calcipotriol / Generic mfg. - LARVOL DELTA

Multimodal PAI/OCT Imaging System for Precision Diagnosis and Therapy in Atopic Dermatitis: A Pilot Study. (PubMed, J Biophotonics) - "This study introduces an integrated photoacoustic imaging (PAI)/optical coherence tomography (OCT) system for noninvasive, quantitative evaluation of MC903-induced AD-like dermatitis in mice and Crisaborole efficacy. PAI/OCT synergistically provides complementary functional-structural biomarkers, advancing precision diagnosis and therapy in AD models. This work pioneers real-time monitoring of AD pathophysiology, supporting clinical translation through quantitative multiparametric characterization for tailored therapeutic strategies."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation

Molybdenum nanoparticles alleviate MC903-induce atopic dermatitis-like symptoms in ten mice by amendment the ROS-through NF-κB and Nrf2/HO-1 signaling pathways‏ (EADV 2025) - No abstract available

Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Briquilimab, an Anti-Human CD117 Antibody, Treats Low-Calcemic Vitamin D3 Analog MC903-Induced Dermatitis in Mouse Model Expressing Chimeric Human/Mouse CD117 (EADV 2025) - No abstract available

Preclinical • Dermatitis • Dermatology • Immunology • KIT

Keratinocyte-derived VEGF-A is an essential pro-migratory autocrine mediator, acting through the KDR/GEF-H1/RhoA pathway. (PubMed, Front Cell Dev Biol) - "Key proteins were visualized using immunohistochemistry in an MC903-induced mouse model of atopic dermatitis...Thus, GEF-H1 is critical for keratinocyte migration and VEGF-A secretion. Targeting the KDR/GEF-H1/RhoA pathway may reduce keratinocyte inflammatory responses, providing benefits in inflammatory skin disease."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Oncology • HIF1A • KDR • RHOA • TNFA

The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner. (PubMed, Sci Rep) - "Herein, we used mice with MC903-induced AD-like dermatitis and tumor necrosis factor (TNF)-α/interferon (IFN)-γ (T/I)-treated HaCaT cells to investigate the effects of SDBS on AD...Furthermore, our results showed that SDBS alleviated AD via the nuclear factor kappa B/mitogen-activated protein kinase pathways in a signal transducer and activator of transcription 3-dependent manner. In conclusion, our findings suggest for the first time that the surfactant SDBS has anti-inflammatory properties, which raises new possibilities for detergent use among patients with AD."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Oncology • STAT3 • TNFA

Ruxolitinib Alleviates Inflammation and Fortifies Skin Barrier Function Through Dampening IL-13. (PubMed, Exp Dermatol) - "AD-related symptoms were assessed in MC903/ruxolitinib-treated mice, including ear swelling, histological analysis, pruritus, serum biomarker quantification and immune cell analysis. Consistently, ruxolitinib-treated human skin explants demonstrated enhanced expression of skin barrier proteins, while IL-13 treatment of RHS led to downregulation of these proteins. These findings support data from human clinical trials indicating reduced SCORAD, pruritus and inflammatory phenotypes in AD patients treated with ruxolitinib."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Pruritus • FLG • IL13 • STAT3

Myricetin alleviates DNCB-induced atopic dermatitis by modulating macrophage M1/M2 polarization. (PubMed, Int Immunopharmacol) - "Our findings demonstrate that Myricetin significantly ameliorates skin lesions of DNCB-induced AD mice and reduces inflammatory factor levels by inhibiting the STAT1 and NF-κB signaling pathways to prevent M1 macrophage polarization, while activating the STAT6 signaling pathway to promote M2 macrophage polarization."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Pain • CD86 • CXCL10 • CXCL9 • IFNG • IL10 • IL18 • IL1B • IL4 • IL6 • JAK1 • JAK2 • MRC1 • TGFB1 • TNFA

Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis. (PubMed, J Transl Med) - "BX-BC08 mitigates AD-like inflammation by producing the anti-inflammatory metabolite AKG. BX-BC08 could serve as a novel prophylactic agent for AD prevention."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation

Elephantopus scaber attenuates MC903-caused atopic dermatitis and decreases TNF-α/IFN-γ-induced chemokines by suppressing MKP-1-mediated AP-1 signaling in keratinocytes. (PubMed, J Ethnopharmacol) - "ESE alleviates the skin lesions of AD mice through suppressing Th2-related chemokines and cytokines. In vitro, it reduces the levels of Th2-related chemokines in TNF-α/IFN-γ-activated HaCaT cells, which is attributed to the inhibition of MKP-1-mediated AP-1 signaling."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • CCL2 • CCL22 • IFNG • IL13 • IL4 • STAT1 • TNFA • TSLP

Phytic Acid Improves the Skin Barrier Function in Murine Models of Atopic Dermatitis Through Skin Microbiota-Derived Indole-3-Propionic Acid. (PubMed, Allergy) - "Our findings showed that diet-derived PA improved barrier function in AD via altering skin microbiota-derived metabolites, highlighting PA as a novel therapeutic strategy for the treatment of AD."

Journal • Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • KRT10

Neural-Inflammation Mechanism of Spinal Palmitic Acid Promoting Atopic Dermatitis in Mice. (PubMed, J Inflamm Res) - "MC903 was applied topically to the nape of C57BL/6 mice to induce AD. Spinal PA promotes AD involving spinal TRPV1 and MRGPRD signaling, and IRGEs increments in DRG. Intrathecal lidocaine suppresses AD aggravated by PA via inhibiting spinal ERK phosphorylation and reducing IRGEs in DRG."

Journal • Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • TRPV1

Intralesional 5-Fluorouracil (5FU), Topical Calcipotriene Treatment for SCC (clinicaltrials.gov) - P1 | N=30 | Recruiting | Sponsor: Melissa Pugliano-Mauro | Trial completion date: Oct 2025 ➔ Oct 2026 | Trial primary completion date: Sep 2025 ➔ Sep 2026

Trial completion date • Trial primary completion date • Oncology • Squamous Cell Carcinoma

AI-Guided Design and Development of HXN-1011: A Potent Anti-TSLP Biparatopic Antibody (EAACI 2025) - "Results Epitope mapping confirmed that HXN-1011 simultaneously binds to both Site I and Site II, while other TSLP antibodies, including Tezepelumab (AstraZeneca), GSK5784283 (GSK/Hengrui), and CM326 (Keymed), bind only to Site I. HXN-1011 exhibited a binding affinity approximately 100-fold higher than Tezepelumab and achieved IC90 values 15- to 100-fold lower in functional assays...HXN-1011 also showed superior efficacy across all tested parameters in OVA+MC903-induced lung and skin inflammation...Conclusion HXN-1011 is a next-generation biparatopic antibody with exceptional potency and significant potential to improve clinical efficacy in treating TSLP-driven inflammatory diseases, such as asthma, COPD, and beyond. Preclinical studies and IND-enabling research for HXN-1011 are currently in progress."

Late-breaking abstract • Dermatitis • Immunology • Inflammation • CRLF2 • IL7R • STAT5 • STAT5AWqe • TSLP

Bruton's Tyrosine Kinase Inhibitor Attenuates Skin Lesions in an Atopic Dermatitis Mouse Model by Suppressing Th2 Inflammation and Mast Cell Activation (EAACI 2025) - "Method An atopic dermatitis (AD)-like mouse model was established through topical application of MC903 from day 0 (D0) to D14. These findings were corroborated at the protein level using IHC and ELISA, confirming the suppression of key cytokine expression. Conclusion This study highlights the role of remibrutinib in reducing clinical symptoms, suppress mast cell degranulation, and downregulate key Th2 cytokines, supporting its role as a promising therapeutic strategy for AD."

IO biomarker • Late-breaking abstract • Preclinical • Atopic Dermatitis • Dermatitis • Immunology • Inflammation

Therapeutic Potential of LCAA-PSF in Atopic Dermatitis: Insights from an MC903-Induced Mouse Model (EAACI 2025) - "Conclusion LCAA-PSF demonstrates significant anti-inflammatory and immunomodulatory effects by targeting the JAK-STAT signaling pathway in an AD murine model. These findings position LCAA-PSF as a promising adjunctive therapy for AD, offering a potential new approach to disease management."

IO biomarker • Preclinical • Atopic Dermatitis • Dermatitis • Immunology • IL13 • IL4 • IL5

Opsin 3 in keratinocytes mediates the light-induced exaggeration of atopic dermatitis. (PubMed, J Allergy Clin Immunol) - "OPN3 plays a microenvironment-specific proinflammatory role in KCs upon light exposure, and may serve as a candidate of therapeutic targets for AD."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Psoriasis • CXCL8 • IL1B • TNFA

Natural product-based compounds demonstrate potent anti-inflammatory and anti-itch effects in a mouse model of atopic dermatitis (SID 2025) - "In a MC903-induced mouse model of AD, DB007-5 demonstrated strong and concentration dependent inhibition of inflammation score (p<0.05 for 0.5%, 0.75% and 1% concentrations). Further, at 0.75%, DB007-5 reduced scratching (itch) score at Day 12 from 7.2+/-2.70 in vehicle treated group to 0.70+/-0.33, p<0.05), while ruxolitinib 1.5% reduced the scratching score to 1.7+/-0.62, p<0.05). In summary, DB007-5 demonstrated strong anti-inflammatory effects as well as potent inhibition of the primary symptom of AD, namely itch. Further studies are underway to evaluate the potential of DB007-5 as a therapy for AD."

Late-breaking abstract • Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • IL13 • IL4 • IL5

Allergic Skin Inflammation Drives IL-4-Dependent Differentiation of Dermal CD11b-low Dendritic Cells. (PubMed, J Invest Dermatol) - "We employed a model of MC903-induced atopic dermatitis in which CD11b-low DC2s migrate from skin to the draining lymph node (dLN) in a thymic stromal lymphopoietin receptor (TSLPR)-dependent manner, temporarily depleting the skin CD11b-low population...We confirmed this latter finding by showing that IL-4 treatment was sufficient to induce CD11b-low differentiation both in DC cultures and in IL-13 KO mice. Our findings suggest that, in the absence of IL-13, IL-4 produced during type-2 skin inflammation can induce CD11b-low DC2 differentiation, providing insight into how inflammation can drive an environment that supports further allergic sensitization."

Journal • Allergy • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • CD4 • CRLF2 • IL13 • IL4 • IL4R • ITGAM • KLF4 • TSLP

Thymic stromal lymphopoietin-activated basophil promotes lung inflammation in mouse atopic march model. (PubMed, Front Immunol) - "Mouse AM models were established in C57BL/6 mice using MC903 and OVA epicutaneous sensitization, followed by intranasal OVA challenges...Basophils play a crucial role in OVA-induced lung inflammation in the context of AD-like skin lesions, and TSLP appears to drive basophil activation. Understanding these interactions provides insights for potential therapeutic interventions in AM-associated conditions."

Journal • Preclinical • Asthma • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • Systemic Inflammatory Response Syndrome • CRLF2 • IL4 • PTPRC • TSLP

Electroacupuncture exerts antipruritic and anti-inflammatory effects on atopic dermatitis by activating CB2 receptor. (PubMed, Chin Med) - "EA exerts therapeutic effects on persistent itch and skin inflammation in AD mice by activating CB2R, thereby inhibiting mast cell and CD4+ T cell proliferation and the expression of associated inflammatory factors, as well as downstream ERK phosphorylation."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • CD4 • IL13 • IL1R1 • IL4R

A murine model of psoriasis and atopic dermatitis induced with a combination of systemic IL-23 overexpression and topical application of the vitamin D3 analog MC903 (SID 2025) - "Combined treatment with IL-23/MC903 resulted in earlier and more severe lesions than single treatment with IL-23 or MC903 alone, accompanied by increased epidermal thickness and Munro microabscesses. Elevated Th17 (IL-17A, IL-22) and Th2 (IL-4, IL-13, TSLP) cytokines were observed, along with high IL-36G levels. Flow cytometry showed increased infiltration of IL-4+ T cells, γδ T cells, and neutrophils."

Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Psoriasis • IL13 • IL17A • IL22 • IL23A • IL33 • IL4 • TSLP

Streptococcus in the skin microbiome of children exacerbates inflammation in atopic dermatitis (SID 2025) - "This synergy also directly exacerbated inflammation in a mouse model of AD (MC903), where application of both S. aureus and S. oralis each at 5x105 CFU/cm2 intensified skin barrier disruption and type 2 inflammation compared to applying either species alone at 1x106 CFU/cm2 (P=0.028)...aureusstrains lacking phenol-soluble module-α or δ-toxin did not synergize with Strep, and skin inflammation was blocked by a novel antimicrobial strain of Staph hominis (ShC2) that kills both S. aureus and Strep, while a mutant strain of ShC2 lacking the active lantibiotic (ShC2-Δlanti) did not. These findings reveal a previously unknown cooperation between S. aureus and Strep, suggesting that synergy and competition between bacteria likely play an important role in the pathophysiology of AD in children."

Clinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Pediatrics

Dermal fibroblasts subsets activate Ccr3 to promote allergic inflammation (SID 2025) - "Analysis of scRNA-seq data in a mouse AD model (MC903 +S...Finally, administering a Ccr3 antagonist in the AD mouse model via intraperitoneal injection reduced inflammation and T-cell migration into the skin. These findings demonstrate that fibroblasts are key responders to Th2 cytokines and that Ccr3 ligands, particularly Ccl8 from fibroblasts, may play a role in leukocyte recruitment during allergic inflammation."

Acne Vulgaris • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Psoriasis • CCL11 • CCL2 • CCL5 • CCL8 • CCR3 • IL13 • IL17A • IL1B • IL4 • IL4R • PDGFRA • TNFA

Streptococcal species with high protease activity promote IL-4 expression and correlate with atopic dermatitis severity in infants (SID 2025) - "In a Balb/c MC903 AD mouse model, the application of streptococcal species with gelE+ activity induced elevated expression of both IL-17A and IL-4 mRNA (75.2-fold increase). In addition, streptococcal species with high gelE+ activity inhibited AMP expression (Camp) (43.6-fold decrease) compared to strains of the same streptococcal species without gelE- activity. These data suggest that in children, colonization with Streptococcal species other than S. pyogenes may contribute to AD flares by producing a metalloprotease that promotes its own survival, enhances the survival of other streptococcal species, and induces a potent type 2 inflammatory response."

Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Pediatrics • IL17A • IL4

Involucrin-casein kinase 1e-vitamin D receptor is a functional regulatory axis for human skin evolution and diversity (SID 2025) - "Ck1e inhibition in MC903-treated HaCAT and mouse KCs resulted in a significant decrease in nuclear VDR and TSLP expression, with lower migrating VDR band in human KCs revealing CK1e phosphorylation of VDR that was confirmed by λ phosphatase treatment. Taken together, we identify a functional IVL/CK1e/ VDR regulatory axis whose dosage for IVL underlies human skin barrier evolution and diversity out-of-Africa."

Dermatitis • Inflammation • FOS • TSLP • VDR