sPIF / BioIncept - LARVOL DELTA

Murine glial progenitor cells transplantation and synthetic PreImplantation Factor (sPIF) reduces inflammation and early motor impairment in ALS mice. (PubMed, Sci Rep) - "Finally, sPIF and CB reduced the number of microglial cells and prevented neuronal number loss. Given the safety profile and a neuroprotective potential of sPIF, we envision its clinical application in near future."

Journal • Preclinical • Amyotrophic Lateral Sclerosis • CNS Disorders • Immune Modulation • Immunology • Inflammation • Transplantation

Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2. (PubMed, JCI Insight) - "Accordingly, after hypoxic-ischemic brain injury in rodents, myelin protection and oligodendrocytes' fate are in part modulated by sPIF and H19. Our results revealed an unexpected mechanism of the H19/SAHH axis underlying myelin preservation during brain recovery and its use in treating neurodegenerative diseases can be envisioned."

Journal • CNS Disorders • Solid Tumor • Vascular Neurology • NCOR2

Preimplantation factor modulates trophoblastic invasion throughout the decidualization of human endometrial stromal cells. (PubMed, Reprod Biol Endocrinol) - "Taken as a whole, our results suggest that PIF accentuates the decidualization process and the production of endometrial factors that limit trophoblast invasion. By controlling both trophoblast and endometrial cells, PIF therefore appears to be a pivotal player in the human embryo implantation process."

Journal • IGFBP1 • MMP9