Stronger Neo-Minophagen C (ammoniated glycyrrhizin intravenous) / Eisai, Minophagen - LARVOL DELTA

Meta-analysis of the efficacy of glycyrrhizin for postoperative liver preservation in patients with liver cancer. (PubMed, J Cancer Res Ther) - "CG affects liver preservation in treating liver cancer, which can reduce ALT, AST, and TBIL levels in patients; increase the ALB level; and protect liver cells. The CG-treated group showed improvement compared with the control group; although adverse reactions occurred in the treated group, the duration was shortened."

Journal • Retrospective data • Gastrointestinal Cancer • Hepatology • Liver Cancer • Oncology • Solid Tumor

A rare pediatric case report: Salvage transcatheter closure of atrial septal defect before parent-to-offspring living-donor liver transplantation. (PubMed, FASEB J) - "Her symptoms aggravated progressively despite various medications (e.g. Ursodeoxycholic Acid, Stronger Neo-Minophagen C Tablets) were prescribed...Accordingly, CPAP-assisted ventilation, injections of meropenem, vancomycin, and carprofen, as well as IVIG (2g/kg) and vitamin K1 were admitted...The large left-to-right shunt volume in the 9.7mm ASD was further exacerbated by heavy fluid loads formed during the rescues. Thus, transcatheter ASD occlusion was performed before liver transplantation to effectively manage the hemodynamic stability in perioperative period."

Journal • Anesthesia • Cardiovascular • Congestive Heart Failure • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Hepatology • Hypertension • Hypotension • Immunology • Infectious Disease • Liver Cirrhosis • Pediatrics • Pneumonia • Portal Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Transplantation

A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy. (PubMed, Ann Pharmacother) - " The percentages of concomitant use of Stronger Neo-Minophagen C (SNMC), a glycyrrhizin preparation, and vincristine were higher in the delayed group. Multiple logistic regression analysis revealed that the concomitant use of SNMC solely was a significant risk factor for delayed MTX (odds ratio = 12.20; 95% CI = 1.06-139.84). Conclusion and Relevance: Concomitant use of SNMC was shown to be related to delayed elimination of serum MTX, and our results suggested a previously unknown drug-drug interaction between MTX and SNMC."

Journal • Hematological Malignancies • Leukemia • Oncology • Osteosarcoma • Sarcoma

Initial Clinical Experience of the Herbal Medicine Inchinkoto for Refractory Hyperbilirubinemia Following Open-heart Surgery (PubMed, Kyobu Geka) - "They were initially treated with ursodeoxycholic acid and/or Stronger Neo-Minophagen C containing monoammonium glycyrrhizinate, glycine, aminoacetic acid, and L-cysteine hydrochloride hydrate. Hyperbilirubinemia improved in all patients after the introduction of Inchinkoto:1 day after in 1 case, 2 days after in 2 cases, 3 days after in 2 cases, and 4 days after in 1 case. These results indicate the potential of Inchinkoto to attenuate refractory hyperbilirubinemia following cardiac surgery with cardiopulmonary bypass."

Clinical • Journal

SNMC (Stronger Neo-Minophagen C ) for Acute Hepatitis Post Transarterial Chemoembolization Therapy (clinicaltrials.gov) - P4; N=60; Completed; Sponsor: Chimei Medical Center

Clinical • New P4 trial