MV1 / Roche - LARVOL DELTA

THE PHENOTYPIC SPECTRUM OF SPORADIC CREUTZFELDT-JAKOB DISEASE CORTICAL VARIANT (MM/MV2C) (ADPD 2026) - "The clinicopathologic phenotype of sCJDMM/MV2C diverges from that of the typical MM/MV1 subtype. Moreover, the histomolecular heterogeneity within MM/MV2C influences both clinical features and results of diagnostic investigations, challenging its identification in vitam. Nonetheless, our analysis suggests that DW-MRI and CSF RT-QuIC allow an accurate clinical diagnosis of sCJD in most patients."

CNS Disorders

SnSe/PVDF-HFP Composite Fibrous Membrane with Excellent Piezoelectric and Photocatalytic Dual Properties. (PubMed, ACS Omega) - "Experimental results demonstrate that the composite fibrous membrane exhibits outstanding dual functionality: On one hand, the flexible sensor based on its piezoelectric properties achieves an output voltage of 23.1 V and a sensitivity of 440 mV-1, enabling precise monitoring of human motion...Under the combined action of light irradiation and ultrasonic vibration, the composite fibrous membrane as a catalyst achieves 99.0% degradation rate of methylene blue within 120 min while maintaining excellent stability and recyclability, effectively addressing the recovery challenges of traditional powder catalysts. This work not only provides a novel material design strategy for integrating piezoelectric sensing and photocatalytic dual functions but also opens innovative pathways for developing wearable flexible electronic devices and easily recoverable catalysts."

Journal

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer-Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice. (PubMed, MedComm (2020)) - "All four vaccine candidates elicited varying degrees of humoral and cellular immune responses and conferred differential protection against MPXV and vaccinia virus (VACV) in BALB/c mice; notably, the dual-antigen vaccines MV1 and MV2 induced more potent immunogenicity, including higher neutralizing antibody titers and cytokine secretion levels...Notably, MV2-which was designed via structural truncation and recombination based on poxvirus-broad-spectrum antibodies using the AlphaFold3 prediction platform and adopts a single-chain "dimer-like" configuration-exhibited not only optimal protective efficacy but also sustained durable immune responses and protection. These findings indicate that MV2 induces favorable immunogenicity and has potential for preventing MPXV and VACV infections, supporting its promise as a clinical vaccine candidate for MPXV."

Journal • Preclinical • Infectious Disease

Canadian Creutzfeldt-Jakob disease incidence remained stable during the coronavirus disease (COVID-19) pandemic. (PubMed, Front Neurol) - "Demographics, disease durations, and molecular subtypes of sporadic CJD (sCJD) were largely consistent across periods, although a higher proportion of females were tested during COVID and the prevalence of sCJD MV1 declined post-COVID. CJD prevalence and characteristics remained stable during COVID-19 despite increased EP-QuIC test submissions. These findings verify that CJD surveillance in Canada remained vigilant during the pandemic and highlight the value of EP-QuIC CSF testing for comprehensive CJD monitoring."

Journal • CNS Disorders • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

The Phenotypic Spectrum of Sporadic Creutzfeldt-Jakob Disease Cortical Subtype. (PubMed, Ann Neurol) - "The clinicopathologic phenotype of sCJDMM/MV2C diverges from that of typical sCJDMM/MV1. Moreover, the histomolecular heterogeneity within MM/MV2C influences clinical features and results of diagnostic investigations, challenging its identification in vivo. Nonetheless, results suggest that DW-MRI and CSF RT-QuIC allow an accurate clinical diagnosis of Creutzfeldt-Jakob disease in most patients. ANN NEUROL 2025."

Journal • CNS Disorders

Measles vaccine-induced sero-protection among children with sickle cell anemia (ASH 2025) - P=N/A, P3 | "Among 35 children with samples available aftertheir first measles vaccine (MV1), the median age at MV1 was 1.1 (IQR 1.0-1.3) years, and 5 of 18 (28%)with available labs had elevated pit counts within one year of vaccination. In this retrospective cohort, sero-protection from measles vaccinations in children with SCAwas robust and comparable to rates observed in the general population. Notably, hydroxyurea treatmentdid not impair measles antibody responses. Older age at vaccination was associated with lower rates ofsero-protection, an important finding for families considering delayed vaccine schedules."

Clinical • Anemia • Genetic Disorders • Hematological Disorders • Infectious Disease • Measles • Sickle Cell Disease

Impact of heart failure on in-hospital outcomes of pulmonary valve interventions: a nationwide analysis. (PubMed, Future Cardiol) - "Patients with heart failure had an increased risk of mortality, odds ratio (OR) 3.42 (95% confidence interval [CI] 1.19-6.12); p-value < 0.0001, heart block 1.75 (1.45-2.13); < 0.0001, bleeding 1.31 (1.12-1.52); 0.0005, AKI 1.35 (1.12-1.61); 0.001, vasopressor use 1.33 (1.08-1.65); 0.007, cardiogenic shock 2.34 (1.87-2.93); < 0.0001, MV 1.45 (1.09-1.94); 0.01, in-hospital cardiac arrest 2.29 (1.35-3.91); 0.002, ECMO 2.23 (1.43-3.45); 0.0003...Heart failure is associated with worse in-hospital outcomes following surgical pulmonic valve replacement or repair. Preoperative optimization and considering earlier surgical intervention may improve outcomes in this high-risk population."

Journal • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Differential Host Responses and Viral Replication of Highly Pathogenic Avian Influenza H5N1 Strains in Diverse Cell Lines with a Raw Milk Supplement. (PubMed, Life (Basel)) - "This study investigates the host cell responses to distinct H5N1 strains (bovine- and mink-derived H5N1) in the presence and absence of raw milk across diverse mammalian cell lines (MDCK, MDBK, A549, Vero, MV1)...These host gene modulations are cell-type- and strain-specific, suggesting a complex interplay that may theoretically influence virus-host dynamics, though the biological significance of these in vitro observations requires validation through infectious virus assays and in vivo studies. This hypothesis-generating work provides preliminary insights into H5N1-milk interactions, highlighting the need for further mechanistic investigation to assess potential implications for viral transmission in dairy environments."

Journal • Preclinical • Infectious Disease • Influenza • Respiratory Diseases

Elevated regulatory T cells in pediatric patients recovering from multisystem inflammatory syndrome (MIS-C) are evident five months post-COVID-19. (PubMed, Hum Immunol) - "Children recovering from COVID-19 showed changes in regulatory T cell populations associated with disease severity. Those who developed MIS-C had higher Treg cell counts and a temporary immunosuppressive state that persisted in the early convalescence period, normalizing around a year after infection."

IO biomarker • Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Respiratory Diseases • CTLA4 • CXCL8 • FOXP3 • IL10 • IL12A • IL1B • IL6 • TGFB1 • TNFA

Construction and Preclinical Evaluation of a Recombinant Attenuated Measles Vaccine Candidate of the H1a Genotype. (PubMed, Vaccines (Basel)) - "Based on a newly isolated wild-type measles virus strain (genotype H1a), designated MVs/Jiangsu.CHN/38.16/1[H1a] (MV-1), this study aims to develop and evaluate a novel recombinant measles virus vaccine candidate designed to enhance immunogenicity and broaden protection against multiple epidemic genotypes. It has the potential to strengthen current measles vaccination strategies by providing improved immunogenicity and broader protection against different circulating genotypes. Further clinical trials are warranted to confirm these promising preclinical results."

Journal • Preclinical • Infectious Disease • Measles

Immune checkpoint inhibitor-associated myocarditis: a novel risk score. (PubMed, Eur Heart J) - P, P=N/A | "ICI-associated myocarditis can manifest with high morbidity and mortality. Myocarditis severity is associated with magnitude of troponin, thymoma, low QRS voltage, depressed LVEF, and cardiomuscular symptoms. A risk score incorporating these features performed well."

Checkpoint inhibition • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Immunology • Inflammation • Myositis • Oncology • Respiratory Diseases • Solid Tumor • Thymoma • Thymus Cancer

Gold Nanorods Non-Functionalized and Associated with Gallic Acid: Effects on Non-Albicans candida Species (ASM Microbe 2025) - "AuNpAG exhibited mean length of 66.2 ± 1.9 nm, mean diameter of 33.1 ± 1.5 nm, and Zeta potential of +36.90 ± 2.0 mV1...Furthermore, AuNpGA and AuNp significantly decreased the viability of all Candida biofilms at 7.8 and 15.6 µg/mL, respectively. In summary, both gold nanoparticles exhibited potent activity against planktonic cells and biofilms, highlighting their potential as therapeutic agents for Candida infections."

Candidiasis • Infectious Disease

Identification of fungal diseases in strawberry by analysis of hyperspectral images using machine learning methods. (PubMed, Vavilovskii Zhurnal Genet Selektsii) - "The reflection spectrum of leaves was acquired with a Photonfocus MV1-D2048x1088-HS05-96-G2-10 hyperspectral camera under laboratory conditions using the line scanning method...When using vegetation indices and optimal wavelengths, the overall classification accuracy of all methods decreased slightly compared to the classification on the full range spectral data. The results of the study confirm the potential of using hyperspectral imaging methods in combination with machine learning for differentiating fungal diseases of strawberries."

Journal • Infectious Disease

Combining RAS(ON) G12C-selective and RAS(ON) multi-selective inhibitors overcomes sotorasib resistance driven byKRASG12C amplification or NRASG13R mutation (AACR 2025) - "Amplification of the KRASG12C mutant allele and acquisition of NRAS mutations have been reported as resistance mechanisms in tumors progressing on sotorasib and adagrasib...We generated five sotorasib-resistant cell lines from relapsed tumors of sotorasib-treated H358 xenografts (MR1-MR5) and two vehicle-treated tumors (MV1 and MV2). We created an additional isogenic cell line model, H358-MX1, by treating H358 cells with sotorasib and a SHP2 inhibitor, RMC-4550...In H358-MX1 mouse xenografts, RMC-7977 + RMC-4998 significantly inhibited tumor growth compared to single-agent treatments or other combination regimens. These preclinical data suggest that combination of RAS(ON) mutant-selective and RAS(ON) multi-selective inhibitors overcome resistance to KRASG12C (OFF) inhibitors driven by KRASG12C amplification and secondary NRASG13R mutation in KRASG12C mutated lung cancer models."

Lung Cancer • Oncology • Solid Tumor • KRAS • MX1 • NRAS

HEART FAILURE IS ASSOCIATED WITH WORSE IN-HOSPITAL OUTCOMES IN PATIENTS UNDERGOING SURGICAL PULMONARY VALVE REPLACEMENT OR REPAIR: A NATIONWIDE STUDY - Jacob Klein (ACC 2025) - "There is an increased risk of mortality and adverse cardiovascular events in patients with heart failure undergoing surgical pulmonary valve replacement or repair. Further research is needed to identify modifiable risk factors for better outcomes and optimize surgical timing and planning."

Clinical • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Adaptive changes in infant emotion regulation persist three months following birthing parent receipt of cognitive behavioral therapy for postpartum depression. (PubMed, J Affect Disord) - "Treating PPD may set infants on a persistent adaptive ER trajectory."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Postpartum Depression • Psychiatry

Creutzfeldt-Jakob Disease: How Rare is Rare? (AAN 2025) - "Seven patients underwent autopsy and were confirmed as sporadic CJD and subtypes included MM1, MV2, VV2 and MV1-2...Our 45-month retrospective study found 14 CJD cases in Corewell Health, one of the large health systems in Michigan, which challenges the prevailing understanding that CJD is a rare disease. We also found higher incidence of CJD in 2022 and 2023 of unclear etiology. Further studies will be needed to investigate cases with negative RT-QuIC, high T-tau value and positive 14-3-3, to understand the true CJD incidence."

CNS Disorders • Rare Diseases

Case report: Atypical young case of MV1 Creutzfeldt-Jakob disease with unusually long survival. (PubMed, Front Cell Neurosci) - "Very young onset sCJD often has atypical clinical presentations and disease progression, neuropathological examination results, and/or laboratory test results that may confound diagnosis. It is critical to perform thorough, comprehensive evaluations to make an accurate diagnosis, which includes autopsy confirmation with histology, prion protein typing and prion gene sequencing."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Psychiatry • PRNP

Pathological spectrum of sporadic Creutzfeldt-Jakob disease. (PubMed, Pathology) - "Six major clinicopathological subtypes of sCJD are internationally recognised, largely correlating with the combination of the two distinct types of the protease-resistant prion protein (PrPres type 1 or 2) and the methionine (M)/valine (V) polymorphism at codon 129 of the prion protein gene (PRNP): MM1/MV1, MM2-cortical, MM2-thalamic, MV2, VV1 and VV2...In this review, we will provide an up-to-date overview of the current classification of sCJD based on the prominent neuropathological features. In addition, with levels of infectivity at their highest in the brain, we will also discuss the additional precautions that are recommended when handling and examining postmortem tissues from patients with suspected prion disease."

Journal • Review • CNS Disorders • PRNP

Heating Efficiency of Different Magnetotactic Bacterial Species: Influence of Magnetosome Morphology and Chain Arrangement. (PubMed, ACS Appl Mater Interfaces) - "Here, we study three different bacterial species, Magnetospirillum gryphiswaldense (MSR-1), Magnetospirillum magneticum (AMB-1), and Magnetovibrio blakemorei (MV-1), which synthesize magnetite nanoparticles with different morphologies and chain arrangements...As the Keff value increases, the saturated SAR values are higher; however, the threshold magnetic field required to observe a SAR response simultaneously increases. This factor is crucial to choose a bacterial species as the optimal hyperthermia agent."

Journal • Oncology

Strain-Mediated Second Harmonic Generation Enhancement of Bimetallic Metal-Organic Frameworks. (PubMed, J Phys Chem Lett) - "The determined second-order nonlinear susceptibility of MOF3 (∼19.86 p mV-1) is one order of magnitude larger than that of pristine Zn-MOF (1.65 p mV-1) and Cu-MOF (3.88 p mV-1) and much higher than the commonly used NLO crystals...The anisotropy ratio of MOF4 (∼118.8) is much higher than that of the most excellent 2D material to date, to our best knowledge. A first-order perturbation of second-order polarization based on point group description was introduced to explore the regulation mechanism of the NLO response under the strain field of MOFs."

Journal

Preliminary signs of clinical activity of tuvusertib (M1774), a highly potent oral ATR inhibitor, in refractory IDH mutated glioma patients with P53 and ATRX mutations; A case series from a FiH Study (EANO 2024) - P1 | "The observed decrease in tumor growth rate associated with prolonged disease stabilization in treatment-refractory glioma warrants further investigation of tuvusertib in this indication. [MV1]All patients had molecular G3 IDH mutant astrocytoma, but one case has the diagnosis of G3 IDH mutant oligo-astrocytoma based on morphology [MV2]We can mention here that IDH inhibitors efficacy seems to be limited to low-grade, treatment naive non enhancing disease, where tuvusertib is active in high grade refractory tumors"

Clinical • Astrocytoma • Brain Cancer • CNS Tumor • Glioma • Oncology • Solid Tumor • ATRX • DAXX • TP53

Analysis of promoter region and regulatory elements of Rhizobium giardinii DNA-binding response regulator A3AY_RS01 genes. (PubMed, J Genet Eng Biotechnol) - "MV1 motif can serve as a binding site for the Fur transcription factor gene family in R. giardinii to regulate the expression of R. giardinii A3AY_RS01 genes. R. giardinii A3AY_RS01 genes are rich in CpG Islands, and play an important role in the regulation of the gene expression of nitrogen fixing in this bacterium."

Epigenetic controller • Journal

Enhancing Oxygen Evolution Reaction Performance of Metal-Organic Frameworks through Cathode Activation. (PubMed, ChemSusChem) - "As a prototype, the activated Ni-HHTP (HA-Ni-HHTP) demonstrates outstanding OER performance, with an overpotential as low as 140 mV at 20 mA cm-2 and a small Tafel slope of 78.7 mV-1, surpassing commercial RuO2 and rivaling state-of-the-art MOFs-based electrocatalysts...Electrochemical impedance spectroscopy analysis using the transmission line model confirms that cathodic activation accelerates charge transport, enhancing the OER process. Furthermore, the cathodic activation strategy holds promise for improving the water oxidation performance of other MOFs such as Fe-HHTP, Co-HHTP, and Cu-HHTP."

Journal

A Phase 1, Randomized, Double-blind, Placebo-controlled, First in Human Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of single and multiple doses of MVD1 in healthy adult volunteers (ANZCTR) - P1 | N=42 | Completed | Sponsor: Eolo Pharma Pty Ltd | Recruiting ➔ Completed

Trial completion • Genetic Disorders • Metabolic Disorders • Obesity • CRP • LEP