niacin immediate release / Generic mfg. - LARVOL DELTA

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes (clinicaltrials.gov) - P1 | N=60 | Completed | Sponsor: University Hospital Schleswig-Holstein | Recruiting ➔ Completed | Trial completion date: Jun 2025 ➔ Nov 2024

Trial completion • Trial completion date • Metabolic Disorders

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: University Hospital Schleswig-Holstein

New P1 trial • Metabolic Disorders

Immediate-release niacin and a monounsaturated fatty acid-rich meal on postprandial inflammation and monocyte characteristics in men with metabolic syndrome. (PubMed, Clin Nutr) - "The co-administration of a single-dose of immediate-release niacin with a fatty meal rich in MUFA, in contrast to SFA, suppresses postprandial inflammation at the levels of both secretory profile and monocyte response in individuals with metabolic syndrome. These findings highlight a potential role of combining niacin and dietary MUFA for the homeostatic control of inflammation and the innate immune system, identifying a new search direction for the management of disorders associated with the metabolic syndrome."

Journal • Inflammation • Metabolic Disorders • CCL2 • CCR2 • CD14 • IL1B • IL6 • TNFA

"Literally approved by @US_FDA -- FLUSH NIACIN immediate release as MONOTHERAPY (bioharma docs don't know difference between even niacinamide and niacin or extended/sustained vs. immediate & misinform) -- against CVD per Level 1A top evidence by @harvardmed https://t.co/HujRosAdWu" (@GPR109A)

Monotherapy

Lipid-lowering drugs. (PubMed, Med Lett Drugs Ther) - No abstract available

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Comparison table: Some lipid-lowering drugs. (PubMed, Med Lett Drugs Ther) - No abstract available

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"Yes, march 2021, a year later, my partner was ready to die it was so bad. We had heard of high dose niacin helping but initially bought the wrong type, extended release. Once he took high dose immediate release flush niacin he was off the couch in 2 weeks. But both ongoing issues" (@pain_error)

Nutrient Composition of a Selection of Plant-Based Ground Beef Alternative Products Available in the United States. (PubMed, J Acad Nutr Diet) - "The major brands of plant-based ground beef alternative products examined in this study have nutritional strengths as well as some shortcomings. Additional research to examine a broader set of plant-based meat alternative products, such as those designed as substitutes for chicken and pork, is warranted."

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