MV1 / Roche - LARVOL DELTA

A family of ultrathin non-van der waals kamiokite-type oxides for two-dimensional electronics. (PubMed, Nat Commun) - "Benefiting from the good dielectric properties and high-quality interface of Zn2Mo3O8, MoS2 transistors with a Zn2Mo3O8 top-gate dielectric exhibit near-Boltzmann-limit subthreshold swing (~63.8 mV dec-1), an on/off ratio exceeding 107, and an ultralow hysteresis width of 1.6 mV MV-1 cm under ambient conditions. The A2Mo3O8 family offers a versatile materials platform for the development of high‑κ dielectrics and a broad range of functional components for next-generation high-performance 2D electronics."

Journal

Seroprotection after Measles Vaccination in Children with Sickle Cell Anemia Receiving Hydroxyurea. (PubMed, Blood Adv) - P=N/A | "We conducted a retrospective cohort study of children with SCA enrolled on the TREAT trial (NCT02286154) to determine anti-measles seroprotection (IgG ≥ 200 IU/L via ELISA) after first (MV1) and second (MV2) measles vaccine. Hydroxyurea treatment at the time of vaccination did not reduce seroprotection; rather, earlier hydroxyurea initiation was associated with increased seroprotection (OR 4.4, p=0.02). The majority of children with SCA are adequately protected following measles vaccination, similar to the general population, and seroprotection is increased with timely vaccination and early hydroxyurea treatment."

Journal • Anemia • Genetic Disorders • Hematological Disorders • Infectious Disease • Measles • Sickle Cell Disease

Altered EEG in Creutzfeldt-Jakob Disease: Improving Diagnostic Accuracy Using American Clinical Neurophysiology Society 2021 Criteria. (PubMed, Neurol Clin Pract) - "Assessing the EEGs according to the 2021 ACNS criteria may help prevent misdiagnosis of nonconvulsive status epilepticus, and repetitive recordings may help in earlier diagnosis of CJD."

Journal • CNS Disorders • Epilepsy

Development of an ex vivo skin model for quantitative recovery and preservation of donor-specific human microbiota. (PubMed, BMC Microbiol) - "The Perfex model enables transfer of donor-specific skin microbiota to ex vivo human skin while preserving tissue integrity over short-term culture. This model provides a human-relevant platform for studying host-microbiota interactions under controlled conditions and for preclinical evaluation of microbiome-targeted therapies and dermo-cosmetic treatments."

Journal • Preclinical • Aesthetic Medicine

Study on the Micro-mechanism of Controlling CH4 and CO2 Adsorption by Constructing Structural Defects in Coal Based on DFT. (PubMed, Langmuir) - "To elucidate the regulatory patterns and microscopic mechanisms of different structural defects in tectonic coal on CH4 and CO2 adsorption, periodic graphene models were constructed based on 7 × 7 aromatic layers, including single vacancy (SV), double vacancy (DV), multiple vacancies (MV1, MV2), Stone-Wales (SW) line defects, and nitrogen (G-N) and sulfur (G-S) substitution point defects...Defects significantly enhance gas adsorption capacity in tectonic coal by regulating electron transfer efficiency and electrostatic interaction strength. This study reveals the microscopic mechanism by which structural defects in tectonic coal regulate CH4 and CO2 adsorption, providing crucial theoretical support for preventing coal and gas outbursts, efficient coalbed methane development, and CO2 geological sequestration."

Journal

Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt-Jakob Disease MV1 Subtype. (PubMed, Neuropathol Appl Neurobiol) - "Overall, we propose that MV1 is a more heterogeneous subtype than previously appreciated, potentially existing along a spectrum from MM1-like to VV1-like phenotypes. Importantly, this biochemical heterogeneity may be underrepresented when subtyping is done at pH 8.0, so we recommend CJD subtyping be performed at pH 6.9 to avoid missing atypical or mixed cases."

Heterogeneity • Journal • CNS Disorders • PRNP

Vanishing Polarizability of Dark Excitons in WSe2: Implications for Noise-Resilient Quantum States. (PubMed, Nano Lett) - "Contrary to the large Stark shifts observed in interlayer excitons, we demonstrate that the D0 exciton exhibits a vanishingly small polarizability (<6.7 × 10-10 D·mV-1)...Crucially, we show that this insensitivity extends to the magnetic response, where the g-factor remains robust against electric field variations. Our results establish the dark exciton as a noise-resilient building block for future spin-valley quantum information processing."

Journal

Analysis of morphological diversity, phenolic content, and antioxidant activity of mutant MV1 shallots treated with gamma irradiation. (PubMed, Braz J Biol) - "Overall, gamma irradiation significantly influenced the morphological traits and metabolic profiles of A. cepa mutants. Notably, the 100 and 125 Gy treatments formed distinct mutant groupings, indicating pronounced morphological and metabolic alterations."

Journal

Combining RAS(ON) G12C-selective and RAS(ON) multi-selective inhibitors overcomes sotorasib resistance driven byKRASG12C amplification or NRASG13R mutation (AACR 2025) - "Amplification of the KRASG12C mutant allele and acquisition of NRAS mutations have been reported as resistance mechanisms in tumors progressing on sotorasib and adagrasib...We generated five sotorasib-resistant cell lines from relapsed tumors of sotorasib-treated H358 xenografts (MR1-MR5) and two vehicle-treated tumors (MV1 and MV2). We created an additional isogenic cell line model, H358-MX1, by treating H358 cells with sotorasib and a SHP2 inhibitor, RMC-4550...In H358-MX1 mouse xenografts, RMC-7977 + RMC-4998 significantly inhibited tumor growth compared to single-agent treatments or other combination regimens. These preclinical data suggest that combination of RAS(ON) mutant-selective and RAS(ON) multi-selective inhibitors overcome resistance to KRASG12C (OFF) inhibitors driven by KRASG12C amplification and secondary NRASG13R mutation in KRASG12C mutated lung cancer models."

Lung Cancer • Oncology • Solid Tumor • KRAS • MX1 • NRAS

THE PHENOTYPIC SPECTRUM OF SPORADIC CREUTZFELDT-JAKOB DISEASE CORTICAL VARIANT (MM/MV2C) (ADPD 2026) - "The clinicopathologic phenotype of sCJDMM/MV2C diverges from that of the typical MM/MV1 subtype. Moreover, the histomolecular heterogeneity within MM/MV2C influences both clinical features and results of diagnostic investigations, challenging its identification in vitam. Nonetheless, our analysis suggests that DW-MRI and CSF RT-QuIC allow an accurate clinical diagnosis of sCJD in most patients."

CNS Disorders

SnSe/PVDF-HFP Composite Fibrous Membrane with Excellent Piezoelectric and Photocatalytic Dual Properties. (PubMed, ACS Omega) - "Experimental results demonstrate that the composite fibrous membrane exhibits outstanding dual functionality: On one hand, the flexible sensor based on its piezoelectric properties achieves an output voltage of 23.1 V and a sensitivity of 440 mV-1, enabling precise monitoring of human motion...Under the combined action of light irradiation and ultrasonic vibration, the composite fibrous membrane as a catalyst achieves 99.0% degradation rate of methylene blue within 120 min while maintaining excellent stability and recyclability, effectively addressing the recovery challenges of traditional powder catalysts. This work not only provides a novel material design strategy for integrating piezoelectric sensing and photocatalytic dual functions but also opens innovative pathways for developing wearable flexible electronic devices and easily recoverable catalysts."

Journal

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer-Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice. (PubMed, MedComm (2020)) - "All four vaccine candidates elicited varying degrees of humoral and cellular immune responses and conferred differential protection against MPXV and vaccinia virus (VACV) in BALB/c mice; notably, the dual-antigen vaccines MV1 and MV2 induced more potent immunogenicity, including higher neutralizing antibody titers and cytokine secretion levels...Notably, MV2-which was designed via structural truncation and recombination based on poxvirus-broad-spectrum antibodies using the AlphaFold3 prediction platform and adopts a single-chain "dimer-like" configuration-exhibited not only optimal protective efficacy but also sustained durable immune responses and protection. These findings indicate that MV2 induces favorable immunogenicity and has potential for preventing MPXV and VACV infections, supporting its promise as a clinical vaccine candidate for MPXV."

Journal • Preclinical • Infectious Disease

Canadian Creutzfeldt-Jakob disease incidence remained stable during the coronavirus disease (COVID-19) pandemic. (PubMed, Front Neurol) - "Demographics, disease durations, and molecular subtypes of sporadic CJD (sCJD) were largely consistent across periods, although a higher proportion of females were tested during COVID and the prevalence of sCJD MV1 declined post-COVID. CJD prevalence and characteristics remained stable during COVID-19 despite increased EP-QuIC test submissions. These findings verify that CJD surveillance in Canada remained vigilant during the pandemic and highlight the value of EP-QuIC CSF testing for comprehensive CJD monitoring."

Journal • CNS Disorders • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

The Phenotypic Spectrum of Sporadic Creutzfeldt-Jakob Disease Cortical Subtype. (PubMed, Ann Neurol) - "The clinicopathologic phenotype of sCJDMM/MV2C diverges from that of typical sCJDMM/MV1. Moreover, the histomolecular heterogeneity within MM/MV2C influences clinical features and results of diagnostic investigations, challenging its identification in vivo. Nonetheless, results suggest that DW-MRI and CSF RT-QuIC allow an accurate clinical diagnosis of Creutzfeldt-Jakob disease in most patients. ANN NEUROL 2025."

Journal • CNS Disorders

Measles vaccine-induced sero-protection among children with sickle cell anemia (ASH 2025) - P=N/A, P3 | "Among 35 children with samples available aftertheir first measles vaccine (MV1), the median age at MV1 was 1.1 (IQR 1.0-1.3) years, and 5 of 18 (28%)with available labs had elevated pit counts within one year of vaccination. In this retrospective cohort, sero-protection from measles vaccinations in children with SCAwas robust and comparable to rates observed in the general population. Notably, hydroxyurea treatmentdid not impair measles antibody responses. Older age at vaccination was associated with lower rates ofsero-protection, an important finding for families considering delayed vaccine schedules."

Clinical • Anemia • Genetic Disorders • Hematological Disorders • Infectious Disease • Measles • Sickle Cell Disease

Impact of heart failure on in-hospital outcomes of pulmonary valve interventions: a nationwide analysis. (PubMed, Future Cardiol) - "Patients with heart failure had an increased risk of mortality, odds ratio (OR) 3.42 (95% confidence interval [CI] 1.19-6.12); p-value < 0.0001, heart block 1.75 (1.45-2.13); < 0.0001, bleeding 1.31 (1.12-1.52); 0.0005, AKI 1.35 (1.12-1.61); 0.001, vasopressor use 1.33 (1.08-1.65); 0.007, cardiogenic shock 2.34 (1.87-2.93); < 0.0001, MV 1.45 (1.09-1.94); 0.01, in-hospital cardiac arrest 2.29 (1.35-3.91); 0.002, ECMO 2.23 (1.43-3.45); 0.0003...Heart failure is associated with worse in-hospital outcomes following surgical pulmonic valve replacement or repair. Preoperative optimization and considering earlier surgical intervention may improve outcomes in this high-risk population."

Journal • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Differential Host Responses and Viral Replication of Highly Pathogenic Avian Influenza H5N1 Strains in Diverse Cell Lines with a Raw Milk Supplement. (PubMed, Life (Basel)) - "This study investigates the host cell responses to distinct H5N1 strains (bovine- and mink-derived H5N1) in the presence and absence of raw milk across diverse mammalian cell lines (MDCK, MDBK, A549, Vero, MV1)...These host gene modulations are cell-type- and strain-specific, suggesting a complex interplay that may theoretically influence virus-host dynamics, though the biological significance of these in vitro observations requires validation through infectious virus assays and in vivo studies. This hypothesis-generating work provides preliminary insights into H5N1-milk interactions, highlighting the need for further mechanistic investigation to assess potential implications for viral transmission in dairy environments."

Journal • Preclinical • Infectious Disease • Influenza • Respiratory Diseases

Elevated regulatory T cells in pediatric patients recovering from multisystem inflammatory syndrome (MIS-C) are evident five months post-COVID-19. (PubMed, Hum Immunol) - "Children recovering from COVID-19 showed changes in regulatory T cell populations associated with disease severity. Those who developed MIS-C had higher Treg cell counts and a temporary immunosuppressive state that persisted in the early convalescence period, normalizing around a year after infection."

IO biomarker • Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Respiratory Diseases • CTLA4 • CXCL8 • FOXP3 • IL10 • IL12A • IL1B • IL6 • TGFB1 • TNFA

Construction and Preclinical Evaluation of a Recombinant Attenuated Measles Vaccine Candidate of the H1a Genotype. (PubMed, Vaccines (Basel)) - "Based on a newly isolated wild-type measles virus strain (genotype H1a), designated MVs/Jiangsu.CHN/38.16/1[H1a] (MV-1), this study aims to develop and evaluate a novel recombinant measles virus vaccine candidate designed to enhance immunogenicity and broaden protection against multiple epidemic genotypes. It has the potential to strengthen current measles vaccination strategies by providing improved immunogenicity and broader protection against different circulating genotypes. Further clinical trials are warranted to confirm these promising preclinical results."

Journal • Preclinical • Infectious Disease • Measles

Immune checkpoint inhibitor-associated myocarditis: a novel risk score. (PubMed, Eur Heart J) - P, P=N/A | "ICI-associated myocarditis can manifest with high morbidity and mortality. Myocarditis severity is associated with magnitude of troponin, thymoma, low QRS voltage, depressed LVEF, and cardiomuscular symptoms. A risk score incorporating these features performed well."

Checkpoint inhibition • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Immunology • Inflammation • Myositis • Oncology • Respiratory Diseases • Solid Tumor • Thymoma • Thymus Cancer

Gold Nanorods Non-Functionalized and Associated with Gallic Acid: Effects on Non-Albicans candida Species (ASM Microbe 2025) - "AuNpAG exhibited mean length of 66.2 ± 1.9 nm, mean diameter of 33.1 ± 1.5 nm, and Zeta potential of +36.90 ± 2.0 mV1...Furthermore, AuNpGA and AuNp significantly decreased the viability of all Candida biofilms at 7.8 and 15.6 µg/mL, respectively. In summary, both gold nanoparticles exhibited potent activity against planktonic cells and biofilms, highlighting their potential as therapeutic agents for Candida infections."

Candidiasis • Infectious Disease

Identification of fungal diseases in strawberry by analysis of hyperspectral images using machine learning methods. (PubMed, Vavilovskii Zhurnal Genet Selektsii) - "The reflection spectrum of leaves was acquired with a Photonfocus MV1-D2048x1088-HS05-96-G2-10 hyperspectral camera under laboratory conditions using the line scanning method...When using vegetation indices and optimal wavelengths, the overall classification accuracy of all methods decreased slightly compared to the classification on the full range spectral data. The results of the study confirm the potential of using hyperspectral imaging methods in combination with machine learning for differentiating fungal diseases of strawberries."

Journal • Infectious Disease

HEART FAILURE IS ASSOCIATED WITH WORSE IN-HOSPITAL OUTCOMES IN PATIENTS UNDERGOING SURGICAL PULMONARY VALVE REPLACEMENT OR REPAIR: A NATIONWIDE STUDY - Jacob Klein (ACC 2025) - "There is an increased risk of mortality and adverse cardiovascular events in patients with heart failure undergoing surgical pulmonary valve replacement or repair. Further research is needed to identify modifiable risk factors for better outcomes and optimize surgical timing and planning."

Clinical • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Adaptive changes in infant emotion regulation persist three months following birthing parent receipt of cognitive behavioral therapy for postpartum depression. (PubMed, J Affect Disord) - "Treating PPD may set infants on a persistent adaptive ER trajectory."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Postpartum Depression • Psychiatry

Creutzfeldt-Jakob Disease: How Rare is Rare? (AAN 2025) - "Seven patients underwent autopsy and were confirmed as sporadic CJD and subtypes included MM1, MV2, VV2 and MV1-2...Our 45-month retrospective study found 14 CJD cases in Corewell Health, one of the large health systems in Michigan, which challenges the prevailing understanding that CJD is a rare disease. We also found higher incidence of CJD in 2022 and 2023 of unclear etiology. Further studies will be needed to investigate cases with negative RT-QuIC, high T-tau value and positive 14-3-3, to understand the true CJD incidence."

CNS Disorders • Rare Diseases