CPH 102 / Crimson Pharma, Octamer - LARVOL DELTA

[VIRTUAL] CPHM102 - Verification and Validation of Microbiology Tests: How to Stay Sane During a Pandemic and Otherwise (WMF 2021) - "Design appropriate verification studies for FDA approved and Laboratory developed tests include multiplex assays and antimicrobial susceptibility tests. Define the appropriate components of an acceptable validation process for continued analysis of test and operator performance."

New Insight into the Structure-Activity Relationships of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors UCPH-101 and UCPH-102. (PubMed) - ChemMedChem - "Finally, separation of the four stereoisomers of analogue 14 g (2-amino-4-([1,1'-biphenyl]-4-yl)-3-cyano-7-isopropyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene) was carried out, and in agreement with a study of a related scaffold, the R configuration at C4 was found to be mandatory for inhibitory activity, while both the C7 diastereomers were found to be active as EAAT1 inhibitors. A study of the stereochemical stability of the four pure stereoisomers 14 g-A-D showed that epimerization takes places at C7 via a ring-opening, CC bond rotation, ring-closing mechanism."

Journal • Biosimilar