Silverzine Tulle (Silver Sulfadiazine) / MinaPharm - LARVOL DELTA

A randomized open-label study comparing the safety and efficacy of a natural antimicrobial dressing with silver sulfadiazine in the management of second-degree burn wounds. (PubMed, Int J Burns Trauma) - "These findings suggest that VELVERT may serve as a more effective alternative for second-degree burn treatment, offering improved healing rates. Further research with larger sample sizes is recommended to validate its clinical benefits over standard treatments."

Journal • Infectious Disease • Pain • Thermal Injury

Umbilical cord antiseptics for preventing sepsis and death among newborns. (PubMed, Cochrane Database Syst Rev) - "Topical application of 4.0% chlorhexidine to the umbilical cord likely reduces the risk of cord infection and may reduce neonatal mortality in low- and middle-income countries, though it probably delays cord separation by about two days. In high-income countries, evidence for chlorhexidine is very uncertain. For 70% alcohol, evidence from low- and middle-income countries is very uncertain for prevention of infection, and its use may result in little or no difference in cord separation time. In high-income countries, moderate-certainty evidence suggests that alcohol likely delays cord separation slightly."

Clinical • Journal • Review • Addiction (Opioid and Alcohol) • Infectious Disease • Septic Shock

Observation on the Efficacy of Nano-Silver Dressing Combined With Silver Sulfadiazine Cream in the Treatment of Second-Degree Burn Wounds. (PubMed, J Craniofac Surg) - "The bacterial infection rate in the nanosilver antibacterial dressing group was significantly lower than that in the silver sulfadiazine cream group. Nano-silver dressing combined with silver sulfadiazine cream has a significant therapeutic effect on burn wounds, which can improve the overall treatment efficiency, shorten wound healing time, pigmentation subsidence time, and reduce inflammatory reaction."

Journal • Infectious Disease • IL6 • TNFA

Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns (clinicaltrials.gov) - P2 | N=60 | Recruiting | Sponsor: Skingenix, Inc. | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Thermal Injury

Investıgatıon of the In vitro and In vivo effect of a mixture of Ficus carica L. and Hippophae rhamnoides L. on experımentally induced burns in rats. (PubMed, Burns) - "The FCHR cream formulation effectively promotes wound healing in both in vitro and in vivo models through its anti-inflammatory and pro-angiogenic effects. These findings highlight the potential of FCHR in enhancing tissue regeneration and provide a foundation for further detailed histopathological, biochemical, and molecular investigations of the wound healing process."

Journal • Preclinical • Thermal Injury • IL6 • MMP2 • TGFB1 • TNFA

Injection molded multidrug intravaginal rings with antimicrobial properties for prophylaxis and cancer treatment in women's health context. (PubMed, Drug Dev Ind Pharm) - " The selected drugs were copper sulfate (CuSo4), silver sulfadiazine (AgSD), and fluorouracil (FU), which offer a combination of antibacterial, antifungal and antiviral properties. Preliminary results suggest that drug release was sustained for more than 40 days, with high drug incorporation capacity, and high process reproducibility, with LDPE mechanical properties minimally affected. This study demonstrates the feasibility of using injection molding to produce multidrug LDPE intravaginal rings with stable mechanical properties, drug-loading capacity, and sustained release, highlighting a promising and scalable platform for future therapeutic and prophylactic applications in women's health."

Journal • Cervical Cancer • Gynecology • Human Immunodeficiency Virus • Infectious Disease • Oncology • Solid Tumor • Women's Health

A thermoresponsive spray-based no-contact delivery system for burn and diabetic wound care. (PubMed, Int J Biol Macromol) - "In-vivo studies in rats showed the optimised spray significantly promoted re-epithelialization and neovascularisation during the inflammatory phase, outperforming both silver sulfadiazine cream and conventional Asiatic acid-curcumin gel. The histopathology images also support the hypothesis."

Journal

Effectiveness of silver sulfadiazine-coated catheters in preventing thrombophlebitis in hospitalized foals. (PubMed, J Vet Intern Med) - "Silver sulfadiazine-coated catheters delay thrombophlebitis development and are well tolerated."

Journal • Cardiovascular • Critical care • Hematological Disorders • Infectious Disease • Thrombosis

Photobiomodulation and Sericin in the Treatment of Second-Degree Burns Induced in Wistar Rats. (PubMed, Wound Repair Regen) - "To assess their therapeutic value, 60 rats were randomised into six groups: untreated control (CON), silver sulfadiazine (SUL), sericin cream (SER), PBM alone, SUL + PBM and SER + PBM...Overall, the results indicate that both sericin and PBM positively influence tissue repair, with combined therapy-particularly SER + PBM-yielding enhanced collagen deposition and biochemical markers consistent with improved healing. Further studies are warranted to clarify the underlying biological mechanisms driving these outcomes."

Journal • Preclinical • Oncology • Thermal Injury • CAT

Silver sulfadiazine in modern dermatology. (PubMed, Dermatol Online J) - "Despite these limitations, silver sulfadiazine remains a cornerstone of dermatological wound care. Continued research is needed to optimize its use alongside emerging therapies."

Journal • Review • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Thermal Injury

Addition of Copper Chloride and Zinc Chloride to Liquid-Stored Pig Semen Reduces Bacterial Growth Without Impairing Sperm Quality. (PubMed, Int J Mol Sci) - "Separate metal ions (Ag, silver sulfadiazine; Al, aluminum chloride; Zn, zinc chloride; and Cu, and cooper chloride) were added at different concentrations (100 μM, 300 μM, 500 μM, 1 mM, and 10 mM) to seminal doses, which were stored at 17 °C for 48 h. Motility, viability, and the intracellular levels of reactive oxygen species (ROS) were tested to determine their effects on sperm quality maintenance...In spite of this, the inhibition of bacterial growth was not complete, thus suggesting that these two ions could contribute to reducing bacterial growth but should be combined with other strategies, such as a lower storage temperature and a decreased concentration of antibiotics. Further research is warranted to address whether copper and zinc chloride could have a synergistic effect when added together."

Journal

Silver Sulfadiazine With Hyaluronic Acid Versus Silver Sulfadiazine Alone in Partial-Thickness Burns (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Dr Muhammad Naveed Shahzad

New trial • Thermal Injury

The role of negative pressure wound therapy on TGF-β1, MMP-9, α-SMA, and collagen type III in preventing burn contractures in a porcine model. (PubMed, J Plast Reconstr Aesthet Surg) - "NPWT may reduce wound contraction and accelerates re-epithelialization without impairing wound healing, confirmed by modulation of MMP-9, TGFβ1, α-SMA, and COL3, suggesting the potential to minimize contracture scar formation."

Journal • Preclinical • Thermal Injury • MMP9 • TGFB1

Case Report of Wound Treatment with Hyiodine Gel in an Occasional KID Syndrome Patient. (PubMed, J Clin Med) - "Initial outpatient treatment included serial sharp surgical debridement under local anesthesia, combined with topical keratolytics and silver sulfadiazine with hyaluronic acid. Surgical debridement and excision, when combined with targeted dermatological and antimicrobial therapy, can be an effective and safe strategy for managing chronic wounds in KID syndrome. This case highlights the importance of multidisciplinary collaboration and individualized surgical planning in this extremely rare disorder."

Journal • Alopecia • Anesthesia • Atopic Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Psoriasis • Rare Diseases • Vitiligo

Substance-Based Medical Device in Wound Care: Bridging Regulatory Clarity and Therapeutic Innovation. (PubMed, Polymers (Basel)) - "These products often incorporate biopolymers such as hyaluronic acid or chitosan, alone or in combination with antimicrobial agents like silver nanoparticles (AgNPs) or silver sulfadiazine (SSD), offering hydration, tissue protection, and control of microbial burden in both acute and chronic wounds...Through selected examples and case analyses, the review highlights inconsistencies in classification across Member States and underscores the need for a more harmonized, evidence-based, and proportionate regulatory approach. Overall, SBMDs challenge traditional regulatory boundaries and call for a framework capable of accommodating complex, multifunctional products while ensuring patient safety and regulatory coherence."

Journal • Review

Re-Epithelialization Comparison Between Topical Administration of 1% Feracrylum and Silver Sulfadiazine in the Treatment of Deep Dermal Burns in Wistar Rats. (PubMed, Ann Burns Fire Disasters) - "In this animal study, 1FA administration showed improved wound healing and re-epithelialization of the skin after deep dermal burns. These findings may lead to a new therapeutic approach for burn wound healing."

Journal • Preclinical • Anesthesia • Thermal Injury

Innovative Therapeutic Strategies for Chronic Ulcer Healing. (PubMed, Adv Exp Med Biol) - "This study investigates the effects of ascorbic acid, arginine, silver sulfadiazine, and colloidal silver on ulcer healing, aiming to elucidate their role in the restoration of skin integrity...The results of this study contribute to the growing body of evidence supporting alternative and complementary treatments for chronic wound management. By refining clinical protocols and integrating these bioactive agents into standardized treatment regimens, healthcare professionals may improve healing rates, reduce complications, and enhance overall patient care."

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Therapeutic effects of skin repair plus ointment on molecular and morphological changes in burn wounds: A rat model. (PubMed, PLoS One) - "The groups were designated as follows: negative control (burn treated with normal saline), positive control (burn treated with 1% silver sulfadiazine), and tested (burn treated with Remanco cream)...Molecular investigations revealed that the Remanco-treated group demonstrated a significant increase in the levels of two essential growth factors: TGF-beta on day 3 and IGF-1 on day 9, with a p-value less than 0.05. In summary, Remanco cream holds potential for enhancing wound healing in animal models, but further studies are necessary to investigate its potential clinical applications."

Journal • Preclinical • Thermal Injury • IGF1 • TGFB1

Evaluation of in vitro antioxidant activity of chrysin and in vivo wound healing potential of an optimized chrysin emulgel formulation. (PubMed, J Biomater Sci Polym Ed) - "In the excision model, the chrysin emulgel achieved 97.93% wound contraction by day 12 with an epithelization period of 14.83 ± 0.30 days, similar to the standard (98.17%; 14.33 ± 0.42 days). Overall, the optimized chrysin emulgel demonstrated strong antioxidant activity, effective wound healing, and excellent safety, suggesting its potential as a natural alternative to silver sulfadiazine for topical wound management."

Journal • Preclinical

Repurposing amlexanox as a topical anti-inflammatory and antioxidant intervention for diabetic foot ulcers: insights from in-silico and in-vivo studies. (PubMed, Inflammopharmacology) - "Taken together, the present work highlights the mechanisms associated with ALX mediated wound healing in diabetic rats thereby demonstrating its potential as a promising strategy for DFU management."

Journal • Preclinical • Diabetes • Inflammation • Metabolic Disorders • IL1B • IL6 • MMP9 • TNFA

From Vineyard to Hydrogel: Antioxidant, Anti-Inflammatory, and Regenerative Potential of Grape Skin Extract in Diabetic Wound Repair. (PubMed, Pharmaceutics) - "Afterwards, male Wistar rats were divided into four groups: untreated control (NC), silver sulfadiazine-treated (PC), hydrogel without extract (HG), and hydrogel with GSE (HG + GSE)...These outcomes are attributed to the sustained release of bioactive polyphenols such as naringin, caffeic acid, and epicatechin. Overall, this GSE-based hydrogel presents a multifunctional, biocompatible, sustainable, and effective strategy for diabetic wound care."

Journal • Dermatology • Inflammation • IL6 • TNFA

WITHDRAWN Wound healing effect of Ethanolic extract of Newbouldia laevis leaf in Albino Sprague-Dawley rats (ASTMH 2025) - "The 20% ethanolic leaves extract of Newbouldia laevis leaves formulated into cream demonstrated a better potential for wound healing at the end of the study and can be used as an alternative medicine at an optimal concentration for the management and treatment of wounds as1% Silver Sulfadiazine cream. We however recommend further studies of toxicological tests to ensure the complete safety of the extract on humans and on the optimal concentration of the extract with the highest wound healing effect."

Preclinical • Diabetes • Fibrosis • Immunology • Infectious Disease • Malaria • Metabolic Disorders

Assessment of In Vivo Analgesic, Anti-Inflammatory and Wound Healing Properties of Aqueous Leaf Extract of Annona reticulata Linn. (PubMed, ScientificWorldJournal) - "Remarkable wound healing activity was also noted in the test extract in the burn wound model; the observed epithelialisation period for 10% ointment of aqueous extract was 13 ± 0.32 days, whereas the epithelialisation period for standard medication silver sulfadiazine was 14.20 ± 0.38 days. Moreover, probable components responsible for achieving these potentials were identified by utilising GC-MS analytical data."

Journal • Preclinical • Pain

Bioinspired Membranes with Silver Sulfadiazine and Piperine for Enhanced Cutaneous Permeability. (PubMed, ACS Omega) - "For E. coli clinical strains, the addition of PIP enhanced the bactericidal effect of SSD (76% vs 33% reduction), consistent with its reported role as an efflux pump inhibitor. Overall, these multifunctional membranes combine sustained SSD release, improved and reproducible skin permeation, and enhanced antimicrobial efficacy in the evaluated strains, offering a promising platform for advanced wound dressings in burn care and other skin injuries."

Journal

Bacterial cellulose nanofibers fabricated using electrospinning as a wound dressing material. (PubMed, Int J Biol Macromol) - "To further enhance the therapeutic efficacy, the scaffold surface was modified with a gum arabic matrix loaded with silver sulfadiazine, resulting in a dual-functional composite (BCP-LSD) with both antimicrobial and anesthetic properties...Lidocaine exhibited a 29 % burst release in the first 30 min, with complete release achieved within 108 h. These findings underscore the potential of the BCP-LSD nanofiber scaffold as a next-generation wound dressing, offering a synergistic combination of antimicrobial protection, sustained analgesic release, and a bioactive environment favorable for wound healing."

Journal • Anesthesia • Infectious Disease • Pain