Silverzine Tulle (Silver Sulfadiazine) / MinaPharm - LARVOL DELTA

Chitosan Hydrogel Enriched with Propolis from Chihuahua, Mexico: Physicochemical Characterization and Exploratory In Vivo Evaluation in a Murine Second-Degree Burn Model. (PubMed, Polymers (Basel)) - "At 144 h, the 1% EEP hydrogel produced greater wound contraction than silver sulfadiazine (p = 0.021), although it did not differ significantly from the propolis-free chitosan hydrogel or untreated control... Chihuahua propolis-loaded chitosan hydrogels showed promising physico-chemical, release, antioxidant, antimicrobial, and short-term in vivo findings. The in vitro reduction in metabolic activity observed under static extraction conditions warrants further evaluation using physiologically relevant exposure models, extended follow-up, and comprehensive safety assessment."

Journal • Preclinical • Thermal Injury

Overcoming cytotoxicity of antibiotics by 2-deoxy-d-ribose: A dual-functional antibiotic and angiogenic hydrogel for potential healing of infected wounds. (PubMed, Biomater Adv) - "This beneficial effect of 2dDR toward ciprofloxacin did not extend to ofloxacin to any useful extent and not at all to silver sulfadiazine. Histological analysis also showed enhanced angiogenesis, reduced inflammation, stimulated re-epithelialization, and augmented collagen deposition indicating good wound healing by the hydrogel. Collectively, Gel-CIP/2dDR is a therapeutic strategy that overcomes the cytotoxicity of an antibacterial drug with its proangiogenic ability and ensures strong potential for treating chronic and infected wounds."

Journal • Infectious Disease • Inflammation

Zinc silicate microspheres-mediated bacterial metabolic interference and microenvironment remodeling for chronic wound repair. (PubMed, Bioact Mater) - "Hence, in both S. aureus-infected and diabetic wound models (mice and minipigs), ZnSi FMPs exhibited superior chronic wound healing capacity compared with commercial silver sulfadiazine® (AgSD) and 45S5 bioglass®. This improved healing was achieved through enhanced antibacterial activity, anti-inflammatory effects, and angiogenesis, accompanied by elevated expression of CD163, CD206, CD31 and α-SMA. By synergizing bacterial metabolic interference with microenvironment regulation, ZnSi FMPs effectively facilitate tissue healing and provide a promising candidate for clinical wound treatment."

Journal • Infectious Disease • Inflammation • CD163 • CD31 • EGF • HBEGF • MRC1 • PECAM1

Healing potential of curcumin gel in experimental wounds infected with resistant Pseudomonas aeruginosa: a comparative study with silver sulfadiazine. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "This study compared the therapeutic efficacy of a topical curcumin gel with 1% SSD cream in MDR P. aeruginosa-infected excision wounds in rabbits. Epithelial thickness in the curcumin group (40.20 µm) was statistically similar to SSD (39.74 µm) and superior to controls. Overall, curcumin gel demonstrated potent antibacterial activity, superior early wound healing kinetics, effective immunomodulation, and complete tissue restoration, highlighting its preclinical potential as a biocompatible and efficacious alternative to SSD for MDR-infected wounds, warranting further clinical validation."

Journal • Immunology • Inflammation

ATriple Comparative Study for Burn Wound Healing: Standard Treatment vs Quantum-Smart Proteins vs Laser-Activated QSPs Using in silico Simulation. (PubMed, Clin Cosmet Investig Dermatol) - "This study employed in silico simulations to compare three therapeutic strategies: (1) silver sulfadiazine (standard care), (2) Quantum-Smart Proteins (QSPs) designed using AI and structural modeling, and (3) QSPs combined with Low-Level Laser Therapy (LLLT, 808 nm, 2 J/cm2)...These findings are preliminary and computational in nature but highlight QSPs as a promising avenue for regenerative therapeutics that warrants experimental validation. All findings in this study represent computational predictions only and have not been experimentally validated."

Journal • Fibrosis • Immunology • Infectious Disease

Exudate-guided Janus trilayer bioelectronic dressing for multiplexed sensing and therapy of infected wounds. (PubMed, Biosens Bioelectron) - "The vertically stacked trilayer architecture separately incorporates a multiplexed electrochemical sensor array (glucose, lactate, pH), a silver sulfadiazine drug reservoir, and stimulation electrodes...Preclinical evaluations confirm the dressing achieves accelerated infected wound healing and reliable in-situ wound monitoring. This integrated platform offers a promising strategy for next-generation wound care and regenerative medicine."

Journal

Severe Acute Radiation Dermatitis Following Ultra-Hypofractionated Whole Breast Radiation Therapy in a Patient With Systemic Lupus Erythematosus. (PubMed, Pract Radiat Oncol) - "Although causality cannot be proven, the severity of acute dermatitis was atypical for FAST-Forward whole-breast irradiation and suggests that SLE-associated radiosensitivity may have contributed. Modern data indicate that connective tissue disease is not an absolute contraindication to breast radiation, and hypofractionation can be feasible. However, evidence is sparse for whole-breast ultra-hypofractionation in patients with SLE on chronic DMARD therapy. Multidisciplinary assessment, explicit counseling, consideration of moderate hypofractionation or reduced-volume treatment when oncologically acceptable, and systematic reporting of severe toxicity are warranted."

Journal • Breast Cancer • Dermatitis • Dermatology • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Positive Breast Cancer • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Oncology • Pain • Rheumatology • Sjogren's Syndrome • Solid Tumor • Systemic Lupus Erythematosus • HER-2 • PGR

Berberine-Pretreated Bone Marrow Mesenchymal Stem Cells Accelerate Skin Wound Healing in Rats With Burn Injuries. (PubMed, Int Wound J) - "A burn wound model was established in Wistar rats, and the model rats were randomly allocated to four groups treated with placebo gel, standard BMSCs-CM gel, BMSCs-BBR CM gel, or silver sulfadiazine cream...Our findings demonstrate that the topical application of BMSCs-BBR CM gel potently promotes burn wound healing by improving the quality of tissue regeneration and stimulating angiogenesis via the activation of the PI3K/AKT/eNOS signalling pathway. This preconditioning strategy represents a promising acellular therapeutic approach for burn wound management."

Journal • Preclinical • CD31 • NOS3 • PECAM1

Association between postoperative silver sulfadiazine dressings and surgical site infection after skin cancer excision: an observational cohort study with historical controls. (PubMed, Front Surg) - "Because of the non-randomized design and the use of non-concurrent historical controls, the observed reduction should be interpreted as an association rather than proof of causality. Further prospective randomized studies are warranted."

Journal • Observational data • Basal Cell Carcinoma • Genetic Disorders • Infectious Disease • Non-melanoma Skin Cancer • Oncology • Skin Cancer • Squamous Cell Carcinoma

Effects of topical Turkish propolis on burn wound healing in an experimental burn model. (PubMed, Ulus Travma Acil Cerrahi Derg) - "The application of water-soluble propolis to burn wounds in rats appears to promote wound healing."

Journal • Anesthesia • Fibrosis • Immunology • Thermal Injury

Impact of modified SSD soft brace on surgical outcomes and wound healing duration following hand scar contracture release in RDEB patients. (PubMed, Front Surg) - "To investigate the clinical efficacy of a modified soft brace incorporating a Silver Sulfadiazine (SSD) oil-based dressing in improving wound healing and home care quality following hand scar contracture release surgery in patients with RDEB...In this retrospective cohort, the SSD-containing non-adherent dressing used with a soft brace was associated with fewer dressing changes, less dressing-related trauma, and better reported tolerance. Prospective controlled studies with validated functional and compliance outcomes are required."

Journal

Hyaluronic Acid Hydrogel Associated with Silver in the Treatment of Experimentally Induced Partial-Thickness Burn Wounds in Mice. (PubMed, An Acad Bras Cienc) - "Seventy-two BALB/c mice were divided into four groups: Control (saline), SSD (1.0% silver sulfadiazine cream), HA (1.0% hyaluronic acid hydrogel), and HA+Ag (1.0% hyaluronic acid hydrogel + 0.5% silver)...These differences were transient and were no longer observed at later time points. Therefore, the findings suggest that HA-based hydrogels, particularly when combined with silver, promote wound healing during the initial phase and represent a promising therapeutic alternative for partial-thickness burns."

Journal • Preclinical • Inflammation • Thermal Injury • IL10 • IL1B • TNFA

A Novel Foam-Forming Hydrogel Containing Antibiotics Reduces the Degree of Bacterial Colonization and Improves Wound Healing in Thermal Burns When Compared to Silver Sulfadiazine. (PubMed, Mil Med) - "In a 7-day porcine partial thickness burn model, an antibiotic hydrogel foam reduced the degree of bacterial colonization and improved wound healing when compared to non-antibiotic hydrogel vehicle, standard of care, and control. Strengths of this study include the randomization of multiple treatment conditions, blinded pathology, and the inclusion of both inoculated and non-inoculated wounds with clinically relevant bacterial strains. Limitations include a modest sample size and limited quantitative bacteriology. A lightweight, portable foam-based antibiotic hydrogel spray may improve the early, prehospital treatment of thermal burns. Future work may assess use over longer time periods and body surface areas and increased quantitative microbiology."

Clinical • Journal • Fibrosis • Hematological Disorders • Immunology • Thermal Injury

Chemical characterization of iridoid glycosides from Veronica persica by UHPLC-MS/MS and their in vitro anti-inflammatory activity. (PubMed, Front Pharmacol) - "The results indicated that V. persica treatment significantly promoted wound healing, reducing the recovery period from 24 days (untreated controls) to 11 days (aqueous extract), comparable to the 10-day recovery observed with silver sulfadiazine ointment (positive control), while the ground plant material showed even faster healing in only 6 days...Additionally, these iridoid glycosides exhibited dose-dependent suppression of NO production and notably reduced the secretion of pro-inflammatory cytokines TNF-α and IL-1β in an LPS-stimulated RAW264.7 macrophage model. These results provide fundamental insights into the pharmacological mechanisms that may underlie the burn-healing activity of V. persica."

Journal • Preclinical • Thermal Injury • IL1B • TNFA

Castanea sativa Flower Extract Accelerates Burn Wound Healing via Antioxidant and Anti-Inflammatory Mechanisms in Juvenile Rats. (PubMed, Pharmaceuticals (Basel)) - "Background/Objectives: Burn injuries in children represent a significant clinical challenge, as current standard-of-care agents such as silver sulfadiazine (SSD) present limitations, including delayed re-epithelialization...When combined with SSD, a synergistic effect is observed that overcomes the re-epithelialization delays associated with SSD monotherapy. These findings support C. sativa flower extract as a promising candidate for further preclinical and clinical investigation in pediatric burn management, supporting the ethnopharmacological relevance of this plant in traditional wound care practices; further safety and efficacy validation is required before clinical translation."

Journal • Preclinical • Pediatrics • IL10 • IL1B • IL6 • TNFA

Topical application of Pinus seed oil enhances third-degree burn wound healing in rats. (PubMed, Burns) - "Topical application of Pinus gerardiana and Pinus koraiensis seed oils accelerates burn wound healing potentially via antioxidant and anti-inflammatory mechanisms. These findings suggest promising adjuvant therapies for burn management deserving further molecular and clinical exploration."

Journal • Preclinical

In vivo Activity of Combination of N-acetyl Cysteine and Levofloxacin against Colonization and Catheter-Associated Infection. (PubMed, Curr Microbiol) - "We evaluated in vivo the activities of intravascular catheters impregnated with a combination of N-acetyl cysteine, an antibiofilm agent, and levofloxacin (NACLEV) compared to chlorhexidine/silver sulfadiazine-treated catheters (CHSS) against bacterial colonization and device-associated infection with representatives of both Gram-positive and Gram-negative bacteria including Staphylococcus aureus, vancomycin-resistant enterococcus (VRE), Pseudomonas aeruginosa, or Klebsiella pneumoniae. However, NACLEV catheters inoculated with P. aeruginosa were significantly more effective compared to CHSS catheters against both colonization (80% vs. 10% colonization reduction, P < 0.001) and device-associated infection (55% vs. 5% device-associated infection reduction, P = 0.001). Furthermore, impregnation of catheters with the N-acetyl cysteine and levofloxacin combination did not affect the mechanical integrity of the catheters since the mean force at break of 30.91 N for..."

Journal • Preclinical • Infectious Disease • Pneumonia

UPLC-MS/mS-based metabolite profiling and wound healing mechanisms of Careya arborea roxb. Explored through in silico and in vivo approaches. (PubMed, Nat Prod Res) - "In vivo, topical application of the extract on rat burn wounds accelerated healing (98.53% contraction by Day 25), outperforming silver sulfadiazine (96.48%)...Overall, C. arborea Roxb. demonstrated multi-targeted mechanisms supporting tissue repair, highlighting its potential as a natural therapeutic for burn wound treatment."

Journal • Preclinical • TNFA

Effectiveness of Alovera Gel vs 1% Silver Sulfadiazine in Superficial Partial Thickness Burn Patients in Pediatric Population. (clinicaltrials.gov) - P=N/A | N=60 | Completed | Sponsor: University of Child Health Sciences and Children's Hospital, Lahore

New trial • Pediatrics • Thermal Injury

In-situ forming alginate dialdehyde-gelatin hydrogel for sustained silver sulfadiazine delivery: in-vivo evaluation in a preclinical burn wound model. (PubMed, J Biomater Sci Polym Ed) - "In vivo, the SSD loaded hydrogel achieved ∼99% wound closure by day 14, outperforming the hydrogel base (∼93%) and a marketed SSD cream (∼84%). Overall, the ADA-gelatin in situ hydrogel provided rapid wound conformability, sustained SSD release, and improved burn healing, supporting its potential as an advanced topical therapy for burn wound management."

Journal • Preclinical

Evaluation of Functional Electrospun Chitosan-Based Nanofibers Loaded with Norfloxacin for Enhanced Burn Wound Healing Response. (PubMed, Polymers (Basel)) - "Their therapeutic performance was evaluated in a standardized deep dermal burn model in Wistar rats, with Vaseline gauze and silver sulfadiazine serving as reference treatments. Trimethyl chitosan-based nanofibers loaded with norfloxacin show strong potential as multifunctional wound dressing platforms capable of controlled drug release. The findings indicate that formulation composition plays a critical role in regulating inflammation and tissue regeneration, underscoring the need for continued refinement of chitosan-derived nanosystems for burn wound therapy."

Journal • Inflammation • CD163 • CXCL8 • IL17A • IL1B • TNFA

Prospective Multicenter Multinational Cohort Study: Time-to-central line-associated bloodstream infection with Plain vs Chlorhexidine/Silver Sulfadiazine Impregnated Central Venous Catheters. (PubMed, Am J Infect Control) - "CH/SSD-CVCs were associated with a significant reduction in the CLABSI hazard, supporting further study of their use as tools to prevent CLABSI."

Journal • Infectious Disease

Assessment of the enhanced antibacterial activity of snail mucus, thymol, and ferulic acid in a rat model of burn wounds infected with Staphylococcus aureus and Pseudomonas aeruginosa. (PubMed, Future Microbiol) - "In the in vivo model, the group treated with STF showed significantly faster wound healing and decreased inflammation compared to all other groups, including the silver sulfadiazine group. The combination of snail mucus in STF is a highly effective remedy for infected wounds, providing complementary benefits in vivo by coupling antimicrobial activity with pro-regenerative functions, and demonstrates superiority over silver sulfadiazine."

Journal • Preclinical • Infectious Disease • Inflammation

Antimicrobial Central Venous Catheters vs. Uncoated Central Venous Catheters in Reducing Catheter-Related Bloodstream Infections in ICU: A Retrospective, Multicenter Study. (PubMed, Medicina (Kaunas)) - "Antimicrobial-impregnated catheters, including chlorhexidine-silver sulfadiazine (CSS)-coated CVCs, have been proposed to reduce this risk... CSS-coated CVCs were associated with a significant reduction in CRBSI incidence and catheter replacement rates in ICU patients. However, given the retrospective design, univariable analysis, and highly unequal pandemic-related systemic stressors between the two periods, these findings demonstrate a clinical association rather than direct causation, and should be interpreted with caution due to potential residual confounding."

Clinical • Journal • Retrospective data • Critical care • Infectious Disease

Evaluation of the efficacy of a Propionibacterium extract gel in wound healing and symptom relief after open excisional hemorrhoidectomy: a randomized clinical study. (PubMed, Tech Coloproctol) - P4 | "PeG was more efficient than HA-SSD in promoting wound healing, alleviating burning and itching, and enhancing patient satisfaction following hemorrhoidectomy. This study supports the safety and effectiveness of PeG as a therapeutic option for postoperative management."

Journal • Gastroenterology • Pain