elomotecan (BN 80927) / Ipsen, Roche - LARVOL DELTA

Haplotype analysis of long-chain non-coding RNA NONHSAT102891 promoter polymorphisms and depression in Chinese individuals: A case-control association study. (PubMed, World J Psychiatry) - "The rs3792747 and rs6230 CG haplotypes of the lncRNA NONHSA T102891 promoter may be related to a reduced risk of depression in the Han Chinese population."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Association Between Single Nucleotide Polymorphisms Within lncRNA NONHSAT102891 and Depression Susceptibility in a Chinese Population. (PubMed, Neuropsychiatr Dis Treat) - "The rs155979 polymorphism may be associated with the occurrence of depression in the Chinese population. However, further studies are needed to verify the reliability of our results in large populations and different ethnic groups."

Journal • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Psychiatry

Insilico prediction and functional analysis of nonsynonymous SNPs in human CTLA4 gene. (PubMed, Sci Rep) - "Our study identified three damaging missense SNPs rs1553657429, rs1559591863 and rs778534474 in coding region of CTLA4 gene...The prediction of gene-gene interaction showed the interaction of CTlA4 with other genes and its importance in different pathways. This investigation of damaging nsSNPs can be considered in future while studying CTLA4 related diseases and can be of great importance in precision medicine."

IO biomarker • Journal • Endocrine Disorders • Idiopathic Arthritis • Immune Modulation • Immunology • Inflammation • Inflammatory Arthritis • Rare Diseases • Rheumatoid Arthritis • Rheumatology • CTLA4

Gene-diet interaction in response to defatted flaxseed flour supplementation on obesity-related traits in Chinese overweight and obese adults: A randomized controlled trial. (PubMed, Nutrition) - "Compared with the control biscuits, defatted flaxseed flour significantly reduced body weight (P < 0.001) in T-allele carriers (TT + TC) of rs155971 on the PCSK1 gene but not in non-carriers (CC) (P for the interaction = 0.041) and reduced body weight (P = 0.001) and BMI (P < 0.001) in A-allele carriers (AA + AG) of rs6265 on the BDNF gene but not non-carriers (GG) (P for the interaction = 0.017 and 0.018). Variants of genes related to satiety and appetite could modulate the effect of defatted flaxseed flour on obesity-related traits."

Journal • Genetic Disorders • Obesity • BDNF • FTO

Polymorphisms of pharmacogenetic candidate genes affect etomidate anesthesia susceptibility. (PubMed, Front Genet) - " GABRA2 rs279858, GABRB2 rs2561, CYP2C9 rs1559 and UGT1A9 rs11692021 are the SNPs with individual differences during etomidate anesthesia. This is the first to study the SNPs of etomidate, which can provide certain evidence for the future use of etomidate anesthesia and theoretical basis for precision anesthesia."

Biomarker • Journal • Anesthesia • CYP2C9 • UGT1A9

Common variants in genes involved in islet amyloid polypeptide (IAPP) processing and the degradation pathway are associated with T2DM risk: A Chinese population study. (PubMed, Diabetes Res Clin Pract) - "Our study showed that common variants in genes involved in IAPP processing and the degradation pathway were associated with T2DM in Chinese population. Subjects with high GRS exhibited poorer glucose metabolism and insulin secretion."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Contiguity and Structural Impacts of a Non-Myosin Protein within the Thick Filament Myosin Layers. (PubMed, Biology (Basel)) - "Mutations in the corresponding Drosophila residues (E1554K and R1559H) are known to interfere with flightin accumulation and phosphorylation in Drosophila...We find that the red density is associated within an expanse of the myosin coiled-coil that is unwound by the third skip residue and the coiled-coil is re-oriented while in contact with the red density. These findings suggest a mechanism by which flightin induces ordered assembly of myosin dimers through its contacts with multiple myosin dimers and brings about reinforcement on the level of a single myosin dimer by stabilization of the myosin coiled-coil."

Journal

Irinotecan: 25 years of cancer treatment. (PubMed, Pharmacol Res) - "This review highlights recent discoveries in the field of IRT and its derivatives, including analogues of the active metabolite SN38 (such as FL118), the recently approved liposomal form Nal-IRI and SN38-based immuno-conjugates currently in development (such as sacituzumab govitecan)...It offers a large range of drug combinations with cytotoxic agents, targeted products and immuno-active biotherapeutics, to treat a variety of advanced solid carcinoma, sarcoma and cancers with progressive central nervous system diseases. A quarter of century after its first launch, IRT remains an essential anticancer drug, largely prescribed, useful to many patients and scientifically inspiring."

Biomarker • Journal • Review • CNS Disorders • Gastrointestinal Cancer • Hematological Disorders • Immunology • Neutropenia • Oncology • Pancreatic Cancer • Sarcoma