linezolid IV / Generic mfg. - LARVOL DELTA

AN UNCONVENTIONAL APPROACH TO TREATING VRE EMPYEMA WITH INTRAPLEURAL DAPTOMYCIN (CHEST 2025) - "The inappropriate use of antimicrobials over the last five decades has led to increased resistance, as seen with Vancomycin-Resistant Enterococci (VRE)...Intravenous linezolid was initiated in addition to amphotericin, but repeated fluid cultures continued to grow VRE... We illustrate the successful use of intrapleural Daptomycin in treating VRE empyema, despite early termination. Recurrent complications following the administration of a usually asymptomatic clinical entity may warrant further investigation considering its questionable association. Nonetheless, clinician awareness towards the effective use of intrapleural Daptomycin as a treatment for VRE infections, should couple with monitoring for adverse reactions, especially in immunocompromised patients."

CNS Disorders • Epilepsy • Gastrointestinal Disorder • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases

TUBERCULOSIS-IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME WITH WORSENING LYMPHADENOPATHY AND PULMONARY INFILTRATES IN HIV-NEGATIVE, IMMUNOCOMPETENT INDIVIDUAL (CHEST 2025) - "RIPE (Rifampin, Isoniazid, Pyrazinamide, Ethambutol) regimen was initiated, leading to clinical improvement with weight gain...RIPE was therefore continued with added intravenous linezolid and levofloxacin. Prednisone was initiated for suspected TB-IRIS and within two days, symptoms improved, including reduced neck swelling and odynophagia... Identifying clear predictive factors and clinically proven treatment for TB-IRIS can ultimately prevent excessive inflammation and clinical deterioration despite anti-TB treatment. Additional studies are needed to characterize and optimize management of TB-IRIS in HIV-negative, immunocompetent patients."

Clinical • Cough • Immunology • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis • CD4

ISOLATED PULMONARY MUCORMYCOSIS: A RARE MANIFESTATION OF INVASIVE FUNGAL DISEASE AND BACTERIAL COINFECTION (CHEST 2025) - "Despite initiating empiric antibiotic treatment with linezolid and ceftriaxone, intravenous fluids, and insulin drip for DKA, he subsequently developed worsening respiratory failure and suffered brief cardiac arrest requiring mechanical ventilation. Given the fatality of this infection, early detection is paramount in immunocompromised patients to ensure therapeutic interventions are promptly initiated."

Cardiovascular • Diabetes • Hypotension • Infectious Disease • Metabolic Disorders • Pneumonia • Respiratory Diseases • Type 1 Diabetes Mellitus

Clinical use and safety profile of intravenous linezolid in hospitalised children: A retrospective cohort experience. (PubMed, Eur J Pediatr) - "In a restricted cohort excluding chemotherapy/HSCT and any myelotoxic agent (including meropenem), event rates declined while the early-onset pattern persisted. • Paediatric evidence is limited and often confounded by concomitant myelotoxic therapies What is New: • In paediatric inpatients on IV linezolid, anaemia and thrombocytopenia often occur in week 1, with anaemia prominent when myelotoxic co-therapy or prior glycopeptides are present. • In a restricted cohort excluding myelotoxic co-therapy/chemotherapy, event rates declined, yet early onset persisted, supporting robustness beyond confounding."

Journal • Retrospective data • Bone Marrow Transplantation • Hematological Disorders • Oncology • Pediatrics • Thrombocytopenia

Linezolid continuous infusion protects from subtherapeutic linezolid concentrations in critically ill patients. (PubMed, Med Intensiva (Engl Ed)) - "As far as we know, this is the largest study reporting data on factors associated with subtherapeutic linezolid concentrations in critically ill patients. To our knowledge, our study is the first to report that linezolid continuous infusion was independently associated with lower risk of subtherapeutic linezolid concentrations in critically ill patients."

Journal • Critical care • Infectious Disease

Efficacy of linezolid in treating upper-extremity arteriovenous graft infection in maintenance hemodialysis patients. (PubMed, Postgrad Med) - "The AVG infections were divided into two groups: the control group (teicoplanin 200 mg/day iv) and the linezolid group (600 mg/day iv). Additionally, the average cost in the linezolid group was significantly lower than that in the control group (CNY 15,050 ± 1,611 versus 23,920 ± 4,097, p = 0.039). Linezolid was found to effectively control most cases of AVG infections, resulting in shorter hospital stays and significantly reducing the clinical burden on MHD patients especially when the blood or wound cultures were negative."

Journal • Chronic Kidney Disease • Infectious Disease • Nephrology • Pain

A Case of Maltreated Scabies (EADV 2025) - "Management included tapering systemic steroids, oral ivermectin, topical permethrin, oral and topical antifungals, IV antibiotics (linezolid), and antihypertensives... This case highlights the risks of unregulated steroid use and improper management of scabies, a disease that is simple to treat but often neglected. Education on early diagnosis, avoidance of self-medication or quack remedies, and timely access to dermatological care are critical to prevent iatrogenic complications. Public health awareness, especially in under-served communities, is essential to manage scabies effectively and prevent its morbidity."

Clinical • Cardiovascular • Cushing’s Disease • Dermatology • Diabetes • Endocrine Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Pruritus

Towards model-informed precision dosing of intravenous linezolid: a multicentre external evaluation of pharmacokinetic models in critically ill adults. (PubMed, Clin Microbiol Infect) - "Predictive performance varied substantially underlining the importance of model evaluation prior to MIPD implementation for linezolid. Using the aforementioned models promises target attainment rates up to 80% in critically ill patients."

Journal • PK/PD data • Infectious Disease

Author Response: Continuous Infusion of Linezolid: Explaining the Discrepant Survival Outcomes between Two Studies. (PubMed, Indian J Crit Care Med) - No abstract available

Journal

Continuous Infusion of Linezolid: Explaining the Discrepant Survival Outcomes between Two Studies. (PubMed, Indian J Crit Care Med) - No abstract available

Journal • Critical care • Infectious Disease • Pneumonia

Not all species are the same: Treatment of Actinomyces europaeus and Clostridium innocuum necrotizing fasciitis: Case report and literature review. (PubMed, Am J Health Syst Pharm) - "It is important to rapidly identify the species for both Actinomyces and Clostridium infections and obtain sensitivity values to help ensure proper therapy is given. Interpretation of minimum inhibitory concentrations is difficult without established breakpoints. Piperacillin/tazobactam resistance has been reported for A. europaeus, while vancomycin resistance has been reported for C. innocuum. For Actinomyces infections, duration of therapy should be individualized and can range from 14 days to 1 year based on patient response and the species."

Journal • Infectious Disease • Pain

High feasibility of salivary therapeutic drug monitoring in linezolid, but lower feasibility in tedizolid: a single-dose study in healthy subjects and a monocentric prospective exploratory study in patients who received linezolid. (PubMed, J Antimicrob Chemother) - "Salivary TDM is a promising alternative to conventional serum sampling for linezolid but is less feasible for tedizolid."

Journal

Atypical Presentation of Lemierre's Syndrome Due to Pseudomonal Parotitis (ATS 2025) - "Despite initiation of Ampicillin and Sulbactam, continued decline ensued...Treatment course included IV Linezolid and Piperacillin/Tazobactam...Physicians and advanced practitioners should consider Lemierre's Syndrome as a differential in severe clinical contexts. Our patient had a successful clinical outcome, underscoring the high survival rate with prompt recognition and treatment."

Cardiovascular • Mumps • Musculoskeletal Diseases • Novel Coronavirus Disease • Orthopedics • Otorhinolaryngology • Pain • Pneumonia • Pulmonary Embolism • Respiratory Diseases • Xerostomia

When Asthma Isn't Just Asthma: Uncovering Bronchiectasis and Staph in APECED (ATS 2025) - "Bronchoalveolar lavage samples were positive for Staphylococcus aureus, prompting targeted antibiotic therapy with intravenous Linezolid... This case emphasizes the value of proactive monitoring and early intervention to prevent prolonged complications in APECED. The presence of bronchiectasis and Staphylococcus aureus colonization in this patient highlights the need for heightened clinical vigilance regarding respiratory complications in immunocompromised individuals such as those with APECED. As recent studies suggest, mutations in the AIRE gene may disrupt immune tolerance, predisposing patients to complex infections that extend beyond typical autoimmune presentations."

Asthma • Bronchiectasis • Candidiasis • Cough • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • AIRE

An Unexpected Presentation of MRSA Pneumonia (ATS 2025) - "Empiric treatment with piperacillin-tazobactam was initiated...Pleural fluid cultures grew Streptococcus anginosus and antibiotic coverage was narrowed to ampicillin-sulbactam...Antibiotics were broadened to cefepime, vancomycin, and metronidazole...Patient was continued on all three antibiotics and therapeutic IV heparin was initiated. Once the patient showed clinical improvement on day 9, antibiotic coverage was narrowed to IV linezolid and later to oral doxycycline to complete a total antibiotic course of 36 days...However, despite a high negative predictive value (96.1%-99.8%), nasal MRSA screens may fail to detect pulmonary MRSA infections, so it remains a possibility that MRSA was a contributing pathogen on admission. Thus, providers should maintain a high degree of suspicion when there is evidence of clinical deterioration."

Acute Respiratory Distress Syndrome • Cardiovascular • Cerebral Palsy • CNS Disorders • Epilepsy • Infectious Disease • Pediatrics • Pneumonia • Pulmonary Embolism

PERICARDIAL ABSCESS IN A CHILD DUE TO PRE-XDR TUBERCULOSIS WITH MULTI-SYSTEMIC COMPLICATIONS (ESPID 2025) - "GeneXpertTB-Rif TM on the drained pus detected Mycobacterium tuberculosis(Mtb) with rifampicin resistance. The patient was started on moxifloxacin, injectable amikacin, linezolid, clofazamine, ethionamide, cycloserine and Pyridoxine as per prevailing WHO recommendations...Pre-XDR regimen was started- delamanid, moxifloxacin, linezolid, clofazamine, ethionamide, cycloserine and pyridoxine. Culture grew Mtb resistant to 1st line agents, levofloxacin, ofloxacin and clofazamine and sensitive to para-aminosalicylic acid, ethionamide, kanamycin, caperomycin, amikacin, linezolid and moxifloxacin...Adrenocorticotropic hormone (ACTH) was detected to be below 1.5 pg/mL and low serum cortisol levels (0.32µg/mL), he improved on hydrocortisone therapy...Learning Points/Discussion Serious complications during treatment of DRTB could be managed by timely detection and multi-disciplinary team. Child-friendly formulations are required."

Clinical • Infectious Disease • Tuberculosis

NEONATAL SEPSIS FROM VANCOMYCIN-RESISTANT ENTEROCOCCUS FAECIUM: THE ROLE OF MATERNAL GUT COLONIZATION (ESPID 2025) - "Cefotaxime was suspended; IV ampicillin and gentamicin were continued for 14 and 7 days, respectively. IV linezolid was administered for 7 days following the discontinuation of gentamicin...This case highlights the role of maternal gut colonization in neonatal sepsis caused by VRE. To prevent the spread of these pathogens, it is crucial to enhance infection control measures, improve early VRE detection in microbiology laboratories, and support antimicrobial stewardship and screening programs."

Infectious Disease • Septic Shock

A rare case of multiple brain abscesses caused by Nocardia abscessus co-infection with tuberculous meningitis in an immunocompetent patient. (PubMed, BMC Infect Dis) - "Nocardial brain abscesses are associated with a high mortality rate, especially among immunocompromised patients and those with multiple abscesses. Prompt diagnosis, aggressive surgical intervention, and sensitive antibiotic treatment offer the best prospects for curing nocardiosis. Tuberculous meningitis, the most lethal manifestation of Mycobacterium tuberculosis infection, often leads to severe outcomes primarily due to delayed diagnosis and treatment. The GeneXpert/RIF assay, an emerging diagnostic tool, provides a more sensitive and rapid means of detecting TBM. For patients with a high clinical suspicion of TBM, empirical anti-tuberculosis treatment should be initiated immediately. Timely and accurate management, coupled with continuous monitoring of the patient's condition, is crucial for achieving a favorable prognosis."

Journal • CNS Disorders • Infectious Disease • Pain • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock • Tuberculosis • Ventriculomegaly

Continuous infusion of linezolid for critically ill patients: toward a new standard of care. (PubMed, Intensive Care Med) - No abstract available

Journal

Mycobacterium Abscessus Infection in Left Ventricular Assist Device Patient (ISHLT 2025) - "Infectious disease service was consulted, and the patient was started on a regimen of omadacycline 100 mg IV daily, linezolid 600 mg IV daily, and clarithromycin 500 mg PO every 12 hours and continued for a total of six weeks. Based on final sensitivity (Fig1B), he was transitioned to IV amikacin...Further information is warranted to explore the role of omadacycline and other novel agents in managing such rare infections. This case underscores the need for individualized, tailored antimicrobial regimens in the management of uncommon LVAD-related infections."

Clinical • Cardiomyopathy • Cardiovascular • Diabetes • Infectious Disease • Metabolic Disorders

Genomic characteristics of extraintestinal pathogenic Escherichia coli/ST88 and monophasic Salmonella Typhimurium/ST34 in a patient with double bacteremia (PubMed, Zhonghua Yi Xue Za Zhi) - "The patient's temperature returned to normal after anti-infection treatment with linezolid and glucose injection, imipenem and cistatin, and meropenem successively. ExPEC/ST88 is the primary pathogen causing bloodstream infection in this patient, marking the first case reported in Asia, and the coexistence with colistin-resistant MST makes this case even more rare. ExPEC/ST88 has the characteristics of high antibiotic resistance, high virulence, and high recombination of zoonotic and foodborne invasive diseases."

Journal • Retrospective data • Infectious Disease • Respiratory Diseases

OraPAT-IEGAMES: Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis (clinicaltrials.gov) - P4 | N=360 | Recruiting | Sponsor: Fundacion Clinic per a la Recerca Biomédica | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2024 ➔ Dec 2027 | Trial primary completion date: Jun 2024 ➔ Oct 2026

Enrollment open • Trial completion date • Trial primary completion date • Cardiovascular • CRP

Maxillary MRSA osteomyelitis in a paediatric patient: non-surgical management. (PubMed, BMJ Case Rep) - "The patient was treated with intravenous linezolid and amikacin for 5 days, followed by 8 weeks of oral linezolid...This case highlights the importance of early diagnosis, tailored antibiotic therapy and conservative surgical management to ensure positive outcomes in paediatric maxillary osteomyelitis cases. Further research is needed to establish standardised treatment protocols for facial osteomyelitis in children."

Journal • Infectious Disease • Inflammation • Mood Disorders • Pain • Pediatrics

Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency. (PubMed, Drug Des Devel Ther) - "The retrospective study enrolled adult patients treated with intravenous linezolid or teicoplanin at Suzhou Municipal Hospital between July 2018 and August 2023. Linezolid-treated patients with HAP and renal insufficiency had higher bacterial eradication rates, supratherapeutic exposure and adverse reactions than teicoplanin-treated patients. Linezolid dose reduction in patients with renal insufficiency improved the probability of achieving optimal exposure."

Journal • PK/PD data • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

LOVip: Linezolid or Vancomycin Surgical Site Infection Prophylaxis (clinicaltrials.gov) - P4 | N=1160 | Recruiting | Sponsor: Assistance Publique Hopitaux De Marseille | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease