hydrocortisone / Generic mfg. - LARVOL DELTA

Episodic hypercortisolemia-mediated periods of worsening hyperglycemia in cyclic Cushing syndrome. (PubMed, JCEM Case Rep) - "After declining bilateral adrenalectomy and opting for a block-and-replace regimen with osilodrostat and hydrocortisone, he was able to anticipate and initiate this treatment based on his CGMS readings, facilitating improved glycemic control during these periods. This case highlights the diagnostic complexity of CCS and the utility of CGMS as both a monitoring tool and treatment guide for CCS in patients with concurrent type 2 diabetes mellitus."

Journal • Cushing’s Disease • Diabetes • Endocrine Disorders • Metabolic Disorders • Type 2 Diabetes Mellitus

Essential Oil-Loaded Lipid Nanocarriers with Anti-Inflammatory Activity: Quality Control, Safety, and Efficacy. (PubMed, Biomedicines) - "In selected works using the same experimental conditions, some formulations produced responses of similar magnitude to hydrocortisone, diclofenac, or other anti-inflammatory drugs, but these results cannot be directly correlated with therapeutic equivalence...Overall, lipid-based nanocarriers represent platforms for investigating the stability, delivery and biological performance of EO. However, further standardization and controlled assays are required to determine their therapeutic and translational potential."

Journal • Review • Cardiovascular • Inflammation

ShenRongGuBenHuanShao Pill Ameliorates Hydrocortisone-Induced Erectile Dysfunction: Insights from Integrated Multi-Omics Analysis. (PubMed, Pharmaceuticals (Basel)) - "Rats exposed to HC received SRGBHSP (1.08, 2.16, or 4.32 g/kg), Yougui Pill, or sildenafil concurrently with HC administration. Flavonoids may represent important bioactive constituents associated with the observed effects of SRGBHSP. Overall, this study provides an integrated pharmacological and multi-omics framework for understanding the effects of SRGBHSP on HC-associated ED-related alterations."

Journal • Erectile Dysfunction • Metabolic Disorders • AKT1

Transition from Pediatric to Adult Endocrine Care in Patients with Congenital Adrenal Hyperplasia: A Single-Center Retrospective Analysis. (PubMed, Medicina (Kaunas)) - "No significant longitudinal changes in hormonal outcomes, BMI, or body-surface-area-adjusted hydrocortisone-equivalent glucocorticoid doses were observed within either group...Most patients remained engaged with adult endocrine care, and hormonal control showed no evident deterioration following transfer in either group. Given the small sample size and high overall retention, these findings should not be interpreted as evidence of equivalence between the two transition approaches."

Journal • Observational data • Retrospective data • Congenital Adrenal Hyperplasia • Endocrine Cancer • Endocrine Disorders • Pediatrics

Severe Transaminitis as a Misleading Presenting Feature of Myxedema Coma (ACG 2026) - "IV hydrocortisone and levothyroxine were initiated for presumed myxedema coma with ICU transfer. Figure: Axial contrast-enhanced CT of the abdomen at the level of the liver and stomach. Arrow indicates thickening of the gastric wall, one of several sites of luminal wall thickening (also involving the distal esophagus and ascending colon) attributable to hypothyroidism-induced gastrointestinal dysmotility and myxedematous mucosal edema."

Cardiovascular • Endocrine Disorders • Gastrointestinal Disorder • Hepatology • Hypotension • Immunology • Liver Failure • Pruritus

Unmasked by Steroids: CMV Colitis Mimicking IEC-Enterocolitis After CAR-T Therapy (ACG 2026) - "Case Description/ A 48-year-old male with relapsed/refractory diffuse large B-cell lymphoma received CAR-T therapy (axicabtagene ciloleucel)...11 weeks post-infusion, he presented with sepsis requiring stress-dose hydrocortisone...Due to the high mortality of IEC-EC, IV steroids were started until CMV immunostaining returned with numerous inclusions and CMV PCR from HD2 resulted at 316,000 IU/mL (HD 11); valganciclovir was initiated...Standard valacyclovir prophylaxis has no CMV activity yet may create false reassurance...(A) H&E stain showing crypt dropout, apoptotic bodies - features that overlap with both CMV colitis and IEC-EC, and were initially interpreted as a GVHD/IEC-EC pattern of injury. (B) CMV immunohistochemical stain with numerous positive cells (brown) confirming the diagnosis of CMV colitis."

CAR T-Cell Therapy • B Cell Lymphoma • Cytomegalovirus Infection • Diffuse Large B Cell Lymphoma • Gastroenterology • Gastrointestinal Disorder • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Septic Shock

Severe Nirogacestat-Induced Colitis Responsive to Budesonide After Failure of Standard Therapies (ACG 2026) - "Despite treatment with cholestyramine, loperamide, dicyclomine, tincture of opium, octreotide, and high-dose hydrocortisone, diarrhea persisted at 3-5 L/day. Budesonide's potent local anti-inflammatory activity and limited systemic absorption may make it a valuable treatment option for inflammatory chemotherapy-related colitis, particularly when associated with targeted therapies. Further studies are needed to evaluate its efficacy in similar cases."

Desmoid Tumors • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Immunology • Sarcoma • Solid Tumor • CRP

Progressive Hepatocellular Injury Revealing Secondary Adrenal Insufficiency (ACG 2026) - "Atorvastatin and divalproex sodium were discontinued without improvement in liver enzymes...Stress-dose hydrocortisone was initiated with rapid improvement in liver enzymes and metabolic abnormalities...In this case, infectious, autoimmune, vascular, and medication-related evaluation was unrevealing, while liver enzymes improved rapidly after corticosteroid replacement, strongly supporting adrenal insufficiency-associated liver injury. Adrenal insufficiency should be considered in patients with unexplained hepatocellular injury with hypoglycemia, electrolyte abnormalities, hypothyroidism, or pituitary disease."

Autoimmune Hepatitis • Bipolar Disorder • Cardiovascular • CNS Disorders • Endocrine Disorders • Heart Failure • Hepatology • Hypoglycemia • Hypotension • Immunology • Infectious Disease • Inflammation • Liver Failure • Nephrology • Pituitary Gland Carcinoma • Renal Disease • Vascular Neurology

Granulomatous Hepatitis and Adrenal Insufficiency Revealing Disseminated Histoplasmosis (ACG 2026) - "Given the electrolyte abnormalities and adrenal enlargement, primary adrenal insufficiency was suspected, and hydrocortisone and fludrocortisone were initiated with clinical improvement. Prompt initiation of itraconazole resulted in normalization of transaminases and clinical improvement, emphasizing the importance of early recognition and targeted antifungal therapy for potentially reversible hepatic injury Figure: CT abdomen demonstrating bilateral adrenal enlargement in the setting of disseminated Histoplasmosis. Figure: Liver biopsy demonstrating granulomatous hepatitis with lobular granulomatous inflammation (H&E stain)."

Cardiovascular • Endocrine Disorders • Fibrosis • Heart Failure • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Nephrology • Renal Disease

Listeria Septicemia in the Setting of an Ulcerative Colitis Flare (ACG 2026) - "We present a case of Listeria septicemia in the setting of a UC flare in a patient not on biologic agent and recently started on prednisone...Blood cultures grew gram-positive bacilli, eventually speciating to Listeria monocytogenes, and antibiotics were narrowed to ampicillin. She continued mesalamine enemas twice daily, with hydrocortisone enemas added...Severe infections are more often linked to biological agents with few case reports involving corticosteroid therapy alone. [2,3]"

Acute Kidney Injury • CNS Disorders • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Nephrology • Renal Disease • Septic Shock • Ulcerative Colitis

Phase 3 CESSA Investigational Trial: Results Across Patient Disease Characteristics and Demographics [Post Hoc Analyses] (ACG 2026) - P3 | "The n ext-generation hydrocortisone acetate combination product (ngHCA) suppositories with an FDA-cleared suppository applicator was investigated for treatment of active UC... Rates of clinical response were similar across patients with varying disease and demographic characteristics. No significant differences were observed with respect to overall efficacy when analyzed by extent of disease, disease duration, total MMS, nor demographic characteristics ( Table ). ngHCA is an important treatment option for active UC regardless of patient disease characteristics and demographics."

Clinical • P3 data • Retrospective data • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Insurance Coverage and Patient Out-of-Pocket Costs Influence Physicians in Choosing Off-Label Over FDA-Approved Treatments for Patients With Eosinophilic Esophagitis: Results From a U.S. Physician Survey (ACG 2026) - "PPIs were dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole and vonoprazan (although vonoprazan is not a PPI, it is a potassium-competitive acid blocker and is included as part of this group for the purposes of this survey); â For example, elemental diet, 6-/4-/2-food elimination diet; â¡Off-label swallowed topical corticosteroids were inhaled budesonide and fluticasone propionate formulations that are swallowed, rather than inhaled (off-label use); §Systemic corticosteroids were betamethasone, hydrocortisone and prednisone. In total, 100 physicians completed the survey (gastroenterologists, 36%; allergists/immunologists, 35%; primary care providers, 29%); the majority had been practicing for >15 years. Proton-pump inhibitors (PPIs), dietary intervention and off-label swallowed topical corticosteroids were the most common first-line treatments for adults with EoE. FDA-approved treatments, BOS and dupilumab, were..."

Clinical • Reimbursement • US reimbursement • Eosinophilic Esophagitis • Gastrointestinal Disorder • Immunology

Rare but Fatal: Acute Graft vs Host Disease Following Liver Transplantation (ACG 2026) - "Induction consisted of methylprednisolone 500 mg IV, followed by tacrolimus 1 mg BID and mycophenolate mofetil (MMF) 500 mg BID...The patient received hydrocortisone 100 mg IV every 8 hours and was transferred to the transplant center, where he was treated with etanercept and intravenous immunoglobulin followed by a steroid taper...The donor-recipient age difference was 12 years, below the >20-year threshold associated with increased mortality, and the absence of basiliximab induction may also have been favorable...B) Milibiform-like eczematous patches. Figure: Figure 2: Right chest punch biopsy showing vacuolar interface dermatitis with adnexal involvement and eosinophils consistent with acute graft-versus-host disease."

Acute Graft versus Host Disease • Atopic Dermatitis • Colorectal Cancer • Dermatitis • Eosinophilia • Fibrosis • Graft versus Host Disease • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Leukopenia • Metabolic Disorders • Thrombocytopenia • Transplantation

The Hidden Cost of Persistent Inflammation: Increased Risk of Multiple Malignancies in Inflammatory Bowel Disease (ACG 2026) - "Uncontrolled inflammation was defined by corticosteroid exposure (prednisone, methylprednisolone, hydrocortisone, or budesonide) and/or elevated C-reactive protein within one year of IBD diagnosis. Before matching, 290,475 patients with uncontrolled inflammation and 421,836 controls were identified. After propensity matching, 226,715 patients remained in each cohort. Compared with controls, patients with uncontrolled inflammation had significantly increased risks of colorectal cancer (RR 1.15, 95% CI 1.07-1.25; p< 0.001), lymphoma/leukemia (RR 1.48, 95% CI 1.36-1.62; p< 0.001), small bowel cancer (RR 1.55, 95% CI 1.29-1.87; p< 0.001), anal cancer (RR 1.27, 95% CI 1.02-1.57; p=0.032), breast cancer (RR 1.23, 95% CI 1.13-1.33; p< 0.001), and skin cancer (RR 1.33, 95% CI 1.26-1.39; p< 0.001)."

Addiction (Opioid and Alcohol) • Anal Carcinoma • Biliary Cancer • Bone Marrow Transplantation • Breast Cancer • Cervical Cancer • Colorectal Cancer • Crohn's disease • Diabetes • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Genito-urinary Cancer • Hematological Malignancies • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammatory Bowel Disease • Leukemia • Lymphoma • Metabolic Disorders • Obesity • Oncology • Pancreatic Cancer • Pancreatitis • Primary Sclerosing Cholangitis • Prostate Cancer • Skin Cancer • Small Intestinal Carcinoma • Solid Tumor • Ulcerative Colitis • CRP

Fecal Management System as a Novel Rectal Drug Delivery Platform for Refractory Collagenous Colitis in a PEG-Dependent Patient With Fecal Incontinence (ACG 2026) - "She developed an acute CC flare with more than ten watery bowel movements daily, refractory to loperamide, banana flakes, and cholestyramine. Figure: Figure 2. Components of the indwelling stool management system used for rectal hydrocortisone delivery."

Clinical • Cerebral Palsy • CNS Disorders • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Pneumonia • Respiratory Diseases

Serial Lipase Measurements and Sequential Organ Failure Assessment Scores for Mortality Prediction in Acute Pancreatitis: Insight From the Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP) Trial (ACG 2026) - P2 | " This is an analysis of participants in the Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP; NCT05160506), our ongoing randomized, double-blind, placebo controlled study to investigate the effect of intravenous hydrocortisone in patients with severe acute pancreatitis... A total of 44 patients were analyzed, of them, 12 (23%) died. At each time point, median serum lipase levels were numerically higher in patients who died compared to survivors, although they did not differ statistically. Lipase discriminated in-hospital mortality better at later timepoints (0h: 0.63 (95% CI: 0.45-0.81) vs."

Inflammation • Pancreatitis

Pituitary Stalk Enlargement With Panhypopituitarism and Arginine Vasopressin Deficiency in Lung Adenocarcinoma: Metastatic Infundibular Disease or Paraneoplastic Hypophysitis? (PubMed, Cureus) - "The patient was initiated on hydrocortisone and levothyroxine replacement therapy...The patient showed subsequent clinical improvement with desmopressin. Serum prolactin was mildly elevated, likely reflecting both pituitary stalk infiltration and concomitant metoclopramide therapy. This case discusses an exceptionally rare presentation of lung adenocarcinoma with isolated pituitary stalk infiltration, panhypopituitarism, and AVP-D before exposure to immune checkpoint inhibitors. Clinicians should be aware of this unusual manifestation, as prompt hormone replacement can significantly reduce morbidity and improve patient outcomes."

Journal • Endocrine Disorders • Growth Hormone Deficiency • Lung Adenocarcinoma • Lung Cancer • Metabolic Disorders • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • PRL

Comparative efficacy and safety of hydrocortisone-based regimens in septic shock: A network meta-analysis. (PubMed, J Crit Care) - "Higher-dose hydrocortisone was associated with improved survival but also increased adverse events, whereas adjunctive fludrocortisone may provide additional benefit without substantially increasing complications. These findings should be interpreted with caution and highlight the need for further dose-specific trials."

Journal • Retrospective data • Critical care • Hematological Disorders • Infectious Disease • Septic Shock

Very-early-onset autosomal dominant polycystic kidney disease coexisting with congenital adrenal hyperplasia in a newborn: a case report. (PubMed, Child Kidney Dis) - "The patient presented with prenatally detected kidney cysts and exhibited clinical and laboratory features consistent with salt-wasting, including markedly elevated 17-hydroxyprogesterone levels, requiring treatment with hydrocortisone, fludrocortisone, and sodium chloride. Hypertension developed at 3 years and 7 months despite unchanged steroid replacement doses, requiring antihypertensive treatment, and resolved after mineralocorticoid dose reduction. This case highlights the competing therapeutic demands of concurrent salt-wasting CAH and VEO-ADPKD, underscoring the importance of early genetic evaluation and integrated multidisciplinary surveillance."

Journal • Autosomal Dominant Polycystic Kidney Disease • Cardiovascular • Congenital Adrenal Hyperplasia • Endocrine Disorders • Genetic Disorders • Hypertension • Nephrology • Polycystic Kidney Disease • Renal Disease • CYP1A2 • CYP21A2 • PKD1 • PRKD1

Clinical Outcomes and Predictors of Survival in Central Nervous System (CNS) Multiple Myeloma: A Retrospective Cohort Study (IMS 2026) - "Sixteen patients received combination IT therapy (methotrexate, cytarabine and hydrocortisone) and 3 received IT thiotepa. CNS-MM remains an aggressive manifestation of MM with poor survival outcomes. Although patients receiving CAR T-cell therapy and/or BsAbs in our cohort demonstrated numerically longer overall survival, these findings did not reach statistical significance, likely due to the small sample size. Effect of novel immunotherapies in patients with CNS MM may require further investigation in larger cohort studies."

Clinical data • Retrospective data • Hematological Malignancies • Multiple Myeloma

Pre-Treatment Corticosteroids on Survival in Head and Neck Cancer Treated with Immune Checkpoint Inhibitors (AAO-HNSF 2026) - "Patients with HNC treated with ICIs (pembrolizumab, nivolumab, cemiplimab, or durvalumab) were stratified based on systemic corticosteroid exposure (prednisone, methylprednisolone, hydrocortisone, dexamethasone, or prednisolone) within three months before or up to one day after ICI initiation. Pre-treatment corticosteroid exposure is associated with inferior overall survival in patients with head and neck cancer treated with ICIs. These findings suggest corticosteroid use around ICI initiation should be minimized when clinically feasible and highlight the need for prospective studies to clarify optimal management strategies."

Checkpoint inhibition • Head and Neck Cancer • Hematological Malignancies • Oncology • Solid Tumor

Diagnostic Challenge of Immune Checkpoint Inhibitor-Induced Hypophysitis in Patient With Melanoma. (PubMed, Fed Pract) - "A 73-year-old male with a history of metastatic melanoma who had received 5 cycles of pembrolizumab (anti-PD-1) and 2 cycles of combination ICI therapy with ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) presented to a US Department of Veterans Affairs medical center 3 weeks after completing his second cycle of therapy with fatigue, headache, and hyponatremia...The patient was treated with intravenous hydrocortisone for suspected central adrenal insufficiency...ICI-induced hypophysitis is irreversible, can impact quality of life, and requires maintenance replacement therapy. As ICI therapies become more prevalent in the treatment of solid cancers, it is expected that clinicians will see more cases of ICI-related irAEs, such as hypophysitis, and must become comfortable with diagnosis, treatment, and management."

Checkpoint inhibition • Journal • Cardiovascular • Endocrine Disorders • Fatigue • Heart Failure • Immunology • Melanoma • Nephrology • Oncology • Pain • Renal Disease • Solid Tumor

A Case of Isolated ACTH Deficiency after Conversion Surgery Following Gemcitabine, Cisplatin, and Pembrolizumab for Distal Cholangiocarcinoma (PubMed, Gan To Kagaku Ryoho) - "Suspecting adrenal insufficiency, hydrocortisone replacement was initiated on day 27. Clinicians should be aware of irAEs during the perioperative period after ICI therapy. Serious complications can be prevented through multidisciplinary collaboration."

Journal • Biliary Cancer • Cardiovascular • Cholangiocarcinoma • Endocrine Disorders • Heart Failure • Nephrology • Oncology • Renal Disease • Solid Tumor

Protective Effect of Soy Lecithin Liposomes in Oxazolone-Induced Dermatitis in a Mouse Model: A Comparative Evaluation. (PubMed, Iran J Pharm Res) - "The effects of SL and hydrocortisone (HC), used as the standard drug, on behavioral responses such as scratching and grooming were evaluated during a 35-day trial...Topical SL significantly improved AD severity in an OX-induced mouse model of AD. These results support further preclinical studies before clinical investigations in humans are undertaken."

Journal • Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Hematological Disorders • Immunology • Infectious Disease • Inflammation • CXCL8 • TNFA

Drug spectrum and disproportionality signals for diabetes insipidus in FAERS: multi-method analysis, JADER cross-database assessment, and PubMed-based case-level evidence. (PubMed, Front Pharmacol) - "Lithium, hydrocortisone, and propofol were positive across all four JADER methods...Several non-treatment drugs showed persistent disproportionality, but JADER support was limited. These findings are hypothesis-generating signals, not causal evidence."

Journal • Metabolic Disorders • Oncology