PAS-IL-1Ra / XL-protein - LARVOL DELTA

PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis. (PubMed, J Biol Chem) - "Surface plasmon resonance analyses revealed significant  binding between PAS-IL‑1Ra and IL‑1R1, although with a slightly lower affinity than anakinra. These results validate PAS-IL‑1Ra as an active IL‑1 antagonist with marked in vivo potency and a significantly extended half-life compared with anakinra."

Journal • Preclinical • Immunology • Lung Cancer • Oncology • Solid Tumor • Thoracic Cancer