 7, which corresponded to a significant increase in ESC. Further research is warranted to confirm these findings."

Journal • Infectious Disease • Thermal Injury • CK19 • KRT19

Laponite®-Based Smart Hydrogels for Sustained Topical Delivery of Silver Sulfadiazine: A Strategy for the Treatment of Contaminated or Biofilm-Forming Wounds. (PubMed, Pharmaceutics) - " LAP-based hydrogels are promising smart delivery systems for AgSD, combining mechanical robustness, controlled drug release, and effective antibacterial and antibiofilm activities. These findings support their potential use in topical therapies for infected and chronic wounds, particularly where biofilm formation is a challenge."

Journal • Thermal Injury

Multifunctional Metal Oxide-Doped Nanofluorophosphate Glass: A Bioactive Topical Formulation for Ischemic Wound Repair. (PubMed, ACS Biomater Sci Eng) - "In vivo, the MgFP-PPG formulation resulted in 72.5% wound contraction by day 7, compared to 61.3% with silver sulfadiazine and 45.8% in untreated wounds. Histopathological evaluation further revealed greater granulation tissue formation, increased Cluster of Differentiation 34 (CD34) expression, and enhanced VEGF signaling in burn wound models treated with MgFP-PPG and appreciably enhanced the wound healing by promoting cellular proliferation (Ki67). This study presents a promising approach for next-generation ischemic wound healing therapies."

Journal • CD34

Effects of Photobiomodulation Adjunct Therapy via Superpulsed 904 nm Laser in Patients With Second-Degree Burns: Randomized Controlled Clinical Trial. (PubMed, J Biophotonics) - "This randomized, active-controlled trial evaluated the effects of 904 nm superpulsed laser NIR-PBMT as an adjunct to standard care (SOC; 1% silver-sulfadiazine, paraffin-gauze) for second-degree burn patients...These findings indicate that NIR-PBMT is an effective non-invasive adjunct therapy for faster repair of second-degree burns. Further, large-scale trials are needed."

Clinical • Journal • Infectious Disease • Inflammation • Pain • Thermal Injury • CRP

Heterotopic Ossification Secondary to Chronic Venous Insufficiency A Case Report (EADV 2025) - "The patient received a 7-day course of colistin (6 million units/day) and ceftriaxone (4 g/day) systemic therapy. Locally, wet dressings with boric acid and silver sulfadiazine ointment were recommended... There are no established treatment guidelines for heterotopic ossification secondary to chronic venous insufficiency. This case shows a rare presentation of heterotopic ossification, emphasizing the importance of effective preventive strategies in patients with venous leg ulcers."

Case report • Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Metabolic Disorders • Nephrology • Pulmonary Arterial Hypertension • Renal Disease • Venous Ulcer

Erysipelas-like pathomimia: Unraveling the diagnostic complexity of self-induced dermatosis and psychological distress (EADV 2025) - "The patient was initially managed with a reparative cream, topical silver sulfadiazine, and oral antibiotic therapy... Pathomimia remains a rare condition that should be considered in atypical clinical presentations when no clear organic cause is identified. Self-inflicted lesions are typically located within the reach of the dominant hand. Management requires a multidisciplinary approach, with a primary focus on psychological support."

CNS Disorders • Dermatology • Mood Disorders • Psychiatry • Sleep Disorder

Dual functional chitosan-coated spanlastics for topical delivery of ceftazidime in the treatment of bacterial burn wound infections. (PubMed, Int J Biol Macromol) - "Burn wound infections (BWIs) remain a significant cause of morbidity and mortality due to persistent biofilms, enzymatic antibiotic degradation, and limited drug penetration. In vivo evaluation in rats burn wound model showed accelerated wound healing, significant reduction in bacterial burden, downregulation of pro-inflammatory cytokines, and superior histopathological recovery compared to marketed 1 % silver sulfadiazine cream USP. Collectively, CCNP-G represents a dual-functional therapeutic platform that combines the antimicrobial and biofilm-disrupting properties of chitosan with the penetration and sustained release benefits of spanlastics within a hydrogel matrix, offering a clinically relevant strategy for effective burn wound infection management."

Journal • Infectious Disease

Histopathological assessment of fibrin sealants in burn injury treatment: insights from a rat model (ECP 2025) - " Sprague-Dawley rats underwent partial thickness contact thermal burn wound, divided into three groups: control group (no treatment), silver sulfadiazine cream group and TISSEEL™ group... TISSEELTM appears to be a safe and effective choice for treating partial-thickness burn injuries. Thus, TISSEELTM could be used in clinical settings for the initial treatment of partial-thickness burn injuries."

Preclinical • Inflammation • Thermal Injury • CD31 • PECAM1 • VIM

Efficacy and safety of compound sulfadiazine zinc gel in treating second-degree burn wounds: A prospective, multicenter, randomized, positive drug-controlled clinical trial (ChiCTR) - P4 | N=210 | Not yet recruiting | Sponsor: Chengdu City Second People's Hospital; Chengdu City Second People's Hospital

New P4 trial

Efficacy of Topical Folic Acid in the Healing of Deep Second-Degree Burn Wound via Redox Modulation in Rat. (PubMed, Biomed Res Int) - "Animals were randomly placed into five groups (n = 5) as follows: (1) non-treatment group, (2) cream base treated group, (3) silver sulfadiazine (SSD) 1% treated group, (4) folic acid 1% cream treated group, and (5) folic acid 4% cream treated group...Furthermore, 1% and 4% folic acid creams significantly (p < 0.05) increased the TAC content of skin tissue and suppressed the ROS levels compared to non-treatment and cream base groups. In conclusion, folic acid is capable of accelerating the burn wound healing process possibly via modulating oxidative stress."

Journal • Preclinical

Review of Applications of Zeolites in Dermatology: Molecular Perspectives and Translational Potentials. (PubMed, Int J Mol Sci) - "Formulations such as silver-sulfadiazine-zeolite composites, Zn-clinoptilolite for acne, and zeolite-integrated microneedles offer innovative avenues for targeted therapy. Zeolite-based systems represent a promising shift toward multifunctional, localized dermatologic treatments. However, further research into long-term safety, formulation optimization, and clinical validation is essential to transition these materials into mainstream therapeutic use."

Journal • Review • Acne Vulgaris • Aesthetic Medicine • Dermatology • Infectious Disease • Melanoma • Oncology • Solid Tumor

Assessment of the Impact of Astragalus floccosus Boiss. Extract on Wound Based on Phytoestrogenic Properties: An In vitro and In vivo Study. (PubMed, Iran J Med Sci) - "For the in vivo test, rats were categorized into five groups and received daily applications of a cream containing different concentrations of the extract: 5%, 10%, silver sulfadiazine, the ointment base, and no treatment for a duration of 21 days...Wound healing processes were observed in rats treated with a 5% A. floccosus extract cream. This finding highlights the potential for future studies on wound healing processes using this extract."

Journal • Preclinical • Fibrosis • Immunology

Evaluation of the Effectiveness of a Topical Medical Device in Wound Healing and Symptom Relief in the Postoperative Period of Open Excisional Hemorrhoidectomy (The Emor Study) (clinicaltrials.gov) - P4 | N=114 | Completed | Sponsor: University of Cagliari | Recruiting ➔ Completed

Trial completion • Gastroenterology • Gastrointestinal Disorder • Pain • Pruritus