hydrocortisone / Generic mfg. - LARVOL DELTA

A Case of Metastatic Renal Cell Carcinoma Developing Isolated Adrenocorticotropic Hormone (ACTH) Deficiency During Nivolumab Therapy. (PubMed, Cureus) - "The patient presented with nonspecific symptoms that improved promptly after discontinuation of nivolumab and initiation of hydrocortisone replacement therapy. Despite permanently requiring glucocorticoid supplementation, the patient has maintained a durable partial response for more than four years after cessation of nivolumab. This case highlights the importance of early recognition of immune-related endocrinopathies and demonstrates that long-term tumor control may be achieved even after discontinuation of immune checkpoint inhibitors."

Journal • Endocrine Disorders • Genito-urinary Cancer • Nephrology • Oncology • Pancreatic Cancer • Renal Cell Carcinoma • Renal Disease • Solid Tumor

Adrenal Emergencies. (PubMed, Endocrinol Metab Clin North Am) - "Paragangliomas including pheochromocytoma can cause multisystem end-organ dysfunction due to catecholaminergic storm, which require rapid blood pressure control with phentolamine and identification of lesions amenable to surgical resection. Adrenal insufficiency states in contrast can result in hypotension and decompensation refractory to vasopressor administration, requiring adrenal supplementation via hydrocortisone."

Journal • Review • Cardiovascular • Cushing’s Disease • Endocrine Disorders • Hypertension • Hypotension • Nephrology • Oncology • Rare Diseases • Renal Disease • Solid Tumor

Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+) or ABL-class Ph-like Acute Lymphoblastic Leukemia (ALL) (clinicaltrials.gov) - P1/2 | N=50 | Not yet recruiting | Sponsor: Novartis Pharmaceuticals

New P1/2 trial • Acute Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Oncology • Pediatrics • ABL1 • CD19

AML16: A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia (clinicaltrials.gov) - P2 | N=206 | Active, not recruiting | Sponsor: St. Jude Children's Research Hospital | Trial primary completion date: Jun 2025 ➔ Sep 2025

Trial primary completion date • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Oncology

PALETTE: Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial (clinicaltrials.gov) - P2 | N=2000 | Not yet recruiting | Sponsor: Assistance Publique - Hôpitaux de Paris | Phase classification: P3 ➔ P2 | Trial completion date: Apr 2032 ➔ May 2031 | Trial primary completion date: May 2029 ➔ Jun 2028

Pan tumor • Phase classification • Trial completion date • Trial primary completion date • Infectious Disease • Septic Shock

Low Intensity Mini-Hypercvd (mHCVD), Inotuzumab Ozogamicin (Ino) with/without Blinatumomab (Blina) in Older Patients with Newly Diagnosed Philadelphia Negative B-Cell Acute Lymphoblastic Leukemia (B-ALL): 10 Years Update (ASH 2024) - "The chemotherapy backbone was mHCVD (mHCVD : cyclophosphamide 150mg/m2 q12h [day] D1-3, dexamethasone 20mg/day D1-4, 11-14, and vincristine 2 mg D1, 8; alternating with methotrexate (MTX) 250mg/m2 D1 & cytarabine 500mg/m2 q12h D2, 3) for up to 8 cycles (C). 12 doses of intrathecal IT MTX /cytarabine were given for CNS prophylaxis; pts with CNS disease had IT hydrocortisone, MTX, and cytarabine 2/week till CNS clearance, then weekly x 4. 8 doses of rituximab 375mg/m2 were given on D1, 8 of C1-4 if CD20 was ≥20% by flow cytometry (FCM)...Ursodeoxycholic acid was given to all pts...Maintenance was initially with vincristine 2mg D1, prednisolone 50mg daily D1-5, 6-mercaptopurine 50mg BID & MTX 10mg/m2 weekly (POMP) for 3 years...Conclusion : mHCVD-InO ± Blina is an efficacious and tolerable regimen with promising PFS and OS benefit even on long-term F/U. Further reduction of chemo doses and assessment of mutations that increase risk of myeloid neoplasms,..."

Clinical • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • CNS Disorders • Epilepsy • Hematological Malignancies • Leukemia • Multiple Myeloma • Oncology • CD20 • CRLF2 • KMT2A • TP53

When and How Much? Steroids in Sepsis. (PubMed, Clin Chest Med) - "More recent evidence from large randomized clinical trials has overall supported use of hydrocortisone in those with septic shock, particularly when refractory or severe. The aim of this article is to guide clinical practice regarding steroid administration in septic shock from an evidence-based perspective."

Clinical • Journal • Review • Infectious Disease • Septic Shock

Cardiovascular Risk Profile of Low-dose Prednisolone and Its Effect on the Quality of Life in Patients with Adrenal Insufficiency: The HYPER-AID Observational Study. (PubMed, Endocr Connect) - "Low-dose once-daily prednisolone offers comparable cardiovascular risk to hydrocortisone while improving treatment convenience, systolic blood pressure, and SF-36 subjective energy scores. These findings support its use as a potentially preferable alternative in patients with adrenal insufficiency."

HEOR • Journal • Observational data • Cardiovascular • Endocrine Disorders • Nephrology • Renal Disease • CRP

Bilateral Adrenal Hemorrhage After Laminectomy: A Rare Complication. (PubMed, JCEM Case Rep) - "The patient was treated with intravenous hydrocortisone, leading to rapid clinical improvement. He was discharged on oral steroid therapy and remains well on follow-up. This case highlights the importance of considering bilateral adrenal hemorrhage in postoperative patients presenting with nonspecific symptoms and hemodynamic instability."

Journal • Cardiovascular • Endocrine Disorders • Hematological Disorders • Hypotension • Musculoskeletal Diseases • Nephrology • Orthopedics • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Thrombocytopenia

Primary Adrenal Insufficiency Due to Recurrent Unilateral Adrenal Infarction in a Patient With Myelodysplastic Syndrome With Isolated del(5q). (PubMed, AACE Endocrinol Diabetes) - "A 72-year-old woman with thrombocythemia secondary to MDS with isolated del(5q) on cilostazol therapy presented with left-sided lumbago...We present the first case of recurrent unilateral adrenal infarctions associated with MDS with isolated del(5q), which progressively led to bilateral involvement and PAI. This case suggests the importance of assessing adrenal function and individualized consideration of prophylactic antithrombotic therapy in patients with adrenal infarction."

Journal • Endocrine Disorders • Hematological Disorders • Hematological Malignancies • Lumbar Back Pain • Myelodysplastic Syndrome • Nephrology • Oncology • Renal Disease • Thrombocytosis

Real World Evaluation of Ciltacabtagene Autoleucel (cilta-cel) Toxicity Management: A Single Center Experience (TCT-ASTCT-CIBMTR 2026) - "Seven patients required no interventions for their CRS; 10 received tocilizumab, 7 received dexamethasone...A month later, the patient presented with return of gait disturbances and masked faces so was given a 4th dose of IT chemotherapy with thiotepa and hydrocortisone, with mild symptom improvement. At last follow-up, the patient had just initiated carbidopa-levodopa... Cilta-cel-related toxicities were manageable with early intervention and tailored supportive care, including delayed neurotoxicity. Further research is essential for optimal monitoring and treatment strategies for MNTs and CNPs to improve long-term safety and patient outcomes. 1."

Adverse events • Clinical • HEOR • Real-world • Real-world evidence • Hematological Malignancies • Infectious Disease • Inflammation • Movement Disorders • Multiple Myeloma • Septic Shock

Hydrocortisone replacement therapy in patients with glucocorticoid withdrawal syndrome after cessation of glucocorticoid treatment: REPLACE, a multicentre, randomised, double-blinded, placebo-controlled, 16-week study protocol. (PubMed, BMJ Open) - P4 | "21/27119), the Regional Committees on Health Research Ethics for Southern Denmark (project ID: S-20210076), the Danish Patient Safety Authority and the Danish Medicines Agency. NCT05193396."

Clinical protocol • Journal • Cardiovascular • Endocrine Disorders • Giant Cell Arteritis • Immunology • Musculoskeletal Pain • Nephrology • Pain • Rare Diseases • Renal Disease • Rheumatology

Effects of Intratympanic Administration of Glucocorticoids on the Guinea Pig Inner Ear (ARO 2026) - "Methods : Fifteen Hartley guinea pigs were used and divided into five groups: dexamethasone-treated (n=5), contralateral dexamethasone-treated (n=5), hydrocortisone-treated (n=5), contralateral hydrocortisone-treated (n=5), and control (n=5). This is the first report to investigate the effects of intratympanic administration of glucocorticoids on the guinea pig cochlea. Dilated endolymphatic space was observed in the steroid-treated ears. Although the underlying mechanism of these histological changes remains unclear, great care must be taken when administering steroids to patients with endolymphatic hydrops-related diseases, such as Meniere's disease."

Otorhinolaryngology

Establishment of mouse endometrial assembloids with luminal epithelial-like structures in vitro. (PubMed, Zool Res) - "Optimization of the GLO culture was achieved by fine-tuning the concentrations of Wnt3a and R-Spondin1, while stromal viability and functionality were enhanced by supplementation with hydrocortisone, L-ascorbic acid, and ITS-X. Compared to existing mEOs, analyses confirmed that ALI-mEnAOs closely mimic in vivo endometrial architecture, lineage composition, phase-specific gene expression signatures, and dynamic hormonal response. This model offers a physiologically relevant platform for mechanistic investigation of endometrial function and embryo implantation dynamics."

Journal • Preclinical • WNT3A

Determination of hydrocortisone and cortisone in artificial saliva by spray assisted fine droplet formation liquid phase microextraction coupled to LC-MS/MS. (PubMed, Sci Rep) - "Using external-standard calibration, recoveries were 105.3-129.4%/110.4-141.1% for cortisone and 110.0-134.9%/94.1-142.8% for hydrocortisone; with matrix-matched calibration, recoveries were 80.3-103.2%/98.1-117.8% for cortisone and 79.8-105.7%/97.3-114.0% for hydrocortisone. The developed SA-FDF-LPME-LC-MS/MS method enables sensitive, accurate, and simultaneous quantification of hydrocortisone and cortisone at saliva-relevant concentrations and offers a practical platform for selective bioanalysis of related small molecules."

Journal

Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock (clinicaltrials.gov) - P4 | N=336 | Not yet recruiting | Sponsor: Northern Jiangsu People's Hospital

New P4 trial • Septic Shock

Subcutaneous hematoma due to submental liposuction: a case report. (PubMed, J Surg Case Rep) - "Treatment included antibiotics, hydrocortisone, and clot removal...A doctor's expertise in techniques and anatomical knowledge can prevent vascular damage. Timely diagnosis and intervention can effectively manage complications and enhance liposuction results."

Journal • Aesthetic Medicine • Musculoskeletal Pain • Pain

Observational pharmacy-based study provides real-world insights into the patient-perceived effectiveness and tolerability of a topically used hydrocortisone acetate in treating various allergic or mild inflammatory skin reactions. (PubMed, Curr Med Res Opin) - "This non-interventional study provides valuable real-world insights about the patient-perceived effectiveness and tolerability of Soventol HCA in treating insect bites, but also other inflammatory or allergic skin reactions as e.g. sunburn, allergies or eczema in adults. Patient satisfaction with effectiveness and tolerability was high in all application fields, especially regarding itch reduction of insect bites."

Journal • Real-world evidence • Allergy • Atopic Dermatitis • Dermatology • Immunology • Pain

Pediatric craniopharyngioma: when hypoglycemia reveals a brain tumor. Illustrative case. (PubMed, J Neurosurg Case Lessons) - "CP, although relatively frequent, may exceptionally present with severe recurrent hypoglycemia and coma. Unexplained pediatric hypoglycemia warrants prompt endocrine evaluation and sellar imaging. Early recognition and multidisciplinary management (neurosurgery and endocrinology teams) are crucial for favorable outcomes. https://thejns.org/doi/10.3171/CASE25727."

Journal • Adrenal Cortex Carcinoma • Brain Cancer • Cardiovascular • CNS Disorders • CNS Tumor • Endocrine Disorders • Hypertension • Hypoglycemia • Nephrology • Oncology • Pain • Pediatrics • Renal Disease • Solid Tumor • Ventriculomegaly

Feasibility and Safety of Perioperative Hydrocortisone for Modulating Stress and Inflammation after Microvascular Decompression: A Single-Center, Randomized, Assessor-Blinded, Controlled Trial Protocol (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: The Second People's Hospital of Liaocheng City; The Second People's Hospital of Liaocheng City

New trial • Inflammation

Unravelling the paradox of vitamin C research in sepsis. (PubMed, Crit Care Resusc) - "This landmark study compared vitamin C, hydrocortisone, and thiamine to hydrocortisone alone in septic shock and found no clinical benefit...Rinaldo's legacy is defined by scientific rigour, mentorship, and humility. His visionary, disciplined approach remains a model for impactful research and continues to guide ongoing efforts to advance care for critically ill patients."

Journal • Review • Acute Kidney Injury • Critical care • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Isolated Menarche and Empty Sella Turca: A Rare Pediatric Case. (PubMed, Cureus) - "At 14 years, she developed symptoms of adrenal insufficiency supported by a low morning cortisol value, requiring hydrocortisone treatment. Puberty progressed spontaneously, and menarche occurred at 15 years. At 17 years, she continues treatment with improved growth and resolution of symptoms."

Journal • Endocrine Disorders • Nephrology • Pediatrics • Renal Disease

Intrathecal Chemotherapy and Steroids for ICANS after CAR-T: A Single-Center Retrospective Review (TCT-ASTCT-CIBMTR 2026) - "Methods A SlicerDicer Epic report was run for all patients > 18 years old who received a commercial CAR-T therapy and subsequent IT therapy with methotrexate 12 mg and hydrocortisone 50 mg from January 2017 through June 2025...Twelve patients were treated for DLBCL, 11 with axicabtagene ciloleucel and 1 with lisocabtagene maraleucel. Two patients received brexucabtagene autoleucel, 1 for MCL and 1 for B-ALL. Twelve patients received tocilizumab for cytokine release syndrome (CRS); median doses given was 2. Seven patients received anakinra...3. Develop a treatment plan for patients with steroid refractory ICANS after CAR-T."

Retrospective data • Review • Diffuse Large B Cell Lymphoma • Infectious Disease • Inflammation

Impact of Intrathecal Therapy on Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) Compared to a Historical Cohort: A Single Center Analysis (TCT-ASTCT-CIBMTR 2026) - "Intrathecal therapy most often consisted of cytarabine and hydrocortisone (90.5%). Patients in the IT cohort received more systemic steroids within the first 30 days after infusion (360mg dexamethasone equivalents) compared to the historical ICANS cohort (110mg) (p=0.0045), suggesting more severe ICANS in the IT cohort... In our retrospective analysis, intrathecal therapy was used for treatment of ICANS, and did not impact survival outcomes compared to a historical cohort. Longer ICANS duration in the cohort receiving IT therapy likely reflects a patient sample with higher baseline inflammatory milieu and greater CAR toxicity, as proxied by higher rate of grade 3-4 ICANS with resultant greater steroid need in this cohort. This trend may be influenced by a higher proportion of patients in the IT cohort receiving axi-cel as their CAR product compared to the historical control, which bears a higher toxicity profile."

Clinical • Hematological Malignancies • Lymphoma

Impact of Isosorbide Diesters from Coconut and Sunflower Fatty Acids on Pediatric Atopic Dermatitis and the Skin Microbiome: A Randomized, Double-Blind, Vehicle-Controlled Trial. (PubMed, J Clin Med) - "Hydrocortisone 2.5% was used as needed...Use of topical steroids was lower in the IDEAS group (3.4 g vs. 13.3 g, p = 0.012) and the relative abundance of Staphylococcus aureus was reduced after 8 weeks. The addition of IDEAS to colloidal lotion improved AD, improved itch, reduced the use of topical steroids, and reduced the relative abundance of S. aureus in the skin microbiome."

Clinical • Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pediatrics