doxycycline / Generic mfg. - LARVOL DELTA

Identification of a novel small-molecule compound that suppresses depolarization-induced CYP11B2 expression and aldosterone production in KCNJ5 mutant adrenocortical cells. (PubMed, Biochem Biophys Res Commun) - "To address this need, we performed high-throughput screening of a compound library using a KCl stimulation-dependent CYP11B2 reporter system, with multi-step filtering incorporating cytotoxicity evaluation and validation in doxycycline-inducible KCNJ5-L168R mutant-expressing cells...Notably, compound 35 showed no significant effect on CYP11B1 mRNA expression, suggesting selectivity at the transcriptional level that is mechanistically distinct from the structural similarity-based selectivity challenges faced by CYP11B2 enzyme inhibitors. These results identify compound 35 as a chemically tractable lead with a mechanism of action distinct from MRAs, Ca2+ channel blockers, and CYP11B2 enzyme inhibitors, providing a starting point for the development of transcriptional suppressors of CYP11B2 as a novel therapeutic strategy for KCNJ5 mutation-associated PA."

Journal • Cardiovascular • Endocrine Disorders • Hypertension • CYP11B1 • NR4A2

Trends and regional variation in antibiotic prescribing by dentists in Finland, 2012-2025: A register-based study. (PubMed, Eur J Oral Sci) - "Phenoxymethylpenicillin was the most frequently prescribed antibiotic, and its prescribing decreased by 28% in 2012-2019...Prescribing of amoxicillin increased by 41%, whereas prescribing of clindamycin decreased by 74% and that of doxycycline by 79%. There were up to 3- to 4-fold differences between counties in antibiotic prescription rates by dentists. Overall, there was a modest decline in the overall antibiotic prescribing rate by Finnish dentists, but regional variation in antibiotic prescribing was substantial."

Journal

Single-Bacterium Biosensing: A Rapid Electrochemical Strategy to Differentiate Antibacterial Efficacy and Mechanism. (PubMed, ACS Sens) - "The bacteriostatic effect of doxycycline yielded negligible immediate signal change due to its protein synthesis inhibition mechanism...Based on these unique electrochemical signatures, we successfully identified polymyxin B-resistant E. coli mutants and achieved rapid validation of alternative antibiotics against this drug-resistant strain. This work expanded the analytical capabilities of SIE, offering a highly efficient platform for bacterial phenotypic screening and drug resistance monitoring."

Journal

Slow-Cycling and Cycling Persister Cells in Multiple Myeloma Share Adaptive Apoptotic Priming as a Common Resistance Mechanism (IMS 2026) - " To investigate persister emergence, we utilized the doxycycline (dox ) inducible Histone-2B-mCherry (H2B-mCherry) from the watermelon library to measure cell proliferation...KMS-11 cells were treated with lenalidomide (LEN), MCL1 inhibitor S63845 (S63), the DNA alkylating agent melphalan (MPN) and proteasome inhibitor bortezomib (BTZ) . OCI-MY5 cells were treated with the BCL2 inhibitor venetoclax (VEN), MPN, S63 and BTZ... T ogether, t hese data demonstrate that drug - tolerant persister cells exist and are phenotypically heterogeneous in MM . It remains to be determined if these pers ister cells are an acquired state or are pre -exis ting within tumors ."

Hematological Malignancies • Multiple Myeloma • BCL2L1

Resetting the Aberrant Methylation Landscape and DNA Damage Response in Multiple Myeloma Through MAT2A Targeting Reveals Novel Combination Strategies. (IMS 2026) - " MAT2A knockdown (KD) in OPM2 and AMO-1 cell lines was achieved using doxycycline inducible lentiviral shRNA vectors targeting MAT2A. In conclusion, targeting MAT2A in MM cells reverts aberrant methylation and impairs pro-tumoral signalling offering promising avenues for more effective combination therapies."

Hematological Malignancies • Multiple Myeloma • ANXA5 • KRAS • MAT2A

Ultramutagenesis through Combined Msh2 Depletion and Proofreading-Deficient DNA Polymerase ε Expression Enhances Small-Molecule Target Identification in Forward Genetic Screens. (PubMed, ACS Chem Biol) - "Here, we combine auxin-inducible degradation of Msh2 with doxycycline-inducible expression of the proofreading-deficient PolεP286R mutant in murine small cell lung cancer (SCLC) cells. Simultaneous MMR deficiency and mutant Polε expression markedly increased the emergence of bortezomib-resistant clones relative to either perturbation alone, and targeted sequencing of Psmb5 in bortezomib-resistant clones identified recurrent mutations previously reported in resistance screens using MMR-deficient cells and chemical mutagenesis...Whole-exome sequencing revealed recurrent loss-of-function alterations in nucleotide excision repair (NER) genes, most notably Ercc5 and Ercc4, implicating NER deficiency as a major mechanism of lurbinectedin resistance and supporting a central role for NER in mediating lurbinectedin-induced cytotoxicity. Collectively, these findings establish inducible ultramutagenesis as a powerful and versatile platform for the unbiased discovery of drug..."

Journal • Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • ERCC4 • ERCC5 • MSH2 • PSMB5

From Antibiotic to Anticancer: Repurposing Doxycycline as a Co-Therapy With Targeted Lung Cancer Drugs (IASLC-WCLC 2026) - "Methods : Lung cancer cell lines A549, H1975 and HCC827Luc were treated with either (1) doxycycline, (2) EGFR TKIs (osimertinib or erlotinib), or (3) their combinations. Previously, doxycycline has been linked to multiple anticancer mechanisms, including the disruption of mitochondrial biogenesis, enhancement of anti-tumor immunity, and inhibition of matrix metalloproteinases; therefore, it is a promising therapeutic avenue to enhance lung cancer treatment. Future studies will further validate the synergistic combinations and molecular mechanisms involved in 3D cell culture models and in vivo xenograft models."

Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Efficacy and Safety of Various Medications in the Treatment of Hereditary Hemorrhagic Telangiectasia Epistaxis. (PubMed, Otolaryngol Head Neck Surg) - "No pharmacologic agent demonstrated consistent, clinically robust superiority over placebo across primary endpoints. Bevacizumab may modestly reduce bleeding burden, whereas tranexamic acid increases gastrointestinal toxicity without clear efficacy. Pharmacologic control of HHT-related epistaxis remains suboptimal, underscoring the need for adequately powered trials with standardized outcome measures and optimized dosing and delivery strategies."

Journal • Review • Hematological Disorders

Type II Minocycline-Induced Hyperpigmentation During Long-Term Management of an Epidermal Growth Factor Receptor (EGFR) Inhibitor-Associated Acneiform Eruption. (PubMed, Cureus) - "We report the case of a 40-year-old man with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) who developed an EGFR inhibitor-associated papulopustular eruption shortly after initiating erlotinib and bevacizumab. Persistent disease despite doxycycline therapy and concern for doxycycline-associated photosensitivity prompted a transition to long-term minocycline...This case highlights the importance of longitudinal dermatologic follow-up in patients receiving prolonged tetracycline therapy for EGFR inhibitor-associated cutaneous toxicities. Periodic reassessment of treatment necessity, dose optimization, and early recognition of delayed medication-related adverse effects may minimize cumulative toxicity while preserving effective oncologic therapy."

Journal • Dermatology • Genito-urinary Cancer • Nephrology • Oncology • Renal Cell Carcinoma • Solid Tumor

Evaluating Outcomes Following Sclerotherapy and Surgery for Pediatric Lymphatic Malformations Using a Large Multicentric Database (AAO-HNSF 2026) - "This study evaluates 5-year recurrence, complications, and retreatment rates in a propensity-matched pediatric cohort. Retrospective study of patients < 18 years undergoing sclerotherapy (n=645; doxycycline 386, bleomycin 124, STS 108) versus surgery (n=1007) for LMs. Sclerotherapy and surgery achieve comparable long-term LM control with similar recurrence and complications. While sclerotherapy requires more retreatment, both are effective. Treatment selection should consider disease complexity, anatomic location, and family preferences."

Clinical • Surgery • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

YAP/TAZ Suppression of Paclitaxel-Induced Antiviral Signaling Is a Putative Mechanism of Chemoresistance in Lung Cancer (IASLC-WCLC 2026) - "Methods : LUAD cells with low YAP/TAZ expression (H2122) were engineered with doxycycline-inducible expression of YAP, TAZ, or a LacZ control. Future experiments will characterize the generalizability of our findings in additional models, and define whether this mechanism operates independently of TAZ transcriptional activity. Our work could rationalize the development of novel YAP/TAZ inhibitors to potentiate the efficacy of chemotherapy in LC patients."

Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CXCL10 • IFNB1 • OASL • TAFAZZIN • TBK1 • YAP1

Extragenital Mycoplasma hominis infection following obinutuzumab therapy in a patient with chronic lymphocytic leukemia. (PubMed, IDCases) - "Such infections have been reported primarily in patients receiving rituximab; however, they have not been previously described with obinutuzumab therapy...Antimicrobial therapy was transitioned to levofloxacin and doxycycline, which were administered for six weeks with good tolerance and sustained clinical improvement...Because M. hominis lacks a cell wall, routine diagnostic methods and empiric β-lactam therapy may be ineffective, resulting in diagnostic delays. Awareness of this organism and early consideration of targeted therapy are critical to improving outcomes in immunocompromised patients."

Journal • Chronic Lymphocytic Leukemia • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Lymphoma • Musculoskeletal Pain • Non-Hodgkin’s Lymphoma • Oncology • Pain • Rheumatology • Small Lymphocytic Lymphoma

Q Fever Visceral Abscesses After Contact With Native Australian Marsupials. (PubMed, Med J Aust) - "One patient had their infection complicated by a splenic abscess, the other developed a hepatic abscess. Both patients had contact with small Australian marsupials in the weeks before presentation and both required prolonged doxycycline to treat their infection."

Journal • Hepatology • Infectious Disease

Infant Scrub Typhus: A 10-Year Experience from a Tertiary Center in South India (The ScrubIn Study). (PubMed, Am J Trop Med Hyg) - "The overall mortality was 10.2%, which was considerably higher than the 1% to 3% reported in broader pediatric cohorts, underscoring infants as a uniquely vulnerable group. This was one of the largest infant scrub typhus cohorts, highlighting distinctive epidemiological and clinical features, possible transmission pathways, susceptibility, outcomes, and early markers of severity, underscoring the need for heightened clinical suspicion and timely doxycycline therapy in endemic regions."

Journal • Acute Respiratory Distress Syndrome • Cardiovascular • CNS Disorders • Critical care • Hematological Disorders • Hepatology • Infectious Disease • Inflammation • Liver Failure • Pediatrics • Pulmonary Disease • Renal Disease • Respiratory Diseases • Thrombocytopenia

Challenges and opportunities in the drug design and pharmacological applications of MMP inhibitors. (PubMed, Enzymes) - "Recent developments in the field saw the design of highly selective inhibitors for several MMPs, belonging to the modified tetracyclines class, as well as mechanism based, suicide inhibitors belonging to the substituted thiiranes class, exosite and allosteric inhibitors which spare the zinc ion from the enzyme active site. Two compounds are in clinical use for the management of periodontitis (doxycycline, at submicrobial dosages) and abametapir for the treatment of lice infestation. Clinical trials in various types of cancer, in different inflammatory conditions, and microbial infections (tuberculosis) with some of the new generation MMPIs are ongoing, and the expected results will demonstrate their efficacy, probably in combination therapy with other drugs. More selective new inhibitors, better planned clinical trials and a better understanding of the biology/pharmacology of these enzymes may lead to other breakthroughs in the field."

Journal • Review • Asthma • Dental Disorders • Fibrosis • Immunology • Infectious Disease • Oncology • Periodontitis • Pulmonary Disease • Respiratory Diseases • Rheumatology • Septic Shock • Tuberculosis

Community dissemination of blaCTX-M-dominant extended-spectrum β-lactamase-producing Escherichia coli with widespread multidrug resistance in domestic cats from Ecuador: A One Health molecular epidemiological study. (PubMed, Vet World) - "All isolates remained susceptible to imipenem and meropenem, whereas the highest resistance rates were recorded for trimethoprim-sulfamethoxazole, tetracycline, cefepime, levofloxacin, and doxycycline. Domestic cats in Machala showed a high prevalence of -dominant, multidrug-resistant ESBL-producing E. coli. These findings indicate widespread community dissemination and support the inclusion of companion animals in Ecuadorian antimicrobial resistance surveillance and stewardship programs under a coordinated One Health framework."

Journal

Species Diversity, Antimicrobial Susceptibility, and Provisional Epidemiological Cut-Off Values of Vibrio spp. Isolated From Pacific White Shrimp (Litopenaeus vannamei) Farms in Southern Thailand. (PubMed, J Fish Dis) - "Overall, the isolates were susceptible to oxytetracycline, doxycycline, ciprofloxacin, enrofloxacin, and florfenicol, with MIC50 ranging from ≤ 0.25 to 2 μg/mL...were resistant to amoxicillin, ceftriaxone, and sulfadimethoxine, with MIC50 values of at least 128 μg/mL...isolates, 83.10% were classified as wild type. Our findings highlight the need for strict regulation of antibiotic use in shrimp aquaculture to minimize the emergence and spread of antibiotic-resistant bacteria."

Journal

A light-cured and doxycycline stabilized silk fibroin/tannin acid tissue adhesive for emergency hemorrhage. (PubMed, Colloids Surf B Biointerfaces) - "Histological analysis revealed reduced fibrosis, accelerated collagen deposition, and minimal adhesion in treated wounds. This multifunctional adhesive combines compact storage characteristics, rapid deployment, and mechanical resilience, offering a practical alternative to sutures for emergency hemostasis and regenerative wound repair."

Journal • Fibrosis • Hematological Disorders • Immunology • Mood Disorders

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial. (PubMed, J Thorac Oncol) - P2 | "An uncomplicated, widely available, prophylactic regimen (COCOON DM) reduced the incidence of DAEIs with amivantamab-lazertinib and the impact of symptoms on QoL."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

Dermatologic prophylaxis and impact on patient-reported outcomes in first-line EGFR-mutant advanced NSCLC treated with amivantamab plus lazertinib: Results from the phase 2 COCOON trial. (ASCO 2025) - P2 | "COCOON DM included oral doxycycline/minocycline (100 mg BID Wks 1–12), clindamycin 1% lotion on scalp (QD Wks 13–52), chlorhexidine 4% to wash hands and feet QD, and non-comedogenic ceramide-based moisturizer to body and face QD. Among pts with EGFR-mutant advanced NSCLC, COCOON DM reduced the severity of dermatologic AEs and reduced the impact of those AEs on QoL compared to SoC DM."

Clinical • Metastases • P2 data • Patient reported outcomes • Dermatopathology • Infectious Disease • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

Acneiform eruption induced by gefitinib in EGFR-mutated lung squamous cell carcinoma: successful management with doxycycline and topical therapy (EADV 2026) - No abstract available

Dermatology • Non Small Cell Lung Cancer • Oncology • EGFR

A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer. (PubMed, Mol Med Rep) - "Functional validation using reverse transcription‑quantitative PCR, doxycycline‑inducible short hairpin RNA knockdown and β‑galactosidase staining assays demonstrated rapid induction of these genes during osimertinib treatment and showed that depletion of each gene markedly impaired drug‑tolerant persister cell formation. Mechanistically, ZLN005 enhanced mitochondrial oxidative metabolism and reactive oxygen species accumulation, leading to caspase‑3 activation and gasdermin E‑associated pyroptotic cell death. Collectively, these findings defined the transcriptional and metabolic features of targeted therapy‑induced persister cells and revealed a metabolic vulnerability to ZLN005 in EGFR‑mutant lung adenocarcinoma."

Gene Signature • Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CASP3 • EGFR • GSDME • NCOA1

MertK-Mediated Efferocytosis Suppresses Anti-Tumor Immunity After EGFR-TKI Treatment in EGFR-Mutant Lung Cancer (IASLC-WCLC 2026) - "Methods : Lung tumors were induced in TetO-EGFR L858R /CCSP-rtTA bitransgenic C57BL/6 mice by doxycycline administration and monitored by MRI...Osimertinib treatment significantly increased IFN-β (p<0.05) but simultaneously elevated immunosuppressive mediators IL-10 (p<0.05) and CCL22 (p<0.05), and reduced ATP (p<0.001) while increasing adenosine levels (p<0.01), indicating concurrent immune activation and efferocytosis-driven suppression...Pharmacological MertK inhibition redirects TAMs toward STING-mediated innate immune activation and, combined with immune checkpoint blockade, significantly enhances anti-tumor T cell immunity. These findings provide a rationale for combining EGFR-TKIs with efferocytosis inhibitors and immunotherapy in EGFR-mutant NSCLC."

IO biomarker • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CCL2 • CCL22 • CD68 • CD8 • GZMB • IFNB1 • IFNG • IL10 • MERTK • MRC1 • STING • TNFA

Doxycycline Prophylaxis (Doxy-PEP): Are We Preventing STIs or Creating Resistance? - A 15-Patient Case Series on Real-World Implementation (EADV 2026) - No abstract available

Clinical • Real-world • Real-world evidence • Gene Therapies • Human Immunodeficiency Virus • Infectious Disease

Common dermatology medication triggers a dermatological emergency: Stevens-Johnson Syndrome caused by doxycycline (EADV 2026) - No abstract available

Dermatology • Steven-Johnson Syndrome