NDV HUJ / Theravir Management - LARVOL DELTA

Automatic target delineation for online adaptive H&N IMPT with a plan library approach - A feasibility study. (PubMed, Phys Med) - "Carefully selected commercially available auto-contouring for plan library based on-line adaptive IMPT generally resulted in adequate patient dose."

Journal • Head and Neck Cancer • Oncology • Solid Tumor

Clinical Acceptability of the Next Generation in Modulated Arc Therapy for Nasopharyngeal Carcinoma (ESTRO 2025) - " Compared with the clinical plans, RAD1 increased D98% of GTVp_7000 (mean increase 0.82Gy, p=0.01) and PTV_7000 (mean increase 0.42Gy, p=0.14)... Quantitative and qualitative evaluation of RAD demonstrates that this next generation of arc therapy may assist with achieving higher quality treatment plans than current practice."

Clinical • Nasopharyngeal Carcinoma • Oncology • Solid Tumor • ERCC4 • FEN1

Validation of automated IMPT- and joint proton transmission beam-IMPT planning for nasopharyngeal cancer patients (ESTRO 2025) - "Dose prescription was 7000 cGy (RBE) to the primary tumor (CTV7000) and 5425 cGy (RBE) to the bilateral elective nodal volumes (CTV5425)... Erasmus-iCycle can generate robust IMPT- and IMPT+TB plans automatically with similar or improved dosimetric metrics for target coverage, OARs and NTCPs, as compared to clinical manual planning. Incorporation of TB to IMPT enhanced dose reductions in serial OARs."

Clinical • Dental Disorders • Gastrointestinal Disorder • Head and Neck Cancer • Nasopharyngeal Carcinoma • Oncology • Solid Tumor • Xerostomia

Coping with CT number inaccuracies in CBCT-based online-adaptive IMPT planning (ESTRO 2025) - "From RRS=3% to RRS=10%, the population 90th percentiles of CTV 7000 V 94% improved from 92.8% to 96.4%, and CTV 5425 V 94% from 89.6% to 96.4% (Fig.1)... Daily robust optimization with enlarged RRS can effectively mitigate dose degradation resulting from CT number errors in CBCT-based online-adaptive IMPT planning. Even for relatively large CT number errors, the online CBCT- based plans outperformed our current clinical trigger-based offline adaptive approach in terms of mitigation of extreme coverage losses and toxicity risks. With the expected introduction of CBCT-based online-adaptive IMPT for head-and-neck, this clinically available method can ensure robustness against (residual) CT-number errors."

Dental Disorders • Gastrointestinal Disorder • Head and Neck Cancer • Oncology • Solid Tumor • Xerostomia

Potential toxicity benefit and inter-fraction robustness of proton arc therapy compared to IMPT and VMAT for nasopharyngeal cancer patients. (PubMed, Phys Med Biol) - "The impact of PAT on dose to organs-at-risk (OARs), predicted acute- and late radiation toxicities and robust target coverage to inter-fraction changes in NPC patients were investigated. Approach: Robustly optimized PAT plans were compared to clinical VMAT and IMPT plans for 10 NPC patients treated with 70.00 Gy to the primary target (CTV 7000) and 54.25 Gy to the prophylactic lymph nodal area (CTV 5425)...Approaches to improve PAT inter-fraction target coverage were successful, while maintaining the reduction in NTCP compared to IMPT. Significance: Compared to IMPT and VMAT, PAT reduces healthy tissue dose and subsequent estimated toxicity risks in NPC patients. PAT planning approaches to improve inter-fraction robustness were employed successfully, while NTCP benefits of PAT were maintained.&#xD."

Journal • Head and Neck Cancer • Nasopharyngeal Carcinoma • Oncology • Solid Tumor

A planning approach for online adaptive proton therapy to cope with cone beam computed tomography inaccuracies. (PubMed, Phys Imaging Radiat Oncol) - "Coverage (voxelwise-minimum) of the primary clinical target volume (CTV7000) and elective lymph nodes (CTV5425) and grade ≥ II normal tissue complication probabilities were compared between strategies...Moreover, for RRS = 10 % the average risk of xerostomia improved by 2.4 percentage point compared to TB-Offline. Robust optimization with increased range robustness settings effectively mitigated dose degradation from CT number errors in CBCT-based online-adaptive proton therapy."

Journal • Dental Disorders • Head and Neck Cancer • Oncology • Solid Tumor • Xerostomia

OVT001-OVT004: Adult Reconstruction Hip (AAOS 2025) - No abstract available

Clinical • Orthopedics

Partial and full arc with DynamicARC technique in pencil beam scanning proton therapy for bilateral head and neck cancer: A feasibility and dosimetric study. (PubMed, J Appl Clin Med Phys) - "On the ProteusOne with a partial gantry system, DPA and SPA, in conjunction with DynamicARC PBS protons, provided clear dosimetric advantages over three-field IMPT. Future clinical implementation and further research into optimizing DynamicARC protocols are warranted to fully realize the benefits of these techniques in clinical settings."

Journal • Head and Neck Cancer • Oncology • Solid Tumor

A fast and robust constraint-based online re-optimization approach for automated online adaptive intensity modulated proton therapy in head and neck cancer. (PubMed, Phys Med Biol) - "With offlineTB re-planning, eight repeat-CTs had zero probability of obtaining D98%≥95%Dpres for CTV7000, while the minimum probability with online re-optimization was 81%... Significance - The fast online re-optimization strategy always prevented substantial losses of target coverage caused by day-to-day anatomical variations, as opposed to the clinical trigger-based offline re-planning schedule. On top of this, online re-optimization could be performed with smaller setup robustness settings, contributing to improved organs-at-risk sparing. &#xD."

Journal • Dental Disorders • Gastrointestinal Disorder • Head and Neck Cancer • Oncology • Solid Tumor • Xerostomia

OVT001-OVT012: Award Winner (AAOS 2024) - No abstract available

Orthopedics

Validation of Fully Automated Robust Multicriterial Treatment Planning for Head and Neck Cancer IMPT. (PubMed, Int J Radiat Oncol Biol Phys) - "Erasmus-iCycle was able to produce IMPT dose distributions fully automatically with similar (robust) target coverage and improved OAR doses and NTCPs compared with clinical manual planning, with negligible hands-on planning workload."

Journal • Dental Disorders • Gastrointestinal Disorder • Head and Neck Cancer • Oncology • Solid Tumor • Xerostomia

Evaluation treatment planning system for oropharyngeal cancer patient using machine learning. (PubMed, Appl Radiat Isot) - "Organs at risk were observed that the volume of L-Eye in clinical plan (AF) for the case1 treatment planning could be successfully used ensuring efficiency and lower than MLVMAT and MLVMAT-org plans were 372 cGy, 697 cGy and 667 cGy respectively, while showed case2, case3, case4 and case5 are better to protect the critical organs in ML plan compare with a clinical plan. DHI for the PTV-7000 and PTV-5425 is between 1 and 1.34, While DCI for PTV-7000 and PTV-5425 is between 0.98 and 1."

Journal • Machine learning • Head and Neck Cancer • Oncology • Oropharyngeal Cancer • Solid Tumor

"5 mm PTV margins and no major CTV_7000 adaptation prob didn't make it easier. Not a big fan of intermediate dose either -- again makes sparing more difficult." (@JJCaudell)

Fully automated robust multi-criterial treatment planning for HNC IMPT (ESTRO 2023) - "Material and Methods iCycle automated planning was applied to 30 HNC patients who were previously treated with IMPT with 7000 cGy prescription dose to the primary tumor (CTV7000) and 5425 cGy dose prescription to the elective volumes (CTV5425)...This difference was statistically significant for all evaluated OARs, with p<0.05. Conclusion iCycle was able to automatically produce acceptable HNC IMPT plans with comparable (robust) target coverage D98 and statistically significant lower mean doses to OARs."

Head and Neck Cancer • Oncology • Solid Tumor

Comparison of static and dynamic proton arc treatment planning algorithms in oropharyngeal cancer (ESTRO 2023) - "The fraction-wise CTV7000 coverage fell below the replanning threshold in at least 3 out of 5 patients in the PAT plans, while this occurred just once in the IMPT plans...Conclusion All PAT planning algorithms showed potential to reduce expected toxicity compared to IMPT. However, fraction-wise robustness suffered more than course-wise robustness from changes found in repeated CTs, indicating the need to improve PAT robustness and/or increased necessity for adaptive strategies, especially in the context of hypo fractionated treatments."

Dental Disorders • Gastrointestinal Disorder • Head and Neck Cancer • Oncology • Oropharyngeal Cancer • Solid Tumor • Xerostomia

Automatic target delineation in on-line adaptive H&N IMPT with plan library approach. Are we ready? (ESTRO 2023) - "For the purpose of the study, we also automatically propagated the CTV7000 and CTV5425 planning contours to each rCT, using the Velocity software (Varian, Palo Alto)...Conclusion With majority (70%) of plans selected as for ground truth contours, and 22% plans selected with greater SR, automatic target delineation proves to be sufficient for plan library on-line APT. From the investigated methods we would recommend using combination of Rigid and MultiPass methods with post-processing."

Dental Disorders • Gastrointestinal Disorder • Xerostomia

[VIRTUAL] Application of volumetric modulated arc therapy (VMAT) in head and neck cancers: 5-year single institutional experience (ESMO Asia 2020) - "Results Twenty two (ages 26-75 years-old; average age: 54.14±11.41, male-female ratio: 14/8) non-distant metastatic head and neck cancer patients, [14 nasopharyngeal carcinomas (NPC), 2 oropharyngeal carcinomas (OPC), 6 laryngo-hypopharyngeal carcinomas (HPC), stage II- 8 patients (36.4%); stage III 7 patients (31.8%) and stage IV 7 patients (31.8%)] were curatively treated with simultaneous integrated boost- volumetric modulated arc therapy (SIB-VMAT) in combination with chemotherapy, given fractionation was 70Gy (2Gy/fraction for 35 fractions as standard fractionation) for high-risk planning target volume (PTV7000), 63Gy for intermediate-risk PTV (PTV6300) and 56Gy for low-risk PTV (PTV5600). Legal entity responsible for the study: Vinmec Times City International Hospital. Funding: Has not received any funding."

Clinical • Dental Disorders • Dermatitis • Dermatology • Head and Neck Cancer • Hypopharyngeal Cancer • Immunology • Nasopharyngeal Carcinoma • Oncology • Oropharyngeal Cancer • Palliative care • Solid Tumor • Squamous Cell Carcinoma • Stomatitis • Xerostomia