hydrocortisone / Generic mfg. - LARVOL DELTA

A phase 2 study of prophylactic intrathecal chemotherapy to prevent high-grade immune effector cell–associated neurotoxicity syndrome (ASH 2025) - "While prophylactic corticosteroids and cytokine-directed therapies like the IL-1 receptor antagonist anakinra have been explored, they carry potential risks and inconsistent efficacy...Study Design and This is a single-center, open-label, phase 2 trial evaluating the prophylactic use of IT methotrexate (12 mg), cytarabine (50 mg), and hydrocortisone (50 mg) in patients receiving standard-of-care axi-cel or brexu-cel for relapsed/refractory large cell or mantle cell lymphoma respectively...If effective, this approach could reduce the need for systemic corticosteroids, which are associated with significant morbidity. Further, prophylactic intrathecal therapy may be generalizable across existing and emerging CAR T-cell platforms, expanding eligibility to patients who might otherwise be excluded due to a high risk of neurologic toxicity."

P2 data • Acute Lymphocytic Leukemia • Brain Cancer • CNS Disorders • Epilepsy • Hematological Malignancies • Leukemia • Lymphoma • Mantle Cell Lymphoma

HSV-1 infection as a rare trigger of methotrexate toxicity: A diagnostic and therapeutic challenge (ASH 2025) - "Four days earlier, she was seen in an outpatient clinic for a cold sore near the corner of her right lip and was prescribed valacyclovir 500 mg twice daily for three days for HSV infection. Her home medications included prednisone 2.5 mg, leucovorin 5 mg and methotrexate 12.5 mg weekly along with adalimumab 40 mg every 14 days...Intravenous hydrocortisone 50 mg twice daily was initiated...After a five-day course of IV steroids and a seven-day course of IV cefepime, she was discharged home on oral acyclovir to complete a 14-day total antiviral course... This case suggests that corticosteroids may be a valuable adjunct in patients with suspected methotrexate toxicity who do not respond to leucovorin. Further studies are needed to evaluate the role of corticosteroids in such cases."

Cardiovascular • Congestive Heart Failure • Diabetes • Endocrine Disorders • Febrile Neutropenia • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Herpes Simplex • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Metabolic Disorders • Nephrology • Neutropenia • Renal Disease • Rheumatoid Arthritis • Rheumatology • Scleroderma • Systemic Sclerosis • Thrombocytopenia • Type 2 Diabetes Mellitus

Intrathecal chemotherapy for management of immune effector cell-associated neurotoxicity syndrome (ICANS): A multi-center, real-world analysis of clinical outcomes (ASH 2025) - "IT regimens included hydrocortisone(HC) alone in 14% and HC plus methotrexate, cytarabine, or both in the remainder.ICANS recovery did not differ significantly between IT and systemic‑only pts (83% vs 93%)...The benefit of anakinra remains uncertain given increased infectious risk and worsesurvival in high-grade ICANS. Together, the findings of this study support IT therapy as a potentialstrategy for CS‑refractory, high‑grade ICANS and underscore the need for large‑scale prospective trials toclarify the role of CSF‑directed IT steroids and/or chemotherapy."

Clinical • Clinical data • Real-world • Real-world evidence • B Cell Lymphoma • CNS Disorders • Epilepsy • Hematological Malignancies • Infectious Disease • Large B Cell Lymphoma • Lymphoma • Non-Hodgkin’s Lymphoma

Motixafortide + G-CSF hematopoietic stem cell mobilization in patients with multiple myeloma following quadruplet induction therapy (ASH 2025) - P1, P3 | "All patients received"enhanced" premeds with: loratadine (10 mg, PO), famotidine (20 mg, PO) and montelukast (10 mg, PO)daily on Day 1-5; plus acetaminophen (975mg, PO), hydrocortisone (200 mg, IV), diphenhydramine (25mg, IV) and famotidine (20 mg, IV) on Day 4 (30-45 mins pre-M). Meanwhile,enhanced premeds were associated with a low rate of AEs relative to standard premeds. Ongoingextended immunophenotyping may shed insight into the mechanism of impaired HSC mobilization post-quad induction, possibly via targeted depletion of a large population of CD38+ HSCs within the CD34+graft."

Clinical • Dermatology • Hematological Malignancies • Multiple Myeloma • Pruritus • CD34

Central nervous system disease status significantly impacts survival in pediatric acute myeloid leukemia: A report from Children's Oncology Group study AAML1831 (ASH 2025) - "Here we evaluate outcomes based on CNS status from recent COG trial AAML1831compared to historical COG trials AAML0531/1031, to assess the impact of CNS diagnosis andmanagement changes in AAML1831 including delayed evaluation of CNS status at diagnosis,incorporation of intrathecal triple (ITT; methotrexate/hydrocortisone/cytarabine) chemotherapy, andincreased utilization of hematopoietic stem cell transplant (HSCT) in high-risk patients. This analysis from COG study AAML1831 indicates that delayed LP better identifies patientswith CNS disease compared to prior studies AAML0531/1031. Despite fewer patients receiving additionalIT therapy intensification due to CNS disease, the rates of CNS relapse were lower than prior COG studiesAAML0531/1031, indicating a likely protective effect of using IT triple therapy and increased utilization ofHSCT for high-risk patients. Unfortunately, patients with CNS3 disease on AAML1831 (similar toAAML0531/1031) had inferior EFS and high..."

Clinical • Acute Myelogenous Leukemia • Bone Marrow Transplantation • CNS Disorders • Hematological Malignancies • Leukemia • Pediatrics • FLT3

A rare presentation of cardiomyopathy associated with Addison's disease: a case report. (PubMed, Eur Heart J Case Rep) - "A short synacthen test confirmed the diagnosis, and he was started on dual therapy with hydrocortisone and fludrocortisone. It serves as a reminder of the complex physiological interactions that can cause cardiomyopathy, and further research is vital to improve understanding. Timely recognition and prompt treatment with steroids can lead to rapid reversal of cardiac function."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Nephrology • Rare Diseases • Renal Disease

BH08 Unprovoked pulmonary emboli in a patient with alopecia areata treated with ritlecitinib: a case report. (PubMed, Br J Dermatol) - "The efficacy of ritlecitinib, an oral Janus kinase 3/TEC family inhibitor, has been demonstrated in the Allegro clinical trials...The US Food and Drug Administration issued black box warnings, citing increased risks of major adverse cardiovascular events, malignancies, venous thromboembolism (VTE) and mortality based on data from tofacitinib, baricitinib and upadacitinib in rheumatoid arthritis...The patient received intravenous broad-spectrum antibiotics for sepsis of unknown origin, hydrocortisone and vasopressor support for hypotension. She was anticoagulated with dalteparin and transitioned to apixaban as per respiratory advice for unprovoked pulmonary emboli...This case highlights a probable severe adverse event associated with ritlecitinib therapy, including pulmonary emboli and infection of unidentified source, associated with new-onset atrial fibrillation and acute kidney injury in a patient without known risk factors for VTE. Ongoing pharmacovigilance is..."

Journal • Acute Kidney Injury • Alopecia • Atrial Fibrillation • Cardiovascular • Dermatology • Endocrine Disorders • Hematological Disorders • Herpes Zoster • Hypotension • Immunology • Infectious Disease • Inflammatory Arthritis • Influenza • Musculoskeletal Pain • Nephrology • Novel Coronavirus Disease • Oncology • Pain • Pneumococcal Infections • Pruritus • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Septic Shock • Varicella Zoster • Venous Thromboembolism • CRP • JAK3

Inpatient Management of Bronchiolitis Before and After the COVID-19 Pandemic. (PubMed, Cureus) - "There was also increased use of hypertonic saline (p = 0.0464), antibiotics (p < 0.001), and corticosteroids (prednisolone p < 0.001; hydrocortisone p = 0.0355) in 2024...Post-COVID, there was a notable increase in admissions, investigations, and non-guideline-supported treatments, suggesting a drift from evidence-based care. Improved documentation and the development of local protocols are essential to standardise care and reduce unnecessary interventions."

Journal • Cough • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

DE06 Harnessing active in-depth learning for students and residents through a competitive card game: 'Skin Stacks: Dermatology Therapeutics'. (PubMed, Br J Dermatol) - "A range of treatments were included, varying from potent topical corticosteroids, ultraviolet B phototherapy and methotrexate to rarer therapies such as thalidomide and ultraviolet A1...During phases of card creation, students, residents and dermatologists had lively debates expressing their differences in their view of the individual ratings, for example the efficacy of hydrocortisone compared with nicotinamide...The use of a card game is an engaging way to teach complex medical information. We developed a simple but effective learning tool that promotes interest in dermatology treatments promoting deeper active learning of dermatology therapies."

Journal • Dermatology

DP11 A case of Langerhans cell histiocytosis masquerading as lymphocytic hypophysitis and panhypopituitarism. (PubMed, Br J Dermatol) - "The patient was initiated on replacement therapy for panhypopituitarism, including hydrocortisone, desmopressin, thyroxine and gonadotropin. Treatment with 12 cycles of single-agent cytarabine achieved complete remission. However, during follow-up, the patient experienced a limited recurrence of cutaneous lesions, which was managed effectively with cycles of high-dose methotrexate...The complexity of this rare condition emphasizes the need for a multidisciplinary approach to manage its aggressive course. Early diagnosis and treatment are crucial, especially in cases affecting high-risk end organs."

Journal • Endocrine Disorders • Hematological Disorders • Langerhans Cell Histiocytosis • Metabolic Disorders • Rare Diseases • CCND1 • CD1a • CD20 • CD68 • TNFRSF8 • TP63

Current and emerging therapeutic options for refractory septic shock: A systematic review. (PubMed, World J Crit Care Med) - "Adjunctive therapies for refractory septic shock may improve hemodynamics and organ function, however, they have not been shown to consistently reduce mortality. Larger trials are needed to confirm these findings. Multimodal approaches targeting inflammation are critical."

Journal • Critical care • Infectious Disease • Inflammation • Septic Shock

Phase 2 Trial of Mini-Hyper-CVD Plus Inotuzumab Ozogamicin, with or without Blinatumomab, in Older Patients with Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia (ASH 2023) - "Patients received mini-Hyper-CVD (mHCVD, cyclophosphamide 150mg/m2 q12h D1-3, dexamethasone 20mg daily D1-4, 11-14, and vincristine 2mg D1, 8 alternating with methotrexate (MTX) 250mg/m2 D1 & cytarabine 500mg/m2 q12h D2, 3) for up to 8 cycles. Eight doses of intrathecal (IT) MTX /cytarabine were given for CNS prophylaxis; patients with CNS disease had IT hydrocortisone, MTX, and cytarabine twice weekly till CNS clearance, then weekly x4. Eight doses of rituximab 375mg/m2 were given on D1, 8 of C1-4 if CD20 was ≥20% by flow cytometry...Ursodeoxycholic acid was given to all patients...Maintenance was initially with vincristine 2mg D1, prednisolone 50mg daily D1-5, 6-mercaptopurine 50mg BID & MTX 10mg/m2 weekly (POMP) for three years...Conclusion Older patients with ND Ph-negative ALL treated with mHCVD plus InO, with or without blina had excellent response rates and deep remissions. However, further adjustment of the regimen is needed, especially in patients ≥70..."

Clinical • P2 data • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • B Acute Lymphoblastic Leukemia • CNS Disorders • Hematological Malignancies • Hepatology • Infectious Disease • Leukemia • Myelodysplastic Syndrome • Oncology • Septic Shock • CD20 • TP53

Low Intensity Mini-Hypercvd (mHCVD), Inotuzumab Ozogamicin (Ino) with/without Blinatumomab (Blina) in Older Patients with Newly Diagnosed Philadelphia Negative B-Cell Acute Lymphoblastic Leukemia (B-ALL): 10 Years Update (ASH 2024) - "The chemotherapy backbone was mHCVD (mHCVD : cyclophosphamide 150mg/m2 q12h [day] D1-3, dexamethasone 20mg/day D1-4, 11-14, and vincristine 2 mg D1, 8; alternating with methotrexate (MTX) 250mg/m2 D1 & cytarabine 500mg/m2 q12h D2, 3) for up to 8 cycles (C). 12 doses of intrathecal IT MTX /cytarabine were given for CNS prophylaxis; pts with CNS disease had IT hydrocortisone, MTX, and cytarabine 2/week till CNS clearance, then weekly x 4. 8 doses of rituximab 375mg/m2 were given on D1, 8 of C1-4 if CD20 was ≥20% by flow cytometry (FCM)...Ursodeoxycholic acid was given to all pts...Maintenance was initially with vincristine 2mg D1, prednisolone 50mg daily D1-5, 6-mercaptopurine 50mg BID & MTX 10mg/m2 weekly (POMP) for 3 years...Conclusion : mHCVD-InO ± Blina is an efficacious and tolerable regimen with promising PFS and OS benefit even on long-term F/U. Further reduction of chemo doses and assessment of mutations that increase risk of myeloid neoplasms,..."

Clinical • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • CNS Disorders • Epilepsy • Hematological Malignancies • Leukemia • Multiple Myeloma • Oncology • CD20 • CRLF2 • KMT2A • TP53

Radiation therapy alleviates Doege-Potter syndrome accompanied with severe aortic valve insufficiency: a case report and literature review. (PubMed, Front Oncol) - "Following multidisciplinary team (MDT) consultation, the surgically ineligible patient received tumor-directed radiotherapy (60 Gy in 30 fractions), glucocorticoid replacement (hydrocortisone 40 mg daily), and overnight carbohydrate supplementation to alleviate hypoglycemia...This report describes a case of DPS with refractory hypoglycemia complicated by severe cardiac structural and conduction abnormalities. Radiotherapy combined with endocrine intervention effectively controlled tumor-associated hypoglycemia in this surgically ineligible patient."

Journal • Cardiovascular • Hypoglycemia • Oncology • Pancreatic Cancer • Solid Tumor • CD34 • IGF1 • IGF2 • STAT6

IMPACT: Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections (clinicaltrials.gov) - P4 | N=300 | Not yet recruiting | Sponsor: Theis S. Itenov

New P4 trial • Infectious Disease • Septic Shock

Webb-Dattani syndrome in a 17-year-old girl. (PubMed, Endocrinol Diabetes Metab Case Rep) - "Management included hormone replacement with hydrocortisone, levothyroxine, and desmopressin, as well as fluid regulation and supportive care. Long-term survival, although rare, is possible with coordinated multidisciplinary care addressing endocrine, neurological, renal, and infectious complications. This case underscores the importance of individualized endocrine replacement therapy and caregiver education in managing complex syndromic conditions such as WEDAS."

Journal • Developmental Disorders • Endocrine Disorders • Growth Hormone Deficiency • Infectious Disease • Metabolic Disorders

Progression From Isolated Posterior Pituitary Dysfunction to Combined Anterior Hormone Deficiencies With Pituitary Stalk Enlargement in Suspected Lymphocytic Hypophysitis: A Case Report. (PubMed, Cureus) - "Combined anterior pituitary hormone deficiencies were diagnosed, and replacement therapy with hydrocortisone and levothyroxine was initiated, resulting in symptomatic improvement. This case was considered to represent LYH, showing possible dynamic changes in pituitary function and morphology over time. Administration of pharmacologic-dose steroids or pituitary biopsy should be considered if further progressive pituitary enlargement or new mass effects, such as headache or visual disturbance, become evident."

Journal • Immunology • Inflammation • Metabolic Disorders • Pain • Xerostomia • PRL

Retrospective Analysis of Nivolumab-Induced Isolated Adrenocorticotropin Deficiency. (PubMed, Horm Metab Res) - "To investigate the clinical features of nivolumab-induced isolated adrenocorticotropin deficiency and to provide a reference for the diagnosis, treatment and rational use of nivolumab, clinical reports of nivolumab induced isolated adrenocorticotropin deficiency were collected by searching the database until August 31, 2025. Serum sodium and eosinophil ratios should also be closely monitored. The prognosis is good after hydrocortisone replacement therapy."

Journal • Retrospective data • Anorexia • Cardiovascular • Endocrine Disorders • Eosinophilia • Fatigue • Heart Failure • Melanoma • Oncology • Rare Diseases • Solid Tumor

More Than a Headache: Unveiling Pituitary Apoplexy Following Acute Coronary Syndrome. (PubMed, Cureus) - "An initial computed tomography (CT) scan revealed no remarkable findings; however, due to high clinical suspicion of PA, hydrocortisone treatment was initiated, and anticoagulation therapy was discontinued...Although many patients require surgical intervention, certain cases may be managed effectively through conservative measures. This case demonstrates a successful outcome with a conservative approach, a strategy suitable for clinically stable patients who do not have severe or worsening visual deficits."

Journal • Acute Coronary Syndrome • Cardiovascular • Genetic Disorders • Hematological Disorders • Hypertension • Obesity • Pain • Pituitary Gland Carcinoma

Septic Shock Precipitating a Pheochromocytoma Crisis: A Case of Sequential Acute Myocardial Infarction and Cardiogenic Shock. (PubMed, Cureus) - "She rapidly deteriorated into septic shock, requiring vasopressor support and hydrocortisone...Early recognition of this potential trigger and the underlying tumor is critical for guiding appropriate management and preventing catastrophic outcomes. Physicians should maintain a high index of suspicion for pheochromocytoma in patients with unexplained hemodynamic instability, even in the setting of a common infectious illness."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Infectious Disease • Myocardial Infarction • Neuroendocrine Tumor • Oncology • Pain • Septic Shock • Solid Tumor

Underutilized crop-wild variant of popular leafy vegetable Basella alba L. - a source of nutrients and novel bioactive components. (PubMed, Nat Prod Res) - "GC-MS analysis of methanolic leaf extracts of both the cultivated and crop-wild underutilised member revealed the presence of nutritive as well as novel bioactive compounds like - 14B-pregnane, hydrocortisone or cortisol, α-tocospiro A and B, triterpenoid - lupeol and simiarenol, vitamin C conjugate, phytol, etc. This is the first report of the presence of steroid hydrocortisone in any plant source and 14B-pregnane, a precursor of progesterone in the family Basellaceae, though the latter is of wide occurrence in the members of Apocynaceae and Asclepiadaceae. The crop-wild variant appeared very competitive even better than its popular cultivated relative in terms of palatability, nutritive value as well as novel bioactive compounds."

Journal

Hydrocortisone in Preterm Infants and School-Age Functional Outcomes: Follow-Up of a Randomized Clinical Trial. (PubMed, JAMA Pediatr) - P3 | "In this study, neonatal hydrocortisone treatment of preterm infants with high risk for BPD did not impact functional impairment or its components; nearly three-quarters of the children demonstrated functional impairment at school age. ClinicalTrials.gov Identifier: NCT01353313."

Clinical • Journal • Bronchopulmonary Dysplasia • Developmental Disorders • Pulmonary Disease • Respiratory Diseases

Evaluation of Stress-Dose Steroid Weaning Strategies in Patients Following Septic Shock. (PubMed, Ann Pharmacother) - "Rapid corticosteroid tapering in septic shock patients was associated with a reduced incidence of vasopressor reinitiation, shorter ICU and hospital stay, and a lower incidence of hypernatremia. These findings enhance our understanding of tapering strategies and suggest that rapid tapering (<72 hours) in septic shock may improve patient outcomes, informing future clinical guidelines."

Journal • Critical care • Diabetes • Infectious Disease • Septic Shock

Pharmacological Hypotensive Treatment in Very Preterm Newborns: Systematic Review and Meta-Analysis of Randomised Controlled Trials. (PubMed, Acta Paediatr) - "Pharmacological treatment of neonatal hypotension may improve blood pressure without positive effects on mortality and neurodevelopment in very preterm newborns. However, associated adverse effects such as intraventricular haemorrhage and hyperglycemia appear relevant."

Journal • Retrospective data • Review • Diabetes • Hypotension

Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA): an International Randomized Controlled Multicenter Trial (clinicaltrials.gov) - P4 | N=400 | Recruiting | Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

New P4 trial • Ampulla of Vater Adenocarcinoma • Ampulla of Vater Carcinoma • Cholangiocarcinoma • Head and Neck Cancer • Neuroendocrine Tumor • Oncology • Pancreatic Cancer • Pancreatitis • Small Intestinal Carcinoma • Solid Tumor