MV1 / Roche - LARVOL DELTA

Identification of fungal diseases in strawberry by analysis of hyperspectral images using machine learning methods. (PubMed, Vavilovskii Zhurnal Genet Selektsii) - "The reflection spectrum of leaves was acquired with a Photonfocus MV1-D2048x1088-HS05-96-G2-10 hyperspectral camera under laboratory conditions using the line scanning method...When using vegetation indices and optimal wavelengths, the overall classification accuracy of all methods decreased slightly compared to the classification on the full range spectral data. The results of the study confirm the potential of using hyperspectral imaging methods in combination with machine learning for differentiating fungal diseases of strawberries."

Journal • Infectious Disease

Combining RAS(ON) G12C-selective and RAS(ON) multi-selective inhibitors overcomes sotorasib resistance driven byKRASG12C amplification or NRASG13R mutation (AACR 2025) - "Amplification of the KRASG12C mutant allele and acquisition of NRAS mutations have been reported as resistance mechanisms in tumors progressing on sotorasib and adagrasib...We generated five sotorasib-resistant cell lines from relapsed tumors of sotorasib-treated H358 xenografts (MR1-MR5) and two vehicle-treated tumors (MV1 and MV2). We created an additional isogenic cell line model, H358-MX1, by treating H358 cells with sotorasib and a SHP2 inhibitor, RMC-4550...In H358-MX1 mouse xenografts, RMC-7977 + RMC-4998 significantly inhibited tumor growth compared to single-agent treatments or other combination regimens. These preclinical data suggest that combination of RAS(ON) mutant-selective and RAS(ON) multi-selective inhibitors overcome resistance to KRASG12C (OFF) inhibitors driven by KRASG12C amplification and secondary NRASG13R mutation in KRASG12C mutated lung cancer models."

Lung Cancer • Oncology • Solid Tumor • KRAS • MX1 • NRAS

HEART FAILURE IS ASSOCIATED WITH WORSE IN-HOSPITAL OUTCOMES IN PATIENTS UNDERGOING SURGICAL PULMONARY VALVE REPLACEMENT OR REPAIR: A NATIONWIDE STUDY - Jacob Klein (ACC 2025) - "There is an increased risk of mortality and adverse cardiovascular events in patients with heart failure undergoing surgical pulmonary valve replacement or repair. Further research is needed to identify modifiable risk factors for better outcomes and optimize surgical timing and planning."

Clinical • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Adaptive changes in infant emotion regulation persist three months following birthing parent receipt of cognitive behavioral therapy for postpartum depression. (PubMed, J Affect Disord) - "Treating PPD may set infants on a persistent adaptive ER trajectory."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Postpartum Depression • Psychiatry

Creutzfeldt-Jakob Disease: How Rare is Rare? (AAN 2025) - "Seven patients underwent autopsy and were confirmed as sporadic CJD and subtypes included MM1, MV2, VV2 and MV1-2...Our 45-month retrospective study found 14 CJD cases in Corewell Health, one of the large health systems in Michigan, which challenges the prevailing understanding that CJD is a rare disease. We also found higher incidence of CJD in 2022 and 2023 of unclear etiology. Further studies will be needed to investigate cases with negative RT-QuIC, high T-tau value and positive 14-3-3, to understand the true CJD incidence."

CNS Disorders • Rare Diseases

Case report: Atypical young case of MV1 Creutzfeldt-Jakob disease with unusually long survival. (PubMed, Front Cell Neurosci) - "Very young onset sCJD often has atypical clinical presentations and disease progression, neuropathological examination results, and/or laboratory test results that may confound diagnosis. It is critical to perform thorough, comprehensive evaluations to make an accurate diagnosis, which includes autopsy confirmation with histology, prion protein typing and prion gene sequencing."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Psychiatry • PRNP

Pathological spectrum of sporadic Creutzfeldt-Jakob disease. (PubMed, Pathology) - "Six major clinicopathological subtypes of sCJD are internationally recognised, largely correlating with the combination of the two distinct types of the protease-resistant prion protein (PrPres type 1 or 2) and the methionine (M)/valine (V) polymorphism at codon 129 of the prion protein gene (PRNP): MM1/MV1, MM2-cortical, MM2-thalamic, MV2, VV1 and VV2...In this review, we will provide an up-to-date overview of the current classification of sCJD based on the prominent neuropathological features. In addition, with levels of infectivity at their highest in the brain, we will also discuss the additional precautions that are recommended when handling and examining postmortem tissues from patients with suspected prion disease."

Journal • Review • CNS Disorders • PRNP

Heating Efficiency of Different Magnetotactic Bacterial Species: Influence of Magnetosome Morphology and Chain Arrangement. (PubMed, ACS Appl Mater Interfaces) - "Here, we study three different bacterial species, Magnetospirillum gryphiswaldense (MSR-1), Magnetospirillum magneticum (AMB-1), and Magnetovibrio blakemorei (MV-1), which synthesize magnetite nanoparticles with different morphologies and chain arrangements...As the Keff value increases, the saturated SAR values are higher; however, the threshold magnetic field required to observe a SAR response simultaneously increases. This factor is crucial to choose a bacterial species as the optimal hyperthermia agent."

Journal • Oncology

Strain-Mediated Second Harmonic Generation Enhancement of Bimetallic Metal-Organic Frameworks. (PubMed, J Phys Chem Lett) - "The determined second-order nonlinear susceptibility of MOF3 (∼19.86 p mV-1) is one order of magnitude larger than that of pristine Zn-MOF (1.65 p mV-1) and Cu-MOF (3.88 p mV-1) and much higher than the commonly used NLO crystals...The anisotropy ratio of MOF4 (∼118.8) is much higher than that of the most excellent 2D material to date, to our best knowledge. A first-order perturbation of second-order polarization based on point group description was introduced to explore the regulation mechanism of the NLO response under the strain field of MOFs."

Journal

Preliminary signs of clinical activity of tuvusertib (M1774), a highly potent oral ATR inhibitor, in refractory IDH mutated glioma patients with P53 and ATRX mutations; A case series from a FiH Study (EANO 2024) - P1 | "The observed decrease in tumor growth rate associated with prolonged disease stabilization in treatment-refractory glioma warrants further investigation of tuvusertib in this indication. [MV1]All patients had molecular G3 IDH mutant astrocytoma, but one case has the diagnosis of G3 IDH mutant oligo-astrocytoma based on morphology [MV2]We can mention here that IDH inhibitors efficacy seems to be limited to low-grade, treatment naive non enhancing disease, where tuvusertib is active in high grade refractory tumors"

Clinical • Astrocytoma • Brain Cancer • CNS Tumor • Glioma • Oncology • Solid Tumor • ATRX • DAXX • TP53

Analysis of promoter region and regulatory elements of Rhizobium giardinii DNA-binding response regulator A3AY_RS01 genes. (PubMed, J Genet Eng Biotechnol) - "MV1 motif can serve as a binding site for the Fur transcription factor gene family in R. giardinii to regulate the expression of R. giardinii A3AY_RS01 genes. R. giardinii A3AY_RS01 genes are rich in CpG Islands, and play an important role in the regulation of the gene expression of nitrogen fixing in this bacterium."

Epigenetic controller • Journal

Enhancing Oxygen Evolution Reaction Performance of Metal-Organic Frameworks through Cathode Activation. (PubMed, ChemSusChem) - "As a prototype, the activated Ni-HHTP (HA-Ni-HHTP) demonstrates outstanding OER performance, with an overpotential as low as 140 mV at 20 mA cm-2 and a small Tafel slope of 78.7 mV-1, surpassing commercial RuO2 and rivaling state-of-the-art MOFs-based electrocatalysts...Electrochemical impedance spectroscopy analysis using the transmission line model confirms that cathodic activation accelerates charge transport, enhancing the OER process. Furthermore, the cathodic activation strategy holds promise for improving the water oxidation performance of other MOFs such as Fe-HHTP, Co-HHTP, and Cu-HHTP."

Journal

A Phase 1, Randomized, Double-blind, Placebo-controlled, First in Human Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of single and multiple doses of MVD1 in healthy adult volunteers (ANZCTR) - P1 | N=42 | Completed | Sponsor: Eolo Pharma Pty Ltd | Recruiting ➔ Completed

Trial completion • Genetic Disorders • Metabolic Disorders • Obesity • CRP • LEP

Proton conductance and regulation of proton/potassium fluxes in Escherichia coli FhlA-lacking cells during fermentation of mixed carbon sources. (PubMed, Arch Biochem Biophys) - "CMH+ was 13.4 nmol min-1 mV-1 in WT at 20 h, which decreased by 20% in fhlA. Taken together, FHL complexes have a significant contribution to the modulation of H+/ K+ fluxes and the CMH+ for efficient energy transduction and regulation of the proton motive force during mixed carbon sources fermentation."

Journal

Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases. (PubMed, Acta Neuropathol) - "The sensitivity of skin RT-QuIC was subtype dependent, being highest in sCJDVV1-2 subtype, followed by VV2, MV1-2, MV1, MV2, MM1, MM1-2, MM2, and VV1...Although no difference in brain PrP-SA was detected between the cases with false negative and true positive skin RT-QuIC results, the disease duration was significantly longer with the false negatives [12.0 ± 13.3 (months, SD) vs. 6.5 ± 6.4, p < 0.001]. Our study validates skin PrP-SA as a biomarker for the detection of prion diseases, which is influenced by the PrP types, PRNP 129 polymorphisms, dermatome sampled, and disease duration."

Biomarker • Journal • CNS Disorders • PRNP

Review of a series of cases of Creutzfeldt-Jakob disease in a tertiary care hospital (PubMed, Rev Neurol) - "MRI with DWI sequences is a particularly sensitive test for the diagnosis of the disease, although its sensitivity decreases in the early stages. The high specificity and sensitivity of RT-QuIC, together with a characteristic clinical diagnosis and radiological pattern, are proposed as an alternative to the pathological definitive diagnosis."

Journal • Review • Alzheimer's Disease • Ataxia • CNS Disorders • Cognitive Disorders • Movement Disorders

A Phase 1, Randomized, Double-blind, Placebo-controlled, First in Human Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of single and multiple doses of MVD1 in healthy adult volunteers (ANZCTR) - P1 | N=42 | Recruiting | Sponsor: Eolo Pharma Pty Ltd | Initiation date: Mar 2023

Trial initiation date • Genetic Disorders • Metabolic Disorders • Obesity • CRP • LEP

Effect of different multichannel ventilation methods on aerobic composting and vegetable waste gas emissions. (PubMed, Environ Sci Pollut Res Int) - "The results for the groups (MV1, MV2, and MV3) with bottom ventilation plus multichannel ventilation and the group (BV) with single bottom ventilation were compared here...Compared to those of the BV group, the CH, NO, and NH emissions of MV2 were reduced by 32.67%, 21.52%, and 22.57%, respectively, with the total greenhouse gas emissions decreasing by 24.17%. Overall, this study demonstrated a multichannel ventilation system as a new method for improving the composting efficiency of vegetable waste whilst reducing gas emissions."

Journal

Detection of prions in the urine of patients affected by sporadic Creutzfeldt-Jakob disease. (PubMed, Ann Clin Transl Neurol) - "Our findings indicate that potentially infectious prions are secreted in urine of some sCJD patients, suggesting a possible risk for inter-individual transmission. Prion detection in urine might be used as a noninvasive preliminary screening test to detect sCJD."

Journal • CNS Disorders • Infectious Disease

Novel histotypes of sporadic Creutzfeldt-Jakob disease linked to 129MV genotype. (PubMed, Acta Neuropathol Commun) - "The MV1 and MV2 subtypes of sporadic Creutzfeldt-Jakob disease (sCJD) are linked to the heterozygous methionine (M)/valine (V) polymorphism at codon 129 of the prion protein (PrP) gene...Lesion profiles of 1C, 1V, and 1C-2C are similar, but differ from 1C-2PL and 1C-2K, as the latter two groups show prominent hippocampal and nigral degeneration. We believe that the novel "C-PL" histotypes are distinct entities rather than intermediate forms between "C" and "C-K" groups, and that 1C-2PL and 1C-2K histotypes may be characterized by different T1 variants of the same size."

Journal

Baseline left atrial low voltage area predicts recurrence after pulmonary vein isolation: WAVE-MAP AF results. (PubMed, Europace) - "Larger extension of low voltage area was associated with increased risk of arrhythmia recurrence. These subjects may benefit from substrate modification beyond PVI."

Journal • Atrial Fibrillation • Cardiovascular

Potential application of a newly isolated microalga Desmodesmus sp. GXU-A4 for recycling Molasses vinasse. (PubMed, Chemosphere) - "Accordingly, GXU-A4 removed more than 90% of the COD from molasses vinasse (MV1, MV2, and MV3) with initial COD concentrations of 1193 mgL, 2100 mgL, and 3180 mgL, respectively...Meanwhile, the removal rates of NH-N and chroma in ADMV3 reached 91.10% and 47.89%, respectively, significantly reducing the concentration of ammonia nitrogen and color in ADMV. Thus, the results demonstrate that GXU-A4 has a high fouling tolerance, a rapid growth rate in MV and ADMV, the ability to achieve biomass accumulation and nutrient removal from wastewater, and a high potential for MV recycling."

Journal

Development of an Automated Capillary Immunoassay to Detect Prion Glycotypes in Creutzfeldt-Jakob Disease. (PubMed, Lab Invest) - "Sporadic CJD heterogeneity is predominantly influenced by the genotype at codon 129 of the prion-encoding gene and the molecular weight of PrP fragments after protease digestion, resulting in a classification of 6 subtypes of CJD (MM1, MM2, MV1, MV2, VV1, and VV2)...Cases with CJD in which type 1 and type 2 coexist within the same brain region can be detected using type 1-specific and type 2-specific antibodies, and we found that there was remarkable specificity for the detection of cases with variably protease-sensitive prionopathy. The assay presented displays outstanding sensitivity, allowing for the preservation of valuable samples and enhancing current detection methods."

Journal • CNS Disorders

Gastroesophageal reflux disease and its health-related quality of life among adult ICU survivors (ISICEM 2023) - P=N/A | "In remaining 48 patients, 17 (24%) had new-onset GERD with OR [95%CI] for risk factors: age 0.95 [0.9-0.9] (p=0.02), comorbidity 0.92 [0.7-1.2], SOFA score 0.92 [0.7-1.2], GI disease 0.97 [0.3-3.2], ICU stay 1.0 [0.9-1.0], MV 1.33 [0.4-4.4], vasopressor 1.2 [0.3-4.2], RRT 0.69 [0.1- 4.0], NG days 1.0 [0.9-1], TT days 0.99 [0.9-1.0], sedation 1.78 [0.5-5.9], steroid 0.66 [0.1-2.3], prokinetic 0.66 [0.1- 2.3] and at-risk drugs 0.3 [0-1]. One-fourth ICU survivors had new onset GERD; and its HRQL score improved significantly at 6-week follow-up."

Clinical • HEOR • Anesthesia • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder

Defining the phenotypic spectrum of sporadic Creutzfeldt-Jakob disease MV2K: the kuru plaque type. (PubMed, Brain) - "The current classification of sporadic Creutzfeldt-Jakob disease identifies six major subtypes mainly defined by the combination of the genotype at polymorphic codon 129 (methionine/M or valine/V) of the prion protein gene and the type (1 or 2) of misfolded prion protein accumulating in the brain (e.g., MM1, MM2, MV1, MV2, etc.)...The plaque-type aggregation of the misfolded prion protein accounts for most of the atypical clinical features. Nonetheless, our data strongly suggest that the consistent use of the real-time quaking-induced conversion assay and brain diffusion-weighted magnetic resonance imaging allows an accurate early clinical diagnosis in most patients."

Journal • CNS Disorders • Psychiatry • Sleep Disorder