linezolid IV / Generic mfg. - LARVOL DELTA

Acute Necrotizing Gastritis Secondary to Vancomycin-Resistant Enterococcus faecium : A Non-Surgical Approach (ACG 2026) - "The patient was treated with intravenous (IV) fluconazole, meropenem, vancomycin, and acyclovir...The patient completed a two-week course of IV linezolid with continued clinical improvement and was discharged with outpatient gastroenterology follow-up...Multiple Forrest III ulcers with gastric erosions noted throughout the stomach. Abundant food material was noted."

Diabetes • Gastrointestinal Disorder • Hypotension • Infectious Disease • Metabolic Disorders • Pancreatitis • Peptic Ulcer • Pneumonia • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

Coronary stent infection causing perforation and thrombotic occlusion after early post-PCI methicillin-resistant Staphylococcus aureus bacteraemia: an autopsy case report. (PubMed, Eur Heart J Case Rep) - "Intravenous linezolid was started because of renal dysfunction...This case raises the possibility that a recently implanted DES may serve as an occult endovascular focus during SAB. Negative follow-up blood cultures, defervescence, normalized inflammatory markers, and unrevealing imaging may not exclude CSI; persistent or recurrent chest symptoms after recent PCI should prompt targeted reassessment."

Journal • Dermatology • Infectious Disease • Nephrology • Renal Disease

Comparative pharmacovigilance analysis of intravenous versus oral linezolid: Insights from the FDA Adverse Event Reporting System. (PubMed, Medicine (Baltimore)) - "The safety profiles of linezolid differ significantly between intravenous and oral routes, largely driven by treatment duration, patient population, and clinical setting. These findings support route-specific monitoring strategies: acute toxicity surveillance for intravenous therapy and long-term neurotoxicity and hematologic monitoring for oral therapy."

Adverse events • Clinical • Journal • Acute Kidney Injury • Agranulocytosis • Granulocytopenia • Hematological Disorders • Leukopenia • Metabolic Disorders • Nephrology • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Renal Disease

Acromegaly Discovered After Head Trauma: Multivessel Coronary Disease and Postoperative Meningitis Complicating a Pituitary Macroadenoma. (PubMed, Cureus) - "The early postoperative course was complicated by bacterial sinusitis and subsequent bacterial meningitis treated with intravenous cefepime and linezolid. By three months postoperatively, IGF-1 had normalized, and the patient had achieved substantial weight loss and improved glycemic control, although follow-up polysomnography showed worsening OSA despite biochemical remission. This case illustrates the diagnostic delay typical of acromegaly, the impact of unrecognized cardiovascular comorbidity on surgical timing, and the infectious complications that can follow transsphenoidal surgery."

Journal • Acromegaly • Cardiovascular • CNS Disorders • Coronary Artery Disease • Diabetes • Endocrine Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Obstructive Sleep Apnea • Oncology • Otorhinolaryngology • Respiratory Diseases • Sinusitis • Sleep Disorder • Type 2 Diabetes Mellitus • IGF1

Differential salivary disposition of linezolid and its two major metabolites (PNU-142300 and PNU-142586) after a single dose in healthy adults. (PubMed, J Antimicrob Chemother) - "Under the conditions studied, linezolid was quantifiable in saliva, whereas its two major metabolites were not, indicating different salivary disposition profiles for the parent drug and its metabolites. Salivary concentrations were consistent with protein-unbound serum exposure to linezolid under the conditions studied, whereas exposure to PNU-142300 and PNU-142586 could not be assessed using saliva and required blood-based measurements in the present study."

Journal

Impact of Elexacaftor/Tezacaftor/Ivacaftor on Systemic Antibiotic Utilization in Pediatric Patients With Cystic Fibrosis. (PubMed, Pediatr Pulmonol) - "ETI therapy was associated with decreased antibiotic days for many therapeutic classes of both enteral and IV antibiotics."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pediatrics • Pulmonary Disease • Respiratory Diseases • CFTR

Optimization of linezolid infusion duration in critically ill patients: a population pharmacokinetic analysis of the trade-off between efficacy and toxicity. (PubMed, Front Pharmacol) - "In critically ill patients, the optimal infusion duration for linezolid exhibits a non-linear dependency on dose and MIC. For high-MIC pathogens requiring intensified dosing (e.g., 900 mg q12 h), a prolonged infusion of 2-5 h optimizes the therapeutic index, synergizing maximal efficacy with a necessary elimination phase to mitigate toxicity."

Journal • PK/PD data • Infectious Disease

Polyarticular Septic Arthritis Following Hemodialysis in an Immunocompetent Patient With Acute Renal Failure. (PubMed, Cureus) - "The patient underwent multiple joint washouts and was treated with intravenous vancomycin and linezolid. This case highlights the potential for PASA in an immunocompetent individual after a single hemodialysis session, emphasizing the role of catheter-related bloodstream infection (CRBSI) in its pathogenesis and underscoring the importance of timely diagnosis and treatment to prevent severe outcomes. Such presentations underscore the importance of heightened clinical vigilance, as delayed recognition can result in significant morbidity."

Journal • Acute Kidney Injury • Dermatology • Immunology • Infectious Disease • Musculoskeletal Diseases • Nephrology • Orthopedics • Renal Disease • Rheumatology • Septic Shock

Daptomycin and linezolid salvage therapy for persistent ampicillin-susceptible Enterococcus faecalis bacteremia in a patient with possible anaphylaxis to β-lactam and glycopeptide antimicrobials: A case report. (PubMed, J Assoc Med Microbiol Infect Dis Can) - "His management was complicated by a suspected anaphylactic reaction shortly after receiving vancomycin and ceftriaxone that progressed after receiving ampicillin and cefazolin, as well as delayed source control due to safety concerns withholding anticoagulation for concurrent high-burden bilateral pulmonary emboli, ultimately resulting in persistent bacteremia. His bacteremia cleared with combination therapy of daptomycin 10 mg/kg intravenously daily and linezolid 600 mg orally every 12 hours...The bacteremia cleared with combination daptomycin and linezolid therapy on day 9 of admission, prior to achieving source control with nephrostomy tube insertion 2 days later. The patient made a complete recovery."

Journal • Cardiovascular • Infectious Disease • Pulmonary Embolism • Renal Calculi • Urolithiasis

Mycobacterium Abscessus Infection after Breast Augmentation: Case Reports and Literature Review. (PubMed, Aesthetic Plast Surg) - "This study reports two rare cases of M. abscessus infection occurring after breast aesthetic surgery. Such infections are difficult to diagnose and are often associated with prolonged treatment courses. We successfully identified the causative pathogen through mNGS and implemented a comprehensive treatment strategy that included multiple surgical debridements, local irrigation, and combination antimicrobial therapy with azithromycin, amikacin, and linezolid, which was associated with favorable clinical outcomes. Rather than establishing a definitive management model, this study provides practical, case-based insights into the diagnosis and management of postoperative M. abscessus infections."

Journal • Review • Aesthetic Medicine • Infectious Disease

Therapeutic drug monitoring-guided linezolid salvage therapy for Lacticaseibacillus paracasei infective endocarditis: A case report. (PubMed, J Infect Chemother) - "We report a rare case of infective endocarditis (IE) caused by Lacticaseibacillus paracasei (formerly Lactobacillus paracasei) that was managed with intravenous linezolid as salvage therapy...The initial ampicillin/clindamycin therapy was discontinued due to suspected drug fever, and subsequent levofloxacin monotherapy was complicated by a drug-induced rash...To our knowledge, reports of Lactobacillus IE managed with linezolid TDM are ecseedingly rare. This case suggests that linezolid, guided by TDM, may be considered as a salvage option for Lactobacillus IE."

Journal • Cardiovascular • Hematological Disorders • Thrombocytopenia

When Wheezing Is Not Asthma: Pulmonary Manifestations of AIRE-Related Autoimmune Polyendocrine Syndrome (ENDO 2026) - "Targeted therapy with intravenous linezolid led to rapid clinical improvement...Persistent wheezing or dyspnea in patients with autoimmune polyendocrine syndromes should prompt evaluation for structural lung disease and infection. Long-term pulmonary surveillance may be warranted in symptomatic patients to prevent irreversible lung damage."

Asthma • Bronchiectasis • Candidiasis • Chronic Cough • Cough • Endocrine Disorders • Immunology • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • AIRE • IL17A • IL22

LINEZOLID-ASSOCIATED LACTIC ACIDOSIS IN PEDIATRIC PATIENTS: A RETROSPECTIVE COHORT ANALYSIS (ESPID 2026) - "Method We conducted a retrospective cohort analysis of 223 pediatric patients receiving intravenous linezolid at a tertiary children's hospital...Conclusions/Learning Points Lactic acidosis represents a clinically relevant complication of linezolid therapy in selected pediatric populations, particularly in those with critical illness or metabolic vulnerability. Early lactate monitoring may facilitate timely recognition and improved safety during treatment."

Retrospective data • Infectious Disease

MULTIFOCAL OSTEOMYELITIS AND ABSCESSES IN A NEWLY ARRIVED ADOLESCENT FROM NIGERIA: A DIAGNOSTIC CHALLENGE (ESPID 2026) - "Targeted therapy with intravenous linezolid and clindamycin was administered for four weeks, along with surgical curettage and apposition of endo-canal calcium sulphate mixed with vancomycin, with progressive clinical improvement. Two doses of dalbavancin were subsequently administered as outpatient parenteral therapy...Partial response to empirical antibiotics and a broad-spectrum of differential diagnoses contributed to diagnostic delay. Multidisciplinary evaluations, prolonged targeted antibiotic therapy with antitoxin activity and surgery were pivotal for effective management."

Infectious Disease • Septic Shock • CRP

COMLPICATED MASTOIDITIS IN CHILDREN: CASE SERIES HIGHLIGHTING DIVERSE SEVERE INTRACRANIAL AND VASCULAR COMPLICATIONS (ESPID 2026) - "Managed with mastoidectomy and intravenous meropenem/linezolid. Mastoidectomy, IV antibiotics (meropenem/linezolid) 2 8½ y.o. / ♀ Acute torticollis, hearing loss Internal jugular vein thrombosis Not isolated Mastoidectomy, ventilation tubes, IV antibiotics, anticoagulation 3 5½ y.o. / ♂ Fever, lethargy, neck stiffness Petrous bone, carotid artery and meningeal involvement Streptococcus pyogenes Mastoidectomy, IV antibiotics (meropenem/linezolid) Learning Points/Discussion Early diagnosis and multidisciplinary management are essential in complicated mastoiditis. Combined surgical intervention and intravenous antimicrobial therapy are critical to preventing severe intracranial and vascular complications."

Clinical • Infectious Disease

Pneumococcal Rib Osteomyelitis With Concurrent Lung and Chest Wall Abscess in an Infant. (PubMed, Pediatrics) - "Because of benzylpenicillin and cephalosporin allergy, intravenous linezolid was selected, resulting in rapid clinical improvement...This case underscores the importance of appropriate imaging modalities in febrile infants without respiratory symptoms and the need to consider extrapulmonary spread in chest wall masses. It highlights the diagnostic value of metagenomic sequencing and susceptibility testing in guiding individualized antimicrobial therapy, particularly in macrolide-resistant settings."

Journal • Allergy • Immunology • Infectious Disease • Inflammation • Pneumococcal Infections • Pneumonia

Top-down measurement uncertainty for subvisible particles by light obscuration in injections - Uncertainties from precision and recovery studies. (PubMed, J Pharm Biomed Anal) - "Four intravenous drug products (linezolid, fluconazole, metronidazole and ciprofloxacin) were analyzed under different sampling volumes and discard flow rates...Uncertainty estimation integrated contributions from precision and trueness supported by recovery studies using an independent particle counter. The application of a top-down enhances the reliability of conformity decisions, reducing the risk of false acceptance or rejection of injectable drugs and supports robust pharmaceutical quality control practices."

Journal

Refractory Mycobacterium fortuitum skin and soft tissue infection following dog bite in a pediatric patient: a case report. (PubMed, BMC Pediatr) - "This case underscores three critical findings: (1) NTM infections warrant inclusion in the differential diagnosis of animal bite wounds refractory to β-lactams; (2) tNGS facilitates rapid rare pathogen identification, enabling target-directed therapy within 48 h; (3) The multidisciplinary team is imperative to coordinate combined antimicrobial and surgical interventions. Enhanced awareness of the zoonotic potential of NTM is recommended for bite wound management, particularly in pediatric patients."

Journal • Infectious Disease • Inflammation • Mood Disorders • Nontuberculous Mycobacterial Disease • Pediatrics • Respiratory Diseases

Lactate abnormalities during intravenous linezolid therapy in hospitalized children: a brief report. (PubMed, Eur J Pediatr) - "Hyperlactatemia and/or lactic acidosis tended to develop early after treatment initiation and was more frequently observed in younger children and in those with complex underlying conditions, including neurometabolic and hemato-oncologic disorders. These findings suggest that host-related factors may influence susceptibility to lactate disturbances during linezolid therapy and support careful clinical monitoring in selected pediatric populations."

Journal • Retrospective data • Infectious Disease • Metabolic Disorders • Pediatrics

Safety and Efficacy Study of Contezolid Acefosamil and Contezolid Compared to Linezolid Administered Intravenously and Orally to Adults With Moderate or Severe Diabetic Foot Infections (DFI) (clinicaltrials.gov) - P3 | N=865 | Recruiting | Sponsor: MicuRx | N=644 ➔ 865

Enrollment change • Infectious Disease

Increased burden of invasive group A streptococcal disease among Australian children, 2023-2024: a prospective cohort study. (PubMed, Lancet Reg Health West Pac) - "Adjunctive clindamycin, linezolid or intravenous immunoglobulin was used in 201/374 (54%), including 126/147 (86%) of severe disease cases. The dynamic epidemiology and persistent burden of disease highlight the need for continued vigilant public health efforts, surveillance, and vaccine development. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors."

Journal • Critical care • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Septic Shock

Linezolid-Induced Pancytopenia with Hyponatremia: A Case Report. (PubMed, Curr Drug Saf) - "Based on the World Health Organization-Uppsala Monitoring Centre (WHOUMC) causality assessment scale, the association between linezolid and pancytopenia with hyponatremia is considered probable in this case. This case report emphasizes that clinicians should be cautious, as these serious adverse effects can occur on re-exposure to linezolid, even if absent during previous use."

Journal • Cardiovascular • Dermatology • Heart Failure • Hematological Disorders • Thrombocytopenia

Acquisition of bedaquiline and clofazimine resistance in association with a novel loss-of-function mutation in the pepQ gene during treatment of multidrug-resistant tuberculosis. (PubMed, ASM Case Rep) - "Bedaquiline (BDQ) has transformed the management of multidrug-resistant (MDR) and rifampin-resistant tuberculosis (TB)...Therapeutic drug monitoring while on MDR therapy (daily ethambutol, pyrazinamide, linezolid, CFZ, and intravenous amikacin) detected low serum levels of CFZ, which was not addressed prior to the addition of BDQ to her 5-drug regimen and may have selected for BDQ/CFZ cross-resistance. This case contributes to the limited clinical data implicating pepQ in BDQ/CFZ cross-resistance and describes a novel loss-of-function mutation associated with resistance. As our understanding of genotypic BDQ resistance remains elementary, when novel drug mutations arise, practitioners should consider their significance in the context of phenotypic drug susceptibility test results and the patient's clinical response."

Journal • Crohn's disease • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Continuous linezolid infusion: the new way to dose, the old risks to fear. (PubMed, J Antimicrob Chemother) - "We propose a pragmatic framework for candidate selection, regimen design aligned to PK/PD goals, early therapeutic drug monitoring with adaptive adjustments and vigilant safety monitoring. Overall, CI of linezolid is mechanistically attractive but is not established as standard of care; its use should remain individualized, safety-conscious and evidence-generating pending randomized controlled trials."

Journal • Review • Metabolic Disorders

Tailoring antitubercular therapy in a critically ill patient with abdominal tuberculosis. (PubMed, BMJ Case Rep) - "We used an initial antitubercular treatment with the combination of intravenous amikacin, linezolid and levofloxacin until intestinal function recovered. She was then transitioned to standard oral therapy with rifampicin, isoniazid, pyrazinamide and ethambutol, achieving full recovery. This case highlights the value of short-term parenteral antitubercular regimens as a bridge in critically ill patients with gastrointestinal compromise, underscoring the role of pharmacokinetic considerations and multidisciplinary care."

Journal • Critical care • Gastrointestinal Disorder • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis