V934 Vaccine / Merck (MSD) - LARVOL DELTA

Diagnosis of osteoarticular tuberculosis: multi-targeted loop-mediated isothermal amplification assay versus multiplex-PCR. (PubMed, Future Microbiol) - "Moreover, the sensitivities attained by multi-targeted LAMP in total OATB cases were significantly higher (p < 0.05-0.01) than multiplex-PCR (mpt64 + pstS1) and GeneXpert assay. Our LAMP is simple, reliable and cost-effective method, which may develop into an attractive diagnostic kit for early detection of OATB cases."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Microarray-based selection of a serum biomarker panel that can discriminate between latent and active pulmonary TB. (PubMed, Sci Rep) - "Validation of the four candidate biomarkers in ELISA assays using 440 serum samples gave consistent results. The promising sensitivity and specificity of this biomarker panel suggest it merits further investigation for its potential as a diagnostic for discriminating between latent and active TB."

Biomarker • Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

emPAI-assisted strategy enhances screening and assessment of Mycobacterium tuberculosis infection serological markers. (PubMed, Microb Biotechnol) - "This study provides a rationale for the serological marker screening of emPAI-assisted tuberculosis clinical test. The results also provide new technical support for the screening of candidate serological markers of infectious diseases in the future."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Age-Related Immunoreactivity Profiles to Diverse Mycobacterial Antigens in BCG-Vaccinated Chinese Population. (PubMed, Front Immunol) - "In E6C10 population, the immunoreactivity to Rv3841 maintained along with aging, whereas those to Rv3006 and Rv0934 attenuated in E6C10 HDs older than 45 years old. Our study implies the shift of dominant antigens at different infection statuses, providing the clues for the selection of mycobacterial antigens in vaccine development and precision revaccination in the future."

Clinical • Journal • Tuberculosis

Evaluation of multi-antigen serological screening for active tuberculosis among people living with HIV. (PubMed, PLoS One) - "The multi-antigen panels did not achieve the target accuracy for a TB triage test among PLHIV. We identified a new combination that improved performance for TB screening in an HIV-positive sample compared to an existing serological panel in Uganda, and suggests an approach to identify novel antigen combinations specifically for screening TB in PLHIV."

Journal • Human Immunodeficiency Virus • Infectious Disease • Tuberculosis

[VIRTUAL] The clinical using of dual-energy computed tomography and its potential in determining the biomineralogical composition of stones (EAU-I 2020) - "Extensive data on stones in the studied groups were obtained, which give reason to assume the type of mineral. According to preliminary estimates, pronounced differences in indicators can be noted, except for densities of 80 kV, 140 kV and 120 kV for groups of whewellite and Ca- stones without whewellite - in these groups a marked intersection of the intervals of these indicators are noted. Determination of average density and DEO allows determining the type of mineral with a high degree of accuracy and choosing the optimal method of lithotripsy."

Clinical • Urolithiasis

Safety, tolerability and immunogenicity of V934/V935 hTERT vaccination in cancer patients with selected solid tumors: a phase I study. (PubMed, J Transl Med) - P1; "Our results suggest the safety and feasibility of V934/V935 hTERT vaccination in cancer patients with solid tumors Trial Registration Name of the registry: ClinicalTrial.gov Trial registration number: NCT00753415 Date of registration: 16 September 2008 Retrospectively registered URL of trial registry record: https://clinicaltrials.gov/ct2/results?cond=&term=NCT00753415&cntry=&state=&city=&dist=."

Clinical • Journal • P1 data

Polymorphism of MPT64 and PstS1 in Mycobacterium tuberculosis is not likely to affect relative immune reaction in human. (PubMed, Medicine (Baltimore)) - "MPT64 and PstS1 are likely candidate diagnostic antigens for M tuberculosis T-spot test, at least in combination with other proteins. Polymorphisms of MPT64 and PstS1 had little effect on cell-mediated and humoral immunity in the host."

Journal

Quantitative detection of a cocktail of mycobacterial MPT64 and PstS1 in tuberculosis patients by real-time immuno-PCR. (PubMed, Future Microbiol) - "Our RT-I-PCR assay revealed high sensitivity especially for the rapid diagnosis of smear-negative pulmonary TB and paucibacillary extrapulmonary TB samples, which could also monitor the dynamics of disease in patients on therapy."

Clinical • Journal