Synapsine (SNG12) / SyneuRx - LARVOL DELTA

Bdnf-trkb signaling in neuroprotection for HIV-associated neurocognitive disorders (HAND) (Neuroscience 2023) - "On the other hand, Synapsine 1 Synaptophysin, NAMPT, STAT-3 and Nrf-2 expressions were downregulated...These data implicate crosstalk among TrkB, Akt and transcription factors including NF-κB, STAT3 and NRF-2 in neuroprotection of HAND. This research explores the future of DHF which shows promise as a TrkB agonist treatment for HAND patients in conjunction with current antiviral therapies."

CNS Disorders • Cognitive Disorders • AKT1 • FAP • GFAP • NAMPT • Napsin A • NFE2L2 • SIRT1 • STAT3 • SYP

Application of neurotrophic factor-secreting cells (Astrocyte - like cells) in the in-vitro Alzheimer's disease-like pathology on the human neuroblastoma cells. (PubMed, Brain Res Bull) - "To explore the impact of NTF-SCs on synaptogenesis and synaptic functionality, real-time PCR assay was performed to measure the expression of synapsine 1, homer 1 and ZIF268...Moreover, NTF-SCs significantly increased the expression rate of synapsin 1, homer 1 and zif 268 genes in Aβ-treated cells compared to matched-control group coincided with induction of synaptophysin at the protein level(p < 0.05). NTF-SCs reversed AD-like neuropathological alterations in SH-SY5Y cells via paracrine and juxtacrine mechanisms."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Neuroblastoma • Oncology • Solid Tumor • BDNF • EGR1 • GFAP • Napsin A • SYP • TNFA