QX302 / Guangzhou KemRocMed - LARVOL DELTA

Novel imidazotetrazine derivatives overcome temozolomide resistance in glioblastoma by inducing ferroptosis and apoptosis (Nature) - "CCK8 assays demonstrated that QX302 showed remarkable potency and effectively inhibited the viability of U251, U87, T98G, and HCT116 cells in a dose- and time-dependent manner. Proteomic analysis indicated that QX302 affected critical pathways, including nucleotide binding, chromatin organization, cell cycle regulation, and DNA repair processes. Further investigations revealed that QX302 effectively inhibits glioma spheroid growth and induces cell cycle arrest, ferroptosis, and apoptosis. Notably, QX302 induced DNA damage in cancer cells via the alkylation of DNA, leading to increased sensitivity to Olaparib via the base excision repair signaling pathway."

Preclinical • Glioblastoma