doxycycline / Generic mfg. - LARVOL DELTA

MECHANISTIC INTERSECTION OF LRRK2 MUTATIONS AND PROTEOSTASIS IN PARKINSON'S DISEASE (ADPD 2026) - "This study aims to identify mechanisms regulating LRRK2 protein degradation, focusing on proteostasis factors involved in its turnover. A CRISPRi screen targeting ~3,500 proteostasis genes identified pathways regulating LRRK2 turnover in doxycycline-inducible GFP-LRRK2 HEK-293T cells...To investigate how NPLOC4 regulates LRRK2, cells were treated with MG132 (proteasomal inhibitor) and CuET (NPLOC4 inhibitor), followed by biochemical fractionation... Together, these studies suggest VCP-NPLOC4-UFD1L complex and RAD23A, independently or cooperatively, contribute to LRRK2 degradation via proteasomal pathways. Ongoing studies aim to determine how modulation of these ubiquitin processing factors rescues neurodegenerative phenotypes."

CNS Disorders • Movement Disorders • Parkinson's Disease • Targeted Protein Degradation • LRRK2

Combination Therapy with Oral Doxycycline and Intradermal Botulinum Toxin Type A for Moderate-to-Severe Rosacea: A Randomized Controlled Trial. (PubMed, Indian J Dermatol) - "The combination of oral doxycycline and intradermal BTX is more effective than doxycycline monotherapy in reducing erythema, flushing, and inflammatory lesions in moderate-to-severe rosacea, with a comparable safety profile. This combination therapy offers a promising approach for comprehensive management of rosacea symptoms."

Journal • Dermatology • Inflammation • Pain • Rosacea

First Report of Nocardiosis Caused by Nocardia seriolae in Farmed Spotted Scat (Scatophagus argus). (PubMed, J Fish Dis) - "Antimicrobial susceptibility testing showed reduced susceptibility to amoxicillin and universal reduced susceptibility to trimethoprim-sulfamethoxazole, while all isolates remained wild type or susceptible to florfenicol, oxytetracycline, erythromycin, and doxycycline based on previously reported cut-off values. This study extends the known host range of N. seriolae and highlights nocardiosis as an emerging disease threat to spotted scat aquaculture, emphasising the need for early diagnosis and targeted health management strategies."

Journal • Infectious Disease

Pilot study: transduction of primary paraganglioma chromaffin tumour cells with inducible c-MYC drives cell proliferation. (PubMed, Exp Clin Endocrinol Diabetes) - "We successfully transduced primary paraganglioma tumour cells with a lentiviral construct, using the proven strategy of c-MYC¬T58A (c-MYC) controlled by a Tet-On doxycycline-inducible expression system. We present the first evidence that primary paraganglioma chromaffin cells can be induced to proliferate in vitro, even in later passage cultures. Without any prior selection for chromaffin tumour cells, passaged cultures were obtained with over 80% synaptophysin-expressing chromaffin tumour cells, suggesting that this highly promising strategy deserves further exploration."

Journal • Neuroendocrine Tumor • Oncology • Solid Tumor • MYC • SYP

Tularemia from a cat bite: Case report and review of the literature. (PubMed, IDCases) - "Prior to admission, she had been treated with ceftriaxone and clindamycin without improvement. She failed to improve on vancomycin and piperacillin-tazobactam...Her antibiotics were switched to ciprofloxacin (for F. tularensis) and oral amoxicillin-clavulanate (for coverage of other feline oral flora) with improvement...She was then treated with six weeks of doxycycline with complete resolution...This case illustrates the importance of considering F. tularensis in cat-related infections not improving with standard antibiotic therapy. The case also underscores the importance of recognizing relapse of F. tularensis infection as a common complication, as well as the importance of engaging with public health authorities to be aware of changes in epidemiology that may affect patient care."

Journal • Infectious Disease

Feline tuberculosis due to Mycobacterium bovis: case series with clinical course, genotyping and therapeutic outcomes from Buenos Aires, Argentina. (PubMed, JFMS Open Rep) - "All cats received a combination therapy of rifampicin, clarithromycin and doxycycline, achieving full recovery in two cases and treatment failure in one. A raw meat diet was identified as a potential source of infection in one case. This report provides a comprehensive clinical, molecular and therapeutic description of feline M bovis infection, emphasizing its zoonotic relevance and the need for One Health collaboration."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Retinal Disorders • Tuberculosis

CASE REPORT: FIRST DOCUMENTED DIALYSIS-REQUIRING WEIL'S DISEASE IN GORAKHPUR, EASTERN UTTAR PRADESH — A SENTINEL REPORT OF SEVERE LEPTOSPIRA-ASSOCIATED ACUTE KIDNEY INJURY WITH FULL RECOVERY (ISN-WCN 2026) - "Without waiting for specific test results, the patient was given intravenous ceftriaxone at a dose of 1 gram twice a day, in addition to general supportive care, which included intravenous fluids and pantoprazole...Based on this finding, intravenous doxycycline was started at a dose of 100 mg twice a day...https://doi.org/10.12659/AJCR.897741.[iv] Manocha H, Ghoshal U, Singh SK, Kishore J, Ayyagari A. Frequency of leptospirosis in patients of acute febrile illness in Uttar Pradesh...Conclusion This case highlights the important need for doctors to pay closer attention to leptospirosis in people who have fever and yellowing of the skin for unknown reasons, mainly in eastern Uttar Pradesh. If it is found quickly and treated right away, including getting dialysis when needed, people can fully recover, even if they are very sick. Important situations like this one show that we still struggle to find leptospirosis in North India, which makes it even more important to include..."

Case report • Clinical • Acute Kidney Injury • Dengue Fever • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Malaria • Nephrology • Renal Disease

SEVERE LEPTOSPIROSIS & AKI : A REPORT OF 2 CASES FROM BERMUDA (ISN-WCN 2026) - "Rapid institution of beta lactam antibiotics( Ceftazidime & Ceftriaxone) and Doxycycline, along with supportive care in intensive unit led to good outcomes in both cases. Monthly Communicable Disease Report. Sandiego County, 2024; Vol 8, Issue 2, Page 1."

Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Epilepsy • Hematological Disorders • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Malaria • Musculoskeletal Pain • Nephrology • Renal Disease • Septic Shock • Thrombocytopenia • Vasculitis

A VESICULAR TRAFFICKING PATHWAY MEDIATED BY N-ETHYLMALEIMIDE-SENSITIVE FACTOR GOVERNS INTEGRIN MATURATION AND PODOCYTE INTEGRITY (ISN-WCN 2026) - "While adhesion disruption causes podocyte loss, the molecular mechanisms by which impaired focal adhesion drives progressive podocyte dysfunction and cell loss in glomerulosclerosis remain poorly understood.Methods We used doxycycline-inducible podocyte-specific Tln1 knockout (Tln1-cKO) mice, an established model of impaired focal adhesion, and performed single-cell RNA sequencing to identify early molecular changes...This mechanism creates a pathogenic cascade of progressive adhesion failure and glomerular disease. NSF-mediated protein trafficking emerges as a critical mechanism for maintaining podocyte homeostasis and represents a promising therapeutic target for proteinuric kidney diseases."

Fibrosis • Glomerulonephritis • Immunology • Nephrology • Renal Disease • NSF • TLN1

BARTONELLA ENDOCARDITIS MIMICKING ANCA-ASSOCIATED VASCULITIS (ISN-WCN 2026) - "Given his cat exposure, Bartonella endocarditis was suspected, and antibiotic therapy with rifampicin, doxycycline, and ceftriaxone was initiated. These immune responses complicate differentiation from autoimmune vasculitis.Conclusion Bartonella henselae endocarditis can mimic ANCA-associated vasculitis with immune-complex nephritis. Thorough clinical evaluation and molecular diagnostic testing are essential to avoid misdiagnosis and to guide appropriate antimicrobial therapy."

Acute Kidney Injury • ANCA Vasculitis • Cardiovascular • Glomerulonephritis • Infectious Disease • Inflammation • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis • TLR9

IN VIVO EVIDENCE LINKING CELL CYCLE ARREST, CELLULAR SENESCENCE AND FIBROSIS IN THE KIDNEY (ISN-WCN 2026) - "However, the role of p-p38 in cellular senescence induction in vivo and in the progression of chronic kidney disease (CKD) has not been fully elucidated.Methods We established a mouse model (PT-MKK6EE mice) and a cell line (MKK6EE HK-2) that can induce constitutive p38 phosphorylation in proximal tubular cells (PTCs) in response to doxycycline (Dox) administration both in vitro and in vivo...Additionally, time-course RNA-seq analysis revealed time-dependent increase in the expression of cellular senescence-related genes, demonstrating that sustained p38 phosphorylation facilitates cell cycle arrest and subsequent stepwise induction of cellular senescence.Conclusion We demonstrated that p-p38 in PTCs initiates a sequential process of cell cycle arrest and cellular senescence. Moreover, senescent cells induced by p-p38 are present in VCAM1 positive "failed repair PTCs", and contribute to CKD progression.This work was first presented at ASN Kidney Week 2024, and..."

Preclinical • Cardiovascular • Chronic Kidney Disease • Fibrosis • Immunology • Nephrology • Renal Disease • Reperfusion Injury • Targeted Protein Degradation • CCND1 • CDKN1A • KIM1 • SKP2 • VCAM1

SODIUM THIOSULPHATE POTENTIAL RARE ADVERSE EFFECTS (ISN-WCN 2026) - "Patient was treated empirically with ceftriaxone and doxycycline to cover for possible pneumonia. Given the time course and resolution of symptoms after discontinuation of STS, it is safe to attribute it to STS. More studies are needed to establish full spectrum of direct and indirect STS adverse effects for its safe use in dialysis patients."

Adverse events • Calciphylaxis • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Eosinophilia • Hepatology • Hypertension • Immunology • Infectious Disease • Inflammation • Liver Failure • Metabolic Disorders • Nephrology • Pneumonia • Rare Diseases • Renal Disease • Respiratory Diseases • Septic Shock

COLLAPSING GLOMERULOPATHY DRIVEN BY ABERRANT ACTIVATION OF ERK1/2 (ISN-WCN 2026) - "Next, we established transgenic mice and cell lines in which ERK1/2 is constitutively phosphorylated in a doxycycline-dependent manner, specifically within podocytes...Similarly, in wild-type mice, p-ERK1/2 was identified in a subset of podocytes with aging and in the adriamycin-induced nephropathy model...Combined with strong ERK1/2 phosphorylation in podocytes in human collapsing glomerulopathy, these processes may contribute to the pathogenesis of this disease. Our findings underscore the role of ERK1/2 signaling as a pivotal mediator of podocyte pathology and suggest it as a potential therapeutic target for glomerular diseases characterized by podocyte injury and loss.This work was first presented at ASN Kidney Week 2025, and re-submission is permitted by ASN."

Chronic Kidney Disease • Diabetic Nephropathy • Glomerulonephritis • IgA Nephropathy

Functionally redundant Rho GTPases Cdc42 and RacA regulate aflatoxin synthesis and pathogenicity in Aspergillus flavus by controlling morphogenesis, oxidative balance and energy metabolism. (PubMed, Mycology) - "The simultaneous loss of function in both genes is lethal, as evidenced by the inability of the ∆cdc42racA tetOn mutant to grow on plates lacking doxycycline. The study reveals the critical roles of the closely related genes cdc42 and racA in the growth, development, and metabolism of A. flavus. These findings identify potential targets for mitigating the harmful effects of A. flavus and aflatoxins."

Journal • CDC42

Linezolid-Induced Pancytopenia with Hyponatremia: A Case Report. (PubMed, Curr Drug Saf) - "Based on the World Health Organization-Uppsala Monitoring Centre (WHOUMC) causality assessment scale, the association between linezolid and pancytopenia with hyponatremia is considered probable in this case. This case report emphasizes that clinicians should be cautious, as these serious adverse effects can occur on re-exposure to linezolid, even if absent during previous use."

Journal • Cardiovascular • Dermatology • Heart Failure • Hematological Disorders • Thrombocytopenia

Real-world clinical outcomes of doxycycline post-exposure prophylaxis for bacterial STI prevention. (PubMed, Sex Transm Dis) - "In this real-world setting, DoxyPEP awareness and uptake were substantial and highest among cisgender men and PLWH. Current DoxyPEP use was associated with fewer chlamydia diagnoses, higher gonorrhea rates, and no clear benefit in syphilis prevention due to low numbers."

Clinical data • Journal • Real-world evidence • Human Immunodeficiency Virus • Infectious Disease

Temocillin: a therapeutic alternative in bone and joint infections due to third generation cephalosporin-resistant Enterobacterales? (PubMed, J Antimicrob Chemother) - "This study demonstrated the high in vitro efficacy of temocillin against 3GC-R Enterobacterales from BJIs, regardless of the underlying resistance mechanism. However, dosage adjustments based on the strain's MIC and the patient's renal function are crucial for optimal efficacy."

Journal • Infectious Disease

Key findings from the 2024 Mycoplasma genitalium Antimicrobial Resistance Surveillance (MARS) programme. (PubMed, Int J STD AIDS) - "Compared to MARS 2023, high levels of macrolide resistance remain, with increasing fluoroquinolone (p = 0.008) and dual resistance (p = 0.024).Most individuals (87.3%) were prescribed the recommended first- or second-line treatments and 80.8% received doxycycline as a pre-treatment. Resistant genotypes were common among those with a positive test-of-cure (TOC): 90.9% of individuals with a positive TOC following azithromycin were infected with a macrolide-resistant strain, and 51.6% of those with a positive TOC following moxifloxacin were infected with a fluoroquinolone-resistant strain. However, genotype did not consistently predict TOC outcome, as 14.6% of those with negative TOCs following azithromycin had macrolide-resistant infections and 16.6% of those with negative TOCs following moxifloxacin had fluoroquinolone-resistant infections.ConclusionsMARS 2024 is the largest dataset examining antimicrobial resistance in M. genitalium in England, confirming widespread..."

Journal • Infectious Disease

Efficacy and safety of doxycycline versus azithromycin for the treatment of Chlamydia trachomatis in cis-men: A systematic review and meta-analysis. (PubMed, Int J STD AIDS) - "However, moderate heterogeneity was detected across studies and data for rectal and prostate infections were limited. Consequently, further well-designed trials are required to confirm these findings."

Journal • Retrospective data • Infectious Disease

Doxy-PEP in the Dominican Republic: Investigating Healthcare Provider Knowledge, Attitudes, and Practices in a Caribbean Clinical Setting. (PubMed, Sex Transm Dis) - "Providers view Doxy-PEP as a promising prevention tool, but successful implementation will require uniform guidance and education reflecting the local healthcare context. Provider perspectives are essential to guide responsible rollout in the DR and other low- and middle-income settings across the region."

Journal • Infectious Disease

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial. (PubMed, J Thorac Oncol) - P2 | "An uncomplicated, widely available, prophylactic regimen (COCOON DM) reduced the incidence of DAEIs with amivantamab-lazertinib and the impact of symptoms on QoL."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

Doxycycline-Induced Phototoxicity Localized to Vitiligo-Affected and Sun-Exposed Skin. (PubMed, Cureus) - "This case highlights melanin's protective role against ultraviolet-mediated injury and demonstrates that patients with pigmentary disorders may be at higher risk for localized phototoxic reactions from photosensitizing medications. Clinicians should maintain vigilance, emphasize photoprotection, and consider alternative therapies with a lower risk of phototoxicity in such populations."

Journal • Dermatology • Immunology • Vitiligo

Intraoperative sampling for postoperative metagenomic next-generation sequencing to guide biofilm-targeted therapy for Cutibacterium acnes infective endocarditis complicated by ruptured sinus of Valsalva aneurysm: a case report. (PubMed, Front Cardiovasc Med) - "The antibiotic regimen was switched to a regimen with potential activity against biofilms with oral doxycycline and intravenous clindamycin for 6 weeks. The patient's inflammatory markers normalized, and cardiac function recovered to NYHA class I, with no recurrence at 12-month follow-up. This case highlights the diagnostic synergy of intraoperative histopathology and mNGS for pathogen identification, underscores the rationale for biofilm-conscious adjuvant therapy, and reaffirms the crucial role of early surgical debridement and repair in achieving cure."

Biomarker • Journal • Next-generation sequencing • Cardiovascular • Congestive Heart Failure • Heart Failure • Inflammation

Comparison of Adverse Events Associated With Six Common Antibiotics in Lower Respiratory Tract Infections Using the United States Food and Drug Administration Adverse Event Reporting System. (PubMed, Cureus) - "Ciprofloxacin exhibited the highest reporting proportion, with 89 of 809 patients (11.0%), followed by clarithromycin (129/1,572; 8.2%), azithromycin (132/2,048; 6.4%), amoxicillin (90/1,796; 5.0%), levofloxacin (198/4,604; 4.3%), and doxycycline (26/693; 3.8%). Fluoroquinolones (levofloxacin, ciprofloxacin) and macrolides (clarithromycin, azithromycin) showed elevated serious AE reporting relative to amoxicillin, underscoring the need for careful benefit-risk assessment. These drug‑specific patterns and temporal characteristics may help inform targeted clinical monitoring and guide future pharmacoepidemiological research to verify these hypothesis‑generating findings."

Adverse events • Journal • CNS Disorders • Infectious Disease • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases

Histone H2A deubiquitinase BAP1 is required for human neuronal progenitor cell formation. (PubMed, Differentiation) - "We differentiated human pluripotent stem cells into the neuronal lineage and depleted BAP1 via doxycycline inducible shRNA...Bulk RNA seq analysis showed that neuronal progenitor and neural crest specific transcripts were reduced while surface ectoderm transcripts were higher in BAP1 depleted cells. Thus, our results clearly demonstrate that BAP1 is required for human neuronal progenitor cell formation, since it regulates neuronal and EMT genes."

Journal • Eye Cancer • Melanoma • Oncology • Solid Tumor • Targeted Protein Degradation • Uveal Melanoma • BAP1 • CDH1 • ITK • NES • PAX6 • SNAI2 • TWIST1 • VIM