IT603 / ImmuneTarget - LARVOL DELTA

INVESTIGATING THE ROLE OF FIBROBLAST TRAINED IMMUNITY IN THE PATHOGENESIS OF SYSTEMIC SCLEROSIS ASSOCIATED PULMONARY FIBROSIS (SSWC 2026) - "Inhibiting REL with IT603 reduced fibrotic markers in human dermal fibroblasts. This may indicate that trained immunity in lung fibroblasts, driven by cRel/REL, may contribute to lung fibrosis, repre- senting a potential therapeutic target."

Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • Scleroderma • Systemic Sclerosis

c-Rel dependant Chk2 signalling regulates the DNA damage response limiting hepatocarcinogenesis. (PubMed, Hepatology) - "Hepatocyte c-Rel signalling limits genotoxic injury, and subsequent HCC burden. Inhibiting c-Rel as an adjuvant therapy increased the effectiveness of DNA damaging agents and reduced HCC growth."

Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology • Solid Tumor • CHEK2 • TMB

A COMMON METABOLIC SWITCH CONTROLS HEPATOCYTE AND MACROPHAGE PHENOTYPE MODULATION IN LIVER INJURY AND IS REQUIRED FOR FIBROSIS. (AASLD 2019) - "Metabolic reprogramming of epithelial cells and macrophages is a critical event during fibrogenesis that is control by a common transcription factor, c-Rel. As such development of c-Rel inhibitors represents an exciting new approach to treat chronic liver disease and fibrosis."