linezolid IV / Generic mfg. - LARVOL DELTA

Linezolid-Induced Pancytopenia with Hyponatremia: A Case Report. (PubMed, Curr Drug Saf) - "Based on the World Health Organization-Uppsala Monitoring Centre (WHOUMC) causality assessment scale, the association between linezolid and pancytopenia with hyponatremia is considered probable in this case. This case report emphasizes that clinicians should be cautious, as these serious adverse effects can occur on re-exposure to linezolid, even if absent during previous use."

Journal • Cardiovascular • Dermatology • Heart Failure • Hematological Disorders • Thrombocytopenia

Acquisition of bedaquiline and clofazimine resistance in association with a novel loss-of-function mutation in the pepQ gene during treatment of multidrug-resistant tuberculosis. (PubMed, ASM Case Rep) - "Bedaquiline (BDQ) has transformed the management of multidrug-resistant (MDR) and rifampin-resistant tuberculosis (TB)...Therapeutic drug monitoring while on MDR therapy (daily ethambutol, pyrazinamide, linezolid, CFZ, and intravenous amikacin) detected low serum levels of CFZ, which was not addressed prior to the addition of BDQ to her 5-drug regimen and may have selected for BDQ/CFZ cross-resistance. This case contributes to the limited clinical data implicating pepQ in BDQ/CFZ cross-resistance and describes a novel loss-of-function mutation associated with resistance. As our understanding of genotypic BDQ resistance remains elementary, when novel drug mutations arise, practitioners should consider their significance in the context of phenotypic drug susceptibility test results and the patient's clinical response."

Journal • Crohn's disease • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Continuous linezolid infusion: the new way to dose, the old risks to fear. (PubMed, J Antimicrob Chemother) - "We propose a pragmatic framework for candidate selection, regimen design aligned to PK/PD goals, early therapeutic drug monitoring with adaptive adjustments and vigilant safety monitoring. Overall, CI of linezolid is mechanistically attractive but is not established as standard of care; its use should remain individualized, safety-conscious and evidence-generating pending randomized controlled trials."

Journal • Review • Metabolic Disorders

Tailoring antitubercular therapy in a critically ill patient with abdominal tuberculosis. (PubMed, BMJ Case Rep) - "We used an initial antitubercular treatment with the combination of intravenous amikacin, linezolid and levofloxacin until intestinal function recovered. She was then transitioned to standard oral therapy with rifampicin, isoniazid, pyrazinamide and ethambutol, achieving full recovery. This case highlights the value of short-term parenteral antitubercular regimens as a bridge in critically ill patients with gastrointestinal compromise, underscoring the role of pharmacokinetic considerations and multidisciplinary care."

Journal • Critical care • Gastrointestinal Disorder • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

LOVip: Linezolid or Vancomycin Surgical Site Infection Prophylaxis (clinicaltrials.gov) - P4 | N=1160 | Recruiting | Sponsor: Assistance Publique Hopitaux De Marseille | Trial completion date: Apr 2026 ➔ Dec 2029 | Trial primary completion date: Apr 2025 ➔ Dec 2028

Trial completion date • Trial primary completion date • Infectious Disease

Xuebijing Injection in synergy with linezolid alleviates inflammatory injury in mice with MRSA pneumonia by inhibiting the Hla-NLRP3 pathway (PubMed, Nan Fang Yi Ke Da Xue Xue Bao) - "LZD combined with XBJ produces enhanced efficacy for improving MRSA pneumonia possibly due to XBJ-induced inhibition of NLRP3-mediated inflammatory response via inhibiting α-hemolysin secretion."

Journal • Preclinical • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases • CASP1 • IL18 • IL1B • IL6 • NLRP3 • TNFA

Case Report: Fulminant shock due to PVL-positive Staphylococcus aureus in an adolescent-superantigen-negative sepsis with toxic shock-like features. (PubMed, Front Med (Lausanne)) - "Antimicrobial therapy was shifted to include antitoxin agents (clindamycin and linezolid)...PVL-positive S. aureus can, albeit rarely, be associated with an extreme toxic shock-like phenotype even when classical toxin genes are not detected. This case highlights the diagnostic and management challenges posed by atypical presentations and mixed shock physiology, and underscores the need for early recognition and rapid escalation of supportive care."

Journal • Acute Kidney Injury • Cardiovascular • Infectious Disease • Inflammation • Nephrology • Pain • Pulmonary Disease • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Septic Shock

Perinatal tuberculosis presenting as endobronchial tuberculosis diagnosed by bronchoscopy: a case report (PubMed, Zhejiang Da Xue Xue Bao Yi Xue Ban) - "Despite over 20 days of antibiotic therapy (including ceftriaxone, piperacillin-tazobactam, and vancomycin), his condition failed to improve...The infant was started on an HRZLzd anti-tuberculosis regimen (isoniazid 10 mg·kg－¹·d－¹ intravenous infusion, rifampicin 12.5 mg·kg－¹·d－¹ orally, pyrazinamide 30 mg·kg－¹·d－¹ orally, and linezolid 10 mg·kg－¹·d－¹ intravenous infusion). After one month of treatment, both his clinical symptoms and pulmonary imaging findings showed marked improvement."

Journal • Cough • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Central nervous system infection mimicking neuropsychiatric systemic lupus erythematosus: A case report (PubMed, Beijing Da Xue Xue Bao Yi Xue Ban) - "The patient, maintained on glucocorticoids and cyclosporine, presented with fever, headache, and left-sided limb numbness...Targeted anti-infective therapy with meropenem and linezolid, combined with intravenous immunoglobulin support, resulted in significant improvement of neurological symptoms and radiological abnormalities, ultimately confirming central nervous system (CNS) mixed infection rather than NPSLE...We recommend early multidisciplinary collaboration and proactive utilization of precision diagnostic techniques like CSF NGS to guide timely, targeted anti-infective strategies, ultimately improving the patient outcomes. This case provides valuable insights for clinicians regarding the differential diagnosis of CNS complications in immunocompromised patients, emphasizing the necessity of integrated modern diagnostic approaches for personalized therapeutic decision-making."

Journal • CNS Disorders • Herpes Zoster • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Pain • Psychiatry • Systemic Lupus Erythematosus • Varicella Zoster

Disseminated Methicillin-Resistant Staphylococcus aureus (MRSA) Infection Masquerading as Community-Acquired Meningitis. (PubMed, Cureus) - "As he continued to spike and developed the shoulder pain while on vancomycin/rifampicin, IV linezolid was commenced. As a result, the patient's condition improved and was discharged on oral linezolid followed by cotrimoxazole."

Journal • Back Pain • Cardiovascular • CNS Disorders • Infectious Disease • Lumbar Back Pain • Musculoskeletal Pain • Pain

AN UNCONVENTIONAL APPROACH TO TREATING VRE EMPYEMA WITH INTRAPLEURAL DAPTOMYCIN (CHEST 2025) - "The inappropriate use of antimicrobials over the last five decades has led to increased resistance, as seen with Vancomycin-Resistant Enterococci (VRE)...Intravenous linezolid was initiated in addition to amphotericin, but repeated fluid cultures continued to grow VRE... We illustrate the successful use of intrapleural Daptomycin in treating VRE empyema, despite early termination. Recurrent complications following the administration of a usually asymptomatic clinical entity may warrant further investigation considering its questionable association. Nonetheless, clinician awareness towards the effective use of intrapleural Daptomycin as a treatment for VRE infections, should couple with monitoring for adverse reactions, especially in immunocompromised patients."

CNS Disorders • Epilepsy • Gastrointestinal Disorder • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases

TUBERCULOSIS-IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME WITH WORSENING LYMPHADENOPATHY AND PULMONARY INFILTRATES IN HIV-NEGATIVE, IMMUNOCOMPETENT INDIVIDUAL (CHEST 2025) - "RIPE (Rifampin, Isoniazid, Pyrazinamide, Ethambutol) regimen was initiated, leading to clinical improvement with weight gain...RIPE was therefore continued with added intravenous linezolid and levofloxacin. Prednisone was initiated for suspected TB-IRIS and within two days, symptoms improved, including reduced neck swelling and odynophagia... Identifying clear predictive factors and clinically proven treatment for TB-IRIS can ultimately prevent excessive inflammation and clinical deterioration despite anti-TB treatment. Additional studies are needed to characterize and optimize management of TB-IRIS in HIV-negative, immunocompetent patients."

Clinical • Cough • Immunology • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis • CD4

ISOLATED PULMONARY MUCORMYCOSIS: A RARE MANIFESTATION OF INVASIVE FUNGAL DISEASE AND BACTERIAL COINFECTION (CHEST 2025) - "Despite initiating empiric antibiotic treatment with linezolid and ceftriaxone, intravenous fluids, and insulin drip for DKA, he subsequently developed worsening respiratory failure and suffered brief cardiac arrest requiring mechanical ventilation. Given the fatality of this infection, early detection is paramount in immunocompromised patients to ensure therapeutic interventions are promptly initiated."

Cardiovascular • Diabetes • Hypotension • Infectious Disease • Metabolic Disorders • Pneumonia • Respiratory Diseases • Type 1 Diabetes Mellitus

Clinical use and safety profile of intravenous linezolid in hospitalised children: A retrospective cohort experience. (PubMed, Eur J Pediatr) - "In a restricted cohort excluding chemotherapy/HSCT and any myelotoxic agent (including meropenem), event rates declined while the early-onset pattern persisted. • Paediatric evidence is limited and often confounded by concomitant myelotoxic therapies What is New: • In paediatric inpatients on IV linezolid, anaemia and thrombocytopenia often occur in week 1, with anaemia prominent when myelotoxic co-therapy or prior glycopeptides are present. • In a restricted cohort excluding myelotoxic co-therapy/chemotherapy, event rates declined, yet early onset persisted, supporting robustness beyond confounding."

Journal • Retrospective data • Bone Marrow Transplantation • Hematological Disorders • Oncology • Pediatrics • Thrombocytopenia

Linezolid continuous infusion protects from subtherapeutic linezolid concentrations in critically ill patients. (PubMed, Med Intensiva (Engl Ed)) - "As far as we know, this is the largest study reporting data on factors associated with subtherapeutic linezolid concentrations in critically ill patients. To our knowledge, our study is the first to report that linezolid continuous infusion was independently associated with lower risk of subtherapeutic linezolid concentrations in critically ill patients."

Journal • Critical care • Infectious Disease

Efficacy of linezolid in treating upper-extremity arteriovenous graft infection in maintenance hemodialysis patients. (PubMed, Postgrad Med) - "The AVG infections were divided into two groups: the control group (teicoplanin 200 mg/day iv) and the linezolid group (600 mg/day iv). Additionally, the average cost in the linezolid group was significantly lower than that in the control group (CNY 15,050 ± 1,611 versus 23,920 ± 4,097, p = 0.039). Linezolid was found to effectively control most cases of AVG infections, resulting in shorter hospital stays and significantly reducing the clinical burden on MHD patients especially when the blood or wound cultures were negative."

Journal • Chronic Kidney Disease • Infectious Disease • Nephrology • Pain

A Case of Maltreated Scabies (EADV 2025) - "Management included tapering systemic steroids, oral ivermectin, topical permethrin, oral and topical antifungals, IV antibiotics (linezolid), and antihypertensives... This case highlights the risks of unregulated steroid use and improper management of scabies, a disease that is simple to treat but often neglected. Education on early diagnosis, avoidance of self-medication or quack remedies, and timely access to dermatological care are critical to prevent iatrogenic complications. Public health awareness, especially in under-served communities, is essential to manage scabies effectively and prevent its morbidity."

Clinical • Cardiovascular • Cushing’s Disease • Dermatology • Diabetes • Endocrine Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Pruritus

Towards model-informed precision dosing of intravenous linezolid: a multicentre external evaluation of pharmacokinetic models in critically ill adults. (PubMed, Clin Microbiol Infect) - "Predictive performance varied substantially underlining the importance of model evaluation prior to MIPD implementation for linezolid. Using the aforementioned models promises target attainment rates up to 80% in critically ill patients."

Journal • PK/PD data • Infectious Disease

Author Response: Continuous Infusion of Linezolid: Explaining the Discrepant Survival Outcomes between Two Studies. (PubMed, Indian J Crit Care Med) - No abstract available

Journal

Continuous Infusion of Linezolid: Explaining the Discrepant Survival Outcomes between Two Studies. (PubMed, Indian J Crit Care Med) - No abstract available

Journal • Critical care • Infectious Disease • Pneumonia

Not all species are the same: Treatment of Actinomyces europaeus and Clostridium innocuum necrotizing fasciitis: Case report and literature review. (PubMed, Am J Health Syst Pharm) - "It is important to rapidly identify the species for both Actinomyces and Clostridium infections and obtain sensitivity values to help ensure proper therapy is given. Interpretation of minimum inhibitory concentrations is difficult without established breakpoints. Piperacillin/tazobactam resistance has been reported for A. europaeus, while vancomycin resistance has been reported for C. innocuum. For Actinomyces infections, duration of therapy should be individualized and can range from 14 days to 1 year based on patient response and the species."

Journal • Infectious Disease • Pain

High feasibility of salivary therapeutic drug monitoring in linezolid, but lower feasibility in tedizolid: a single-dose study in healthy subjects and a monocentric prospective exploratory study in patients who received linezolid. (PubMed, J Antimicrob Chemother) - "Salivary TDM is a promising alternative to conventional serum sampling for linezolid but is less feasible for tedizolid."

Journal

Atypical Presentation of Lemierre's Syndrome Due to Pseudomonal Parotitis (ATS 2025) - "Despite initiation of Ampicillin and Sulbactam, continued decline ensued...Treatment course included IV Linezolid and Piperacillin/Tazobactam...Physicians and advanced practitioners should consider Lemierre's Syndrome as a differential in severe clinical contexts. Our patient had a successful clinical outcome, underscoring the high survival rate with prompt recognition and treatment."

Cardiovascular • Mumps • Musculoskeletal Diseases • Novel Coronavirus Disease • Orthopedics • Otorhinolaryngology • Pain • Pneumonia • Pulmonary Embolism • Respiratory Diseases • Xerostomia

When Asthma Isn't Just Asthma: Uncovering Bronchiectasis and Staph in APECED (ATS 2025) - "Bronchoalveolar lavage samples were positive for Staphylococcus aureus, prompting targeted antibiotic therapy with intravenous Linezolid... This case emphasizes the value of proactive monitoring and early intervention to prevent prolonged complications in APECED. The presence of bronchiectasis and Staphylococcus aureus colonization in this patient highlights the need for heightened clinical vigilance regarding respiratory complications in immunocompromised individuals such as those with APECED. As recent studies suggest, mutations in the AIRE gene may disrupt immune tolerance, predisposing patients to complex infections that extend beyond typical autoimmune presentations."

Asthma • Bronchiectasis • Candidiasis • Cough • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • AIRE

An Unexpected Presentation of MRSA Pneumonia (ATS 2025) - "Empiric treatment with piperacillin-tazobactam was initiated...Pleural fluid cultures grew Streptococcus anginosus and antibiotic coverage was narrowed to ampicillin-sulbactam...Antibiotics were broadened to cefepime, vancomycin, and metronidazole...Patient was continued on all three antibiotics and therapeutic IV heparin was initiated. Once the patient showed clinical improvement on day 9, antibiotic coverage was narrowed to IV linezolid and later to oral doxycycline to complete a total antibiotic course of 36 days...However, despite a high negative predictive value (96.1%-99.8%), nasal MRSA screens may fail to detect pulmonary MRSA infections, so it remains a possibility that MRSA was a contributing pathogen on admission. Thus, providers should maintain a high degree of suspicion when there is evidence of clinical deterioration."

Acute Respiratory Distress Syndrome • Cardiovascular • Cerebral Palsy • CNS Disorders • Epilepsy • Infectious Disease • Pediatrics • Pneumonia • Pulmonary Embolism